LOCUS       NM_005946                396 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens metallothionein 1A (MT1A), mRNA.
ACCESSION   NM_005946
VERSION     NM_005946.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Korkola,N.C. and Stillman,M.J.
  TITLE     Human apo-metallothionein 1a is not a random coil: Evidence from
            guanidinium chloride, high temperature, and acidic pH unfolding
            studies
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1872 (4), 141010 (2024)
   PUBMED   38490456
  REMARK    GeneRIF: Human apo-metallothionein 1a is not a random coil:
            Evidence from guanidinium chloride, high temperature, and acidic pH
            unfolding studies.
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Michalczyk,K., Kapczuk,P., Witczak,G., Tousty,P., Bosiacki,M.,
            Kurzawski,M., Chlubek,D. and Cymbaluk-Ploska,A.
  TITLE     An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L
            (rs10636) Gene Polymorphisms and MT2 Concentration in Women with
            Endometrial Pathologies
  JOURNAL   Genes (Basel) 14 (3), 773 (2023)
   PUBMED   36981043
  REMARK    GeneRIF: An Assessment of MT1A (rs11076161), MT2A (rs28366003) and
            MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women
            with Endometrial Pathologies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 396)
  AUTHORS   Melenbacher,A., Korkola,N.C. and Stillman,M.J.
  TITLE     The pathways and domain specificity of Cu(I) binding to human
            metallothionein 1A
  JOURNAL   Metallomics 12 (12), 1951-1964 (2020)
   PUBMED   33225329
  REMARK    GeneRIF: The pathways and domain specificity of Cu(I) binding to
            human metallothionein 1A.
REFERENCE   4  (bases 1 to 396)
  AUTHORS   Thirumoorthy,N., Manisenthil Kumar,K.T., Shyam Sundar,A.,
            Panayappan,L. and Chatterjee,M.
  TITLE     Metallothionein: an overview
  JOURNAL   World J Gastroenterol 13 (7), 993-996 (2007)
   PUBMED   17373731
  REMARK    GeneRIF: One biomarker which has recently shown to be expressed in
            various human tumors but still less reported in carcinoma is
            metallothionein.
            Review article
REFERENCE   5  (bases 1 to 396)
  AUTHORS   Levadoux-Martin,M., Hesketh,J.E., Beattie,J.H. and Wallace,H.M.
  TITLE     Influence of metallothionein-1 localization on its function
  JOURNAL   Biochem J 355 (Pt 2), 473-479 (2001)
   PUBMED   11284736
REFERENCE   6  (bases 1 to 396)
  AUTHORS   Masters,B.A., Kelly,E.J., Quaife,C.J., Brinster,R.L. and
            Palmiter,R.D.
  TITLE     Targeted disruption of metallothionein I and II genes increases
            sensitivity to cadmium
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 584-588 (1994)
   PUBMED   8290567
  REMARK    GeneRIF: Disruption of metallothionein I and II genes in mouse
            produced viable mice with increased susceptibility to cadmium
            poisoning.
REFERENCE   7  (bases 1 to 396)
  AUTHORS   Grider,A., Bailey,L.B. and Cousins,R.J.
  TITLE     Erythrocyte metallothionein as an index of zinc status in humans
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1259-1262 (1990)
   PUBMED   2304897
REFERENCE   8  (bases 1 to 396)
  AUTHORS   Sutherland,G.R., Baker,E., Callen,D.F., Garson,O.M. and West,A.K.
  TITLE     The human metallothionein gene cluster is not disrupted in
            myelomonocytic leukemia
  JOURNAL   Genomics 6 (1), 144-148 (1990)
   PUBMED   2303255
REFERENCE   9  (bases 1 to 396)
  AUTHORS   Le Beau,M.M., Diaz,M.O., Karin,M. and Rowley,J.D.
  TITLE     Metallothionein gene cluster is split by chromosome 16
            rearrangements in myelomonocytic leukaemia
  JOURNAL   Nature 313 (6004), 709-711 (1985)
   PUBMED   3856101
REFERENCE   10 (bases 1 to 396)
  AUTHORS   Karin,M., Eddy,R.L., Henry,W.M., Haley,L.L., Byers,M.G. and
            Shows,T.B.
  TITLE     Human metallothionein genes are clustered on chromosome 16
  JOURNAL   Proc Natl Acad Sci U S A 81 (17), 5494-5498 (1984)
   PUBMED   6089206
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY028617.1 and BC029475.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005946.2.
            
            Summary: This gene is a member of the metallothionein family of
            genes. Proteins encoded by this gene family are low in molecular
            weight, are cysteine-rich, lack aromatic residues, and bind
            divalent heavy metal ions. The conserved cysteine residues
            co-ordinate metal ions using mercaptide linkages. These proteins
            act as anti-oxidants, protect against hydroxyl free radicals, are
            important in homeostatic control of metal in the cell, and play a
            role in detoxification of heavy metals. Disruption of two
            metallothionein genes in mouse resulted in defects in protection
            against heavy metals, oxidative stress, immune reactions,
            carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028617.1, BJ995397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290705.12/ ENSP00000290705.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AY028617.1         1-287
            288-396             BC029475.1         285-393
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..396
                     /gene="MT1A"
                     /gene_synonym="MT-1A; MT-IA; MT1; MT1S; MTC"
                     /note="metallothionein 1A"
                     /db_xref="GeneID:4489"
                     /db_xref="HGNC:HGNC:7393"
                     /db_xref="MIM:156350"
     exon            1..101
                     /gene="MT1A"
                     /gene_synonym="MT-1A; MT-IA; MT1; MT1S; MTC"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..259
                     /gene="MT1A"
                     /gene_synonym="MT-1A; MT-IA; MT1; MT1S; MTC"
                     /note="metallothionein 1A (functional); metallothionein
                     1S; metallothionein-IA"
                     /codon_start=1
                     /product="metallothionein-1A"
                     /protein_id="NP_005937.2"
                     /db_xref="CCDS:CCDS32454.1"
                     /db_xref="GeneID:4489"
                     /db_xref="HGNC:HGNC:7393"
                     /db_xref="MIM:156350"
                     /translation="MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKC
                     AQGCICKGASEKCSCCA"
     exon            102..167
                     /gene="MT1A"
                     /gene_synonym="MT-1A; MT-IA; MT1; MT1S; MTC"
                     /inference="alignment:Splign:2.1.0"
     exon            168..396
                     /gene="MT1A"
                     /gene_synonym="MT-1A; MT-IA; MT1; MT1S; MTC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      377..382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MT1A"
                     /gene_synonym="MT-1A; MT-IA; MT1; MT1S; MTC"
                     /note="hexamer: AATAAA"
     polyA_site      396
                     /gene="MT1A"
                     /gene_synonym="MT-1A; MT-IA; MT1; MT1S; MTC"
                     /note="major polyA site"
ORIGIN      
        1 accaagcctt ccacgtgcgc cttatagcct ctcaacttct tgcttgggat ctccaacctc
       61 accgcggctc gaaatggacc ccaactgctc ctgcgccact ggtggctcct gcacctgcac
      121 tggctcctgc aaatgcaaag agtgcaaatg cacctcctgc aagaagagct gctgctcctg
      181 ctgccccatg agctgtgcca agtgtgccca gggctgcatc tgcaaagggg catcagagaa
      241 gtgcagctgc tgtgcctgat gtccggacag ccctgctcga agatatagaa agagtgacct
      301 gcacaaactt ggaatttttt ttccatacaa ccctgaccca tttactgtat tttttttaat
      361 gaaatatgtg aatgataata aaagttgctg acttaa
//
