LOCUS       NM_004689               2871 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens metastasis associated 1 (MTA1), transcript variant 1,
            mRNA.
ACCESSION   NM_004689
VERSION     NM_004689.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Wanka,G., Jueckstock,J., Wild,C.M., Vattai,A., Furst,S.,
            Heidegger,H.H., Kuhn,C., Schmoeckel,E., Jeschke,U. and Dannecker,C.
  TITLE     MTA1 as negative prognostic marker in vulvar carcinoma
  JOURNAL   J Cancer Res Clin Oncol 149 (9), 6191-6201 (2023)
   PUBMED   36689059
  REMARK    GeneRIF: MTA1 as negative prognostic marker in vulvar carcinoma.
REFERENCE   2  (bases 1 to 2871)
  AUTHORS   Sun,F.Z., Wang,J.S., Li,C.X., Wang,T., Zhang,J.Y., Zhou,Y.T.,
            Wang,H.J. and Qian,H.L.
  TITLE     [The role and mechanism of tumor metastasis-associated gene 1 in
            radiosensitivity of HeLa cells]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 44 (9), 962-967 (2022)
   PUBMED   36164698
  REMARK    GeneRIF: [The role and mechanism of tumor metastasis-associated
            gene 1 in radiosensitivity of HeLa cells].
REFERENCE   3  (bases 1 to 2871)
  AUTHORS   Vattem,C. and Pakala,S.B.
  TITLE     Metastasis-associated protein 1: A potential driver and regulator
            of the hallmarks of cancer
  JOURNAL   J Biosci 47 (2022)
   PUBMED   36210748
  REMARK    GeneRIF: Metastasis-associated protein 1: A potential driver and
            regulator of the hallmarks of cancer.
            Review article
REFERENCE   4  (bases 1 to 2871)
  AUTHORS   Kumar,R., Balasenthil,S., Pakala,S.B., Rayala,S.K., Sahin,A.A. and
            Ohshiro,K.
  TITLE     Metastasis-associated protein 1 short form stimulates Wnt1 pathway
            in mammary epithelial and cancer cells
  JOURNAL   Cancer Res 70 (16), 6598-6608 (2010)
   PUBMED   20710043
REFERENCE   5  (bases 1 to 2871)
  AUTHORS   Kumar,R., Balasenthil,S., Manavathi,B., Rayala,S.K. and Pakala,S.B.
  TITLE     Metastasis-associated protein 1 and its short form variant
            stimulates Wnt1 transcription through promoting its derepression
            from Six3 corepressor
  JOURNAL   Cancer Res 70 (16), 6649-6658 (2010)
   PUBMED   20682799
REFERENCE   6  (bases 1 to 2871)
  AUTHORS   Singh,R.R., Kaluarachchi,K., Chen,M., Rayala,S.K., Balasenthil,S.,
            Ma,J. and Kumar,R.
  TITLE     Solution structure and antiestrogenic activity of the unique
            C-terminal, NR-box motif-containing region of MTA1s
  JOURNAL   J Biol Chem 281 (35), 25612-25621 (2006)
   PUBMED   16807247
  REMARK    GeneRIF: structure and antiestrogenic activity of the unique
            C-terminal, NR-box motif-containing region of MTA1
            Erratum:[J Biol Chem. 2013 Sep 20;288(38):27518]
REFERENCE   7  (bases 1 to 2871)
  AUTHORS   Mishra,S.K., Yang,Z., Mazumdar,A., Talukder,A.H., Larose,L. and
            Kumar,R.
  TITLE     Metastatic tumor antigen 1 short form (MTA1s) associates with
            casein kinase I-gamma2, an estrogen-responsive kinase
  JOURNAL   Oncogene 23 (25), 4422-4429 (2004)
   PUBMED   15077195
  REMARK    GeneRIF: MTA1s interacts with CKI-gamma2 in vitro and in vivo and
            colocalizes in the cytoplasm
REFERENCE   8  (bases 1 to 2871)
  AUTHORS   Kumar,R., Wang,R.A., Mazumdar,A., Talukder,A.H., Mandal,M.,
            Yang,Z., Bagheri-Yarmand,R., Sahin,A., Hortobagyi,G., Adam,L.,
            Barnes,C.J. and Vadlamudi,R.K.
  TITLE     A naturally occurring MTA1 variant sequesters oestrogen
            receptor-alpha in the cytoplasm
  JOURNAL   Nature 418 (6898), 654-657 (2002)
   PUBMED   12167865
  REMARK    GeneRIF: naturally occurring short form that contains a previously
            unknown sequence of 33 amino acids with an ER-binding motif,
            Leu-Arg-Ile-Leu-Leu (LRILL); MTA1s localizes in the cytoplasm,
            sequesters ER in the cytoplasm, and enhances non-genomic responses
            of ER
REFERENCE   9  (bases 1 to 2871)
  AUTHORS   Toh,Y., Pencil,S.D. and Nicolson,G.L.
  TITLE     Analysis of the complete sequence of the novel
            metastasis-associated candidate gene, mta1, differentially
            expressed in mammary adenocarcinoma and breast cancer cell lines
  JOURNAL   Gene 159 (1), 97-104 (1995)
   PUBMED   7607577
REFERENCE   10 (bases 1 to 2871)
  AUTHORS   Toh,Y., Pencil,S.D. and Nicolson,G.L.
  TITLE     A novel candidate metastasis-associated gene, mta1, differentially
            expressed in highly metastatic mammary adenocarcinoma cell lines.
            cDNA cloning, expression, and protein analyses
  JOURNAL   J Biol Chem 269 (37), 22958-22963 (1994)
   PUBMED   8083195
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL928654.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004689.3.
            
            Summary: This gene encodes a protein that was identified in a
            screen for genes expressed in metastatic cells, specifically,
            mammary adenocarcinoma cell lines. Expression of this gene has been
            correlated with the metastatic potential of at least two types of
            carcinomas although it is also expressed in many normal tissues.
            The role it plays in metastasis is unclear. It was initially
            thought to be the 70kD component of a nucleosome remodeling
            deacetylase complex, NuRD, but it is more likely that this
            component is a different but very similar protein. These two
            proteins are so closely related, though, that they share the same
            types of domains. These domains include two DNA binding domains, a
            dimerization domain, and a domain commonly found in proteins that
            methylate DNA. The profile and activity of this gene product
            suggest that it is involved in regulating transcription and that
            this may be accomplished by chromatin remodeling. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (MTA1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142941.1, U35113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331320.12/ ENSP00000333633.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AL928654.1         98245-98481
            238-305             AL928654.1         117090-117157
            306-399             AL928654.1         123836-123929
            400-450             AL928654.1         127777-127827
            451-577             AL928654.1         128476-128602
            578-641             AL928654.1         128679-128742
            642-759             AL928654.1         132611-132728
            760-862             AL928654.1         136688-136790
            863-962             AL928654.1         138776-138875
            963-1151            AL928654.1         139183-139371
            1152-1226           AL928654.1         141602-141676
            1227-1285           AL928654.1         141911-141969
            1286-1401           AL928654.1         142450-142565
            1402-1553           AL928654.1         142834-142985
            1554-1743           AL928654.1         143092-143281
            1744-1833           AL928654.1         143512-143601
            1834-1986           AL928654.1         144844-144996
            1987-2022           AL928654.1         145125-145160
            2023-2054           AL928654.1         147885-147916
            2055-2206           AL928654.1         148259-148410
            2207-2871           AL928654.1         148483-149147
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2871
                     /gene="MTA1"
                     /note="metastasis associated 1"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
     exon            1..237
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2357
                     /gene="MTA1"
                     /note="isoform MTA1 is encoded by transcript variant 1;
                     metastasis associated gene 1 protein"
                     /codon_start=1
                     /product="metastasis-associated protein MTA1 isoform MTA1"
                     /protein_id="NP_004680.2"
                     /db_xref="CCDS:CCDS32169.1"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
                     /translation="MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVC
                     FYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQ
                     LRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTL
                     LADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVAR
                     SVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQG
                     GPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTD
                     RYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRA
                     CESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSP
                     HGLPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAI
                     KAECTARLPEASQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPA
                     KVAPVINNGSPTILGKRSYEQHNGVDGNMKKRLLMPSRGLANHGQARHMGPSRNLLLN
                     GKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAAR
                     RPYKPIALRQSQALPPRPPPPAPVNDEPIVIED"
     exon            238..305
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..399
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..450
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..577
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..641
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..759
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..862
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..962
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1151
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1285
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1401
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1553
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1743
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1833
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1986
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2022
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2054
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2206
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2871
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2851..2856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTA1"
                     /note="hexamer: TATAAA"
     polyA_site      2871
                     /gene="MTA1"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcctct cccgcccgcg ccgcggccct cccgtccctg cgcggcctcg gcggcctcgg
       61 cggcggcggc ggcggcggcg gcggcagcag cgcggcccct ttaaacgcct gcggcgcccc
      121 ccgcccccgc catcgcgcct ccattttccc ggccgcccgc gccgagcgcc gcgcccgccc
      181 cgggcccctc cgccgccgcc ggcccggaca tggccgccaa catgtacagg gtcggagact
      241 acgtctactt tgagaactcc tccagcaacc catacctgat ccggagaatc gaggagctca
      301 acaagacggc caatgggaac gtggaggcca aagtggtgtg cttctaccgg aggcgggaca
      361 tctccagcac cctcatcgcc ctggccgaca agcacgcaac cctgtcagtc tgctataagg
      421 ccggaccggg ggcggacaac ggcgaggaag gggaaataga agaggaaatg gagaacccgg
      481 aaatggtgga cctgcccgag aaactaaagc accagctgcg gcatcgggag ctgttcctct
      541 cccggcagct ggagtctctg cccgccacgc acatcagggg caagtgcagc gtcaccctgc
      601 tcaacgagac cgagtcgctc aagtcctacc tggagcggga ggatttcttc ttctattctc
      661 tagtctacga cccacagcag aagaccctgc tggcagataa aggagagatt cgagtaggaa
      721 accggtacca ggcagacatc accgacttgt taaaagaagg cgaggaggat ggccgagacc
      781 agtccaggtt ggagacccag gtgtgggagg cgcacaaccc actcacagac aagcagatcg
      841 accagttcct ggtggtggcc cgctctgtgg gcaccttcgc acgggccctg gactgcagca
      901 gctccgtccg acagcccagc ctgcacatga gcgccgcagc tgcctcccga gacatcaccc
      961 tgttccacgc catggatact ctccacaaga acatctacga catctccaag gccatctcgg
     1021 cgctggtgcc gcagggcggg cccgtgctct gcagggacga gatggaggag tggtctgcat
     1081 cagaggccaa ccttttcgag gaagccctgg aaaaatatgg gaaggatttc acggacattc
     1141 agcaagattt tctcccgtgg aagtcgctga ccagcatcat tgagtactac tacatgtgga
     1201 agaccaccga cagatacgtg cagcagaaac gcttgaaagc agctgaagct gagagcaagt
     1261 taaagcaagt ttatattccc aactataaca agccaaatcc gaaccaaatc agcgtcaaca
     1321 acgtcaaggc cggtgtggtg aacggcacgg gggcgccggg ccagagccct ggggctggcc
     1381 gggcctgcga gagctgttac accacacagt cttaccagtg gtattcttgg ggtcccccta
     1441 acatgcagtg tcgtctctgc gcatcttgtt ggacatattg gaagaaatat ggtggcttga
     1501 aaatgccaac ccggttagat ggagagaggc caggaccaaa ccgcagtaac atgagtcccc
     1561 acggcctccc agcccggagc agcgggagcc ccaagtttgc catgaagacc aggcaggctt
     1621 tctatctgca cacgacgaag ctgacgcgga tcgcccggcg cctgtgccgt gagatcctgc
     1681 gcccgtggca cgctgcgcgg cacccctacc tgcccatcaa cagcgcggcc atcaaggccg
     1741 agtgcacggc gcggctgccc gaagcctccc agagcccgct ggtgctgaag caggcggtac
     1801 gcaagccgct ggaagccgtg cttcggtatc ttgagaccca cccccgcccc cccaagcctg
     1861 accccgtgaa aagcgtgtcc agcgtgctca gcagcctgac gcccgccaag gtggcccccg
     1921 tcatcaacaa cggctccccc accatcctgg gcaagcgcag ctacgagcag cacaacgggg
     1981 tggacggcaa catgaagaag cgcctcttga tgcccagtag gggtctggca aaccacggac
     2041 aggccaggca catgggacca agccggaacc tcctgctcaa cgggaagtcc taccccacca
     2101 aagtgcgcct gatccggggg ggctccctgc ccccagtcaa gcggcggcgg atgaactgga
     2161 tcgacgcccc ggatgacgtg ttctacatgg ccacagagga gaccaggaag atccgcaagc
     2221 tgctctcatc ctcggaaacc aagcgtgctg cccgccggcc ctacaagccc atcgccctgc
     2281 gccagagcca ggccctgccg ccgcggccac cgccacctgc gcccgtcaac gacgagccca
     2341 tcgtcatcga ggactagggg ccgcccccac ctgcggccgc cccccgcccc tcgcccgccc
     2401 acacggcccc ttcccagcca gcccgccgcc cgcccctcag tttggtagtg ccccacctcc
     2461 cgccctcacc tgcagagaaa cgcgctcctt ggcggacact gggggaggag aggaagaagc
     2521 gcggctaact tattccgaga atgccgagga gttgtcgttt ttagctttgt gtttactttt
     2581 tggctggagc ggagatgagg ggccaccccg tgcccctgtg ctgcggggcc ttttgcccgg
     2641 aggccgggcc ctaaggtttt gttgtgttct gttgaaggtg ccattttaaa ttttattttt
     2701 attacttttt ttgtagatga acttgagctc tgtaacttac acctggaatg ttaggatcgt
     2761 gcggccgcgg ccggccgagc tgcctggcgg ggttggccct tgtcttttca agtaattttc
     2821 atattaaaca aaaacaaaga aaaaaaatct tataaaaagg aaaaaaacca a
//
