LOCUS       NM_001044264             677 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens microseminoprotein, prostate associated (MSMP), mRNA.
ACCESSION   NM_001044264 XM_001129664 XM_001130875
VERSION     NM_001044264.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 677)
  AUTHORS   Song,Z., Yao,W., Wang,X., Mo,Y., Liu,Z., Li,Q., Jiang,L., Wang,H.,
            He,H., Li,N., Zhang,Z., Lv,P., Zhang,Y., Yang,L. and Wang,Y.
  TITLE     The novel potential therapeutic target PSMP/MSMP promotes acute
            kidney injury via CCR2
  JOURNAL   Mol Ther 32 (7), 2248-2263 (2024)
   PUBMED   38796708
  REMARK    GeneRIF: The novel potential therapeutic target PSMP/MSMP promotes
            acute kidney injury via CCR2.
REFERENCE   2  (bases 1 to 677)
  AUTHORS   She,S., Wu,X., Zheng,D., Pei,X., Ma,J., Sun,Y., Zhou,J., Nong,L.,
            Guo,C., Lv,P., Song,Q., Zheng,C., Liang,W., Huang,S., Li,Q.,
            Liu,Z., Song,Z., Li,Y., Zhang,Y., Kong,W., You,H., Xi,J. and
            Wang,Y.
  TITLE     PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a
            novel therapeutic target
  JOURNAL   J Hepatol 72 (3), 506-518 (2020)
   PUBMED   31813573
  REMARK    GeneRIF: PSMP/MSMP promotes hepatic fibrosis through CCR2 and
            represents a novel therapeutic target.
REFERENCE   3  (bases 1 to 677)
  AUTHORS   Mitamura,T., Pradeep,S., McGuire,M., Wu,S.Y., Ma,S., Hatakeyama,H.,
            Lyons,Y.A., Hisamatsu,T., Noh,K., Villar-Prados,A., Chen,X.,
            Ivan,C., Rodriguez-Aguayo,C., Hu,W., Lopez-Berestein,G.,
            Coleman,R.L. and Sood,A.K.
  TITLE     Induction of anti-VEGF therapy resistance by upregulated expression
            of microseminoprotein (MSMP)
  JOURNAL   Oncogene 37 (6), 722-731 (2018)
   PUBMED   29059175
  REMARK    GeneRIF: High MSMP expression is associated with drug-resistant
            prostate cancer.
REFERENCE   4  (bases 1 to 677)
  AUTHORS   Pei,X., Sun,Q., Zhang,Y., Wang,P., Peng,X., Guo,C., Xu,E.,
            Zheng,Y., Mo,X., Ma,J., Chen,D., Zhang,Y., Zhang,Y., Song,Q.,
            Guo,S., Shi,T., Zhang,Z., Ma,D. and Wang,Y.
  TITLE     PC3-secreted microprotein is a novel chemoattractant protein and
            functions as a high-affinity ligand for CC chemokine receptor 2
  JOURNAL   J Immunol 192 (4), 1878-1886 (2014)
   PUBMED   24442440
  REMARK    GeneRIF: these data collectively suggest that PSMP is a
            chemoattractant protein acting as a novel CCR2 ligand that may
            influence inflammation and cancer development.
REFERENCE   5  (bases 1 to 677)
  AUTHORS   Valtonen-Andre,C., Bjartell,A., Hellsten,R., Lilja,H., Harkonen,P.
            and Lundwall,A.
  TITLE     A highly conserved protein secreted by the prostate cancer cell
            line PC-3 is expressed in benign and malignant prostate tissue
  JOURNAL   Biol Chem 388 (3), 289-295 (2007)
   PUBMED   17338636
REFERENCE   6  (bases 1 to 677)
  AUTHORS   Gonzalez,P., Epstein,D.L. and Borras,T.
  TITLE     Characterization of gene expression in human trabecular meshwork
            using single-pass sequencing of 1060 clones
  JOURNAL   Invest Ophthalmol Vis Sci 41 (12), 3678-3693 (2000)
   PUBMED   11053263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC071800.1, DQ012170.1 and
            BE439525.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001044264.2.
            
            Summary: This gene encodes a member of the beta-microseminoprotein
            family. Members of this protein family contain ten conserved
            cysteine residues that form intra-molecular disulfide bonds. The
            encoded protein may play a role in prostate cancer tumorigenesis.
            [provided by RefSeq, Jan 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE439730.1, BC105274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436428.3/ ENSP00000419194.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BC071800.1         2-2
            2-673               DQ012170.1         1-672
            674-677             BE439525.1         27-30               c
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..677
                     /gene="MSMP"
                     /gene_synonym="PSMP"
                     /note="microseminoprotein, prostate associated"
                     /db_xref="GeneID:692094"
                     /db_xref="HGNC:HGNC:29663"
                     /db_xref="MIM:612191"
     exon            1..277
                     /gene="MSMP"
                     /gene_synonym="PSMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..567
                     /gene="MSMP"
                     /gene_synonym="PSMP"
                     /note="PC3 prostate cancer cell-secreted microprotein;
                     prostate-associated microseminoprotein"
                     /codon_start=1
                     /product="prostate-associated microseminoprotein
                     precursor"
                     /protein_id="NP_001037729.1"
                     /db_xref="CCDS:CCDS43797.1"
                     /db_xref="GeneID:692094"
                     /db_xref="HGNC:HGNC:29663"
                     /db_xref="MIM:612191"
                     /translation="MALRMLWAGQAKGILGGWGIICLVMSLLLQHPGVYSKCYFQAQA
                     PCHYEGKYFTLGESWLRKDCFHCTCLHPVGVGCCDTSQHPIDFPAGCEVRQEAGTCQF
                     SLVQKSDPRLPCKGGGPDPEWGSANTPVPGAPAPHSS"
     exon            278..386
                     /gene="MSMP"
                     /gene_synonym="PSMP"
                     /inference="alignment:Splign:2.1.0"
     exon            387..677
                     /gene="MSMP"
                     /gene_synonym="PSMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      654..659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSMP"
                     /gene_synonym="PSMP"
                     /note="hexamer: AATAAA"
     polyA_site      677
                     /gene="MSMP"
                     /gene_synonym="PSMP"
                     /note="major polyA site"
ORIGIN      
        1 gagggcaggg agatagtgtg agacaggagc ccaggggaga aagacagaaa ctaagactca
       61 aggagcaacg caaagcaaag tcaaggagtc aagaccagag tagctgagca gaggccaaga
      121 agggtctgag agggctgtgc agcagcaatg gccctaagga tgctctgggc tggacaggcc
      181 aaggggatcc taggaggctg ggggatcatc tgcttggtga tgtctctact cctccagcac
      241 ccaggagtct acagcaagtg ctacttccaa gctcaagccc cctgtcacta tgaggggaaa
      301 tattttaccc tgggtgagtc ttggctccgc aaggactgtt tccattgcac ctgtctgcat
      361 cctgttggcg tgggctgctg tgacacgtcc cagcatccca tcgacttccc ggctgggtgt
      421 gaggtacgtc aggaggcagg aacctgccag ttctccttgg tgcaaaaatc tgaccctcgg
      481 ctgccctgca aagggggagg gcctgaccca gaatggggct cagccaacac ccctgttcct
      541 ggggctcctg ctccccactc cagctaaact caactgatca tccatctgct gactgctcac
      601 tgctgctgcc acttccaggg aaaccactag cagctgccaa tgtattctga acaaataaat
      661 taatgctata gctgaaa
//
