LOCUS       NM_005947                393 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens metallothionein 1B (MT1B), mRNA.
ACCESSION   NM_005947
VERSION     NM_005947.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 393)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 393)
  AUTHORS   Werynska,B., Pula,B., Muszczynska-Bernhard,B., Gomulkiewicz,A.,
            Piotrowska,A., Prus,R., Podhorska-Okolow,M., Jankowska,R. and
            Dziegiel,P.
  TITLE     Metallothionein 1F and 2A overexpression predicts poor outcome of
            non-small cell lung cancer patients
  JOURNAL   Exp Mol Pathol 94 (1), 301-308 (2013)
   PUBMED   23064051
REFERENCE   3  (bases 1 to 393)
  AUTHORS   Sun,N.N., Fastje,C.D., Wong,S.S., Sheppard,P.R., Macdonald,S.J.,
            Ridenour,G., Hyde,J.D. and Witten,M.L.
  TITLE     Dose-dependent transcriptome changes by metal ores on a human acute
            lymphoblastic leukemia cell line
  JOURNAL   Toxicol Ind Health 19 (7-10), 157-163 (2003)
   PUBMED   15747776
  REMARK    GeneRIF: Eight MT genes were up-regulated after treatment of T-ALL
            cells with 0.15 and 1.5 microg/mL of metal ores.
            Copper/cadmium/zinc ore binding.
REFERENCE   4  (bases 1 to 393)
  AUTHORS   Rahman,M.T. and De Ley,M.
  TITLE     Metallothionein isogene transcription in red blood cell precursors
            from human cord blood
  JOURNAL   Eur J Biochem 268 (3), 849-856 (2001)
   PUBMED   11168427
REFERENCE   5  (bases 1 to 393)
  AUTHORS   West,A.K., Stallings,R., Hildebrand,C.E., Chiu,R., Karin,M. and
            Richards,R.I.
  TITLE     Human metallothionein genes: structure of the functional locus at
            16q13
  JOURNAL   Genomics 8 (3), 513-518 (1990)
   PUBMED   2286373
REFERENCE   6  (bases 1 to 393)
  AUTHORS   Heguy,A., West,A., Richards,R.I. and Karin,M.
  TITLE     Structure and tissue-specific expression of the human
            metallothionein IB gene
  JOURNAL   Mol Cell Biol 6 (6), 2149-2157 (1986)
   PUBMED   3785191
REFERENCE   7  (bases 1 to 393)
  AUTHORS   Karin,M., Eddy,R.L., Henry,W.M., Haley,L.L., Byers,M.G. and
            Shows,T.B.
  TITLE     Human metallothionein genes are clustered on chromosome 16
  JOURNAL   Proc Natl Acad Sci U S A 81 (17), 5494-5498 (1984)
   PUBMED   6089206
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026461.11 and AY168638.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005947.2.
            
            Summary: The protein encoded by this gene binds heavy metals and
            protects against toxicity from heavy metal ions. This gene is found
            in a cluster of similar genes on chromosome 16. [provided by
            RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY168638.1, BC069421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334346.3/ ENSP00000334998.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC026461.11        35874-35886         c
            14-393              AY168638.1         2-381
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..393
                     /gene="MT1B"
                     /gene_synonym="MT-1B; MT-IB; MT1; MT1Q; MTP"
                     /note="metallothionein 1B"
                     /db_xref="GeneID:4490"
                     /db_xref="HGNC:HGNC:7394"
                     /db_xref="MIM:156349"
     exon            1..96
                     /gene="MT1B"
                     /gene_synonym="MT-1B; MT-IB; MT1; MT1Q; MTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..254
                     /gene="MT1B"
                     /gene_synonym="MT-1B; MT-IB; MT1; MT1Q; MTP"
                     /note="metallothionein 1B (functional); metallothionein
                     1Q; metallothionein-IB"
                     /codon_start=1
                     /product="metallothionein-1B"
                     /protein_id="NP_005938.1"
                     /db_xref="CCDS:CCDS10765.1"
                     /db_xref="GeneID:4490"
                     /db_xref="HGNC:HGNC:7394"
                     /db_xref="MIM:156349"
                     /translation="MDPNCSCTTGGSCACAGSCKCKECKCTSCKKCCCSCCPVGCAKC
                     AQGCVCKGSSEKCRCCA"
     exon            97..162
                     /gene="MT1B"
                     /gene_synonym="MT-1B; MT-IB; MT1; MT1Q; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            163..393
                     /gene="MT1B"
                     /gene_synonym="MT-1B; MT-IB; MT1; MT1Q; MTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      373..378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1B"
                     /gene_synonym="MT-1B; MT-IB; MT1; MT1Q; MTP"
                     /note="hexamer: AATAAA"
     polyA_site      393
                     /gene="MT1B"
                     /gene_synonym="MT-1B; MT-IB; MT1; MT1Q; MTP"
                     /note="major polyA site"
ORIGIN      
        1 atcacacctt cctcctgccc tgacttctca tatcttgcct aggaactcca ggcttgtctt
       61 ggctccaaat ggatcccaac tgctcctgca ccacaggtgg ctcctgtgcc tgcgccggct
      121 cctgcaagtg caaagagtgc aaatgtacct cctgcaagaa gtgctgctgc tcttgctgcc
      181 ccgtgggctg tgccaagtgt gcccagggct gtgtctgcaa aggctcatca gagaagtgcc
      241 gctgctgtgc ctgatgttgg gagagccctg ctcccagaca taaatagagc aaccagtact
      301 aacctggatt ttttttttta actaccctga ccggtttgct acattctttt ttctattcaa
      361 tatgtgaaag acaataaaac acttttgact tga
//
