LOCUS       NM_020998               3042 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens macrophage stimulating 1 (MST1), transcript variant 1,
            mRNA.
ACCESSION   NM_020998
VERSION     NM_020998.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3042)
  AUTHORS   Ye,H., Cai,T., Shen,Y., Zhao,L., Zhang,H., Yang,J., Li,F., Chen,J.
            and Shui,X.
  TITLE     MST1 knockdown inhibits osteoarthritis progression through
            Parkin-mediated mitophagy and Nrf2/NF-kappaB signalling pathway
  JOURNAL   J Cell Mol Med 28 (11), e18476 (2024)
   PUBMED   38842136
REFERENCE   2  (bases 1 to 3042)
  AUTHORS   Huang,W., Wu,D., Cai,C., Yao,H., Tian,Z., Yang,Y., Pang,M., Rong,L.
            and Liu,B.
  TITLE     Inhibition of MST1 ameliorates neuronal apoptosis via
            GSK3beta/beta-TrCP/NRF2 pathway in spinal cord injury accompanied
            by diabetes
  JOURNAL   Redox Biol 71, 103104 (2024)
   PUBMED   38430683
  REMARK    Erratum:[Redox Biol. 2024 Aug;74:103198. doi:
            10.1016/j.redox.2024.103198.. PMID: 38806302]
REFERENCE   3  (bases 1 to 3042)
  AUTHORS   Xu,Y., Qu,M., He,Y., He,Q., Shen,T., Luo,J., Tan,D., Bao,H., Xu,C.,
            Ji,X., Hu,X., Barkat,M.Q., Zeng,L.H. and Wu,X.
  TITLE     Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to
            attenuate their tumor-suppressor functions
  JOURNAL   J Biol Chem 299 (12), 105395 (2023)
   PUBMED   37890777
REFERENCE   4  (bases 1 to 3042)
  AUTHORS   Abegunde,S.O., Grieve,S., Alfarra,H. and Reiman,T.
  TITLE     MST1 downregulates TAZ tumor suppressor protein in multiple myeloma
            and is a potential therapeutic target
  JOURNAL   Exp Hematol 123, 34-45 (2023)
   PUBMED   37137439
REFERENCE   5  (bases 1 to 3042)
  AUTHORS   Cai,X., Jiang,Y., Cao,Z., Zhang,M., Kong,N., Yu,L., Tang,Y.,
            Kong,S., Deng,W., Wang,H., Sun,J., Ding,L., Jiang,R., Sun,H. and
            Yan,G.
  TITLE     Mst1-mediated phosphorylation of Nur77 improves the endometrial
            receptivity in human and mice
  JOURNAL   EBioMedicine 88, 104433 (2023)
   PUBMED   36623453
  REMARK    GeneRIF: Mst1-mediated phosphorylation of Nur77 improves the
            endometrial receptivity in human and mice.
REFERENCE   6  (bases 1 to 3042)
  AUTHORS   Wang,M.H., Yoshimura,T., Skeel,A. and Leonard,E.J.
  TITLE     Proteolytic conversion of single chain precursor
            macrophage-stimulating protein to a biologically active heterodimer
            by contact enzymes of the coagulation cascade
  JOURNAL   J Biol Chem 269 (5), 3436-3440 (1994)
   PUBMED   7508914
REFERENCE   7  (bases 1 to 3042)
  AUTHORS   Yoshimura,T., Yuhki,N., Wang,M.H., Skeel,A. and Leonard,E.J.
  TITLE     Cloning, sequencing, and expression of human macrophage stimulating
            protein (MSP, MST1) confirms MSP as a member of the family of
            kringle proteins and locates the MSP gene on chromosome 3
  JOURNAL   J Biol Chem 268 (21), 15461-15468 (1993)
   PUBMED   8393443
REFERENCE   8  (bases 1 to 3042)
  AUTHORS   Han,S., Stuart,L.A. and Degen,S.J.
  TITLE     Characterization of the DNF15S2 locus on human chromosome 3:
            identification of a gene coding for four kringle domains with
            homology to hepatocyte growth factor
  JOURNAL   Biochemistry 30 (40), 9768-9780 (1991)
   PUBMED   1655021
REFERENCE   9  (bases 1 to 3042)
  AUTHORS   Skeel,A., Yoshimura,T., Showalter,S.D., Tanaka,S., Appella,E. and
            Leonard,E.J.
  TITLE     Macrophage stimulating protein: purification, partial amino acid
            sequence, and cellular activity
  JOURNAL   J Exp Med 173 (5), 1227-1234 (1991)
   PUBMED   1827141
REFERENCE   10 (bases 1 to 3042)
  AUTHORS   Gerber,M.J., Drabkin,H.A., Firnhaber,C., Miller,Y.E., Scoggin,C.H.
            and Smith,D.I.
  TITLE     Regional localization of chromosome 3-specific DNA fragments by
            using a hybrid cell deletion mapping panel
  JOURNAL   Am J Hum Genet 43 (4), 442-451 (1988)
   PUBMED   2902784
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099668.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 22, 2021 this sequence version replaced NM_020998.3.
            
            Summary: The protein encoded by this gene contains four kringle
            domains and a serine protease domain, similar to that found in
            hepatic growth factor. Despite the presence of the serine protease
            domain, the encoded protein may not have any proteolytic activity.
            The receptor for this protein is RON tyrosine kinase, which upon
            activation stimulates ciliary motility of ciliated epithelial lung
            cells. This protein is secreted and cleaved to form an alpha chain
            and a beta chain bridged by disulfide bonds. [provided by RefSeq,
            Jan 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048330.1, L11924.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449682.3/ ENSP00000414287.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-877               AC099668.2         46799-47675
            878-1025            AC099668.2         48376-48523
            1026-1138           AC099668.2         48605-48717
            1139-1253           AC099668.2         48795-48909
            1254-1390           AC099668.2         48988-49124
            1391-1511           AC099668.2         49206-49326
            1512-1630           AC099668.2         49471-49589
            1631-1799           AC099668.2         49792-49960
            1800-1930           AC099668.2         50081-50211
            1931-2033           AC099668.2         50311-50413
            2034-2170           AC099668.2         50541-50677
            2171-2206           AC099668.2         50767-50802
            2207-2327           AC099668.2         50891-51011
            2328-2405           AC099668.2         51184-51261
            2406-2552           AC099668.2         51389-51535
            2553-2659           AC099668.2         51617-51723
            2660-2799           AC099668.2         51820-51959
            2800-3042           AC099668.2         52084-52326
FEATURES             Location/Qualifiers
     source          1..3042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3042
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /note="macrophage stimulating 1"
                     /db_xref="GeneID:4485"
                     /db_xref="HGNC:HGNC:7380"
                     /db_xref="MIM:142408"
     exon            1..877
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     CDS             784..2961
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hepatocyte growth factor-like protein homolog;
                     macrophage stimulating 1 (hepatocyte growth factor-like);
                     macrophage-stimulating protein"
                     /codon_start=1
                     /product="hepatocyte growth factor-like protein isoform 1
                     precursor"
                     /protein_id="NP_066278.3"
                     /db_xref="CCDS:CCDS33757.2"
                     /db_xref="GeneID:4485"
                     /db_xref="HGNC:HGNC:7380"
                     /db_xref="MIM:142408"
                     /translation="MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLR
                     GTELQHLLHAVVPGPWQEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSP
                     HTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTP
                     TLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVD
                     RTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREF
                     CDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPE
                     KYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQY
                     RGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDP
                     RTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHPGNSPW
                     TVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSL
                     QRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGET
                     KGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGDYGGPLACF
                     THNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG"
     exon            878..1025
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1138
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1253
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1390
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1511
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1630
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1799
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1930
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2033
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2170
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2206
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2327
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2405
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2552
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2659
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2799
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..3042
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /note="hexamer: CATAAA"
     polyA_site      3042
                     /gene="MST1"
                     /gene_synonym="D3F15S2; DNF15S2; HGFL; MSP; NF15S2"
                     /note="major polyA site"
ORIGIN      
        1 cagcctccgc taggggaccc cctccatggc ttcccaccgg gttgttccag gcctcagctt
       61 cgccgaaagg cctcaccacc tccgacctcc gcctgctctg gggatgctcc cagccctgct
      121 gcggcagaac gcgacatgct aaccggaatc cctaggccgc ctgtctccta cccatactta
      181 gaggccccgc tcagacggtc cttaaaacgt ctgaaaggcc gttcctgcca gagtccctgc
      241 tacctgttac ctccacccct atttagtcct agtggacagc ctcgctcacc ttccctggga
      301 tgacacttct ggcggctgag atgagcgagc ctctctgggc tctgccgccg ggtgtgggct
      361 gacctgccta cagctggggc ctgataaggc agcagcaaaa gggtggaggg gaggcagtgt
      421 tgaagctggg gcaagtaatt ttccccaatt tacagggaaa aaccgaaatt cagaaaagtt
      481 taatgtcacc caggggctgg agcccagacc tctggcagct ctcactttca caatgccctt
      541 gggctgacta ggctgcagag gggtttcacc ccaaccccag ggcacctcaa gtgtccccac
      601 caaaccttcc taacacctgt ccactaagct gtactaggcc cttgcaactg acctatggga
      661 cctgaggcct ggcccctcat ggctcctgtc accaggtctc aggtcagggt ccagcaggcc
      721 ctgagctgac gtgtggagcc agagccaccc aatcccgtag ggacaggttt cacaacttcc
      781 cggatggggc tgtggtgggt cacagtgcag cctccagcca gaaggatggg gtggctccca
      841 ctcctgctgc ttctgactca atgcttaggg gtccctgggc agcgctcgcc attgaatgac
      901 ttccaagtgc tccggggcac agagctacag cacctgctac atgcggtggt gcccgggcct
      961 tggcaggagg atgtggcaga tgctgaagag tgtgctggtc gctgtgggcc cttaatggac
     1021 tgccgggcct tccactacaa cgtgagcagc catggttgcc aactgctgcc atggactcaa
     1081 cactcgcccc acacgaggct gcggcgttct gggcgctgtg acctcttcca gaagaaagac
     1141 tacgtacgga cctgcatcat gaacaatggg gttgggtacc ggggcaccat ggccacgacc
     1201 gtgggtggcc tgccctgcca ggcttggagc cacaagttcc caaatgatca caagtacacg
     1261 cccactctcc ggaatggcct ggaagagaac ttctgccgta accctgatgg cgaccccgga
     1321 ggtccttggt gctacacaac agaccctgct gtgcgcttcc agagctgcgg catcaaatcc
     1381 tgccgggagg ccgcgtgtgt ctggtgcaat ggcgaggaat accgcggcgc ggtagaccgc
     1441 acggagtcag ggcgcgagtg ccagcgctgg gatcttcagc acccgcacca gcaccccttc
     1501 gagccgggca agttcctcga ccaaggtctg gacgacaact attgccggaa tcctgacggc
     1561 tccgagcggc catggtgcta cactacggat ccgcagatcg agcgagagtt ctgtgacctc
     1621 ccccgctgcg ggtccgaggc acagccccgc caagaggcca caactgtcag ctgcttccgc
     1681 gggaagggtg agggctaccg gggcacagcc aataccacca ctgcgggcgt accttgccag
     1741 cgttgggacg cgcaaatccc gcatcagcac cgatttacgc cagaaaaata cgcgtgcaaa
     1801 gaccttcggg agaacttctg ccggaacccc gacggctcag aggcgccctg gtgcttcaca
     1861 ctgcggcccg gcatgcgcgc ggccttttgc taccagatcc ggcgttgtac agacgacgtg
     1921 cggccccagg actgctacca cggcgcaggg gagcagtacc gcggcacggt cagcaagacc
     1981 cgcaagggtg tccagtgcca gcgctggtcc gctgagacgc cgcacaagcc gcagttcacg
     2041 tttacctccg aaccgcatgc acaactggag gagaacttct gccggaaccc agatggggat
     2101 agccatgggc cctggtgcta cacgatggac ccaaggaccc cattcgacta ctgtgccctg
     2161 cgacgctgcg ctgatgacca gccgccatca atcctggacc ccccagacca ggtgcagttt
     2221 gagaagtgtg gcaagagggt ggatcggctg gatcagcggc gttccaagct gcgcgtggtt
     2281 gggggccatc cgggcaactc accctggaca gtcagcttgc ggaatcggca gggccagcat
     2341 ttctgcgggg ggtctctagt gaaggagcag tggatactga ctgcccggca gtgcttctcc
     2401 tcctgccata tgcctctcac gggctatgag gtatggttgg gcaccctgtt ccagaaccca
     2461 cagcatggag agccaagcct acagcgggtc ccagtagcca agatggtgtg tgggccctca
     2521 ggctcccagc ttgtcctgct caagctggag agatctgtga ccctgaacca gcgtgtggcc
     2581 ctgatctgcc tgccccctga atggtatgtg gtgcctccag ggaccaagtg tgagattgca
     2641 ggctggggtg agaccaaagg tacgggtaat gacacagtcc taaatgtggc cttgctgaat
     2701 gtcatctcca accaggagtg taacatcaag caccgaggac gtgtgcggga gagtgagatg
     2761 tgcactgagg gactgttggc ccctgtgggg gcctgtgagg gtgactacgg gggcccactt
     2821 gcctgcttta cccacaactg ctgggtcctg gaaggaatta taatccccaa ccgagtatgc
     2881 gcaaggtccc gctggccagc tgtcttcacg cgtgtctctg tgtttgtgga ctggattcac
     2941 aaggtcatga gactgggtta ggcccagcct tgatgccata tgccttgggg aggacaaaac
     3001 ttcttgtcag acataaagcc atgtttcctc tttatgcctg ta
//
