LOCUS       NM_012228               1730 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens methionine sulfoxide reductase B2 (MSRB2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_012228 NM_016064
VERSION     NM_012228.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Huang,K., Fu,W., Wang,A., Du,G., Tang,H., Yin,L., Yin,Z. and Gao,W.
  TITLE     MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative Stress and
            Suppresses Apoptosis in Osteoarthritis
  JOURNAL   Immunol Invest 53 (5), 813-829 (2024)
   PUBMED   38638027
  REMARK    GeneRIF: MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative
            Stress and Suppresses Apoptosis in Osteoarthritis.
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Lee,S.H., Lee,S., Du,J., Jain,K., Ding,M., Kadado,A.J., Atteya,G.,
            Jaji,Z., Tyagi,T., Kim,W.H., Herzog,R.I., Patel,A., Ionescu,C.N.,
            Martin,K.A. and Hwa,J.
  TITLE     Mitochondrial MsrB2 serves as a switch and transducer for mitophagy
  JOURNAL   EMBO Mol Med 11 (8), e10409 (2019)
   PUBMED   31282614
  REMARK    GeneRIF: Release of the enzyme MsrB2 from damaged mitochondria,
            initiating autophagosome formation, represents a novel regulatory
            mechanism for oxidative stress-induced mitophagy.
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Kim,H.Y. and Gladyshev,V.N.
  TITLE     Methionine sulfoxide reduction in mammals: characterization of
            methionine-R-sulfoxide reductases
  JOURNAL   Mol Biol Cell 15 (3), 1055-1064 (2004)
   PUBMED   14699060
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Picot,C.R., Perichon,M., Cintrat,J.C., Friguet,B. and
            Petropoulos,I.
  TITLE     The peptide methionine sulfoxide reductases, MsrA and MsrB
            (hCBS-1), are downregulated during replicative senescence of human
            WI-38 fibroblasts
  JOURNAL   FEBS Lett 558 (1-3), 74-78 (2004)
   PUBMED   14759519
  REMARK    GeneRIF: MSRB is down-regulated during cell aging.
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Jung,S., Hansel,A., Kasperczyk,H., Hoshi,T. and Heinemann,S.H.
  TITLE     Activity, tissue distribution and site-directed mutagenesis of a
            human peptide methionine sulfoxide reductase of type B: hCBS1
  JOURNAL   FEBS Lett 527 (1-3), 91-94 (2002)
   PUBMED   12220640
  REMARK    GeneRIF: CBS1, a methionine sulfoxide reductase of type B, is most
            abundant in muscle tissues, especially in the heart and thereby
            shows an expression pattern different to the human methionine
            sulfoxide reductase A
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Huang,W., Escribano,J., Sarfarazi,M. and Coca-Prados,M.
  TITLE     Identification, expression and chromosome localization of a human
            gene encoding a novel protein with similarity to the pilB family of
            transcriptional factors (pilin) and to bacterial peptide methionine
            sulfoxide reductases
  JOURNAL   Gene 233 (1-2), 233-240 (1999)
   PUBMED   10375640
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Escribano,J., Ortego,J. and Coca-Prados,M.
  TITLE     Isolation and characterization of cell-specific cDNA clones from a
            subtractive library of the ocular ciliary body of a single normal
            human donor: transcription and synthesis of plasma proteins
  JOURNAL   J Biochem 118 (5), 921-931 (1995)
   PUBMED   8749308
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC117471.1, AF151889.1 and AL139281.7.
            
            On Nov 22, 2018 this sequence version replaced NM_012228.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI669177.1, SRR1660805.49668.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376510.8/ ENSP00000365693.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-701               BC117471.1         131-831
            702-807             AF151889.1         731-836
            808-1730            AL139281.7         39237-40159
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..1730
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /note="methionine sulfoxide reductase B2"
                     /db_xref="GeneID:22921"
                     /db_xref="HGNC:HGNC:17061"
                     /db_xref="MIM:613782"
     exon            1..148
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..579
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /EC_number="1.8.4.12"
                     /EC_number="1.8.4.14"
                     /note="pilin-like transcription factor;
                     methionine-R-sulfoxide reductase B2, mitochondrial"
                     /codon_start=1
                     /product="methionine-R-sulfoxide reductase B2,
                     mitochondrial precursor"
                     /protein_id="NP_036360.3"
                     /db_xref="CCDS:CCDS41495.1"
                     /db_xref="GeneID:22921"
                     /db_xref="HGNC:HGNC:17061"
                     /db_xref="MIM:613782"
                     /translation="MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLAT
                     CELPLAKSEWQKKLTPEQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEK
                     KYCSGTGWPSFSEAHGTSGSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDG
                     PGPNGQRFCINSVALKFKPRKH"
     exon            149..249
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /inference="alignment:Splign:2.1.0"
     exon            250..326
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /inference="alignment:Splign:2.1.0"
     exon            327..474
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1730
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      666..671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /note="hexamer: AATAAA"
     polyA_site      687
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /note="major polyA site"
     regulatory      1708..1713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
                     /note="hexamer: AATAAA"
     polyA_site      1730
                     /gene="MSRB2"
                     /gene_synonym="CBS-1; CBS1; CGI-131; MSRB; PILB"
ORIGIN      
        1 agagggcgga gcggcgccgg agcgggcgtc atggcgcggc tcctctggtt gctccggggc
       61 ctgaccctcg gaactgcgcc tcggcgggcg gtgcggggcc aagcgggcgg cggcgggccc
      121 ggcaccgggc cgggactggg ggaggcaggg tctcttgcaa cgtgtgagct gcctcttgcc
      181 aagagtgagt ggcaaaagaa actaaccccg gagcagttct acgtcacaag agaaaaggga
      241 acggaaccgc ctttcagtgg gatctacctg aataacaagg aagcaggaat gtatcattgc
      301 gtgtgctgcg acagtccact cttcagttct gagaaaaagt actgctctgg cactgggtgg
      361 ccttcgtttt ccgaggctca tggtacgtct ggctctgatg aaagccacac agggatcctg
      421 agacgtctgg atacctcgtt aggatcagct cgcacagagg ttgtctgcaa gcagtgtgaa
      481 gctcatctag gtcacgtgtt tcctgatgga cctgggccca atggtcagag gttttgcatc
      541 aacagtgtgg ctttgaagtt caaaccaagg aaacactgac catcttcaag agtcccgttc
      601 ccttgccacc ccttcacgtg caccctcaat ttccacaatt cacttgaatg acttgtttta
      661 tttgcaataa aactgggctg aatttgctgc tgtctccagc gagtcattgc ttctcttaat
      721 ttatttacct ggaatcaact taatcctgtg tgttaggctg ttcttgtgtt gctataaaga
      781 agtacctgat caggatctgg gagaatttga aaaaaaaaga aaaactagaa aaataaacaa
      841 aattaaaaag aaaaaaaaat acctgagact gagtaactta taaagaaaag aggtttaatt
      901 gactcacagt tctgcagggt gtacagaaag catggtgcca gcatttgctc ggattctggg
      961 gagacctgag ggagctttta ctcatggcag aaggtgaagg gggagccggc gtctcacatg
     1021 gcaaagcagg agcaagagag agtggtaggg aggtgccaca tacttttaaa cagccagatc
     1081 tctcaagaac tcactcactg tcaccaggac agcaccaagc catgagggat ccaccctcat
     1141 gacccagtta cctcccggca gggcccacct ccggcactag gaattatact tcaacataag
     1201 atttggagag ggaaaacatc caaaccatat cacccaactc ccacttggag tagaacttca
     1261 caaaacgaca gagggacagc tgtttccatc aaacacttcc acagcttcac ctgagacgag
     1321 ggcatgactc tgggaacatc aggaggctga tggactatta agccaaacaa ttcctacaaa
     1381 aattccctgc accttccact gcgtttcagt ccttgacaga cataagtaag ggatcaagtg
     1441 agaagaggaa ggaaaataca ggatccaagg aatcaacaat gctagcactg aagagcagga
     1501 ttacggagga gctgtgctct gggagcatat atggtgatca atcagatgca tgactttttt
     1561 ttcaaaattt taaatgtctt gagcatgcta cttccaacca ttctacccac aaataaactg
     1621 caataggact tggttagatt tcaatgatta tgaataaatg ttcaccttca taccttctgg
     1681 ttacaaagct aaactttaaa atgtccaaat aaaatattca ctaaaattta
//
