LOCUS       NM_005951                397 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens metallothionein 1H (MT1H), mRNA.
ACCESSION   NM_005951 XM_001124306
VERSION     NM_005951.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 397)
  AUTHORS   Zheng,Y., Jiang,L., Hu,Y., Xiao,C., Xu,N., Zhou,J. and Zhou,X.
  TITLE     Metallothionein 1H (MT1H) functions as a tumor suppressor in
            hepatocellular carcinoma through regulating Wnt/beta-catenin
            signaling pathway
  JOURNAL   BMC Cancer 17 (1), 161 (2017)
   PUBMED   28241806
  REMARK    GeneRIF: Results show that MT1H is downregulated in TCGA dataset
            and a panel of 12 paired tumor/non-tumor tissues. Ectopic
            overexpression of MT1H in HepG2 and Hep3B cells inhibited cell
            proliferation, invasion, and migration through inhibiting
            Wnt/beta-catenin pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 397)
  AUTHORS   Alkamal,I., Ikromov,O., Tolle,A., Fuller,T.F., Magheli,A.,
            Miller,K., Krause,H. and Kempkensteffen,C.
  TITLE     An epigenetic screen unmasks metallothioneins as putative
            contributors to renal cell carcinogenesis
  JOURNAL   Urol Int 94 (1), 99-110 (2015)
   PUBMED   24662736
  REMARK    GeneRIF: MT1H was down-regulated in renal cell carcinogenesis.
REFERENCE   3  (bases 1 to 397)
  AUTHORS   Lind,P.A., Zhu,G., Montgomery,G.W., Madden,P.A., Heath,A.C.,
            Martin,N.G. and Slutske,W.S.
  TITLE     Genome-wide association study of a quantitative disordered gambling
            trait
  JOURNAL   Addict Biol 18 (3), 511-522 (2013)
   PUBMED   22780124
REFERENCE   4  (bases 1 to 397)
  AUTHORS   Raymond,A.D., Gekonge,B., Giri,M.S., Hancock,A., Papasavvas,E.,
            Chehimi,J., Kossenkov,A.V., Nicols,C., Yousef,M., Mounzer,K.,
            Shull,J., Kostman,J., Showe,L. and Montaner,L.J.
  TITLE     Increased metallothionein gene expression, zinc, and zinc-dependent
            resistance to apoptosis in circulating monocytes during HIV viremia
  JOURNAL   J Leukoc Biol 88 (3), 589-596 (2010)
   PUBMED   20551211
  REMARK    GeneRIF: Increases in MT gene expression and intracellular zinc
            levels may contribute directly to maintenance of an
            immune-activated monocyte by mediating an increased resistance to
            apoptosis during active HIV-1 viremia.
            Erratum:[J Leukoc Biol. 2010 Nov;88(5):1061. Kossevkov, Andrew V
            [corrected to Kossenkov, Andrew V]]
REFERENCE   5  (bases 1 to 397)
  AUTHORS   Chang,X.L., Jin,T.Y. and Zhou,Y.F.
  TITLE     Metallothionein 1 isoform gene expression induced by cadmium in
            human peripheral blood lymphocytes
  JOURNAL   Biomed Environ Sci 19 (2), 104-109 (2006)
   PUBMED   16827180
REFERENCE   6  (bases 1 to 397)
  AUTHORS   Mididoddi,S., McGuirt,J.P., Sens,M.A., Todd,J.H. and Sens,D.A.
  TITLE     Isoform-specific expression of metallothionein mRNA in the
            developing and adult human kidney
  JOURNAL   Toxicol Lett 85 (1), 17-27 (1996)
   PUBMED   8619255
REFERENCE   7  (bases 1 to 397)
  AUTHORS   Stennard,F.A., Holloway,A.F., Hamilton,J. and West,A.K.
  TITLE     Characterisation of six additional human metallothionein genes
  JOURNAL   Biochim Biophys Acta 1218 (3), 357-365 (1994)
   PUBMED   8049263
REFERENCE   8  (bases 1 to 397)
  AUTHORS   Pauwels,M., van Weyenbergh,J., Soumillion,A., Proost,P. and De
            Ley,M.
  TITLE     Induction by zinc of specific metallothionein isoforms in human
            monocytes
  JOURNAL   Eur J Biochem 220 (1), 105-110 (1994)
   PUBMED   8119276
REFERENCE   9  (bases 1 to 397)
  AUTHORS   Soumillion,A., Van Damme,J. and De Ley,M.
  TITLE     Cloning and specific polymerised-chain-reaction amplification of a
            third charge-separable human metallothionein isoform
  JOURNAL   Eur J Biochem 209 (3), 999-1004 (1992)
   PUBMED   1425708
REFERENCE   10 (bases 1 to 397)
  AUTHORS   West,A.K., Stallings,R., Hildebrand,C.E., Chiu,R., Karin,M. and
            Richards,R.I.
  TITLE     Human metallothionein genes: structure of the functional locus at
            16q13
  JOURNAL   Genomics 8 (3), 513-518 (1990)
   PUBMED   2286373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008408.1 and BC059780.1.
            
            On or before Jan 27, 2007 this sequence version replaced
            XM_001124306.1, NM_005951.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005436.1, BP274852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332374.5/ ENSP00000330587.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               BC008408.1         1-136
            137-397             BC059780.1         117-377
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..397
                     /gene="MT1H"
                     /gene_synonym="MT-0; MT-1H; MT-IH; MT1"
                     /note="metallothionein 1H"
                     /db_xref="GeneID:4496"
                     /db_xref="HGNC:HGNC:7400"
                     /db_xref="MIM:156354"
     exon            1..99
                     /gene="MT1H"
                     /gene_synonym="MT-0; MT-1H; MT-IH; MT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..257
                     /gene="MT1H"
                     /gene_synonym="MT-0; MT-1H; MT-IH; MT1"
                     /note="metallothionein-IH; metallothionein-0; testicular
                     tissue protein Li 123"
                     /codon_start=1
                     /product="metallothionein-1H"
                     /protein_id="NP_005942.1"
                     /db_xref="CCDS:CCDS10767.1"
                     /db_xref="GeneID:4496"
                     /db_xref="HGNC:HGNC:7400"
                     /db_xref="MIM:156354"
                     /translation="MDPNCSCEAGGSCACAGSCKCKKCKCTSCKKSCCSCCPLGCAKC
                     AQGCICKGASEKCSCCA"
     exon            100..165
                     /gene="MT1H"
                     /gene_synonym="MT-0; MT-1H; MT-IH; MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..397
                     /gene="MT1H"
                     /gene_synonym="MT-0; MT-1H; MT-IH; MT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      379..384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1H"
                     /gene_synonym="MT-0; MT-1H; MT-IH; MT1"
                     /note="hexamer: ATTAAA"
     polyA_site      397
                     /gene="MT1H"
                     /gene_synonym="MT-0; MT-1H; MT-IH; MT1"
                     /note="major polyA site"
ORIGIN      
        1 accacgccct ccacgtgttc cactgcctct tctcttctcg cttgggaact ccagtctcac
       61 ctcggcttgc aatggacccc aactgctcct gcgaggctgg tggctcctgc gcctgcgccg
      121 gctcctgcaa gtgcaaaaag tgcaaatgca cctcctgcaa gaagagctgc tgctcctgtt
      181 gccccctggg ctgtgccaag tgtgcccagg gctgcatctg caaaggggcg tcagagaagt
      241 gcagctgctg tgcctgatgt cgggacagcc ctgctgtcag atgaaaacag aatgacacgt
      301 aaaatccagg attttttttt tctacaactc cgactcattt gctacattcc tttttttctg
      361 tgaaatatgt gaataataat taaacactta gacttga
//
