LOCUS       NM_138715               3618 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens macrophage scavenger receptor 1 (MSR1), transcript
            variant SR-AI, mRNA.
ACCESSION   NM_138715
VERSION     NM_138715.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Saadh,M.J., Pallathadka,H., Abed,H.S., Menon,S.V., Sivaprasad,G.V.,
            Hjazi,A., Rizaev,J., Suri,S., Jawad,M.A. and Husseen,B.
  TITLE     Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and
            therapy
  JOURNAL   Cell Biochem Biophys 82 (3), 1735-1750 (2024)
   PUBMED   38884861
  REMARK    GeneRIF: Detailed role of SR-A1 and SR-E3 in tumor biology,
            progression, and therapy.
            Review article
REFERENCE   2  (bases 1 to 3618)
  AUTHORS   Onyishi,C.U., Desanti,G.E., Wilkinson,A.L., Lara-Reyna,S.,
            Frickel,E.M., Fejer,G., Christophe,O.D., Bryant,C.E.,
            Mukhopadhyay,S., Gordon,S. and May,R.C.
  TITLE     Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk
            regulates phagocytosis of a fungal pathogen
  JOURNAL   Nat Commun 14 (1), 4895 (2023)
   PUBMED   37580395
  REMARK    GeneRIF: Toll-like receptor 4 and macrophage scavenger receptor 1
            crosstalk regulates phagocytosis of a fungal pathogen.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3618)
  AUTHORS   AbdElneam,A.I., Al-Dhubaibi,M.S., Bahaj,S.S. and Mohammed,G.F.
  TITLE     Role of macrophage scavenger receptor 1 in the progression of
            dyslipidemia in acne vulgaris patients
  JOURNAL   Skin Res Technol 29 (8), e13424 (2023)
   PUBMED   37632192
  REMARK    GeneRIF: Role of macrophage scavenger receptor 1 in the progression
            of dyslipidemia in acne vulgaris patients.
REFERENCE   4  (bases 1 to 3618)
  AUTHORS   Cheng,W., Shu,M., Kuang,L., Bai,X., Jia,X., Zhao,Y., Lu,Y., Zhu,L.,
            Wang,L., Zhu,Y., Shu,Y., Song,Y. and Jin,S.
  TITLE     Scavenger receptor a mediates glycated LDL transcytosis across
            endothelial cells to promote atherosclerosis
  JOURNAL   Int J Biol Macromol 235, 123836 (2023)
   PUBMED   36849072
  REMARK    GeneRIF: Scavenger receptor a mediates glycated LDL transcytosis
            across endothelial cells to promote atherosclerosis.
REFERENCE   5  (bases 1 to 3618)
  AUTHORS   Sheng,W., Ji,G. and Zhang,L.
  TITLE     Role of macrophage scavenger receptor MSR1 in the progression of
            non-alcoholic steatohepatitis
  JOURNAL   Front Immunol 13, 1050984 (2022)
   PUBMED   36591228
  REMARK    GeneRIF: Role of macrophage scavenger receptor MSR1 in the
            progression of non-alcoholic steatohepatitis.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3618)
  AUTHORS   Resnick,D., Chatterton,J.E., Schwartz,K., Slayter,H. and Krieger,M.
  TITLE     Structures of class A macrophage scavenger receptors. Electron
            microscopic study of flexible, multidomain, fibrous proteins and
            determination of the disulfide bond pattern of the scavenger
            receptor cysteine-rich domain
  JOURNAL   J Biol Chem 271 (43), 26924-26930 (1996)
   PUBMED   8900177
REFERENCE   7  (bases 1 to 3618)
  AUTHORS   Ashkenas,J., Penman,M., Vasile,E., Acton,S., Freeman,M. and
            Krieger,M.
  TITLE     Structures and high and low affinity ligand binding properties of
            murine type I and type II macrophage scavenger receptors
  JOURNAL   J Lipid Res 34 (6), 983-1000 (1993)
   PUBMED   8394868
REFERENCE   8  (bases 1 to 3618)
  AUTHORS   Emi,M., Asaoka,H., Matsumoto,A., Itakura,H., Kurihara,Y., Wada,Y.,
            Kanamori,H., Yazaki,Y., Takahashi,E., Lepert,M. et al.
  TITLE     Structure, organization, and chromosomal mapping of the human
            macrophage scavenger receptor gene
  JOURNAL   J Biol Chem 268 (3), 2120-2125 (1993)
   PUBMED   8093617
REFERENCE   9  (bases 1 to 3618)
  AUTHORS   Naito,M., Suzuki,H., Mori,T., Matsumoto,A., Kodama,T. and
            Takahashi,K.
  TITLE     Coexpression of type I and type II human macrophage scavenger
            receptors in macrophages of various organs and foam cells in
            atherosclerotic lesions
  JOURNAL   Am J Pathol 141 (3), 591-599 (1992)
   PUBMED   1519666
REFERENCE   10 (bases 1 to 3618)
  AUTHORS   Matsumoto,A., Naito,M., Itakura,H., Ikemoto,S., Asaoka,H.,
            Hayakawa,I., Kanamori,H., Aburatani,H., Takaku,F., Suzuki,H. et al.
  TITLE     Human macrophage scavenger receptors: primary structure,
            expression, and localization in atherosclerotic lesions
  JOURNAL   Proc Natl Acad Sci U S A 87 (23), 9133-9137 (1990)
   PUBMED   2251254
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA995755.1, D90187.1 and
            AC023396.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138715.2.
            
            Summary: This gene encodes the class A macrophage scavenger
            receptors, which include three different types (1, 2, 3) generated
            by alternative splicing of this gene. These receptors or isoforms
            are macrophage-specific trimeric integral membrane glycoproteins
            and have been implicated in many macrophage-associated
            physiological and pathological processes including atherosclerosis,
            Alzheimer's disease, and host defense. The isoforms type 1 and type
            2 are functional receptors and are able to mediate the endocytosis
            of modified low density lipoproteins (LDLs). The isoform type 3
            does not internalize modified LDL (acetyl-LDL) despite having the
            domain shown to mediate this function in the types 1 and 2
            isoforms. It has an altered intracellular processing and is trapped
            within the endoplasmic reticulum, making it unable to perform
            endocytosis. The isoform type 3 can inhibit the function of
            isoforms type 1 and type 2 when co-expressed, indicating a dominant
            negative effect and suggesting a mechanism for regulation of
            scavenger receptor activity in macrophages. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (SR-AI), also known as phSR1,
            encodes the longest isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2508219.1, D90187.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262101.10/ ENSP00000262101.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA995755.1         142-153
            13-1143             D90187.1           1-1131
            1144-1280           AC023396.4         83124-83260
            1281-3618           AC023396.4         93460-95797
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..3618
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /note="macrophage scavenger receptor 1"
                     /db_xref="GeneID:4481"
                     /db_xref="HGNC:HGNC:7376"
                     /db_xref="MIM:153622"
     exon            1..54
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            55..161
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1414
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /note="isoform type 1 is encoded by transcript variant
                     SR-AI; macrophage scavenger receptor type III; macrophage
                     acetylated LDL receptor I and II; macrophage scavenger
                     receptor types I and II; scavenger receptor class A member
                     1"
                     /codon_start=1
                     /product="macrophage scavenger receptor types I and II
                     isoform type 1"
                     /protein_id="NP_619729.1"
                     /db_xref="CCDS:CCDS5995.1"
                     /db_xref="GeneID:4481"
                     /db_xref="HGNC:HGNC:7376"
                     /db_xref="MIM:153622"
                     /translation="MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQE
                     KLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGN
                     DSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLS
                     TLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEER
                     VYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPG
                     PPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQ
                     KGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLG
                     YPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCT
                     L"
     exon            162..275
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            276..688
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            689..875
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            876..956
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1037
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1091
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1280
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..3618
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2977..2982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /note="hexamer: AATACA"
     polyA_site      2998
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /note="major polyA site"
     regulatory      3598..3603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /note="hexamer: ATTAAA"
     polyA_site      3618
                     /gene="MSR1"
                     /gene_synonym="CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI;
                     SR-AII; SR-AIII; SRA"
                     /note="major polyA site"
ORIGIN      
        1 aattgtaaag agagagaagt ggataaatca gtgctgcttt ctttaggacg aaagaagtat
       61 ggagcagtgg gatcactttc acaatcaaca ggaggacact gatagctgct ccgaatctgt
      121 gaaatttgat gctcgctcaa tgacagcttt gcttcctccg aatcctaaaa acagcccttc
      181 ccttcaagag aaactgaagt ccttcaaagc tgcactgatt gccctttacc tcctcgtgtt
      241 tgcagttctc atccctctca ttggaatagt ggcagctcaa ctcctgaagt gggaaacgaa
      301 gaattgctca gttagttcaa ctaatgcaaa tgatataact caaagtctca cgggaaaagg
      361 aaatgacagc gaagaggaaa tgagatttca agaagtcttt atggaacaca tgagcaacat
      421 ggagaagaga atccagcata ttttagacat ggaagccaac ctcatggaca cagagcattt
      481 ccaaaatttc agcatgacaa ctgatcaaag atttaatgac attcttctgc agctaagtac
      541 cttgttttcc tcagtccagg gacatgggaa tgcaatagat gaaatctcca agtccttaat
      601 aagtttgaat accacattgc ttgatttgca gctcaacata gaaaatctga atggcaaaat
      661 ccaagagaat accttcaaac aacaagagga aatcagtaaa ttagaggagc gtgtttacaa
      721 tgtatcagca gaaattatgg ctatgaaaga agaacaagtg catttggaac aggaaataaa
      781 aggagaagtg aaagtactga ataacatcac taatgatctc agactgaaag attgggaaca
      841 ttctcagacc ttgagaaata tcactttaat tcaaggtcct cctggacccc cgggtgaaaa
      901 aggagatcga ggtcccactg gagaaagtgg tccacgagga tttccaggtc caataggtcc
      961 tccgggtctt aaaggtgatc ggggagcaat tggctttcct ggaagtcgag gactcccagg
     1021 atatgccgga aggccaggaa attctggacc aaaaggccag aaaggggaaa aggggagtgg
     1081 aaacacatta actccattta cgaaagttcg actggtcggt gggagcggcc ctcacgaggg
     1141 gagggtggag atactccaca gcggccagtg gggtacaatt tgtgacgatc gctgggaagt
     1201 gcgcgttgga caggtcgtct gtaggagctt gggataccca ggtgttcaag ccgtgcacaa
     1261 ggcagctcac tttggacaag gtactggtcc aatatggctg aatgaagtgt tttgttttgg
     1321 gagagaatca tctattgaag aatgtaaaat tcggcaatgg gggacaagag cctgttcaca
     1381 ttctgaagat gctggagtca cttgcacttt ataatgcatc atattttcat tcacaactat
     1441 gaaatcgctg ctcaaaaatg attttattac cttgttcctg taaaatccat ttaatcaata
     1501 tttaagagat taagaatatt gcccaaataa tattttagat tacaggatta atatattgaa
     1561 caccttcatg cttactattt tatgtctata tttaaatcat tttaacttct ataggttttt
     1621 aaatggaatt ttctaatata atgacttata tgctgaattg aacattttga agtttatagc
     1681 ttccagatta caaaggccaa gggtaataga aatgcatacc agtaattggc tccaattcat
     1741 aatatgttca ccaggagatt acaatttttt gctcttcttg tctttgtaat ctatttagtt
     1801 gattttaatt actttctgaa taacggaagg gatcagaaga tatcttttgt gcctagattg
     1861 caaaatctcc aatccacaca tattgtttta aaataagaat gttatccaac tattaagata
     1921 tctcaatgtg caataacttg tgtattagat atcaatgtta atgatatgtc ttggccacta
     1981 tggaccaggg agcttatttt tcttgtcatg tactgacaac tgtttaattg aatcatgaag
     2041 taaattgaaa gcaggacata tgagaaaact gaccatcagt atatttgtcc agataattgg
     2101 tggatcaaaa atgccactta acaggaagtt tagtttgtta tgcactttaa atggaataat
     2161 tagcttgtta caattctagg acatggtgtt taaaatttaa atctgattaa tccattttaa
     2221 caaacaatgc aaacatcttc agtgcagaag gaagagtggt ttcaactgtt tggagtcttt
     2281 tatgaagtca gtcaacattt acaaccaaag ggcggggggg ggggtggggg gtgcgtcttt
     2341 agtcctaaag ggacaataac tctgagcatg ccccaaaaaa gtagtttagc aaccttttgt
     2401 tggtagtcaa cccatcccca gggccatagt gtagagtgtg aaaagctacc ctgaaaccca
     2461 gtaattctac cctgaaagtg actgcctgca gaaagaccag cagttgatat taaagcgcaa
     2521 atgaattcaa cctcagccct gaaaataaca gaattctgaa gtttcctatg actaattcac
     2581 aaaaaaagta attgtaaact agtactatta tggaattact ctactgttct ttctttaata
     2641 gtggcaaatg aaagcataag cttaagcatt ttttcatatt ctgaagtctc accacacata
     2701 ataaccaagt ggtagactca cagccgtcca acttaaaaag gcaaaacctt accttggaat
     2761 tggaattact gtaaacagcc tactgaaaat gcatttttat catgtaacat tcttctactt
     2821 gtttaacatt gctgattttc tctggcagca taattttgtg gttaagagaa tgaattctga
     2881 atgtacactt tctgtctcaa accctggctg taatttcagc tagttaataa ttctttgtgt
     2941 tcagttccac tatctaggta ttttcttcaa aaggtaaata caatggtttc tgaaagaatc
     3001 atttgcatta tcagcctgtt tgggatgtct gagatcagtg cctctgggtt gttaatactg
     3061 tattgctgta tggtatatgt atgctgattt actacttatg cgtaagtggt atgcatggga
     3121 tgtctgaaat cagtgcctat gggttgtcaa tagtattaac tattagtgtt aactgttagt
     3181 attaactatt agtattatta acactaataa tagtactatt actattacta tttttatttt
     3241 aaaataaaat ttacctttaa aataataata gtactattgc tagtactagt actattgcta
     3301 ttactagtac tattactagt actagtacta tgacactgtt aatagtacta ttaacaaccc
     3361 ataggcactt gggatgtctg agatcagtgc ctatgggttg ttaatactat attgctgtat
     3421 ggtatatgca tgctgattta ccacttatgc atagatatat ctttaataag taatctaaaa
     3481 atcctttttg tatttgagag aatctactaa gttcagtcca gtcaagaaaa gaacctaata
     3541 gcaccaatac aaattgagga cttaatttac tttggaatgt tgaattgcat ttgttccatt
     3601 aaaaaaaaca gaaatttg
//
