LOCUS       NM_002447               4772 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens macrophage stimulating 1 receptor (MST1R), transcript
            variant 1, mRNA.
ACCESSION   NM_002447
VERSION     NM_002447.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4772)
  AUTHORS   Hunt,B.G., Fox,L.H., Davis,J.C., Jones,A., Lu,Z. and Waltz,S.E.
  TITLE     An Introduction and Overview of RON Receptor Tyrosine Kinase
            Signaling
  JOURNAL   Genes (Basel) 14 (2), 517 (2023)
   PUBMED   36833444
  REMARK    GeneRIF: An Introduction and Overview of RON Receptor Tyrosine
            Kinase Signaling.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4772)
  AUTHORS   Franco Nitta,C., Green,E.W., Jhamba,E.D., Keth,J.M.,
            Ortiz-Caraveo,I., Grattan,R.M., Schodt,D.J., Gibson,A.C.,
            Rajput,A., Lidke,K.A., Wilson,B.S., Steinkamp,M.P. and Lidke,D.S.
  TITLE     EGFR transactivates RON to drive oncogenic crosstalk
  JOURNAL   Elife 10, e63678 (2021)
   PUBMED   34821550
  REMARK    GeneRIF: EGFR transactivates RON to drive oncogenic crosstalk.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4772)
  AUTHORS   Kato,A., Ng,S., Thangasamy,A., Han,H., Zhou,W., Raeppel,S.,
            Fallon,M., Guha,S. and Ammanamanchi,S.
  TITLE     A potential signaling axis between RON kinase receptor and
            hypoxia-inducible factor-1 alpha in pancreatic cancer
  JOURNAL   Mol Carcinog 60 (11), 734-745 (2021)
   PUBMED   34347914
  REMARK    GeneRIF: A potential signaling axis between RON kinase receptor and
            hypoxia-inducible factor-1 alpha in pancreatic cancer.
REFERENCE   4  (bases 1 to 4772)
  AUTHORS   Bourn,J.R., Ruiz-Torres,S.J., Hunt,B.G., Benight,N.M. and
            Waltz,S.E.
  TITLE     Tumor cell intrinsic RON signaling suppresses innate immune
            responses in breast cancer through inhibition of IRAK4 signaling
  JOURNAL   Cancer Lett 503, 75-90 (2021)
   PUBMED   33508385
  REMARK    GeneRIF: Tumor cell intrinsic RON signaling suppresses innate
            immune responses in breast cancer through inhibition of IRAK4
            signaling.
REFERENCE   5  (bases 1 to 4772)
  AUTHORS   Batth,I.S., Huang,S.B., Villarreal,M., Gong,J., Chakravarthy,D.,
            Keppler,B., Jayamohan,S., Osmulski,P., Xie,J., Rivas,P.,
            Bedolla,R., Liss,M.A., Yeh,I.T., Reddick,R., Miyamoto,H., Ghosh,R.
            and Kumar,A.P.
  TITLE     Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor
            Tyrosine Kinase RON in the Management of Prostate Cancer
  JOURNAL   Int J Mol Sci 22 (4), 1852 (2021)
   PUBMED   33673346
  REMARK    GeneRIF: Evidence for 2-Methoxyestradiol-Mediated Inhibition of
            Receptor Tyrosine Kinase RON in the Management of Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4772)
  AUTHORS   Collesi,C., Santoro,M.M., Gaudino,G. and Comoglio,P.M.
  TITLE     A splicing variant of the RON transcript induces constitutive
            tyrosine kinase activity and an invasive phenotype
  JOURNAL   Mol Cell Biol 16 (10), 5518-5526 (1996)
   PUBMED   8816464
  REMARK    Erratum:[Mol Cell Biol 1997 Jan;17(1):528]
REFERENCE   7  (bases 1 to 4772)
  AUTHORS   Li,B.Q., Wang,M.H., Kung,H.F., Ronsin,C., Breathnach,R.,
            Leonard,E.J. and Kamata,T.
  TITLE     Macrophage-stimulating protein activates Ras by both activation and
            translocation of SOS nucleotide exchange factor
  JOURNAL   Biochem Biophys Res Commun 216 (1), 110-118 (1995)
   PUBMED   7488076
REFERENCE   8  (bases 1 to 4772)
  AUTHORS   Wang,M.H., Ronsin,C., Gesnel,M.C., Coupey,L., Skeel,A.,
            Leonard,E.J. and Breathnach,R.
  TITLE     Identification of the ron gene product as the receptor for the
            human macrophage stimulating protein
  JOURNAL   Science 266 (5182), 117-119 (1994)
   PUBMED   7939629
REFERENCE   9  (bases 1 to 4772)
  AUTHORS   Gaudino,G., Follenzi,A., Naldini,L., Collesi,C., Santoro,M.,
            Gallo,K.A., Godowski,P.J. and Comoglio,P.M.
  TITLE     RON is a heterodimeric tyrosine kinase receptor activated by the
            HGF homologue MSP
  JOURNAL   EMBO J 13 (15), 3524-3532 (1994)
   PUBMED   8062829
REFERENCE   10 (bases 1 to 4772)
  AUTHORS   Lee,S.T., Strunk,K.M. and Spritz,R.A.
  TITLE     A survey of protein tyrosine kinase mRNAs expressed in normal human
            melanocytes
  JOURNAL   Oncogene 8 (12), 3403-3410 (1993)
   PUBMED   8247543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105935.2, X70040.1 and
            CA503122.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002447.3.
            
            Summary: This gene encodes a cell surface receptor for
            macrophage-stimulating protein (MSP) with tyrosine kinase activity.
            The mature form of this protein is a heterodimer of
            disulfide-linked alpha and beta subunits, generated by proteolytic
            cleavage of a single-chain precursor. The beta subunit undergoes
            tyrosine phosphorylation upon stimulation by MSP. This protein is
            expressed on the ciliated epithelia of the mucociliary transport
            apparatus of the lung, and together with MSP, thought to be
            involved in host defense. Alternative splicing generates multiple
            transcript variants encoding different isoforms that may undergo
            similar proteolytic processing. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            isoform Ron).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70040.1, SRR7346977.1486705.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296474.8/ ENSP00000296474.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC105935.2         99339-99574
            237-889             X70040.1           1-653
            890-1229            AC105935.2         100228-100567
            1230-1831           X70040.1           994-1595
            1832-1832           AC105935.2         104543-104543
            1833-4515           X70040.1           1597-4279
            4516-4772           CA503122.1         14-270              c
FEATURES             Location/Qualifiers
     source          1..4772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4772
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /note="macrophage stimulating 1 receptor"
                     /db_xref="GeneID:4486"
                     /db_xref="HGNC:HGNC:7381"
                     /db_xref="MIM:600168"
     exon            1..1494
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..4467
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; PTK8 protein tyrosine kinase 8; c-met-related
                     tyrosine kinase; MSP receptor; S13 avian erythroblastosis
                     oncogene homolog; S13 erythroblastosis oncogene homolog"
                     /codon_start=1
                     /product="macrophage-stimulating protein receptor isoform
                     1 preproprotein"
                     /protein_id="NP_002438.2"
                     /db_xref="CCDS:CCDS2807.1"
                     /db_xref="GeneID:4486"
                     /db_xref="HGNC:HGNC:7381"
                     /db_xref="MIM:600168"
                     /translation="MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKY
                     VVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQ
                     TCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAP
                     ACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSI
                     RRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSAL
                     HTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLA
                     TELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHP
                     GLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTA
                     LYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDH
                     LLFASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDH
                     CPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSS
                     KLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFM
                     EPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPP
                     GATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWH
                     LVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPG
                     FRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMV
                     VCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAAL
                     ATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLD
                     STTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVI
                     GKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLAL
                     IGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKF
                     VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY
                     RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM
                     QQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQP
                     QFSPMPGNVRRPRPLSEPPRPT"
     exon            1495..1683
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1812
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1983
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2144
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2310
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2447
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2609
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2703
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2913
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3060
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3226
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3328
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3535
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3616
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3798
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3908
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4074
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            4075..4211
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4772
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4749..4754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /note="hexamer: AACAAA"
     polyA_site      4772
                     /gene="MST1R"
                     /gene_synonym="CD136; CDw136; NPCA3; p185-Ron; PTK8; RON;
                     SEA"
                     /note="major polyA site"
ORIGIN      
        1 agtgtacagc ggcggctggg gcggcaggtg aggcggctgg ggcgttgctg tcgtgcgtcc
       61 gcaggcgtca ggtgctcaga cccgagggcc gggaagggat ttgggtttca caggaacctg
      121 gggcgggggt ccgctatctt ggggctgtcg ggaccgctgc ttaaatttgg cccagtccag
      181 acctcgagtc gggcccccag ccaggcccac gcccaggtcc aggcccaggc cggtagggat
      241 cctctagggt cccagctcgc ctcgatggag ctcctcccgc cgctgcctca gtccttcctg
      301 ttgctgctgc tgttgcctgc caagcccgcg gcgggcgagg actggcagtg cccgcgcacc
      361 ccctacgcgg cctctcgcga ctttgacgtg aagtacgtgg tgcccagctt ctccgccgga
      421 ggcctggtac aggccatggt gacctacgag ggcgacagaa atgagagtgc tgtgtttgta
      481 gccatacgca atcgcctgca tgtgcttggg cctgacctga agtctgtcca gagcctggcc
      541 acgggccctg ctggagaccc tggctgccag acgtgtgcag cctgtggccc aggaccccac
      601 ggccctcccg gtgacacaga cacaaaggtg ctggtgctgg atcccgcgct gcctgcgctg
      661 gtcagttgtg gctccagcct gcagggccgc tgcttcctgc atgacctaga gccccaaggg
      721 acagccgtgc atctggcagc gccagcctgc ctcttctcag cccaccataa ccggcccgat
      781 gactgccccg actgtgtggc cagcccattg ggcacccgtg taactgtggt tgagcaaggc
      841 caggcctcct atttctacgt ggcatcctca ctggacgcag ccgtggctgc cagcttcagc
      901 ccacgctcag tgtctatcag gcgtctcaag gctgacgcct cgggattcgc accgggcttt
      961 gtggcgttgt cagtgctgcc caagcatctt gtctcctaca gtattgaata cgtgcacagc
     1021 ttccacacgg gagccttcgt atacttcctg actgtacagc cggccagcgt gacagatgat
     1081 cctagtgccc tgcacacacg cctggcacgg cttagcgcca ctgagccaga gttgggtgac
     1141 tatcgggagc tggtcctcga ctgcagattt gctccaaaac gcaggcgccg gggggcccca
     1201 gaaggcggac agccctaccc tgtgctgcgg gtggcccact ccgctccagt gggtgcccaa
     1261 cttgccactg agctgagcat cgccgagggc caggaagtac tatttggggt ctttgtgact
     1321 ggcaaggatg gtggtcctgg cgtgggcccc aactctgtcg tctgtgcctt ccccattgac
     1381 ctgctggaca cactaattga tgagggtgtg gagcgctgtt gtgaatcccc agtccatcca
     1441 ggcctccggc gaggcctcga cttcttccag tcgcccagtt tttgccccaa cccgcctggc
     1501 ctggaagccc tcagccccaa caccagctgc cgccacttcc ctctgctggt cagtagcagc
     1561 ttctcacgtg tggacctatt caatgggctg ttgggaccag tacaggtcac tgcattgtat
     1621 gtgacacgcc ttgacaacgt cacagtggca cacatgggca caatggatgg gcgtatcctg
     1681 caggtggagc tggtcaggtc actaaactac ttgctgtatg tgtccaactt ctcactgggt
     1741 gacagtgggc agcccgtgca gcgggatgtc agtcgtcttg gggaccacct actctttgcc
     1801 tctggggacc aggttttcca ggtacctatc caaggccctg gctgccgcca cttcctgacc
     1861 tgtgggcgtt gcctaagggc atggcatttc atgggctgtg gctggtgtgg gaacatgtgc
     1921 ggccagcaga aggagtgtcc tggctcctgg caacaggacc actgcccacc taagcttact
     1981 gagttccacc cccacagtgg acctctaagg ggcagtacaa ggctgaccct gtgtggctcc
     2041 aacttctacc ttcacccttc tggtctggtg cctgagggaa cccatcaggt cactgtgggc
     2101 caaagtccct gccggccact gcccaaggac agctcaaaac tcagaccagt gccccggaaa
     2161 gactttgtag aggagtttga gtgtgaactg gagcccttgg gcacccaggc agtggggcct
     2221 accaacgtca gcctcaccgt gactaacatg ccaccgggca agcacttccg ggtagacggc
     2281 acctccgtgc tgagaggctt ctctttcatg gagccagtgc tgatagcagt gcaacccctc
     2341 tttggcccac gggcaggagg cacctgtctc actcttgaag gccagagtct gtctgtaggc
     2401 accagccggg ctgtgctggt caatgggact gagtgtctgc tagcacgggt cagtgagggg
     2461 cagcttttat gtgccacacc ccctggggcc acggtggcca gtgtccccct tagcctgcag
     2521 gtggggggtg cccaggtacc tggttcctgg accttccagt acagagaaga ccctgtcgtg
     2581 ctaagcatca gccccaactg tggctacatc aactcccaca tcaccatctg tggccagcat
     2641 ctaacttcag catggcactt agtgctgtca ttccatgacg ggcttagggc agtggaaagc
     2701 aggtgtgaga ggcagcttcc agagcagcag ctgtgccgcc ttcctgaata tgtggtccga
     2761 gacccccagg gatgggtggc agggaatctg agtgcccgag gggatggagc tgctggcttt
     2821 acactgcctg gctttcgctt cctaccccca ccccatccac ccagtgccaa cctagttcca
     2881 ctgaagcctg aggagcatgc cattaagttt gagtatattg ggctgggcgc tgtggctgac
     2941 tgtgtgggta tcaacgtgac cgtgggtggt gagagctgcc agcacgagtt ccggggggac
     3001 atggttgtct gccccctgcc cccatccctg cagcttggcc aggatggtgc cccattgcag
     3061 gtctgcgtag atggtgaatg tcatatcctg ggtagagtgg tgcggccagg gccagatggg
     3121 gtcccacaga gcacgctcct tggtatcctg ctgcctttgc tgctgcttgt ggctgcactg
     3181 gcgactgcac tggtcttcag ctactggtgg cggaggaagc agctagttct tcctcccaac
     3241 ctgaatgacc tggcatccct ggaccagact gctggagcca cacccctgcc tattctgtac
     3301 tcgggctctg actacagaag tggccttgca ctccctgcca ttgatggtct ggattccacc
     3361 acttgtgtcc atggagcatc cttctccgat agtgaagatg aatcctgtgt gccactgctg
     3421 cggaaagagt ccatccagct aagggacctg gactctgcgc tcttggctga ggtcaaggat
     3481 gtgctgattc cccatgagcg ggtggtcacc cacagtgacc gagtcattgg caaaggccac
     3541 tttggagttg tctaccacgg agaatacata gaccaggccc agaatcgaat ccaatgtgcc
     3601 atcaagtcac taagtcgcat cacagagatg cagcaggtgg aggccttcct gcgagagggg
     3661 ctgctcatgc gtggcctgaa ccacccgaat gtgctggctc tcattggtat catgttgcca
     3721 cctgagggcc tgccccatgt gctgctgccc tatatgtgcc acggtgacct gctccagttc
     3781 atccgctcac ctcagcggaa ccccaccgtg aaggacctca tcagctttgg cctgcaggta
     3841 gcccgcggca tggagtacct ggcagagcag aagtttgtgc acagggacct ggctgcgcgg
     3901 aactgcatgc tggacgagtc attcacagtc aaggtggctg actttggttt ggcccgcgac
     3961 atcctggaca gggagtacta tagtgttcaa cagcatcgcc acgctcgcct acctgtgaag
     4021 tggatggcgc tggagagcct gcagacctat agatttacca ccaagtctga tgtgtggtca
     4081 tttggtgtgc tgctgtggga actgctgaca cggggtgccc caccataccg ccacattgac
     4141 ccttttgacc ttacccactt cctggcccag ggtcggcgcc tgccccagcc tgagtattgc
     4201 cctgattctc tgtaccaagt gatgcagcaa tgctgggagg cagacccagc agtgcgaccc
     4261 accttcagag tactagtggg ggaggtggag cagatagtgt ctgcactgct tggggaccat
     4321 tatgtgcagc tgccagcaac ctacatgaac ttgggcccca gcacctcgca tgagatgaat
     4381 gtgcgtccag aacagccgca gttctcaccc atgccaggga atgtacgccg gccccggcca
     4441 ctctcagagc ctcctcggcc cacttgactt agttcttggg ctggacctgc ttagctgcct
     4501 tgagctaacc ccaagctgcc tctgggccat gccaggccag agggcagtgg ccctccacct
     4561 tgttcctgcc ctttaacttt cagaggcaat aggtaaatgg ggcccattag gtccctcact
     4621 ccacagagtg agccagtgag ggcagtcctg caacatgtat ttatggagtg cctgctgtgg
     4681 accctgtctt ctgggcacag tggactcagc agtgaccaca ccaacactga cccttgaacc
     4741 aataaaggaa caaatgacta ttaaagcaca aa
//
