LOCUS       NM_005952                404 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens metallothionein 1X (MT1X), mRNA.
ACCESSION   NM_005952
VERSION     NM_005952.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 404)
  AUTHORS   Ding,Y., Fang,J., Chen,M., Xu,Y., Liu,N., Fang,S., Xiang,W.,
            Chen,R., Wu,C. and Yu,H.
  TITLE     MT1X is an oncogene and indicates prognosis in ccRCC
  JOURNAL   Biosci Rep 42 (10) (2022)
   PUBMED   36149322
  REMARK    GeneRIF: MT1X is an oncogene and indicates prognosis in ccRCC.
REFERENCE   2  (bases 1 to 404)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 404)
  AUTHORS   Masiulionyte,B., Valiulyte,I., Tamasauskas,A. and Skiriute,D.
  TITLE     Metallothionein Genes are Highly Expressed in Malignant
            Astrocytomas and Associated with Patient Survival
  JOURNAL   Sci Rep 9 (1), 5406 (2019)
   PUBMED   30932010
  REMARK    GeneRIF: Metallothionein Genes are Highly Expressed in Malignant
            Astrocytomas and Associated with Patient Survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 404)
  AUTHORS   Liu,Z., Ye,Q., Wu,L., Gao,F., Xie,H., Zhou,L., Zheng,S. and Xu,X.
  TITLE     Metallothionein 1 family profiling identifies MT1X as a tumor
            suppressor involved in the progression and metastastatic capacity
            of hepatocellular carcinoma
  JOURNAL   Mol Carcinog 57 (11), 1435-1444 (2018)
   PUBMED   29873415
  REMARK    GeneRIF: we featured the expression patterns of MT1s in tissue
            obtained from various points along the spectrum of
            hepatocarcinogenesis. Most MT1 members were down-regulated, and
            MT1X were associated with HCC prognosis. Additionally, MT1X was
            shown to play a suppressive role in HCC metastasis.
REFERENCE   5  (bases 1 to 404)
  AUTHORS   Farahani,N., Nikpou,P., Emami,M.H., Hashemzadeh,M., Zeinalian,M.,
            Shariatpanahi,S.S. and Salehi,R.
  TITLE     Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide
            Marker for Characterizing Microsatellite Instability in Persian
            Lynch Syndrome Patients
  JOURNAL   Asian Pac J Cancer Prev 17 (9), 4259-4265 (2016)
   PUBMED   27797228
  REMARK    GeneRIF: MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker
            showing Microsatellite Instability is associated with Persian Lynch
            Syndrome
REFERENCE   6  (bases 1 to 404)
  AUTHORS   Holloway,A.F., Stennard,F.A. and West,A.K.
  TITLE     Human metallothionein gene MT1L mRNA is present in several human
            tissues but is unlikely to produce a metallothionein protein
  JOURNAL   FEBS Lett 404 (1), 41-44 (1997)
   PUBMED   9074634
REFERENCE   7  (bases 1 to 404)
  AUTHORS   Mididoddi,S., McGuirt,J.P., Sens,M.A., Todd,J.H. and Sens,D.A.
  TITLE     Isoform-specific expression of metallothionein mRNA in the
            developing and adult human kidney
  JOURNAL   Toxicol Lett 85 (1), 17-27 (1996)
   PUBMED   8619255
REFERENCE   8  (bases 1 to 404)
  AUTHORS   Stennard,F.A., Holloway,A.F., Hamilton,J. and West,A.K.
  TITLE     Characterisation of six additional human metallothionein genes
  JOURNAL   Biochim Biophys Acta 1218 (3), 357-365 (1994)
   PUBMED   8049263
REFERENCE   9  (bases 1 to 404)
  AUTHORS   Pauwels,M., van Weyenbergh,J., Soumillion,A., Proost,P. and De
            Ley,M.
  TITLE     Induction by zinc of specific metallothionein isoforms in human
            monocytes
  JOURNAL   Eur J Biochem 220 (1), 105-110 (1994)
   PUBMED   8119276
REFERENCE   10 (bases 1 to 404)
  AUTHORS   West,A.K., Stallings,R., Hildebrand,C.E., Chiu,R., Karin,M. and
            Richards,R.I.
  TITLE     Human metallothionein genes: structure of the functional locus at
            16q13
  JOURNAL   Genomics 8 (3), 513-518 (1990)
   PUBMED   2286373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD101947.1 and BC032338.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005952.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005437.1, CD101947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394485.5/ ENSP00000377995.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CD101947.1         5-17
            14-330              BC032338.1         1-317
            331-403             CD101947.1         335-407
            404-404             BC032338.1         390-390
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..404
                     /gene="MT1X"
                     /gene_synonym="MT-1l; MT1"
                     /note="metallothionein 1X"
                     /db_xref="GeneID:4501"
                     /db_xref="HGNC:HGNC:7405"
                     /db_xref="MIM:156359"
     exon            1..99
                     /gene="MT1X"
                     /gene_synonym="MT-1l; MT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..257
                     /gene="MT1X"
                     /gene_synonym="MT-1l; MT1"
                     /note="MT-1X; MT-IX; metallothionein-IX; testicular tissue
                     protein Li 124"
                     /codon_start=1
                     /product="metallothionein-1X"
                     /protein_id="NP_005943.1"
                     /db_xref="CCDS:CCDS10768.1"
                     /db_xref="GeneID:4501"
                     /db_xref="HGNC:HGNC:7405"
                     /db_xref="MIM:156359"
                     /translation="MDPNCSCSPVGSCACAGSCKCKECKCTSCKKSCCSCCPVGCAKC
                     AQGCICKGTSDKCSCCA"
     exon            100..165
                     /gene="MT1X"
                     /gene_synonym="MT-1l; MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..404
                     /gene="MT1X"
                     /gene_synonym="MT-1l; MT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      386..391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1X"
                     /gene_synonym="MT-1l; MT1"
                     /note="hexamer: AATAAA"
     polyA_site      404
                     /gene="MT1X"
                     /gene_synonym="MT-1l; MT1"
                     /note="major polyA site"
ORIGIN      
        1 accacgcttt tcatctgtcc cgctgcgtgt tttcctcttg atcgggaact cctgcttctc
       61 cttgcctcga aatggacccc aactgctcct gctcgcctgt tggctcctgt gcctgtgccg
      121 gctcctgcaa atgcaaagag tgcaaatgca cctcctgcaa gaagagctgc tgctcctgct
      181 gccctgtggg ctgtgccaag tgtgcccagg gctgcatctg caaagggacg tcagacaagt
      241 gcagctgctg tgcctgatgc caggacagct gtgctctcag atgtaaatag agcaacctat
      301 ataaacctgg attttttttt tttttttttt tgtacaaccc tgacccgttt gctacatctt
      361 tttttctatg aaatatgtga atggcaataa attcatctag acta
//
