LOCUS       NM_001363555             746 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens metallothionein 1E (MT1E), transcript variant 1, mRNA.
ACCESSION   NM_001363555 XM_005255956
VERSION     NM_001363555.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 746)
  AUTHORS   Zou,X., Hu,M., Huang,X., Zhou,L., Li,M., Chen,J., Ma,L., Gao,X.,
            Luo,Y., Cai,X., Li,Y., Zhou,X., Li,N., Shi,Y., Han,X. and Ji,L.
  TITLE     Rare Variant in Metallothionein 1E Increases the Risk of Type 2
            Diabetes in a Chinese Population
  JOURNAL   Diabetes Care 46 (12), 2249-2257 (2023)
   PUBMED   37878528
  REMARK    GeneRIF: Rare Variant in Metallothionein 1E Increases the Risk of
            Type 2 Diabetes in a Chinese Population.
REFERENCE   2  (bases 1 to 746)
  AUTHORS   Liu,Q., Lu,F. and Chen,Z.
  TITLE     Identification of MT1E as a novel tumor suppressor in
            hepatocellular carcinoma
  JOURNAL   Pathol Res Pract 216 (11), 153213 (2020)
   PUBMED   32956919
  REMARK    GeneRIF: Identification of MT1E as a novel tumor suppressor in
            hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 746)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 746)
  AUTHORS   Maleckaite,R., Zalimas,A., Bakavicius,A., Jankevicius,F.,
            Jarmalaite,S. and Daniunaite,K.
  TITLE     DNA methylation of metallothionein genes is associated with the
            clinical features of renal cell carcinoma
  JOURNAL   Oncol Rep 41 (6), 3535-3544 (2019)
   PUBMED   31002354
  REMARK    GeneRIF: In clear cell renal cell carcinoma (RCC) MT1E, MT1G and
            MT1M expression was higher than that noted in other histological
            tumor subtypes (all P<0.0500). In addition, some associations were
            observed between metabolic syndromerelated clinical parameters and
            promoter methylation or gene expression
REFERENCE   5  (bases 1 to 746)
  AUTHORS   Masiulionyte,B., Valiulyte,I., Tamasauskas,A. and Skiriute,D.
  TITLE     Metallothionein Genes are Highly Expressed in Malignant
            Astrocytomas and Associated with Patient Survival
  JOURNAL   Sci Rep 9 (1), 5406 (2019)
   PUBMED   30932010
  REMARK    GeneRIF: Metallothionein Genes are Highly Expressed in Malignant
            Astrocytomas and Associated with Patient Survival.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 746)
  AUTHORS   West,A.K., Stallings,R., Hildebrand,C.E., Chiu,R., Karin,M. and
            Richards,R.I.
  TITLE     Human metallothionein genes: structure of the functional locus at
            16q13
  JOURNAL   Genomics 8 (3), 513-518 (1990)
   PUBMED   2286373
REFERENCE   7  (bases 1 to 746)
  AUTHORS   Schmidt,C.J., Jubier,M.F. and Hamer,D.H.
  TITLE     Structure and expression of two human metallothionein-I isoform
            genes and a related pseudogene
  JOURNAL   J Biol Chem 260 (12), 7731-7737 (1985)
   PUBMED   2581970
REFERENCE   8  (bases 1 to 746)
  AUTHORS   Le Beau,M.M., Diaz,M.O., Karin,M. and Rowley,J.D.
  TITLE     Metallothionein gene cluster is split by chromosome 16
            rearrangements in myelomonocytic leukaemia
  JOURNAL   Nature 313 (6004), 709-711 (1985)
   PUBMED   3856101
REFERENCE   9  (bases 1 to 746)
  AUTHORS   Carter,A.D., Felber,B.K., Walling,M.J., Jubier,M.F., Schmidt,C.J.
            and Hamer,D.H.
  TITLE     Duplicated heavy metal control sequences of the mouse
            metallothionein-I gene
  JOURNAL   Proc Natl Acad Sci U S A 81 (23), 7392-7396 (1984)
   PUBMED   6095291
REFERENCE   10 (bases 1 to 746)
  AUTHORS   Karin,M., Eddy,R.L., Henry,W.M., Haley,L.L., Byers,M.G. and
            Shows,T.B.
  TITLE     Human metallothionein genes are clustered on chromosome 16
  JOURNAL   Proc Natl Acad Sci U S A 81 (17), 5494-5498 (1984)
   PUBMED   6089206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC131609.1 and AF495759.1.
            
            On May 17, 2019 this sequence version replaced NM_001363555.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ772029.1, CA426835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330439.7/ ENSP00000328137.6
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BC131609.1         14-38
            26-746              AF495759.1         1-721
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..746
                     /gene="MT1E"
                     /gene_synonym="MT-1E; MT-IE; MT1; MTD"
                     /note="metallothionein 1E"
                     /db_xref="GeneID:4493"
                     /db_xref="HGNC:HGNC:7397"
                     /db_xref="MIM:156351"
     exon            1..99
                     /gene="MT1E"
                     /gene_synonym="MT-1E; MT-IE; MT1; MTD"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..455
                     /gene="MT1E"
                     /gene_synonym="MT-1E; MT-IE; MT1; MTD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metallothionein 1E (functional); metallothionein D;
                     metallothionein-IE"
                     /codon_start=1
                     /product="metallothionein-1E isoform 1"
                     /protein_id="NP_001350484.1"
                     /db_xref="CCDS:CCDS86530.1"
                     /db_xref="GeneID:4493"
                     /db_xref="HGNC:HGNC:7397"
                     /db_xref="MIM:156351"
                     /translation="MDPNCSCATGGSCTCAGSCKCKECKCTSCKKSECGAISRNLGLW
                     LRLGGNSRLALSASFWGTGLSLPSLPVSFPLQAFCPKFRWGRTAFFSWDTNPNCTPYG
                     FRTELCQTKKSILWVWVLSSSQACY"
     exon            100..746
                     /gene="MT1E"
                     /gene_synonym="MT-1E; MT-IE; MT1; MTD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      724..729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1E"
                     /gene_synonym="MT-1E; MT-IE; MT1; MTD"
                     /note="hexamer: AATAAA"
     polyA_site      746
                     /gene="MT1E"
                     /gene_synonym="MT-1E; MT-IE; MT1; MTD"
                     /note="major polyA site"
ORIGIN      
        1 attctgcttt ccaactgcct gactgcttgt tcgtctcact ggtgtgagct ccagcatccc
       61 ctttgctcga aatggacccc aactgctctt gcgccactgg tggctcctgc acgtgcgccg
      121 gctcctgcaa gtgcaaagag tgcaaatgca cctcctgcaa gaagagtgag tgcggggcca
      181 tctccaggaa tctggggctg tggctcaggt tgggagggaa ctcaaggctg gccctgagtg
      241 catccttctg gggaactggg ctttctttgc cctcattgcc cgtgtcattc cctctccagg
      301 ctttctgccc taaattcaga tggggcagga cagcattttt ctcgtgggac acaaacccca
      361 actgtacccc ctatggtttc agaacagagc tgtgccagac gaaaaaaagc atcctctggg
      421 tctgggttct gagctcgagc caggcttgct attagggcag ggaggtgccc ggtcaagtct
      481 actgccacct ctcactctcc ccttcttccc caggctgctg ttcctgctgc cccgtgggct
      541 gtgccaagtg tgcccagggc tgcgtctgca aaggggcatc ggagaagtgc agctgctgtg
      601 cctgatgtgg gaacagctct tctcccagat gtaaatagaa caacctgcac aacctggatt
      661 tttttaaaaa tacaacactg agccatttgc tgcatttctt tttatactaa atatgtgact
      721 gacaataaaa acaattttga ctttaa
//
