LOCUS       NM_001411062            2820 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens metastasis associated 1 (MTA1), transcript variant 4,
            mRNA.
ACCESSION   NM_001411062 XM_047431907
VERSION     NM_001411062.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Wanka,G., Jueckstock,J., Wild,C.M., Vattai,A., Furst,S.,
            Heidegger,H.H., Kuhn,C., Schmoeckel,E., Jeschke,U. and Dannecker,C.
  TITLE     MTA1 as negative prognostic marker in vulvar carcinoma
  JOURNAL   J Cancer Res Clin Oncol 149 (9), 6191-6201 (2023)
   PUBMED   36689059
  REMARK    GeneRIF: MTA1 as negative prognostic marker in vulvar carcinoma.
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Sun,F.Z., Wang,J.S., Li,C.X., Wang,T., Zhang,J.Y., Zhou,Y.T.,
            Wang,H.J. and Qian,H.L.
  TITLE     [The role and mechanism of tumor metastasis-associated gene 1 in
            radiosensitivity of HeLa cells]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 44 (9), 962-967 (2022)
   PUBMED   36164698
  REMARK    GeneRIF: [The role and mechanism of tumor metastasis-associated
            gene 1 in radiosensitivity of HeLa cells].
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Vattem,C. and Pakala,S.B.
  TITLE     Metastasis-associated protein 1: A potential driver and regulator
            of the hallmarks of cancer
  JOURNAL   J Biosci 47 (2022)
   PUBMED   36210748
  REMARK    GeneRIF: Metastasis-associated protein 1: A potential driver and
            regulator of the hallmarks of cancer.
            Review article
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Kumar,R., Balasenthil,S., Pakala,S.B., Rayala,S.K., Sahin,A.A. and
            Ohshiro,K.
  TITLE     Metastasis-associated protein 1 short form stimulates Wnt1 pathway
            in mammary epithelial and cancer cells
  JOURNAL   Cancer Res 70 (16), 6598-6608 (2010)
   PUBMED   20710043
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Kumar,R., Balasenthil,S., Manavathi,B., Rayala,S.K. and Pakala,S.B.
  TITLE     Metastasis-associated protein 1 and its short form variant
            stimulates Wnt1 transcription through promoting its derepression
            from Six3 corepressor
  JOURNAL   Cancer Res 70 (16), 6649-6658 (2010)
   PUBMED   20682799
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Singh,R.R., Kaluarachchi,K., Chen,M., Rayala,S.K., Balasenthil,S.,
            Ma,J. and Kumar,R.
  TITLE     Solution structure and antiestrogenic activity of the unique
            C-terminal, NR-box motif-containing region of MTA1s
  JOURNAL   J Biol Chem 281 (35), 25612-25621 (2006)
   PUBMED   16807247
  REMARK    GeneRIF: structure and antiestrogenic activity of the unique
            C-terminal, NR-box motif-containing region of MTA1
            Erratum:[J Biol Chem. 2013 Sep 20;288(38):27518]
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Mishra,S.K., Yang,Z., Mazumdar,A., Talukder,A.H., Larose,L. and
            Kumar,R.
  TITLE     Metastatic tumor antigen 1 short form (MTA1s) associates with
            casein kinase I-gamma2, an estrogen-responsive kinase
  JOURNAL   Oncogene 23 (25), 4422-4429 (2004)
   PUBMED   15077195
  REMARK    GeneRIF: MTA1s interacts with CKI-gamma2 in vitro and in vivo and
            colocalizes in the cytoplasm
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Kumar,R., Wang,R.A., Mazumdar,A., Talukder,A.H., Mandal,M.,
            Yang,Z., Bagheri-Yarmand,R., Sahin,A., Hortobagyi,G., Adam,L.,
            Barnes,C.J. and Vadlamudi,R.K.
  TITLE     A naturally occurring MTA1 variant sequesters oestrogen
            receptor-alpha in the cytoplasm
  JOURNAL   Nature 418 (6898), 654-657 (2002)
   PUBMED   12167865
  REMARK    GeneRIF: naturally occurring short form that contains a previously
            unknown sequence of 33 amino acids with an ER-binding motif,
            Leu-Arg-Ile-Leu-Leu (LRILL); MTA1s localizes in the cytoplasm,
            sequesters ER in the cytoplasm, and enhances non-genomic responses
            of ER
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Toh,Y., Pencil,S.D. and Nicolson,G.L.
  TITLE     Analysis of the complete sequence of the novel
            metastasis-associated candidate gene, mta1, differentially
            expressed in mammary adenocarcinoma and breast cancer cell lines
  JOURNAL   Gene 159 (1), 97-104 (1995)
   PUBMED   7607577
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Toh,Y., Pencil,S.D. and Nicolson,G.L.
  TITLE     A novel candidate metastasis-associated gene, mta1, differentially
            expressed in highly metastatic mammary adenocarcinoma cell lines.
            cDNA cloning, expression, and protein analyses
  JOURNAL   J Biol Chem 269 (37), 22958-22963 (1994)
   PUBMED   8083195
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL928654.1.
            
            On Aug 20, 2022 this sequence version replaced XM_047431907.1.
            
            Summary: This gene encodes a protein that was identified in a
            screen for genes expressed in metastatic cells, specifically,
            mammary adenocarcinoma cell lines. Expression of this gene has been
            correlated with the metastatic potential of at least two types of
            carcinomas although it is also expressed in many normal tissues.
            The role it plays in metastasis is unclear. It was initially
            thought to be the 70kD component of a nucleosome remodeling
            deacetylase complex, NuRD, but it is more likely that this
            component is a different but very similar protein. These two
            proteins are so closely related, though, that they share the same
            types of domains. These domains include two DNA binding domains, a
            dimerization domain, and a domain commonly found in proteins that
            methylate DNA. The profile and activity of this gene product
            suggest that it is involved in regulating transcription and that
            this may be accomplished by chromatin remodeling. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2056600.1,
                                           SRR14038196.1043885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AL928654.1         98245-98481
            238-305             AL928654.1         117090-117157
            306-399             AL928654.1         123836-123929
            400-526             AL928654.1         128476-128602
            527-590             AL928654.1         128679-128742
            591-708             AL928654.1         132611-132728
            709-811             AL928654.1         136688-136790
            812-911             AL928654.1         138776-138875
            912-1100            AL928654.1         139183-139371
            1101-1175           AL928654.1         141602-141676
            1176-1234           AL928654.1         141911-141969
            1235-1350           AL928654.1         142450-142565
            1351-1502           AL928654.1         142834-142985
            1503-1692           AL928654.1         143092-143281
            1693-1782           AL928654.1         143512-143601
            1783-1935           AL928654.1         144844-144996
            1936-1971           AL928654.1         145125-145160
            1972-2003           AL928654.1         147885-147916
            2004-2155           AL928654.1         148259-148410
            2156-2820           AL928654.1         148483-149147
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2820
                     /gene="MTA1"
                     /note="metastasis associated 1"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
     exon            1..237
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..2306
                     /gene="MTA1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     metastasis associated gene 1 protein"
                     /codon_start=1
                     /product="metastasis-associated protein MTA1 isoform 4"
                     /protein_id="NP_001397991.1"
                     /db_xref="CCDS:CCDS91957.1"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
                     /translation="MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVC
                     FYRRRDISSTLIALADKHAREIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPA
                     THIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADI
                     TDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQ
                     PSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEA
                     NLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKL
                     KQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRACESCYTTQSYQWYSWGP
                     PNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRSNMSPHGLPARSSGSPKFAMKT
                     RQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSPLV
                     LKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAPVINNGSPTILGKR
                     SYEQHNGVDGNMKKRLLMPSRGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLP
                     PVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPPR
                     PPPPAPVNDEPIVIED"
     exon            238..305
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..399
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..526
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..590
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..708
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..811
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..911
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1100
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1175
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1234
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1350
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1502
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1692
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1782
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1935
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..1971
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2003
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2155
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2820
                     /gene="MTA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTA1"
                     /note="hexamer: TATAAA"
     polyA_site      2820
                     /gene="MTA1"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcctct cccgcccgcg ccgcggccct cccgtccctg cgcggcctcg gcggcctcgg
       61 cggcggcggc ggcggcggcg gcggcagcag cgcggcccct ttaaacgcct gcggcgcccc
      121 ccgcccccgc catcgcgcct ccattttccc ggccgcccgc gccgagcgcc gcgcccgccc
      181 cgggcccctc cgccgccgcc ggcccggaca tggccgccaa catgtacagg gtcggagact
      241 acgtctactt tgagaactcc tccagcaacc catacctgat ccggagaatc gaggagctca
      301 acaagacggc caatgggaac gtggaggcca aagtggtgtg cttctaccgg aggcgggaca
      361 tctccagcac cctcatcgcc ctggccgaca agcacgcaag ggaaatagaa gaggaaatgg
      421 agaacccgga aatggtggac ctgcccgaga aactaaagca ccagctgcgg catcgggagc
      481 tgttcctctc ccggcagctg gagtctctgc ccgccacgca catcaggggc aagtgcagcg
      541 tcaccctgct caacgagacc gagtcgctca agtcctacct ggagcgggag gatttcttct
      601 tctattctct agtctacgac ccacagcaga agaccctgct ggcagataaa ggagagattc
      661 gagtaggaaa ccggtaccag gcagacatca ccgacttgtt aaaagaaggc gaggaggatg
      721 gccgagacca gtccaggttg gagacccagg tgtgggaggc gcacaaccca ctcacagaca
      781 agcagatcga ccagttcctg gtggtggccc gctctgtggg caccttcgca cgggccctgg
      841 actgcagcag ctccgtccga cagcccagcc tgcacatgag cgccgcagct gcctcccgag
      901 acatcaccct gttccacgcc atggatactc tccacaagaa catctacgac atctccaagg
      961 ccatctcggc gctggtgccg cagggcgggc ccgtgctctg cagggacgag atggaggagt
     1021 ggtctgcatc agaggccaac cttttcgagg aagccctgga aaaatatggg aaggatttca
     1081 cggacattca gcaagatttt ctcccgtgga agtcgctgac cagcatcatt gagtactact
     1141 acatgtggaa gaccaccgac agatacgtgc agcagaaacg cttgaaagca gctgaagctg
     1201 agagcaagtt aaagcaagtt tatattccca actataacaa gccaaatccg aaccaaatca
     1261 gcgtcaacaa cgtcaaggcc ggtgtggtga acggcacggg ggcgccgggc cagagccctg
     1321 gggctggccg ggcctgcgag agctgttaca ccacacagtc ttaccagtgg tattcttggg
     1381 gtccccctaa catgcagtgt cgtctctgcg catcttgttg gacatattgg aagaaatatg
     1441 gtggcttgaa aatgccaacc cggttagatg gagagaggcc aggaccaaac cgcagtaaca
     1501 tgagtcccca cggcctccca gcccggagca gcgggagccc caagtttgcc atgaagacca
     1561 ggcaggcttt ctatctgcac acgacgaagc tgacgcggat cgcccggcgc ctgtgccgtg
     1621 agatcctgcg cccgtggcac gctgcgcggc acccctacct gcccatcaac agcgcggcca
     1681 tcaaggccga gtgcacggcg cggctgcccg aagcctccca gagcccgctg gtgctgaagc
     1741 aggcggtacg caagccgctg gaagccgtgc ttcggtatct tgagacccac ccccgccccc
     1801 ccaagcctga ccccgtgaaa agcgtgtcca gcgtgctcag cagcctgacg cccgccaagg
     1861 tggcccccgt catcaacaac ggctccccca ccatcctggg caagcgcagc tacgagcagc
     1921 acaacggggt ggacggcaac atgaagaagc gcctcttgat gcccagtagg ggtctggcaa
     1981 accacggaca ggccaggcac atgggaccaa gccggaacct cctgctcaac gggaagtcct
     2041 accccaccaa agtgcgcctg atccgggggg gctccctgcc cccagtcaag cggcggcgga
     2101 tgaactggat cgacgccccg gatgacgtgt tctacatggc cacagaggag accaggaaga
     2161 tccgcaagct gctctcatcc tcggaaacca agcgtgctgc ccgccggccc tacaagccca
     2221 tcgccctgcg ccagagccag gccctgccgc cgcggccacc gccacctgcg cccgtcaacg
     2281 acgagcccat cgtcatcgag gactaggggc cgcccccacc tgcggccgcc ccccgcccct
     2341 cgcccgccca cacggcccct tcccagccag cccgccgccc gcccctcagt ttggtagtgc
     2401 cccacctccc gccctcacct gcagagaaac gcgctccttg gcggacactg ggggaggaga
     2461 ggaagaagcg cggctaactt attccgagaa tgccgaggag ttgtcgtttt tagctttgtg
     2521 tttacttttt ggctggagcg gagatgaggg gccaccccgt gcccctgtgc tgcggggcct
     2581 tttgcccgga ggccgggccc taaggttttg ttgtgttctg ttgaaggtgc cattttaaat
     2641 tttattttta ttactttttt tgtagatgaa cttgagctct gtaacttaca cctggaatgt
     2701 taggatcgtg cggccgcggc cggccgagct gcctggcggg gttggccctt gtcttttcaa
     2761 gtaattttca tattaaacaa aaacaaagaa aaaaaatctt ataaaaagga aaaaaaccaa
//
