LOCUS       NM_002444               3960 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens moesin (MSN), mRNA.
ACCESSION   NM_002444
VERSION     NM_002444.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3960)
  AUTHORS   Ito,Y., Kobori,T., Urashima,Y., Ito,T., Hotta,K. and Obata,T.
  TITLE     Moesin affects the plasma membrane expression and the immune
            checkpoint function of CD47 in human ovarian clear cell carcinoma
  JOURNAL   J Reprod Immunol 161, 104185 (2024)
   PUBMED   38141516
  REMARK    GeneRIF: Moesin affects the plasma membrane expression and the
            immune checkpoint function of CD47 in human ovarian clear cell
            carcinoma.
REFERENCE   2  (bases 1 to 3960)
  AUTHORS   Song,X., Cai,H., Peng,W., Chen,K., Abuduxukuer,Z., Zeng,Y., Zhu,G.,
            Lu,C., Chen,Y., Wang,J., Ye,L. and Jin,M.
  TITLE     The role of moesin in diagnosing and assessing severity of
            lymphangioleiomyomatosis
  JOURNAL   Respir Res 25 (1), 57 (2024)
   PUBMED   38267973
  REMARK    GeneRIF: The role of moesin in diagnosing and assessing severity of
            lymphangioleiomyomatosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3960)
  AUTHORS   Li,M., Luo,S., Zhuo,Z. and Shu,M.
  TITLE     Two cases of pediatric primary immunodeficiency caused by a
            familial moesin(MSN)gene mutation
  JOURNAL   Clin Immunol 258, 109858 (2024)
   PUBMED   38052292
  REMARK    GeneRIF: Two cases of pediatric primary immunodeficiency caused by
            a familial moesin(MSN)gene mutation.
            Review article
REFERENCE   4  (bases 1 to 3960)
  AUTHORS   Kovacs,A.L., Karteszi,J., Prohaszka,Z., Kalmar,T., Kesmarky,G.,
            Koltai,K., Nagy,Z., Sebok,J., Vas,T., Molnar,K., Berki,T.,
            Borocz,K., Gyomorei,C., Szalma,J., Egyed,M., Horvath,S., Olah,P.,
            Csuka,D., Nemeth,V. and Gyulai,R.
  TITLE     Hemizygous nonsense variant in the moesin gene (MSN) leads to a new
            autoimmune phenotype of Immunodeficiency 50
  JOURNAL   Front Immunol 13, 919411 (2022)
   PUBMED   36119109
  REMARK    GeneRIF: Hemizygous nonsense variant in the moesin gene (MSN) leads
            to a new autoimmune phenotype of Immunodeficiency 50.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3960)
  AUTHORS   Yang,Y., Xu,X., Xie,Y., Liu,Y., Ning,C., Ai,Y., Lv,C., Wei,H.,
            Ge,X., Yi,T., Piao,Y., Wang,X. and Jin,X.
  TITLE     Identification of Neural Progenitor Cell-associated
            Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for
            Prognosis of Glioma
  JOURNAL   Curr Pharm Des 28 (26), 2189-2202 (2022)
   PUBMED   35718975
  REMARK    GeneRIF: Identification of Neural Progenitor Cell-associated
            Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for
            Prognosis of Glioma.
REFERENCE   6  (bases 1 to 3960)
  AUTHORS   Gary,R. and Bretscher,A.
  TITLE     Ezrin self-association involves binding of an N-terminal domain to
            a normally masked C-terminal domain that includes the F-actin
            binding site
  JOURNAL   Mol Biol Cell 6 (8), 1061-1075 (1995)
   PUBMED   7579708
REFERENCE   7  (bases 1 to 3960)
  AUTHORS   Amieva,M.R. and Furthmayr,H.
  TITLE     Subcellular localization of moesin in dynamic filopodia, retraction
            fibers, and other structures involved in substrate exploration,
            attachment, and cell-cell contacts
  JOURNAL   Exp Cell Res 219 (1), 180-196 (1995)
   PUBMED   7628534
REFERENCE   8  (bases 1 to 3960)
  AUTHORS   Schwartz-Albiez,R., Merling,A., Spring,H., Moller,P. and Koretz,K.
  TITLE     Differential expression of the microspike-associated protein moesin
            in human tissues
  JOURNAL   Eur J Cell Biol 67 (3), 189-198 (1995)
   PUBMED   7588875
REFERENCE   9  (bases 1 to 3960)
  AUTHORS   Andreoli,C., Martin,M., Le Borgne,R., Reggio,H. and Mangeat,P.
  TITLE     Ezrin has properties to self-associate at the plasma membrane
  JOURNAL   J Cell Sci 107 (Pt 9), 2509-2521 (1994)
   PUBMED   7844168
REFERENCE   10 (bases 1 to 3960)
  AUTHORS   Lankes,W.T. and Furthmayr,H.
  TITLE     Moesin: a member of the protein 4.1-talin-ezrin family of proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (19), 8297-8301 (1991)
   PUBMED   1924289
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN386296.1, BC017293.2 and
            M69066.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002444.2.
            
            Summary: Moesin (for membrane-organizing extension spike protein)
            is a member of the ERM family which includes ezrin and radixin. ERM
            proteins appear to function as cross-linkers between plasma
            membranes and actin-based cytoskeletons. Moesin is localized to
            filopodia and other membranous protrusions that are important for
            cell-cell recognition and signaling and for cell movement.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.53498.1,
                                           SRR1660809.249399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360270.7/ ENSP00000353408.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               CN386296.1         11-644
            635-3955            BC017293.2         598-3918
            3956-3960           M69066.1           3864-3868
FEATURES             Location/Qualifiers
     source          1..3960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..3960
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /note="moesin"
                     /db_xref="GeneID:4478"
                     /db_xref="HGNC:HGNC:7373"
                     /db_xref="MIM:309845"
     exon            1..200
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1922
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /note="membrane-organizing extension spike protein;
                     epididymis luminal protein 70"
                     /codon_start=1
                     /product="moesin"
                     /protein_id="NP_002435.1"
                     /db_xref="CCDS:CCDS14382.1"
                     /db_xref="GeneID:4478"
                     /db_xref="HGNC:HGNC:7373"
                     /db_xref="MIM:309845"
                     /translation="MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWF
                     FGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLF
                     FLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQ
                     HKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWL
                     GVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
                     NKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAE
                     KEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKE
                     RQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQ
                     MVQEDLEKTRAELKTAMSTPHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEER
                     TTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGN
                     TKQRIDEFESM"
     exon            201..284
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            285..380
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            381..655
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            656..739
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            740..886
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            887..983
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1147
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1278
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1439
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1532
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1757
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..3960
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3939..3944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /note="hexamer: AATAAA"
     polyA_site      3960
                     /gene="MSN"
                     /gene_synonym="HEL70; IMD50"
                     /note="major polyA site"
ORIGIN      
        1 ggctctttcc tgggtggggt ttgtgaagtc gtggcccgtt agcaggaagc ctaacagtcg
       61 ccccgacgct agtgagggac ccaatctgag tccccggcca gccgaatcca agccgtgtgt
      121 actgcgtgct cagcactgcc cgacagtcct agctaaactt cgccaactcc gctgcctttg
      181 ccgccaccat gcccaaaacg atcagtgtgc gtgtgaccac catggatgca gagctggagt
      241 ttgccatcca gcccaacacc accgggaagc agctatttga ccaggtggtg aaaactattg
      301 gcttgaggga agtttggttc tttggtctgc agtaccagga cactaaaggt ttctccacct
      361 ggctgaaact caataagaag gtgactgccc aggatgtgcg gaaggaaagc cccctgctct
      421 ttaagttccg tgccaagttc taccctgagg atgtgtccga ggaattgatt caggacatca
      481 ctcagcgcct gttctttctg caagtgaaag agggcattct caatgatgat atttactgcc
      541 cgcctgagac cgctgtgctg ctggcctcgt atgctgtcca gtctaagtat ggcgacttca
      601 ataaggaagt gcataagtct ggctacctgg ccggagacaa gttgctcccg cagagagtcc
      661 tggaacagca caaactcaac aaggaccagt gggaggagcg gatccaggtg tggcatgagg
      721 aacaccgtgg catgctcagg gaggatgctg tcctggaata tctgaagatt gctcaagatc
      781 tggagatgta tggtgtgaac tacttcagca tcaagaacaa gaaaggctca gagctgtggc
      841 tgggggtgga tgccctgggt ctcaacatct atgagcagaa tgacagacta actcccaaga
      901 taggcttccc ctggagtgaa atcaggaaca tctctttcaa tgataagaaa tttgtcatca
      961 agcccattga caaaaaagcc ccggacttcg tcttctatgc tccccggctg cggattaaca
     1021 agcggatctt ggccttgtgc atggggaacc atgaactata catgcgccgt cgcaagcctg
     1081 ataccattga ggtgcagcag atgaaggcac aggcccggga ggagaagcac cagaagcaga
     1141 tggagcgtgc tatgctggaa aatgagaaga agaagcgtga aatggcagag aaggagaaag
     1201 agaagattga acgggagaag gaggagctga tggagaggct gaagcagatc gaggaacaga
     1261 ctaagaaggc tcagcaagaa ctggaagaac agacccgtag ggctctggaa cttgagcagg
     1321 aacggaagcg tgcccagagc gaggctgaaa agctggccaa ggagcgtcaa gaagctgaag
     1381 aggccaagga ggccttgctg caggcctccc gggaccagaa aaagactcag gaacagctgg
     1441 ccttggaaat ggcagagctg acagctcgaa tctcccagct ggagatggcc cgacagaaga
     1501 aggagagtga ggctgtggag tggcagcaga aggcccagat ggtacaggaa gacttggaga
     1561 agacccgtgc tgagctgaag actgccatga gtacacctca tgtggcagag cctgctgaga
     1621 atgagcagga tgagcaggat gagaatgggg cagaggctag tgctgaccta cgggctgatg
     1681 ctatggccaa ggaccgcagt gaggaggaac gtaccactga ggcagagaag aatgagcgtg
     1741 tgcagaagca cctgaaggcc ctcacttcgg agctggccaa tgccagagat gagtccaaga
     1801 agactgccaa tgacatgatc catgctgaga acatgcgact gggccgagac aaatacaaga
     1861 ccctgcgcca gatccggcag ggcaacacca agcagcgcat tgacgaattt gagtctatgt
     1921 aatgggcacc cagcctctag ggacccctcc tccctttttc cttgtcccca cactcctaca
     1981 cctaactcac ctaactcata ctgtgctgga gccactaact agagcagccc tggagtcatg
     2041 ccaagcattt aatgtagcca tgggaccaaa cctagcccct tagcccccac ccacttccct
     2101 gggcaaatga atggctcact atggtgccaa tggaacctcc tttctcttct ctgttccatt
     2161 gaatctgtat ggctagaata tcctacttct ccagcctaga ggtactttcc acttgatttt
     2221 gcaaatgccc ttacacttac tgttgtccta tgggagtcaa gtgtggagta ggttggaagc
     2281 tagctcccct cctctcccct accactgtct tcttcagggt cctgagattt acacggttgg
     2341 agtgttatgc ggtctaggga atgagacagg acctaggata tcttctccag gatgtcaact
     2401 gacctaaaat ttgccctccc atcccgttta gagttattta ggctttgtaa cgattggggg
     2461 ataaaaagat gttcagtcat ttttgtttct acctcccaga tcggatctgt tgcaaactca
     2521 gcctcaataa gccttgtcgt tgactttagg gactcaattt ctccccaggg tggatggggg
     2581 aaatggtgcc ttcaagacct tcaccaaaca tactagaagg gcattggcca ttctattgtg
     2641 gcaaggctga gtagaagatc ctaccccaat tccttgtagg agtataggcc ggtctaaagt
     2701 gagctctatg ggcagatcta ccccttactt attattccag atctgcagtc acttcgtggg
     2761 atctgcccct ccctgcttca atacccaaat cctctccagc tataacagta gggatgagta
     2821 cccaaaagct cagccagccc catcaggact cttgtgaaaa gagaggatat gttcacacct
     2881 agcgtcagta ttttccctgc taggggtttt aggtctcttc ccctctcaga gctacttggg
     2941 ccatagctcc tgctccacag ccatcccagc cttggcatct agagcttgat gccagtaggc
     3001 tcaactaggg agtgagtgca aaaagctgag tatggtgaga gaagcctgtg ccctgatcca
     3061 agtttactca accctctcag gtgaccaaaa tccccttctc atcactcccc tccaaagagg
     3121 tgactgggcc ctgcctctgt ttgacaaacc tctaacccag gtcttgacac cagctgttct
     3181 gtcccttgga gctgtaaacc agagagctgc tggggattct ggcctagtcc cttccacacc
     3241 cccacccctt gctctcaacc caggagcatc cacctccttc tctgtctcat gtgtgctctt
     3301 cttctttcta cagtattatg tactctactg atatctaaat attgatttct gccttccttg
     3361 ctaatgcacc attagaagat attagtcttg gggcaggatg attttggcct cattacttta
     3421 ccacccccac acctggaaag catatactat attacaaaat gacattttgc caaaattatt
     3481 aatataagaa gctttcagta ttagtgatgt catctgtcac tataggtcat acaatccatt
     3541 cttaaagtac ttgttatttg tttttattat tactgtttgt cttctcccca gggttcagtc
     3601 ctcaaggggc catcctgtcc caccatgcag tgcccctagc ttagagcctc cctcaattcc
     3661 ccctggccac caccccccac tctgtgcctg accttgagga gtcttgtgtg cattgctgtg
     3721 aattagctca cttggtgata tgtcctatat tggctaaatt gaaacctgga attgtggggc
     3781 aatctattaa tagctgcctt aaagtcagta acttaccctt agggaggctg ggggaaaagg
     3841 ttagattttg tattcagggg ttttttgtgt actttttggg ttttttaaaa attgtttttg
     3901 gaggggttta tgctcaatcc atgttctatt tcagtgccaa taaaatttag gaagacttca
//
