LOCUS       NM_004739               3083 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens metastasis associated 1 family member 2 (MTA2),
            transcript variant 1, mRNA.
ACCESSION   NM_004739
VERSION     NM_004739.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3083)
  AUTHORS   Morgenstern,E., Molthof,C., Schwartz,U., Graf,J., Bruckmann,A.,
            Hombach,S. and Kretz,M.
  TITLE     lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress
            premature human epidermal differentiation
  JOURNAL   Life Sci Alliance 7 (7), e202302475 (2024)
   PUBMED   38649186
  REMARK    GeneRIF: lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress
            premature human epidermal differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3083)
  AUTHORS   Xie,G., Lei,B., Yin,Z., Xu,F. and Liu,X.
  TITLE     CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2
            Degradation via Interacting with UCHL3
  JOURNAL   Int J Mol Sci 25 (5), 2817 (2024)
   PUBMED   38474064
  REMARK    GeneRIF: CircMTA2 Drives Gastric Cancer Progression through
            Suppressing MTA2 Degradation via Interacting with UCHL3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3083)
  AUTHORS   Huang,X., Tan,J., Chen,M., Zheng,W., Zou,S., Ye,X., Li,Y. and Wu,M.
  TITLE     Prognostic, Immunological, and Mutational Analysis of MTA2 in
            Pan-Cancer and Drug Screening for Hepatocellular Carcinoma
  JOURNAL   Biomolecules 13 (6), 883 (2023)
   PUBMED   37371463
  REMARK    GeneRIF: Prognostic, Immunological, and Mutational Analysis of MTA2
            in Pan-Cancer and Drug Screening for Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3083)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3083)
  AUTHORS   Wade,P.A., Gegonne,A., Jones,P.L., Ballestar,E., Aubry,F. and
            Wolffe,A.P.
  TITLE     Mi-2 complex couples DNA methylation to chromatin remodelling and
            histone deacetylation
  JOURNAL   Nat Genet 23 (1), 62-66 (1999)
   PUBMED   10471500
REFERENCE   6  (bases 1 to 3083)
  AUTHORS   Zhang,Y., Ng,H.H., Erdjument-Bromage,H., Tempst,P., Bird,A. and
            Reinberg,D.
  TITLE     Analysis of the NuRD subunits reveals a histone deacetylase core
            complex and a connection with DNA methylation
  JOURNAL   Genes Dev 13 (15), 1924-1935 (1999)
   PUBMED   10444591
REFERENCE   7  (bases 1 to 3083)
  AUTHORS   Futamura,M., Nishimori,H., Shiratsuchi,T., Saji,S., Nakamura,Y. and
            Tokino,T.
  TITLE     Molecular cloning, mapping, and characterization of a novel human
            gene, MTA1-L1, showing homology to a metastasis-associated gene,
            MTA1
  JOURNAL   J Hum Genet 44 (1), 52-56 (1999)
   PUBMED   9929979
REFERENCE   8  (bases 1 to 3083)
  AUTHORS   Xue,Y., Wong,J., Moreno,G.T., Young,M.K., Cote,J. and Wang,W.
  TITLE     NURD, a novel complex with both ATP-dependent chromatin-remodeling
            and histone deacetylase activities
  JOURNAL   Mol Cell 2 (6), 851-861 (1998)
   PUBMED   9885572
REFERENCE   9  (bases 1 to 3083)
  AUTHORS   Tong,J.K., Hassig,C.A., Schnitzler,G.R., Kingston,R.E. and
            Schreiber,S.L.
  TITLE     Chromatin deacetylation by an ATP-dependent nucleosome remodelling
            complex
  JOURNAL   Nature 395 (6705), 917-921 (1998)
   PUBMED   9804427
REFERENCE   10 (bases 1 to 3083)
  AUTHORS   Zhang,Y., LeRoy,G., Seelig,H.P., Lane,W.S. and Reinberg,D.
  TITLE     The dermatomyositis-specific autoantigen Mi2 is a component of a
            complex containing histone deacetylase and nucleosome remodeling
            activities
  JOURNAL   Cell 95 (2), 279-289 (1998)
   PUBMED   9790534
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001458.6, AL561056.3,
            BC053650.1, BQ574987.1 and AI380395.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004739.3.
            
            Summary: This gene encodes a protein that has been identified as a
            component of NuRD, a nucleosome remodeling deacetylase complex
            identified in the nucleus of human cells. It shows a very broad
            expression pattern and is strongly expressed in many tissues. It
            may represent one member of a small gene family that encode
            different but related proteins involved either directly or
            indirectly in transcriptional regulation. Their indirect effects on
            transcriptional regulation may include chromatin remodeling. It is
            closely related to another member of this family, a protein that
            has been correlated with the metastatic potential of certain
            carcinomas. These two proteins are so closely related that they
            share the same types of domains. These domains include two DNA
            binding domains, a dimerization domain, and a domain commonly found
            in proteins that methylate DNA. One of the proteins known to be a
            target protein for this gene product is p53. Deacetylation of p53
            is correlated with a loss of growth inhibition in transformed cells
            supporting a connection between these gene family members and
            metastasis. [provided by RefSeq, May 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053650.1, AB016591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278823.7/ ENSP00000278823.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AP001458.6         9108-9132           c
            26-207              AL561056.3         1-182
            208-2855            BC053650.1         1-2648
            2856-2861           BQ574987.1         240-245             c
            2862-3083           AI380395.1         12-233              c
FEATURES             Location/Qualifiers
     source          1..3083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..3083
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /note="metastasis associated 1 family member 2"
                     /db_xref="GeneID:9219"
                     /db_xref="HGNC:HGNC:7411"
                     /db_xref="MIM:603947"
     exon            1..443
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..2422
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metastasis-associated protein 2; metastasis associated
                     gene family, member 2; metastasis-associated 1-like 1;
                     metastasis -associated gene 1-like 1;
                     metastasis-associated protein MTA2; MTA1-L1 protein; p53
                     target protein in deacetylase complex"
                     /codon_start=1
                     /product="metastasis-associated protein MTA2 isoform 1"
                     /protein_id="NP_004730.2"
                     /db_xref="CCDS:CCDS8022.1"
                     /db_xref="GeneID:9219"
                     /db_xref="HGNC:HGNC:7411"
                     /db_xref="MIM:603947"
                     /translation="MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVC
                     LFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHI
                     RGKCSVTLLNETDILSQYLEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKYQAEIPDR
                     LVEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSL
                     HMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLF
                     EEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQKRLKAAEADSKLKQV
                     YIPTYTKPNPNQIISVGSKPGMNGAGFQKGLTCESCHTTQSAQWYAWGPPNMQCRLCA
                     SCWIYWKKYGGLKTPTQLEGATRGTTEPHSRGHLSRPEAQSLSPYTTSANRAKLLAKN
                     RQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRLPKAAKTPLK
                     IHPLVRLPLATIVKDLVAQAPLKPKTPRGTKTPINRNQLSQNRGLGGIMVKRAYETMA
                     GAGVPFSANGRPLASGIRSSSQPAAKRQKLNPADAPNPVVFVATKDTRALRKALTHLE
                     MRRAARRPNLPLKVKPTLIAVRPPVPLPAPSHPASTNEPIVLED"
     exon            444..511
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            512..605
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            606..723
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            724..787
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            788..905
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1008
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1108
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1297
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1372
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1431
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1529
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1669
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1898
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1988
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2107
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2256
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..3083
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3002..3007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /note="major polyA site"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /note="hexamer: AATAAA"
     polyA_site      3083
                     /gene="MTA2"
                     /gene_synonym="MTA1L1; PID"
                     /note="major polyA site"
ORIGIN      
        1 agtgggcctt gttctccgga tcggccgaag gtgttccgga aggaggcgaa ccctgaggcg
       61 ggcccggcaa gccttccctg cggccggcag agcccaacga ctagtgggac tccgcggggg
      121 cgggggtagc tggagcctgg ctctggcctg gcaggagccg agctcgttcc ggaagaagcc
      181 gagcggacgg gggccagcct cagcgtcccg ggagtgaggc gatagctgcg gcggcgacag
      241 cgcgggccgg gatgaaccgc gacggctgag gcagcggagg tgccggctgc gcgggcccca
      301 gtgagactcc ctcgaagcgg cagcccaccg ttcggggctt tgcctcgagc cgagccctgc
      361 ccccgcgagc ctcccggacc cctttgtgcg gccggaggcg gcggcgggaa cggccatggc
      421 ggccaacatg taccgggtgg gagattacgt ctattttgag aactcttcca gcaatcctta
      481 cctggttaga cggattgagg agctcaacaa gactgcaaat ggaaatgtgg aggcaaaggt
      541 tgtctgtctt ttccggcgca gggacatttc tagtagcctc aacagcctgg ctgatagtaa
      601 tgccagggag tttgaagagg aatcaaagca gccaggggtg tctgagcagc agcgccatca
      661 actgaagcac cgggaacttt ttctttctcg gcaatttgaa tcattaccag ccacccacat
      721 acgggggaaa tgcagtgtga ccctcttgaa tgagacagat atcttgagcc agtacctgga
      781 aaaggaggac tgcttttttt actcactggt gtttgacccc gtgcagaaga cacttctcgc
      841 tgatcagggc gagattagag ttggttgcaa ataccaagct gagatcccag atcgcctagt
      901 agagggagaa tctgataatc ggaaccagca gaagatggag atgaaggtct gggacccaga
      961 caaccctctc acagaccggc agatcgacca gtttcttgtg gtggcccgag ctgtgggaac
     1021 ctttgcaaga gccctagatt gtagcagctc cattcggcag ccaagcttgc acatgagtgc
     1081 agctgctgcc tcccgagata tcactctgtt tcacgccatg gataccttgc aaaggaacgg
     1141 ctacgacctg gctaaggcca tgtcgaccct ggtaccccag ggaggcccgg tgctgtgtcg
     1201 ggatgagatg gaggaatggt cagcctcaga ggccatgcta tttgaggagg ccctagagaa
     1261 gtatgggaag gacttcaatg atattcgcca ggattttcta ccctggaagt cacttgccag
     1321 catagtccag ttttattaca tgtggaaaac cacagaccgg tatattcagc agaaaaggtt
     1381 gaaagctgct gaagcagaca gcaaactgaa acaggtctac attcccacct acactaagcc
     1441 aaaccctaac cagatcattt ctgtgggttc aaaacctggc atgaatgggg ctggatttca
     1501 gaagggcctg acttgtgaga gttgccacac cacacagtct gctcagtggt atgcctgggg
     1561 cccacctaac atgcagtgcc gcctctgtgc ttcctgttgg atctactgga agaagtatgg
     1621 gggactgaag accccaactc agcttgaggg ggccactcgg ggcaccacgg agccacactc
     1681 aaggggtcat ttatccagac ctgaagctca aagtctctct ccttacacaa ccagcgccaa
     1741 cagggccaag ctactggcta agaacagaca aactttcctg cttcagacca caaagctgac
     1801 ccgtcttgcc agacgcatgt gcagggacct attacagcca aggagggccg cccgacggcc
     1861 ttatgctcct atcaatgcca atgccatcaa agcagagtgc tccattcgac ttcctaaggc
     1921 cgccaagact ccattgaaga ttcaccctct ggtgcggctg cccctggcaa ctatcgtcaa
     1981 agatctggtg gcccaggcac ccctgaaacc aaaaacacct cggggtacca agacaccgat
     2041 caacagaaac cagctgtccc agaaccgggg actggggggc attatggtga aacgggccta
     2101 tgagactatg gcaggggcag gggttccttt ctctgccaat ggaaggcctc tggcttcagg
     2161 gattcgttca agctcacagc cagcagccaa gcgtcagaaa ctaaacccag ctgatgcccc
     2221 caatcctgtg gtgtttgtgg ccacaaagga taccagggcc ctacggaagg ctctgaccca
     2281 tctggaaatg cggcgagctg ctcgccgacc caacttgccc ctgaaggtga agccaacgct
     2341 gattgcagtg cggccccctg tccctctacc tgcaccctca catcctgcca gcaccaatga
     2401 gcctattgtc ctggaggact gagcacctgt ggggaaggga ggtgggctga gaggtagagg
     2461 gtggatgccc agggcaccca aacctccctt ccctttcgtg tcgaagggag tgaggagtga
     2521 attaaggaag agagcaagtg agtgtgtgtc cctggagggg ttgggcgccc tctggtgtta
     2581 ccacctcgag acttgtctca tgcctccatg cttgccgatg gaggacagac tgcaggaact
     2641 tggcccatgt gggaacctag cctgttttgg ggggtaggac ccacagatgt cttggacagt
     2701 tttgggggga gggtttttta attttttaaa aattttgcct ccctttgtga aaggggatgg
     2761 ggaggggaag agtaaacaga taacaggtgg tggtacctgg ttgggggagg ggggcgtgca
     2821 ctgccatgtc tttttttttt tttttttttt tttttttcct aattgggggt ttctctttct
     2881 gtccggtgtc cggactttcc taattggagt ttgaggcccc taagctggca tcaaccccag
     2941 gccacgctcg ctctttcctt ccctcccctc cccctctgcc ttttgtacgc cagttctcag
     3001 aaataaagat cttttgtccg tttttttaac ctcggattct gtaattggtt cttatagtaa
     3061 caaataaaaa gctgttttct tca
//
