LOCUS       NM_176870                398 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens metallothionein 1M (MT1M), mRNA.
ACCESSION   NM_176870
VERSION     NM_176870.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 398)
  AUTHORS   Li,K., Sun,S., Lu,Y., Liang,W., Xu,X., Zhang,H., Chang,Z., Wang,C.,
            Gao,Y. and Chen,L.
  TITLE     MT1M regulates gastric cancer progression and stemness by
            modulating the Hedgehog pathway protein GLI1
  JOURNAL   Biochem Biophys Res Commun 670, 63-72 (2023)
   PUBMED   37276792
  REMARK    GeneRIF: MT1M regulates gastric cancer progression and stemness by
            modulating the Hedgehog pathway protein GLI1.
REFERENCE   2  (bases 1 to 398)
  AUTHORS   Li,D., Peng,W., Wu,B., Liu,H., Zhang,R., Zhou,R., Yao,L. and Ye,L.
  TITLE     Metallothionein MT1M Suppresses Carcinogenesis of Esophageal
            Carcinoma Cells through Inhibition of the Epithelial-Mesenchymal
            Transition and the SOD1/PI3K Axis
  JOURNAL   Mol Cells 44 (4), 267-278 (2021)
   PUBMED   33820882
  REMARK    GeneRIF: Metallothionein MT1M Suppresses Carcinogenesis of
            Esophageal Carcinoma Cells through Inhibition of the
            Epithelial-Mesenchymal Transition and the SOD1/PI3K Axis.
REFERENCE   3  (bases 1 to 398)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 398)
  AUTHORS   Maleckaite,R., Zalimas,A., Bakavicius,A., Jankevicius,F.,
            Jarmalaite,S. and Daniunaite,K.
  TITLE     DNA methylation of metallothionein genes is associated with the
            clinical features of renal cell carcinoma
  JOURNAL   Oncol Rep 41 (6), 3535-3544 (2019)
   PUBMED   31002354
  REMARK    GeneRIF: In clear cell renal cell carcinoma (RCC) MT1E, MT1G and
            MT1M expression was higher than that noted in other histological
            tumor subtypes (all P<0.0500). In addition, some associations were
            observed between metabolic syndromerelated clinical parameters and
            promoter methylation or gene expression
REFERENCE   5  (bases 1 to 398)
  AUTHORS   Changjun,L., Feizhou,H., Dezhen,P., Zhao,L. and Xianhai,M.
  TITLE     MiR-545-3p/MT1M axis regulates cell proliferation, invasion and
            migration in hepatocellular carcinoma
  JOURNAL   Biomed Pharmacother 108, 347-354 (2018)
   PUBMED   30227328
  REMARK    GeneRIF: MiR-545-3p, which served as a tumor promoter,
            post-transcriptionally regulate MT1M in HCC through binding to its
            untranslated region (3'UTR).
REFERENCE   6  (bases 1 to 398)
  AUTHORS   Izmailova,E., Bertley,F.M., Huang,Q., Makori,N., Miller,C.J.,
            Young,R.A. and Aldovini,A.
  TITLE     HIV-1 Tat reprograms immature dendritic cells to express
            chemoattractants for activated T cells and macrophages
  JOURNAL   Nat Med 9 (2), 191-197 (2003)
   PUBMED   12539042
REFERENCE   7  (bases 1 to 398)
  AUTHORS   Vandeghinste,N., Proost,P. and De Ley,M.
  TITLE     Metallothionein isoform gene expression in zinc-treated human
            peripheral blood lymphocytes
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 46 (2), 419-433 (2000)
   PUBMED   10774930
REFERENCE   8  (bases 1 to 398)
  AUTHORS   Hellemans,G., Soumillion,A., Proost,P., Van Damme,J., Van
            Poppel,H., Baert,L. and De Ley,M.
  TITLE     Metallothioneins in human kidneys and associated tumors
  JOURNAL   Nephron 83 (4), 331-340 (1999)
   PUBMED   10575295
REFERENCE   9  (bases 1 to 398)
  AUTHORS   Stennard,F.A., Holloway,A.F., Hamilton,J. and West,A.K.
  TITLE     Characterisation of six additional human metallothionein genes
  JOURNAL   Biochim Biophys Acta 1218 (3), 357-365 (1994)
   PUBMED   8049263
REFERENCE   10 (bases 1 to 398)
  AUTHORS   West,A.K., Stallings,R., Hildebrand,C.E., Chiu,R., Karin,M. and
            Richards,R.I.
  TITLE     Human metallothionein genes: structure of the functional locus at
            16q13
  JOURNAL   Genomics 8 (3), 513-518 (1990)
   PUBMED   2286373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026461.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_176870.2.
            
            Summary: This gene encodes a member of the metallothionein
            superfamily, type 1 family. Metallothioneins have a high content of
            cysteine residues that bind various heavy metals. These genes are
            transcriptionally regulated by both heavy metals and
            glucocorticoids. [provided by RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM918307.1, AF136177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379818.4/ ENSP00000369146.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC026461.11        55013-55113         c
            102-167             AC026461.11        54367-54432         c
            168-398             AC026461.11        53791-54021         c
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..398
                     /gene="MT1M"
                     /gene_synonym="MT-1M; MT-IM; MT1; MT1K"
                     /note="metallothionein 1M"
                     /db_xref="GeneID:4499"
                     /db_xref="HGNC:HGNC:14296"
                     /db_xref="MIM:156357"
     exon            1..101
                     /gene="MT1M"
                     /gene_synonym="MT-1M; MT-IM; MT1; MT1K"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..259
                     /gene="MT1M"
                     /gene_synonym="MT-1M; MT-IM; MT1; MT1K"
                     /note="metallothionein 1K; metallothionein 1Y"
                     /codon_start=1
                     /product="metallothionein-1M"
                     /protein_id="NP_789846.2"
                     /db_xref="CCDS:CCDS42166.1"
                     /db_xref="GeneID:4499"
                     /db_xref="HGNC:HGNC:14296"
                     /db_xref="MIM:156357"
                     /translation="MDPNCSCTTGVSCACTGSCTCKECKCTSCKKSCCSCCPVGCAKC
                     AHGCVCKGTLENCSCCA"
     exon            102..167
                     /gene="MT1M"
                     /gene_synonym="MT-1M; MT-IM; MT1; MT1K"
                     /inference="alignment:Splign:2.1.0"
     exon            168..398
                     /gene="MT1M"
                     /gene_synonym="MT-1M; MT-IM; MT1; MT1K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      377..382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1M"
                     /gene_synonym="MT-1M; MT-IM; MT1; MT1K"
                     /note="hexamer: AATAAA"
     polyA_site      398
                     /gene="MT1M"
                     /gene_synonym="MT-1M; MT-IM; MT1; MT1K"
                     /note="major polyA site"
ORIGIN      
        1 accacgccgt ccgggtgggc ctagcagtcg ctccatttat cgcttgagat ctccagcctt
       61 accgcggctc gaaatggacc ccaactgctc ctgcaccact ggtgtctcct gcgcctgcac
      121 cggctcctgc acgtgcaaag agtgcaaatg cacctcctgc aagaagagct gctgctcctg
      181 ctgccccgtg ggctgtgcca agtgtgccca cggctgtgtc tgcaaaggga cgttggagaa
      241 ctgcagctgc tgtgcctgat gtgggaacag ctcttctccc agatgttaat agaacaagct
      301 gcacaacctg gatttttttt caatacgata ctgagccatt tgctgcattt ctttttatat
      361 taaatatgtg agtgacaata aaacaatttt gacttgaa
//
