LOCUS       NM_005954                406 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens metallothionein 3 (MT3), mRNA.
ACCESSION   NM_005954
VERSION     NM_005954.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 406)
  AUTHORS   Xiong,T., Li,Y., Yang,M., Huo,B., Guo,X., Liu,L., Huang,Y., Zhu,X.,
            Hu,Q., Wei,X., Jiang,D.S. and Yi,X.
  TITLE     Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell
            Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated
            Autophagosome Formation
  JOURNAL   Int J Biol Sci 20 (8), 2904-2921 (2024)
   PUBMED   38904023
  REMARK    GeneRIF: Metallothionein 3 Potentiates Pulmonary Artery Smooth
            Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated
            Autophagosome Formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 406)
  AUTHORS   Yuan,A.T., Korkola,N.C. and Stillman,M.J.
  TITLE     Apo-metallothionein-3 cooperatively forms tightly compact
            structures under physiological conditions
  JOURNAL   J Biol Chem 299 (3), 102899 (2023)
   PUBMED   36639030
  REMARK    GeneRIF: Apo-metallothionein-3 cooperatively forms tightly compact
            structures under physiological conditions.
REFERENCE   3  (bases 1 to 406)
  AUTHORS   Kalyan,G., Slusser-Nore,A., Dunlevy,J.R., Bathula,C.S., Shabb,J.B.,
            Muhonen,W., Somji,S., Sens,D.A. and Garrett,S.H.
  TITLE     Protein interactions with metallothionein-3 promote vectorial
            active transport in human proximal tubular cells
  JOURNAL   PLoS One 17 (5), e0267599 (2022)
   PUBMED   35503771
  REMARK    GeneRIF: Protein interactions with metallothionein-3 promote
            vectorial active transport in human proximal tubular cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 406)
  AUTHORS   Vasak,M. and Meloni,G.
  TITLE     Mammalian Metallothionein-3: New Functional and Structural Insights
  JOURNAL   Int J Mol Sci 18 (6), 1117 (2017)
   PUBMED   28538697
  REMARK    GeneRIF: In recent years, the roles of zinc dynamics and MT3
            function in neurodegeneration are slowly emerging. This short
            review focuses on the recent developments regarding the chemistry
            and biology of MT3. [review]
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 406)
  AUTHORS   Aschner,M.
  TITLE     The functional significance of brain metallothioneins
  JOURNAL   FASEB J 10 (10), 1129-1136 (1996)
   PUBMED   8751715
  REMARK    Review article
REFERENCE   6  (bases 1 to 406)
  AUTHORS   Amoureux,M.C., Wurch,T. and Pauwels,P.J.
  TITLE     Modulation of metallothionein-III mRNA content and growth rate of
            rat C6-glial cells by transfection with human 5-HT1D receptor genes
  JOURNAL   Biochem Biophys Res Commun 214 (2), 639-645 (1995)
   PUBMED   7677777
REFERENCE   7  (bases 1 to 406)
  AUTHORS   Naruse,S., Igarashi,S., Furuya,T., Kobayashi,H., Miyatake,T. and
            Tsuji,S.
  TITLE     Structures of the human and mouse growth inhibitory factor-encoding
            genes
  JOURNAL   Gene 144 (2), 283-287 (1994)
   PUBMED   8039715
REFERENCE   8  (bases 1 to 406)
  AUTHORS   Tsuji,S., Kobayashi,H., Uchida,Y., Ihara,Y. and Miyatake,T.
  TITLE     Molecular cloning of human growth inhibitory factor cDNA and its
            down-regulation in Alzheimer's disease
  JOURNAL   EMBO J 11 (13), 4843-4850 (1992)
   PUBMED   1464312
REFERENCE   9  (bases 1 to 406)
  AUTHORS   Palmiter,R.D., Findley,S.D., Whitmore,T.E. and Durnam,D.M.
  TITLE     MT-III, a brain-specific member of the metallothionein gene family
  JOURNAL   Proc Natl Acad Sci U S A 89 (14), 6333-6337 (1992)
   PUBMED   1631128
REFERENCE   10 (bases 1 to 406)
  AUTHORS   Uchida,Y., Takio,K., Titani,K., Ihara,Y. and Tomonaga,M.
  TITLE     The growth inhibitory factor that is deficient in the Alzheimer's
            disease brain is a 68 amino acid metallothionein-like protein
  JOURNAL   Neuron 7 (2), 337-347 (1991)
   PUBMED   1873033
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP210917.1 and CB155600.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005954.3.
            
            Summary: This gene is a member of the metallothionein family of
            genes. Proteins encoded by this gene family are low in molecular
            weight, are cysteine-rich, lack aromatic residues, and bind
            divalent heavy metal ions. This gene family member displays
            tissue-specific expression, and contains a threonine insert near
            its N-terminus and a glutamate-rich hexapeptide insert near its
            C-terminus relative to the proteins encoded by other gene family
            members. It plays an important role in zinc and copper homeostasis,
            and is induced under hypoxic conditions. The encoded protein is a
            growth inhibitory factor, and reduced levels of the protein are
            observed in the brains of individuals with some metal-linked
            neurodegenerative disorders such as Alzheimer's disease. [provided
            by RefSeq, Sep 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP211991.1, CK001163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000200691.5/ ENSP00000200691.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               BP210917.1         161-565
            406-406             CB155600.1         437-437
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..406
                     /gene="MT3"
                     /gene_synonym="GIF; GIFB; GRIF; ZnMT3"
                     /note="metallothionein 3"
                     /db_xref="GeneID:4504"
                     /db_xref="HGNC:HGNC:7408"
                     /db_xref="MIM:139255"
     exon            1..94
                     /gene="MT3"
                     /gene_synonym="GIF; GIFB; GRIF; ZnMT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..270
                     /gene="MT3"
                     /gene_synonym="GIF; GIFB; GRIF; ZnMT3"
                     /note="metallothionein 3 (growth inhibitory factor
                     (neurotrophic)); metallothionein-III"
                     /codon_start=1
                     /product="metallothionein-3"
                     /protein_id="NP_005945.1"
                     /db_xref="CCDS:CCDS10762.1"
                     /db_xref="GeneID:4504"
                     /db_xref="HGNC:HGNC:7408"
                     /db_xref="MIM:139255"
                     /translation="MDPETCPCPSGGSCTCADSCKCEGCKCTSCKKSCCSCCPAECEK
                     CAKDCVCKGGEAAEAEAEKCSCCQ"
     exon            95..160
                     /gene="MT3"
                     /gene_synonym="GIF; GIFB; GRIF; ZnMT3"
                     /inference="alignment:Splign:2.1.0"
     exon            161..406
                     /gene="MT3"
                     /gene_synonym="GIF; GIFB; GRIF; ZnMT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      387..392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT3"
                     /gene_synonym="GIF; GIFB; GRIF; ZnMT3"
                     /note="hexamer: AATAAA"
     polyA_site      406
                     /gene="MT3"
                     /gene_synonym="GIF; GIFB; GRIF; ZnMT3"
                     /note="major polyA site"
ORIGIN      
        1 aagccgcgcg tccagttgct tggagaagcc cgttcaccgc ctccagctgc tgctctcctc
       61 gacatggacc ctgagacctg cccctgccct tctggtggct cctgcacctg cgcggactcc
      121 tgcaagtgcg agggatgcaa atgcacctcc tgcaagaaga gctgctgctc ctgctgccct
      181 gcggagtgtg agaagtgtgc caaggactgt gtgtgcaaag gcggagaggc agctgaggca
      241 gaagcagaga agtgcagctg ctgccagtga gaaggcaccc ctccgtgtgg agcacgtgga
      301 gatagtgcca ggtggctcag tgccacctat gcctgtggtg aagtgtggct ggtgtcccct
      361 tcccctgctg accttggagg aatgacaata aatcccatga acagca
//
