LOCUS       NM_012331               1512 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens methionine sulfoxide reductase A (MSRA), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012331
VERSION     NM_012331.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1512)
  AUTHORS   Milovanovic,V., Topic,A., Milinkovic,N., Lazic,Z., Ivosevic,A.,
            Radojkovic,D. and Rankov,A.D.
  TITLE     Association of the methionine sulfoxide reductase A rs10903323 gene
            polymorphism with functional activity and oxidative modification of
            alpha-1-antitrypsin in COPD patients
  JOURNAL   Pulmonology 30 (2), 122-129 (2024)
   PUBMED   34674978
  REMARK    GeneRIF: Association of the methionine sulfoxide reductase A
            rs10903323 gene polymorphism with functional activity and oxidative
            modification of alpha-1-antitrypsin in COPD patients.
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1512)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1512)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1512)
  AUTHORS   Kantorow,M., Hawse,J.R., Cowell,T.L., Benhamed,S., Pizarro,G.O.,
            Reddy,V.N. and Hejtmancik,J.F.
  TITLE     Methionine sulfoxide reductase A is important for lens cell
            viability and resistance to oxidative stress
  JOURNAL   Proc Natl Acad Sci U S A 101 (26), 9654-9659 (2004)
   PUBMED   15199188
  REMARK    GeneRIF: MsrA is present throughout the human lens, where it is
            likely to defend lens cells and their components against methionine
            oxidation
REFERENCE   6  (bases 1 to 1512)
  AUTHORS   Picot,C.R., Perichon,M., Cintrat,J.C., Friguet,B. and
            Petropoulos,I.
  TITLE     The peptide methionine sulfoxide reductases, MsrA and MsrB
            (hCBS-1), are downregulated during replicative senescence of human
            WI-38 fibroblasts
  JOURNAL   FEBS Lett 558 (1-3), 74-78 (2004)
   PUBMED   14759519
  REMARK    GeneRIF: MSRA is down-regulated during cell aging.
REFERENCE   7  (bases 1 to 1512)
  AUTHORS   Vougier,S., Mary,J. and Friguet,B.
  TITLE     Subcellular localization of methionine sulphoxide reductase A
            (MsrA): evidence for mitochondrial and cytosolic isoforms in rat
            liver cells
  JOURNAL   Biochem J 373 (Pt 2), 531-537 (2003)
   PUBMED   12693988
REFERENCE   8  (bases 1 to 1512)
  AUTHORS   Hansel,A., Kuschel,L., Hehl,S., Lemke,C., Agricola,H.J., Hoshi,T.
            and Heinemann,S.H.
  TITLE     Mitochondrial targeting of the human peptide methionine sulfoxide
            reductase (MSRA), an enzyme involved in the repair of oxidized
            proteins
  JOURNAL   FASEB J 16 (8), 911-913 (2002)
   PUBMED   12039877
REFERENCE   9  (bases 1 to 1512)
  AUTHORS   Kuschel,L., Hansel,A., Schonherr,R., Weissbach,H., Brot,N.,
            Hoshi,T. and Heinemann,S.H.
  TITLE     Molecular cloning and functional expression of a human peptide
            methionine sulfoxide reductase (hMsrA)
  JOURNAL   FEBS Lett 456 (1), 17-21 (1999)
   PUBMED   10452521
REFERENCE   10 (bases 1 to 1512)
  AUTHORS   Moskovitz,J., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Jursky,F.,
            Weissbach,H. and Brot,N.
  TITLE     Chromosomal localization of the mammalian peptide-methionine
            sulfoxide reductase gene and its differential expression in various
            tissues
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3205-3208 (1996)
   PUBMED   8622914
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034111.6, AC023385.10,
            AC079200.6 and AC112673.7.
            
            On Nov 23, 2018 this sequence version replaced NM_012331.4.
            
            Summary: This gene encodes a ubiquitous and highly conserved
            protein that carries out the enzymatic reduction of methionine
            sulfoxide to methionine. Human and animal studies have shown the
            highest levels of expression in kidney and nervous tissue. The
            protein functions in the repair of oxidatively damaged proteins to
            restore biological activity. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY958429.1, BC054033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317173.9/ ENSP00000313921.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               AC034111.6         31080-31446         c
            368-436             AC023385.10        159698-159766
            437-556             AC079200.6         41051-41170         c
            557-661             AC112673.7         133696-133800       c
            662-768             AC112673.7         115345-115451       c
            769-1512            AC112673.7         6443-7186           c
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1512
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /note="methionine sulfoxide reductase A"
                     /db_xref="GeneID:4482"
                     /db_xref="HGNC:HGNC:7377"
                     /db_xref="MIM:601250"
     exon            1..367
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..933
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /EC_number="1.8.4.11"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; peptide met (O) reductase; mitochondrial
                     peptide methionine sulfoxide reductase; cytosolic
                     methionine-S-sulfoxide reductase; peptide Met(O)
                     reductase; peptide-methionine (S)-S-oxide reductase"
                     /codon_start=1
                     /product="mitochondrial peptide methionine sulfoxide
                     reductase isoform a precursor"
                     /protein_id="NP_036463.1"
                     /db_xref="CCDS:CCDS5975.1"
                     /db_xref="GeneID:4482"
                     /db_xref="HGNC:HGNC:7377"
                     /db_xref="MIM:601250"
                     /translation="MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQT
                     PVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSN
                     PTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSA
                     IYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNG
                     YCGLGGTGVSCPVGIKK"
     exon            368..436
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /inference="alignment:Splign:2.1.0"
     exon            437..556
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /inference="alignment:Splign:2.1.0"
     exon            557..661
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /inference="alignment:Splign:2.1.0"
     exon            662..768
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1512
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      966..971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /note="hexamer: AGTAAA"
     polyA_site      986
                     /gene="MSRA"
                     /gene_synonym="PMSR"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="MSRA"
                     /gene_synonym="PMSR"
                     /note="major polyA site"
ORIGIN      
        1 gtccagggaa ggaacacgcc cccggtgaca gccggtacgg ccccgggttt gggcaacctc
       61 gattacgggc ggcctccagc cccgccagca gcgccccgcg cccgcccgcc cgcgcccctg
      121 ccgccccccg gttccggccg cggaccccac tctctgccgt tccggctgcg gctccgctgc
      181 cggtagcgcc gtcccccggg accacccttc ggctggcgcc ctcccatgct ctcggccacc
      241 cggagggctt gccagctcct cctcctccac agcctctttc ccgtcccgag gatgggcaac
      301 tcggcctcga acatcgtcag cccccaggag gccttgccgg gccggaagga acagacccct
      361 gtagcggcca aacatcatgt caatggcaac agaacagtcg aacctttccc agagggaaca
      421 cagatggctg tatttggaat gggatgtttc tggggagctg aaaggaaatt ctgggtcttg
      481 aaaggagtgt attcaactca agttggtttt gcaggaggct atacttcaaa tcctacttat
      541 aaagaagtct gctcagaaaa aactggccat gcagaagtcg tccgagtggt gtaccagcca
      601 gaacacatga gttttgagga actgctcaag gtcttctggg agaatcacga cccgacccaa
      661 ggtatgcgcc aggggaacga ccatggcact cagtaccgct cggccatcta cccgacctct
      721 gccaagcaaa tggaggcagc cctgagctcc aaagagaact accaaaaggt tctttcagag
      781 cacggcttcg gccccatcac taccgacatc cgggagggac agactttcta ctatgcggaa
      841 gactaccacc agcagtacct gagcaagaac cccaatggct actgcggcct tgggggcacc
      901 ggcgtgtcct gcccagtggg tattaaaaaa taatttctcc ccacatggtg ggcctttgag
      961 gttccagtaa aaatgctttc aacaaattgg gcaatgcttg tgtgattcac aatcgtggca
     1021 tttaaagtgc acaaagtaca aaggaattta tacagattgg gtttaccgaa gtataatcta
     1081 taggaggcgc gatggcaagt tgataaaatg tgacttatct cctaataagt tatggtggga
     1141 gtggagctgt gcagtttcct gtgtcttctg gggtctgagt gaagatagca gggatgctgt
     1201 gttcaccctt cttggtagaa gctaaggtgt gagctgggag gttgctggac aggatggggg
     1261 accccagaag tcctttatct gtgctctctg cccgccagtg ccttacaatt tgcaaacgtg
     1321 tatagcctca gtgactcatt cgctgaaatc cttcgcttta ccaaatctag acatacataa
     1381 ggggctttct ctcccttttc agccctctct gtgcagagaa aagatgtgag tccgcttgat
     1441 gaattctaat gctttgctta gagctatgag aaatgtttgt tttaataaaa acctacagtc
     1501 caataatgcc aa
//
