LOCUS       NM_005949                425 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens metallothionein 1F (MT1F), transcript variant 1, mRNA.
ACCESSION   NM_005949
VERSION     NM_005949.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 425)
  AUTHORS   Ogasawara,Y., Takeda,Y., Takayama,H., Nishimoto,S., Ichikawa,K.,
            Ueki,M., Suzuki,T. and Ishii,K.
  TITLE     Significance of the rapid increase in GSH levels in the protective
            response to cadmium exposure through phosphorylated Nrf2 signaling
            in Jurkat T-cells
  JOURNAL   Free Radic Biol Med 69, 58-66 (2014)
   PUBMED   24440467
  REMARK    GeneRIF: we found that metallothionein expression induced by Cd
            occurred much later, with the expression seen at least 12h or more
            after the Nrf2-dependent immediate responses were almost completed.
REFERENCE   2  (bases 1 to 425)
  AUTHORS   Miranda Viana Ade,C., Ribeiro,D.C., Florencio,T.N., Santos,V.T.,
            Sousa,A.A. and Aguiar,M.C.
  TITLE     Immunohistochemical expression of metallothionein in pleomorphic
            adenoma of minor salivary glands: a role in the control of
            apoptosis?
  JOURNAL   Acta Histochem 115 (6), 564-568 (2013)
   PUBMED   23332881
  REMARK    GeneRIF: Metallothionein may have a role in the control of
            apoptosis in pleomorphic adenoma.
REFERENCE   3  (bases 1 to 425)
  AUTHORS   Lind,P.A., Zhu,G., Montgomery,G.W., Madden,P.A., Heath,A.C.,
            Martin,N.G. and Slutske,W.S.
  TITLE     Genome-wide association study of a quantitative disordered gambling
            trait
  JOURNAL   Addict Biol 18 (3), 511-522 (2013)
   PUBMED   22780124
REFERENCE   4  (bases 1 to 425)
  AUTHORS   Miao,X., Wang,Y., Sun,J., Sun,W., Tan,Y., Cai,L., Zheng,Y., Su,G.,
            Liu,Q. and Wang,Y.
  TITLE     Zinc protects against diabetes-induced pathogenic changes in the
            aorta: roles of metallothionein and nuclear factor
            (erythroid-derived 2)-like 2
  JOURNAL   Cardiovasc Diabetol 12, 54 (2013)
   PUBMED   23536959
  REMARK    GeneRIF: Aortic protection in diabetes by zinc supplementation is
            associated with upregulation of both metallothionein and Nrf2
            expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 425)
  AUTHORS   Werynska,B., Pula,B., Muszczynska-Bernhard,B., Gomulkiewicz,A.,
            Piotrowska,A., Prus,R., Podhorska-Okolow,M., Jankowska,R. and
            Dziegiel,P.
  TITLE     Metallothionein 1F and 2A overexpression predicts poor outcome of
            non-small cell lung cancer patients
  JOURNAL   Exp Mol Pathol 94 (1), 301-308 (2013)
   PUBMED   23064051
  REMARK    GeneRIF: findings show 5 MT isoforms were overexpressed in
            non-small cell lung cancer and overexpression of MT-1F and MT-2A
            predicted poor outcome; both isoforms may be involved in
            progression of this cancer type; upregulated MT-1F expression
            associated with larger primary tumor size and higher grade of
            malignanacy
REFERENCE   6  (bases 1 to 425)
  AUTHORS   West,A.K., Stallings,R., Hildebrand,C.E., Chiu,R., Karin,M. and
            Richards,R.I.
  TITLE     Human metallothionein genes: structure of the functional locus at
            16q13
  JOURNAL   Genomics 8 (3), 513-518 (1990)
   PUBMED   2286373
REFERENCE   7  (bases 1 to 425)
  AUTHORS   Foster,R., Jahroudi,N., Varshney,U. and Gedamu,L.
  TITLE     Structure and expression of the human metallothionein-IG gene.
            Differential promoter activity of two linked metallothionein-I
            genes in response to heavy metals
  JOURNAL   J Biol Chem 263 (23), 11528-11535 (1988)
   PUBMED   3403543
REFERENCE   8  (bases 1 to 425)
  AUTHORS   Gedamu,L., Varshney,U., Jahroudi,N., Foster,R. and Shworak,N.W.
  TITLE     Structure and expression of the human metallothionein genes
  JOURNAL   Experientia Suppl 52, 361-372 (1987)
   PUBMED   2444457
REFERENCE   9  (bases 1 to 425)
  AUTHORS   Varshney,U., Jahroudi,N., Foster,R. and Gedamu,L.
  TITLE     Structure, organization, and regulation of human metallothionein IF
            gene: differential and cell-type-specific expression in response to
            heavy metals and glucocorticoids
  JOURNAL   Mol Cell Biol 6 (1), 26-37 (1986)
   PUBMED   3023827
REFERENCE   10 (bases 1 to 425)
  AUTHORS   Schmidt,C.J., Jubier,M.F. and Hamer,D.H.
  TITLE     Structure and expression of two human metallothionein-I isoform
            genes and a related pseudogene
  JOURNAL   J Biol Chem 260 (12), 7731-7737 (1985)
   PUBMED   2581970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029453.1 and BQ939879.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005949.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI814448.1, CA418635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334350.7/ ENSP00000334872.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               BC029453.1         17-365
            350-425             BQ939879.1         311-386
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..425
                     /gene="MT1F"
                     /gene_synonym="MT1"
                     /note="metallothionein 1F"
                     /db_xref="GeneID:4494"
                     /db_xref="HGNC:HGNC:7398"
                     /db_xref="MIM:156352"
     exon            1..128
                     /gene="MT1F"
                     /gene_synonym="MT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..286
                     /gene="MT1F"
                     /gene_synonym="MT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metallothionein 1F (functional); MT-1F; MT-IF;
                     metallothionein-IF"
                     /codon_start=1
                     /product="metallothionein-1F isoform 1"
                     /protein_id="NP_005940.1"
                     /db_xref="CCDS:CCDS32456.1"
                     /db_xref="GeneID:4494"
                     /db_xref="HGNC:HGNC:7398"
                     /db_xref="MIM:156352"
                     /translation="MDPNCSCAAGVSCTCAGSCKCKECKCTSCKKSCCSCCPVGCSKC
                     AQGCVCKGASEKCSCCD"
     exon            129..194
                     /gene="MT1F"
                     /gene_synonym="MT1"
                     /inference="alignment:Splign:2.1.0"
     exon            195..425
                     /gene="MT1F"
                     /gene_synonym="MT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      406..411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1F"
                     /gene_synonym="MT1"
                     /note="hexamer: ATTAAA"
     polyA_site      425
                     /gene="MT1F"
                     /gene_synonym="MT1"
                     /note="major polyA site"
ORIGIN      
        1 atcaaagcag cggccggctg ttggggtcca ccacgccttc cacctgcccc actgcttctt
       61 cgcttctctc ttggaaagtc cagtctctcc tcggcttgca atggacccca actgctcctg
      121 cgccgctggt gtctcctgca cctgcgctgg ttcctgcaag tgcaaagagt gcaaatgcac
      181 ctcctgcaag aagagctgct gctcctgctg ccccgtgggc tgtagcaagt gtgcccaggg
      241 ctgtgtttgc aaaggggcgt cagagaagtg cagctgctgc gactgatgcc aggacaacct
      301 ttctcccaga tgtaaacaga gagacatgta caaacctgga tttttttttt ataccacctt
      361 gacccatttg ctacattcct tttcctgtga aatatgtgag tgataattaa acactttaga
      421 cctga
//
