LOCUS       NM_001031679            4377 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens methionine sulfoxide reductase B3 (MSRB3), transcript
            variant 2, mRNA.
ACCESSION   NM_001031679
VERSION     NM_001031679.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4377)
  AUTHORS   Dai,Y., Gao,M., Li,L., Mao,Z., Xu,L., Yin,L., Qi,Y. and Peng,J.
  TITLE     MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal Podocyte
            Injury via Targeting Methionine Sulfoxide Reductase B3
  JOURNAL   Oxid Med Cell Longev 2020, 9481841 (2020)
   PUBMED   32908641
  REMARK    GeneRIF: MicroRNA-874-3p Aggravates Doxorubicin-Induced Renal
            Podocyte Injury via Targeting Methionine Sulfoxide Reductase B3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4377)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4377)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4377)
  AUTHORS   Ye,X., Liang,T., Deng,C., Li,Z. and Yan,D.
  TITLE     MSRB3 promotes the progression of clear cell renal cell carcinoma
            via regulating endoplasmic reticulum stress
  JOURNAL   Pathol Res Pract 216 (2), 152780 (2020)
   PUBMED   31889586
  REMARK    GeneRIF: MSRB3 promotes the progression of clear cell renal cell
            carcinoma via regulating endoplasmic reticulum stress.
REFERENCE   5  (bases 1 to 4377)
  AUTHORS   Conner,S.C., Benayoun,L., Himali,J.J., Adams,S.L., Yang,Q.,
            DeCarli,C., Blusztajn,J.K., Beiser,A., Seshadri,S. and Delalle,I.
  TITLE     Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in
            Alzheimer's Disease Associates with Increased Odds for Brain
            Infarcts
  JOURNAL   J Alzheimers Dis 68 (1), 357-365 (2019)
   PUBMED   30775993
  REMARK    GeneRIF: individuals with MSRB3 rs61921502 minor allele had
            increased odds for brain infarcts on MRI compared to those with no
            minor allele
REFERENCE   6  (bases 1 to 4377)
  AUTHORS   Kwak,G.H., Choi,S.H., Kim,J.R. and Kim,H.Y.
  TITLE     Inhibition of methionine sulfoxide reduction by dimethyl sulfoxide
  JOURNAL   BMB Rep 42 (9), 580-585 (2009)
   PUBMED   19788859
REFERENCE   7  (bases 1 to 4377)
  AUTHORS   Waryah,A.M., Rehman,A., Ahmed,Z.M., Bashir,Z.H., Khan,S.Y.,
            Zafar,A.U., Riazuddin,S., Friedman,T.B. and Riazuddin,S.
  TITLE     DFNB74, a novel autosomal recessive nonsyndromic hearing impairment
            locus on chromosome 12q14.2-q15
  JOURNAL   Clin Genet 76 (3), 270-275 (2009)
   PUBMED   19650862
REFERENCE   8  (bases 1 to 4377)
  AUTHORS   Taungjaruwinai,W.M., Bhawan,J., Keady,M. and Thiele,J.J.
  TITLE     Differential expression of the antioxidant repair enzyme methionine
            sulfoxide reductase (MSRA and MSRB) in human skin
  JOURNAL   Am J Dermatopathol 31 (5), 427-431 (2009)
   PUBMED   19542914
REFERENCE   9  (bases 1 to 4377)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
REFERENCE   10 (bases 1 to 4377)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Methionine sulfoxide reduction in mammals: characterization of
            methionine-R-sulfoxide reductases
  JOURNAL   Mol Biol Cell 15 (3), 1055-1064 (2004)
   PUBMED   14699060
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK293084.1, AY358229.1,
            AC025419.42 and BX648776.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001031679.2.
            
            Summary: The protein encoded by this gene catalyzes the reduction
            of methionine sulfoxide to methionine. This enzyme acts as a
            monomer and requires zinc as a cofactor. Several transcript
            variants encoding two different isoforms have been found for this
            gene. One of the isoforms localizes to mitochondria while the other
            localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            Variants 2, 3, and 4 all encode isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648776.1, SRR1660805.147465.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000308259.10/
                                                  ENSP00000312274.6
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1084              AK293084.1         11-1094
            1085-1918           AY358229.1         933-1766
            1919-2742           AC025419.42        78821-79644
            2743-4377           BX648776.1         2703-4337
FEATURES             Location/Qualifiers
     source          1..4377
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.3"
     gene            1..4377
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /note="methionine sulfoxide reductase B3"
                     /db_xref="GeneID:253827"
                     /db_xref="HGNC:HGNC:27375"
                     /db_xref="MIM:613719"
     exon            1..183
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /inference="alignment:Splign:2.1.0"
     exon            184..310
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..792
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /EC_number="1.8.4.12"
                     /EC_number="1.8.4.14"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; methionine-R-sulfoxide reductase B3,
                     mitochondrial"
                     /codon_start=1
                     /product="methionine-R-sulfoxide reductase B3 isoform 2
                     precursor"
                     /protein_id="NP_001026849.1"
                     /db_xref="CCDS:CCDS31853.1"
                     /db_xref="GeneID:253827"
                     /db_xref="HGNC:HGNC:27375"
                     /db_xref="MIM:613719"
                     /translation="MSAFNLLHLVTKSQPVALRACGLPSGSCRDKKNCKVVFSQQELR
                     KRLTPLQYHVTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSETKFDSGSGWPSF
                     HDVINSEAITFTDDFSYGMHRVETSCSQCGAHLGHIFDDGPRPTGKRYCINSAALSFT
                     PADSSGTAEGGSGVASPAQADKAEL"
     exon            311..419
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /inference="alignment:Splign:2.1.0"
     exon            420..497
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /inference="alignment:Splign:2.1.0"
     exon            498..526
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /inference="alignment:Splign:2.1.0"
     exon            527..624
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /inference="alignment:Splign:2.1.0"
     exon            625..4377
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4355..4360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /note="hexamer: AATAAA"
     polyA_site      4377
                     /gene="MSRB3"
                     /gene_synonym="DFNB74"
                     /note="major polyA site"
ORIGIN      
        1 atgcctcccg ccgccccgtc cgtcgcccgg agccggggag ggagggagcg aggttcggac
       61 accggcggcg gctgcctggc ctttccatga gcccgcggcg gaccctcccg cgccccctct
      121 cgctctgcct ctccctctgc ctctgcctct gcctggccgc ggctctggga agtgcgcagt
      181 ccgctcttgc ccctgttctt tgcttctcgt tttgttggtg aagatatcac agtgatgtct
      241 gcattcaacc tgctgcattt ggtgacaaag agccagccag tagcccttcg agcctgtggg
      301 cttccctcag ggtcgtgtag ggataaaaag aactgtaagg tggtcttttc ccagcaggaa
      361 ctgaggaagc ggctaacacc cctgcagtac catgtcactc aggagaaagg gaccgaaagt
      421 gcctttgaag gagaatacac acatcacaaa gatcctggaa tatataaatg tgttgtttgt
      481 ggaactccat tgtttaagtc agaaaccaaa tttgactccg gttcaggttg gccttcattc
      541 cacgatgtga tcaattctga ggcaatcaca ttcacagatg acttttccta tgggatgcac
      601 agggtggaaa caagctgctc tcagtgtggt gctcaccttg ggcacatttt tgatgatggg
      661 cctcgtccaa ctgggaaaag atactgcata aattcggctg ccttgtcttt tacacctgcg
      721 gatagcagtg gcaccgccga gggaggcagt ggggtcgcca gcccggccca ggcagacaaa
      781 gcggagctct agagtaatgg agagtgatgg aaacaaagtg tacttaatgc acagcttatt
      841 aaaaaaatca aaattgttat cttaatagat atattttttc aaaaactata agggcagttt
      901 tgtgctattg atattttttc ttcttttgct taaacagaag ccctggccat ccatgtattt
      961 tgcaattgac tagatcaaga actgtttata gctttagcaa atggagacag ctttgtgaaa
     1021 cttcttcaca agccacttat accctttggc attcttttct ttgagcacat ggcttctttt
     1081 gcagtttttc cccctttgat tcagaagcag agggttcatg gtcttcaaac atgaaaatag
     1141 agatctcctc tgcagtgtag agaccagagc tgggcagtgc agggcatgga gacctgcaag
     1201 acacatggcc ttgaggcctt tgcacagacc cacctaagat aaggttggag tgatgtttta
     1261 atgagactgt tcagctttgt ggaaagtttg agctaaggtc attttttttt ttctcactga
     1321 aagggtgtga aggtctaaag tctttcctta tgttaaattg ttgccagatc caaaggggca
     1381 tactgagtgt tgtggcagag aagtaaacat taccacactg ttaggccttt attttatttt
     1441 attttccatc gaaagcattg gaggcccagt gcaatggctc acgcctgtga tcccagcact
     1501 ttgggaggcc aaggcgggtg gatcacgagg tcaggagatg gagaccatcc tggctaacat
     1561 ggtgaaaccc cgtctctact aaaaatacga aaaattagcc aggcgtggtg gtgggcacct
     1621 gtagtcccag ctactcagga ggctgaggca ggagaatggc gtgaacccgg aaggcggagc
     1681 ttgcagttag ccgagatcat gccactgcac tccagcctac atgacaatgt gacactccat
     1741 ctcaaaaaat aataataata acaatataag aactagctgg gcatggtggc gcatgcatgt
     1801 agtcccagct actcctgagg ctcagtcagg agaatcgctt gaacttggga ggcggaggtt
     1861 gcagtgagct gagctcatac cactgcactc cagcctgaac agagtgagat cctgtcaaaa
     1921 aagaaaagaa aaagaaagca gcattcaaat gtaagacaac tgtaaaatat tgagccccac
     1981 ttggtctaaa attcaaaaag aagaacgcct gtccatcgcc tttttataag tccttctctc
     2041 cacacctaaa agcagctgca gctggaaggg cacaaattcc actgtgtaaa ataaaatatt
     2101 aggggcaaca cacttcatca aggcagcagg aatgagagag agcagagaag atcaaggatg
     2161 aagtcttggg tactgaaaaa ttcagtgctg ggcagaaaaa ctgacagggc agtacaagta
     2221 acaaacagaa tccaagtggg gtggcccttg tgcacagagc tccaggtgac ctctggagag
     2281 acatgggcat tcacatggaa agctaaaacg gaagctcaag tttcatactc aacataatct
     2341 tctgtgtgac aaaggacaag ccatgtagcc tctctgtgcc tatttcttca tgcataaact
     2401 gggactcata atatttgtaa aatgtattga tactctcagg gcaaattcac tatattgcta
     2461 tacagttgag atcagtgttg taaaattaaa ctgatctggt tctaattgcc tcaaaggcca
     2521 aagcccaggc atttgaaatg gaaagaagca gagaggaggc tgacttagct gattggtatg
     2581 gaaacagttg ggccaagagc cagaatttcc ctttgtagca acacggctag ttttactttg
     2641 agaagctctg ctcagctgct ttataacatt aagtctggcg gaatggatgt cactgtgcac
     2701 aataaagttt tcacaagtat aaacaatggt gatgtaagtc aacattgctg tagccaggtg
     2761 tgaaggttgt atggtgtgtg acgaatgtac atcatgtttg taggtttgga tgctaatctt
     2821 gaattgtagt ttaaaaaata cgtatttttg taactctttg aaagtttatg aagactgaca
     2881 gctttccttg taagcactaa gagaaaaaaa agaaagaggg acatttgaca attttaaaga
     2941 aacaacaaga aattagaatg aaaatctgtg acaaacagcg tcagtgtggc catgtccaca
     3001 ttcctacatg tctctctcta caagcacctc tctaagaagc ctgacatccc ggtggactct
     3061 ttatagtcat gtacacttga ttccagatga gctctggtct tatctggatg ctcagataag
     3121 aggtttctat ctgagcatcc agatgttccc tcaggttcca agacatttca ccccaggccc
     3181 tgggttcact ctggaattcg taggcttcac gtctctctag aaatgacgtg taaaatttaa
     3241 gaccagacct cagccatcag cgtccagacc atcctagaag tctttcccaa tctcacagag
     3301 aaagccctag tatttcccag tgaccccagg attccacgtt ggggtggcca aagaaatagg
     3361 tctctcaggg ctttgccaca gcctccagcc catccttcag aggcacacac agcacctctc
     3421 ggctgctcca gctctgtagg atagcctccc ctggggtccg tgggacgcgg gccacagtgt
     3481 tgaggtagac aaggaggatc agtgagaggc ctcttccctc tccacagaga ctggattgtc
     3541 attgttcctt catttatatc gtagggctta acatttcact caaaaaaaag cccctctttt
     3601 tctaatcctt agtctttgtt tcaaggaaag ccagtttttc ttctaccaca ttttccagga
     3661 tcgactttaa gaaaaatgca acatctattg aaaaaaagtg gggtgtatgc atgtggttta
     3721 attccagatt gcttttgggt ttaagtggta tcaaatttca gtatatttct gtcttatgtg
     3781 aaagaaatat attactaaaa cgtcagtgag caataatgtc agctgtcaag cactagattt
     3841 atttttgcag gatatggagt gcaatgaact gagtcaatat ggcaaggtgt atgtgatctg
     3901 tgggagttat gccatttaac ataggaagtg catgggactt tccctctctg cactccagct
     3961 cttactgtac cattagaaga tgcagaattc tgttggtgtg caaaaagtat agccttacat
     4021 tcaagcagaa tggatctgaa gaaagcagca atatctgtta ctagagaaca ttcccatgtg
     4081 tttaaactct tcacttctta gatgcattta aattcttaat gcaaatgacg tagcaatttg
     4141 aaaacttctc cgtattactt gtgtttaaaa tgtcttgctt taaatacaaa acaaatggta
     4201 aaggggatta tcttttgttt agatggttaa atattatttt tgccttagat agctttgtaa
     4261 taatttttct ccagacagtt caacactttt gaaaaatgac atgaattttc attaaaaacc
     4321 cttttcctat gtttattgta tacaagaatt atgcaataaa atttctttat aaaaata
//
