LOCUS       NM_032935                270 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens metallothionein 4 (MT4), mRNA.
ACCESSION   NM_032935
VERSION     NM_032935.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 270)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: MT4 expression is significantly downregulated in human
            masticatory mucosa during wound healing
REFERENCE   2  (bases 1 to 270)
  AUTHORS   Chen,H.I., Chiu,Y.W., Hsu,Y.K., Li,W.F., Chen,Y.C. and Chuang,H.Y.
  TITLE     The association of metallothionein-4 gene polymorphism and renal
            function in long-term lead-exposed workers
  JOURNAL   Biol Trace Elem Res 137 (1), 55-62 (2010)
   PUBMED   19921116
  REMARK    GeneRIF: The association of metallothionein-4 gene polymorphism and
            renal function in long-term lead-exposed workers
            GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 270)
  AUTHORS   Quaife,C.J., Findley,S.D., Erickson,J.C., Froelick,G.J.,
            Kelly,E.J., Zambrowicz,B.P. and Palmiter,R.D.
  TITLE     Induction of a new metallothionein isoform (MT-IV) occurs during
            differentiation of stratified squamous epithelia
  JOURNAL   Biochemistry 33 (23), 7250-7259 (1994)
   PUBMED   8003488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026461.11.
            
            On May 17, 2019 this sequence version replaced NM_032935.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219162.4/ ENSP00000219162.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC026461.11        122613-122699       c
            88-153              AC026461.11        119956-120021       c
            154-270             AC026461.11        118815-118931       c
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..270
                     /gene="MT4"
                     /gene_synonym="MT-4; MT-IV; MTIV"
                     /note="metallothionein 4"
                     /db_xref="GeneID:84560"
                     /db_xref="HGNC:HGNC:18705"
                     /db_xref="MIM:606206"
     exon            1..87
                     /gene="MT4"
                     /gene_synonym="MT-4; MT-IV; MTIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..245
                     /gene="MT4"
                     /gene_synonym="MT-4; MT-IV; MTIV"
                     /note="metallothionein-IV"
                     /codon_start=1
                     /product="metallothionein-4"
                     /protein_id="NP_116324.2"
                     /db_xref="CCDS:CCDS42165.1"
                     /db_xref="GeneID:84560"
                     /db_xref="HGNC:HGNC:18705"
                     /db_xref="MIM:606206"
                     /translation="MDPRECVCMSGGICMCGDNCKCTTCNCKTYWKSCCPCCPPGCAK
                     CARGCICKGGSDKCSCCP"
     exon            88..153
                     /gene="MT4"
                     /gene_synonym="MT-4; MT-IV; MTIV"
                     /inference="alignment:Splign:2.1.0"
     exon            154..270
                     /gene="MT4"
                     /gene_synonym="MT-4; MT-IV; MTIV"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcagcctc ccttccccag ccgtgacagc actggagcct ttcggacacc tggaccatgg
       61 accccaggga atgtgtctgc atgtctggag gaatctgcat gtgtggagac aactgcaaat
      121 gcacaacctg caactgtaaa acatattgga agagctgctg tccctgctgc cccccgggct
      181 gtgccaaatg tgcccggggc tgcatctgca aaggaggctc agacaagtgc agctgctgcc
      241 catgaaagcc atccatcgtg cccacccctt
//
