LOCUS       NM_001330442            5446 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens metastasis associated 1 family member 3 (MTA3),
            transcript variant 4, mRNA.
ACCESSION   NM_001330442 XM_005264456
VERSION     NM_001330442.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5446)
  AUTHORS   You,Y., Cui,Y., Li,Y., Zhang,M., Wang,X., Ji,J., Zhang,X., Zhou,M.,
            Zhang,Z., Ye,S.D. and Wang,X.
  TITLE     Inhibition of MTA2 and MTA3 induces mesendoderm specification of
            human embryonic stem cells
  JOURNAL   Biochem Biophys Res Commun 552, 142-149 (2021)
   PUBMED   33744762
  REMARK    GeneRIF: Inhibition of MTA2 and MTA3 induces mesendoderm
            specification of human embryonic stem cells.
REFERENCE   2  (bases 1 to 5446)
  AUTHORS   Spruijt,C.G., Grawe,C., Kleinendorst,S.C., Baltissen,M.P.A. and
            Vermeulen,M.
  TITLE     Cross-linking mass spectrometry reveals the structural topology of
            peripheral NuRD subunits relative to the core complex
  JOURNAL   FEBS J 288 (10), 3231-3245 (2021)
   PUBMED   33283408
REFERENCE   3  (bases 1 to 5446)
  AUTHORS   Liu,L., Qi,X., Gui,Y., Huo,H., Yang,X. and Yang,L.
  TITLE     Overexpression of circ_0021093 circular RNA forecasts an
            unfavorable prognosis and facilitates cell progression by targeting
            the miR-766-3p/MTA3 pathway in hepatocellular carcinoma
  JOURNAL   Gene 714, 143992 (2019)
   PUBMED   31330234
  REMARK    GeneRIF: The circ_0021093/miR-766-3p/MTA3 regulatory axis may be an
            effective therapeutic target for HCC.
REFERENCE   4  (bases 1 to 5446)
  AUTHORS   Zhang,L., Cao,Y., Kou,X., Che,L., Zhou,X., Chen,G. and Zhao,J.
  TITLE     Long non-coding RNA HCG11 suppresses the growth of glioma by
            cooperating with the miR-4425/MTA3 axis
  JOURNAL   J Gene Med 21 (4), e3074 (2019)
   PUBMED   30706982
  REMARK    GeneRIF: LncRNA HCG11 suppresses the growth of glioma by
            cooperating with the miR-4425/MTA3 axis.
REFERENCE   5  (bases 1 to 5446)
  AUTHORS   Fadista,J., Skotte,L., Geller,F., Bybjerg-Grauholm,J., Gortz,S.,
            Romitti,P.A., Caggana,M., Kay,D.M., Matsson,H., Boyd,H.A.,
            Hougaard,D.M., Nordenskjold,A., Mills,J.L., Melbye,M. and
            Feenstra,B.
  TITLE     Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new
            loci associated with infantile hypertrophic pyloric stenosis
  JOURNAL   Hum Mol Genet 28 (2), 332-340 (2019)
   PUBMED   30281099
  REMARK    GeneRIF: associated with Infantile hypertrophic pyloric stenosis
            risk
REFERENCE   6  (bases 1 to 5446)
  AUTHORS   Fujita,N., Jaye,D.L., Kajita,M., Geigerman,C., Moreno,C.S. and
            Wade,P.A.
  TITLE     MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth
            pathway in breast cancer
  JOURNAL   Cell 113 (2), 207-219 (2003)
   PUBMED   12705869
  REMARK    GeneRIF: The absence of MTA3 leads to aberrant expression of Snail,
            a master regulator of epithelial to mesenchymal transitions. This
            results in loss of expression of E-cadherin, causing changes in
            epithelial architecture and invasive growth.
REFERENCE   7  (bases 1 to 5446)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   8  (bases 1 to 5446)
  AUTHORS   Wade,P.A., Gegonne,A., Jones,P.L., Ballestar,E., Aubry,F. and
            Wolffe,A.P.
  TITLE     Mi-2 complex couples DNA methylation to chromatin remodelling and
            histone deacetylation
  JOURNAL   Nat Genet 23 (1), 62-66 (1999)
   PUBMED   10471500
REFERENCE   9  (bases 1 to 5446)
  AUTHORS   Zhang,Y., Ng,H.H., Erdjument-Bromage,H., Tempst,P., Bird,A. and
            Reinberg,D.
  TITLE     Analysis of the NuRD subunits reveals a histone deacetylase core
            complex and a connection with DNA methylation
  JOURNAL   Genes Dev 13 (15), 1924-1935 (1999)
   PUBMED   10444591
REFERENCE   10 (bases 1 to 5446)
  AUTHORS   Zhang,Y., LeRoy,G., Seelig,H.P., Lane,W.S. and Reinberg,D.
  TITLE     The dermatomyositis-specific autoantigen Mi2 is a component of a
            complex containing histone deacetylase and nucleosome remodeling
            activities
  JOURNAL   Cell 95 (2), 279-289 (1998)
   PUBMED   9790534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025750.10, AC074375.7 and AC098824.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001330442.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (c).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.215135.1,
                                           SRR1803617.44611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405094.2/ ENSP00000385823.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC025750.10        132532-132673
            143-210             AC025750.10        134337-134404
            211-304             AC025750.10        143007-143100
            305-431             AC074375.7         23991-24117
            432-495             AC074375.7         54706-54769
            496-613             AC074375.7         58660-58777
            614-716             AC074375.7         70733-70835
            717-816             AC074375.7         74296-74395
            817-1005            AC074375.7         96934-97122
            1006-1080           AC098824.3         3408-3482
            1081-1139           AC098824.3         5419-5477
            1140-1264           AC098824.3         11837-11961
            1265-1416           AC098824.3         15546-15697
            1417-1639           AC098824.3         16517-16739
            1640-1726           AC098824.3         26631-26717
            1727-1873           AC098824.3         30532-30678
            1874-5446           AC098824.3         61017-64589
FEATURES             Location/Qualifiers
     source          1..5446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..5446
                     /gene="MTA3"
                     /note="metastasis associated 1 family member 3"
                     /db_xref="GeneID:57504"
                     /db_xref="HGNC:HGNC:23784"
                     /db_xref="MIM:609050"
     exon            1..142
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1899
                     /gene="MTA3"
                     /note="isoform c is encoded by transcript variant 4;
                     metastasis associated gene family, member 3;
                     metastasis-associated protein MTA3"
                     /codon_start=1
                     /product="metastasis-associated protein MTA3 isoform c"
                     /protein_id="NP_001317371.1"
                     /db_xref="CCDS:CCDS82441.1"
                     /db_xref="GeneID:57504"
                     /db_xref="HGNC:HGNC:23784"
                     /db_xref="MIM:609050"
                     /translation="MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVC
                     FYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPA
                     THIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADI
                     PEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQ
                     PSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEA
                     SLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKL
                     KQVYIPTYSKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYS
                     WGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGM
                     PVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAE
                     YADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTP
                     NHTSLSILGKRNYSHHNGLDELTCCVSD"
     exon            143..210
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            211..304
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            305..431
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..495
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..613
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..716
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            717..816
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1005
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1080
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1139
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1264
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1416
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1639
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1726
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1873
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..5446
                     /gene="MTA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5427..5432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTA3"
                     /note="hexamer: AATAAA"
     polyA_site      5446
                     /gene="MTA3"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgaggc agcagcgacg gcggcggcgg cagcggcggt cgcggctgag gctgaggagg
       61 aggcggcggc ggcgggcggg gctcggctcg ggctccgcgg gcgggcgggc ggacatggcg
      121 gccaacatgt accgggtcgg agattatgtc tactttgaga attcctccag caacccatac
      181 ctaataagaa ggatagaaga actcaacaag actgcaagtg gcaacgtgga agcaaaagta
      241 gtatgctttt atagacgacg tgatatttcc aacacactta taatgctcgc agataagcat
      301 gctaaagaaa ttgaggaaga atctgaaaca acagttgagg ctgacttgac cgataagcag
      361 aaacatcagt tgaaacatag ggaactcttt ttgtcacgcc agtatgaatc tctgcccgca
      421 acacatatca ggggaaagtg cagtgttgcc cttctgaatg agacagaatc agtattgtca
      481 tatcttgata aggaggatac cttcttctac tcattggtct atgacccctc attgaaaaca
      541 ctattagctg acaaaggtga aatcagagtg ggacctagat atcaagcaga cattccagaa
      601 atgctgttag aaggagaatc agatgagagg gaacaatcaa aattggaagt taaagtttgg
      661 gatccaaata gcccacttac ggatcgacag attgaccagt ttttagttgt agcacgtgct
      721 gttgggacat tcgccagagc cctggattgc agcagttctg tgaggcagcc tagtttgcat
      781 atgagtgctg ctgcagcttc ccgagacatc accttgtttc acgctatgga tacattgtat
      841 agacacagct atgatttgag cagtgccatt agtgtcttag taccactcgg aggacctgtt
      901 ttatgcagag atgaaatgga ggaatggtca gcctctgaag ctagcttatt tgaagaggca
      961 ctggaaaaat atggcaaaga cttcaatgac atacggcaag attttcttcc ttggaaatca
     1021 ttgactagca tcattgaata ttattacatg tggaaaacta ctgacagata tgtgcaacag
     1081 aaacgtctaa aagcagcaga agctgagagt aaactgaaac aagtatatat cccaacctac
     1141 agcaaaccaa atcccaacca aatatccact agtaatggga agcctggtgc tgtgaatgga
     1201 gctgtgggga ccacgttcca gcctcagaat cctctcttag ggagagcctg tgagagctgc
     1261 tatgctacac agtctcacca gtggtattct tggggcccac ctaatatgca gtgtagatta
     1321 tgtgcaattt gttggcttta ttggaaaaaa tatggaggct tgaaaatgcc cacccagtca
     1381 gaagaagaga agttatctcc tagcccaact acagaggacc ctcgtgttag aagtcacgtg
     1441 tcccgccagg ccatgcaggg aatgccagtc cgaaacactg ggagtccaaa gtctgcagtg
     1501 aagacccgcc aagctttctt ccttcatact acatatttca caaaatttgc tcgtcaggtc
     1561 tgcaaaaata ccctccggct gcggcaggca gcaagacggc cgtttgttgc tattaattat
     1621 gctgccatta gggcagaata tgcagacaga catgctgaac tatctggaag tccactgaaa
     1681 agcaaaagca ctaggaagcc tttggcatgt atcattgggt atttagagat ccatcctgca
     1741 aagaaaccta atgtaattcg atctacacca agcctgcaaa ccccaactac caagcggatg
     1801 ctaacaactc caaatcacac atctctgagc attctgggga aaagaaacta cagtcatcac
     1861 aatggtctgg atgaactcac gtgctgtgtg tcagactgag ctttccctga ttcattctac
     1921 aatccaagac ttgctgcact gtcctgctga tgttcacagc cgtgcctggg aagaaggcag
     1981 ccccactccc agtacatttc agtgggagac ctctgcgtgc atccatggag acgcaatggg
     2041 gcggggaagg aactgtggga gtgcacgttc caaatcctgt gtctccacgt gtggatcagc
     2101 agcacctcgc tttcttgtca gagacctcgc tgttacggag cgagacctgc tgagaattga
     2161 ggggctgagg gaacccctcc acctcctccc ttctgcagcg ccctgcgccc cacccagcaa
     2221 cagcggccac ttggcagtgg ggctgctgca agctcagagc cgctgccacc ctgcatgtgt
     2281 ccgctcagct cggtcttatg ctgtatagtt actaaatatg tacaggaggg ccatggcatc
     2341 tttctgaatg gatttttctt aagaaatgcg ccagtgttta tgaggttcaa ggtatttccc
     2401 tgtccttgct gttaccgtca ctcagctttt tctcgatagg cttcatcctt gtttttttga
     2461 aatgggggaa tttgctgttt accctctgca ttcctatatg tgaccctccc tcctactcct
     2521 ccaaggaaca gaattaccga ggttctgaca aaagataagc ctgtaaactc atcatctgtg
     2581 ttttgtggtt ggagagaaac tggtgttctg cccggctctg cttggtcaca gacagctcca
     2641 gcaagagcag ttgttaaaag tgccaagcgt gtgtatcact gtgacaagcc gtttgcttac
     2701 tgccctgttc ccttgcagcc aaaccagctg atgaagaact gctgccaggt gggtcctaca
     2761 gcaggtcaca aatgacctag tttcatttta agcagacaga ctctgtttgg cctagaggtg
     2821 tggagtgaga gaactgtgtt tgtgggtatg agtctgtgtg gccaacccca tgacccccac
     2881 ccctccagcc caacatcttg tgagcacatg tgacctaggc cccgggggac ctgcctgctc
     2941 ctttggcttg ggctcttcgt gtttcccacc tgccctcggc acgagccctt ggtggcatca
     3001 cagttggcca ctcagctgtg ctgagtagct gtgctacttg tgctggcagc tgcaaggata
     3061 ggaatagctc agcgcccgat gagctccctg agcagatgtg aggctggcaa ctcccctgcc
     3121 ctctgtttgc aggcacaggg tcacagtccc aagaaagaca actggagtct gatctcccag
     3181 ccatctctgg ggttactagg aggcagctgg atggcagata cgagaggccc aaatagccaa
     3241 gctgttgcaa gacagagtgg ctacaattga attgacaccc tgggaagcac gaggtaactt
     3301 ggtaaggata atgatgctgt agatgtctgt gtcctcggag gctgagctcc gcttggcaga
     3361 gagagcgtgc tgtgtgaggt ggagggcggt tttgcagaca tctcagcttc ttttctgagg
     3421 aggagttggt tctcatctta ggcttctgca agggcgagca tgggatgtct ccaccaccac
     3481 ccactcttgg agctgtgctg ggtcttggct tggggcgctg agggtggggc ctgtgtcaga
     3541 agcatttggt gagaggggtg gaggtggcag gcaggggttc tcctcagggt tcccactgag
     3601 gggtcccttc agcaaagacc tgggaggagg tgccgcatca cgtggatgtt tcttccctaa
     3661 agaaaaagac acaggaaagc tgtctgtctg taccctgctc tggatttatt gtcgtacttg
     3721 gacccagaag gggaaatgat tccctcaccc tttcactttc tctctgaacc cctactaagt
     3781 ggtgactgca gattctggaa acaattagct gcccgtgact cagctgccag cttcattttc
     3841 tctgcctttt gggagaggcc ctctcaccca ggcccaagag atttggagac aggagtcagg
     3901 ccaggtctga agcaggagaa gggaggcccc tcctatctac ccagttgaca tttggctttg
     3961 ggaaaagcgc agcttgttcg agccacgtgt gccaagcagg cttttccttc ctcttgtaag
     4021 taaagctcgt ggttctgtag tccagtcatc ctaggagggt gatgttgact gagacttcac
     4081 gctctccctt tgtctctgga aactgccccc tcgttctgac agaatccccc aggcaatgga
     4141 ggaagggtgc cgaggcgcct ctagtctgtg cctttgccgt tggaagcatt tggtgctgag
     4201 agggtttccc agccacccgc tccctttctg gggccatggt gtccctgctg tgtgtcagtg
     4261 gcatgtcact gtggttcagt gagcacatgg gtggacgtgc agagactgtc tgcgcagccc
     4321 ccagcagaca tgcccctggg gtgaggacac aggctctgca ggctatctcc ccctctggct
     4381 cagtcatcgc ctgcccaccc ttcacttctt aaaggtgcgc aagagaggag ggccgactgg
     4441 agggtgtcgc cggaaggttt cagcctgccc ttcacaattc cccttgtgca cagcccagtt
     4501 tccatctctc agggcccacc caggaaaatg gatttcaagt gggggttttc atccagagat
     4561 ttgtttaaca caaaacaaga aaagctgaga ggcaaaacag gggagtgagg ggcaacccag
     4621 aggtggggaa caacaacagc aagccgcccc catcctgaga ctggctgggc accaggggag
     4681 gacgcgtcac cagagcctgg ggccaaggcc actgggggac ctgccacact gtggacctgt
     4741 ctggtggggg ctggagcctc gagaagccat gattcttgtc agaaacattt ccccaggcag
     4801 agagaggggg ccccagcctc tcccctcctc ttggcctcca gagtcctgca ggtgcctcac
     4861 agtagtgaaa cccagttgga agcagctgcc ctgggagcct gggacaggcg acccaccggg
     4921 tcagtcccct gccactcaga gcagagcagg gggctgaggg caagcaggtg gggctgtgcg
     4981 tggcctcagt gcactcggtg tcatgtctga gcctggtgtt tatgccccac tgctgtccta
     5041 agtccctggc gaggggaggt ggaggagctg ccccgtgggt gtttggagat tctgttttac
     5101 tctgcctaga gaggaaacgg ctttggggag ggagggggaa gcctttattc tttactgttg
     5161 tccctgtttt cctttggggg aatttactca gttagcagcc cctcctcacc attcccccca
     5221 ggaaggccat gtcccagttt tctgtccacc cctcctgttc ctctgcacta tgtctctgat
     5281 tttccctgcc agggaagcta acccagagca cgcacctgtg ctcatgagtg tttccgcagg
     5341 ataattcgtt ctgagcatga taccacagtg tggattgtct gtctgtaagg agatgccatc
     5401 tactaaccaa tttgtattgt gtttccaata aattcctgga aatttt
//
