LOCUS       NM_001301267             410 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens metallothionein 1G (MT1G), transcript variant 2, mRNA.
ACCESSION   NM_001301267
VERSION     NM_001301267.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 410)
  AUTHORS   Wang,S., Wang,K., Yue,D., Yang,X., Pan,X., Kong,F., Zhao,R.,
            Bie,Q., Tian,D., Zhu,S., He,B. and Bin,Z.
  TITLE     MT1G induces lipid droplet accumulation through modulation of H3K14
            trimethylation accelerating clear cell renal cell carcinoma
            progression
  JOURNAL   Br J Cancer 131 (4), 641-654 (2024)
   PUBMED   38906969
  REMARK    GeneRIF: MT1G induces lipid droplet accumulation through modulation
            of H3K14 trimethylation accelerating clear cell renal cell
            carcinoma progression.
REFERENCE   2  (bases 1 to 410)
  AUTHORS   Zheng,S., Cheng,X., Ke,S., Zhang,L., Wu,H., He,D. and Cheng,X.
  TITLE     Bioinformatics analysis and validation of mesenchymal stem cells
            related gene MT1G in osteosarcoma
  JOURNAL   Aging (Albany NY) 16 (9), 8155-8170 (2024)
   PUBMED   38747739
  REMARK    GeneRIF: Bioinformatics analysis and validation of mesenchymal stem
            cells related gene MT1G in osteosarcoma.
REFERENCE   3  (bases 1 to 410)
  AUTHORS   Li,J., Hu,Q., Li,Z., Feng,K. and Li,K.
  TITLE     MT1G Regulates c-MYC/P53 Signal to Inhibit Proliferation, Invasion
            and Migration and Promote Apoptosis in Colon Cancer Cells
  JOURNAL   Curr Mol Med 24 (3), 379-388 (2024)
   PUBMED   36999424
  REMARK    GeneRIF: MT1G Regulates c-MYC/P53 Signal to Inhibit Proliferation,
            Invasion and Migration and Promote Apoptosis in Colon Cancer Cells.
REFERENCE   4  (bases 1 to 410)
  AUTHORS   Li,K., Zhang,Z., Mei,Y., Yang,Q., Qiao,S., Ni,C., Yao,Y., Li,X.,
            Li,M., Wei,D., Fu,W., Guo,X., Huang,X. and Yang,H.
  TITLE     Metallothionein-1G suppresses pancreatic cancer cell stemness by
            limiting activin A secretion via NF-kappaB inhibition
  JOURNAL   Theranostics 11 (7), 3196-3212 (2021)
   PUBMED   33537082
  REMARK    GeneRIF: Metallothionein-1G suppresses pancreatic cancer cell
            stemness by limiting activin A secretion via NF-kappaB inhibition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 410)
  AUTHORS   Hirako,N. and Takahashi,S.
  TITLE     Upregulation of Metallothionein-1G Accelerates G1/S Transition in
            the Growth Phase of Acute Promyelocytic Leukemia NB4 Cells
  JOURNAL   Ann Clin Lab Sci 51 (1), 38-43 (2021)
   PUBMED   33653779
  REMARK    GeneRIF: Upregulation of Metallothionein-1G Accelerates G1/S
            Transition in the Growth Phase of Acute Promyelocytic Leukemia NB4
            Cells.
REFERENCE   6  (bases 1 to 410)
  AUTHORS   West,A.K., Stallings,R., Hildebrand,C.E., Chiu,R., Karin,M. and
            Richards,R.I.
  TITLE     Human metallothionein genes: structure of the functional locus at
            16q13
  JOURNAL   Genomics 8 (3), 513-518 (1990)
   PUBMED   2286373
REFERENCE   7  (bases 1 to 410)
  AUTHORS   Foster,R., Jahroudi,N., Varshney,U. and Gedamu,L.
  TITLE     Structure and expression of the human metallothionein-IG gene.
            Differential promoter activity of two linked metallothionein-I
            genes in response to heavy metals
  JOURNAL   J Biol Chem 263 (23), 11528-11535 (1988)
   PUBMED   3403543
REFERENCE   8  (bases 1 to 410)
  AUTHORS   Gedamu,L., Varshney,U., Jahroudi,N., Foster,R. and Shworak,N.W.
  TITLE     Structure and expression of the human metallothionein genes
  JOURNAL   Experientia Suppl 52, 361-372 (1987)
   PUBMED   2444457
REFERENCE   9  (bases 1 to 410)
  AUTHORS   Varshney,U., Jahroudi,N., Foster,R. and Gedamu,L.
  TITLE     Structure, organization, and regulation of human metallothionein IF
            gene: differential and cell-type-specific expression in response to
            heavy metals and glucocorticoids
  JOURNAL   Mol Cell Biol 6 (1), 26-37 (1986)
   PUBMED   3023827
REFERENCE   10 (bases 1 to 410)
  AUTHORS   Karin,M., Eddy,R.L., Henry,W.M., Haley,L.L., Byers,M.G. and
            Shows,T.B.
  TITLE     Human metallothionein genes are clustered on chromosome 16
  JOURNAL   Proc Natl Acad Sci U S A 81 (17), 5494-5498 (1984)
   PUBMED   6089206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC020757.1, BM817643.1 and AC026461.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001301267.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            resulting isoform (2) is one aa longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM817643.1, BC020757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379811.4/ ENSP00000369139.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               BC020757.1         1-402
            403-405             BM817643.1         403-405
            406-410             AC026461.11        21038-21042
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..410
                     /gene="MT1G"
                     /gene_synonym="MT1; MT1K"
                     /note="metallothionein 1G"
                     /db_xref="GeneID:4495"
                     /db_xref="HGNC:HGNC:7399"
                     /db_xref="MIM:156353"
     exon            1..100
                     /gene="MT1G"
                     /gene_synonym="MT1; MT1K"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..261
                     /gene="MT1G"
                     /gene_synonym="MT1; MT1K"
                     /note="isoform 2 is encoded by transcript variant 2;
                     MT-1G; MT-1K; MT-IG; metallothionein-1K;
                     metallothionein-IG"
                     /codon_start=1
                     /product="metallothionein-1G isoform 2"
                     /protein_id="NP_001288196.1"
                     /db_xref="CCDS:CCDS76873.1"
                     /db_xref="GeneID:4495"
                     /db_xref="HGNC:HGNC:7399"
                     /db_xref="MIM:156353"
                     /translation="MDPNCSCAAAGVSCTCASSCKCKECKCTSCKKSCCSCCPVGCAK
                     CAQGCICKGASEKCSCCA"
     exon            101..169
                     /gene="MT1G"
                     /gene_synonym="MT1; MT1K"
                     /inference="alignment:Splign:2.1.0"
     exon            170..410
                     /gene="MT1G"
                     /gene_synonym="MT1; MT1K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      387..392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1G"
                     /gene_synonym="MT1; MT1K"
                     /note="hexamer: ATTAAA"
     polyA_site      410
                     /gene="MT1G"
                     /gene_synonym="MT1; MT1K"
                     /note="major polyA site"
ORIGIN      
        1 actccgcctt ccacgtgcac ccactgcctc ttcccttctc gcttgggaac tctagtctcg
       61 cctcgggttg caatggaccc caactgctcc tgtgccgctg caggtgtctc ctgcacctgc
      121 gccagctcct gcaagtgcaa agagtgcaaa tgcacctcct gcaagaagag ctgctgctcc
      181 tgctgccctg tgggctgtgc caagtgtgcc cagggctgca tctgcaaagg ggcatcggag
      241 aagtgcagct gctgcgcctg atgtcgggac agccctgctc ccaagtacaa atagagtgac
      301 ccgtaaaatc caggattttt tgttttttgc tacaatcttg acccctttgc tacattcctt
      361 tttttctgtg aaatatgtga ataataatta aacacttaga cttgattccc
//
