LOCUS       NM_002443                486 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens microseminoprotein beta (MSMB), transcript variant
            PSP94, mRNA.
ACCESSION   NM_002443
VERSION     NM_002443.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Wang,X., Hayes,J.E., Xu,X., Gao,X., Mehta,D., Lilja,H.G. and
            Klein,R.J.
  TITLE     Validation of prostate cancer risk variants rs10993994 and
            rs7098889 by CRISPR/Cas9 mediated genome editing
  JOURNAL   Gene 768, 145265 (2021)
   PUBMED   33122083
  REMARK    GeneRIF: Validation of prostate cancer risk variants rs10993994 and
            rs7098889 by CRISPR/Cas9 mediated genome editing.
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Fu,S., Huang,Y.L., Luan,T., Li,N., Wang,H.F. and Wang,J.S.
  TITLE     A meta-analysis of influence of MSMB promoter rs10993994
            polymorphisms on prostate cancer risk
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (21), 9295-9303 (2019)
   PUBMED   31773691
  REMARK    GeneRIF: A meta-analysis of influence of MSMB promoter rs10993994
            polymorphisms on prostate cancer risk.
            Review article
REFERENCE   3  (bases 1 to 486)
  AUTHORS   Smith Byrne,K., Appleby,P.N., Key,T.J., Holmes,M.V., Fensom,G.K.,
            Agudo,A., Ardanaz,E., Boeing,H., Bueno-de-Mesquita,H.B.,
            Chirlaque,M.D., Kaaks,R., Larranaga,N., Palli,D., Perez-Cornago,A.,
            Quiros,J.R., Ricceri,F., Sanchez,M.J., Tagliabue,G., Tsilidis,K.K.,
            Tumino,R., Fortner,R.T., Ferrari,P., Riboli,E., Lilja,H. and
            Travis,R.C.
  CONSRTM   PRACTICAL Consortium
  TITLE     The role of plasma microseminoprotein-beta in prostate cancer: an
            observational nested case-control and Mendelian randomization study
            in the European prospective investigation into cancer and nutrition
  JOURNAL   Ann Oncol 30 (6), 983-989 (2019)
   PUBMED   31089709
  REMARK    GeneRIF: Low plasma microseminoprotein-beta levels are associated
            with prostate cancer.
REFERENCE   4  (bases 1 to 486)
  AUTHORS   Bergstrom,S.H., Jaremo,H., Nilsson,M., Adamo,H.H. and Bergh,A.
  TITLE     Prostate tumors downregulate microseminoprotein-beta (MSMB) in the
            surrounding benign prostate epithelium and this response is
            associated with tumor aggressiveness
  JOURNAL   Prostate 78 (4), 257-265 (2018)
   PUBMED   29250809
  REMARK    GeneRIF: Aggressive prostate tumors suppress MSMB synthesis in the
            benign prostate and this could explain why serum levels of MSMB are
            decreased in prostate cancer patients.
REFERENCE   5  (bases 1 to 486)
  AUTHORS   Anklesaria,J.H., Mhatre,D.R. and Mahale,S.D.
  TITLE     Structural and molecular biology of PSP94: Its significance in
            prostate pathophysiology
  JOURNAL   Front Biosci (Landmark Ed) 23 (3), 535-562 (2018)
   PUBMED   28930560
  REMARK    GeneRIF: Studies indicate prostate secretory protein of 94 amino
            acids (PSP94) as a prostate tumor marker [Review].
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 486)
  AUTHORS   Liang,Z.G., Kamada,M. and Koide,S.S.
  TITLE     Structural identity of immunoglobulin binding factor and prostatic
            secretory protein of human seminal plasma
  JOURNAL   Biochem Biophys Res Commun 180 (1), 356-359 (1991)
   PUBMED   1930232
REFERENCE   7  (bases 1 to 486)
  AUTHORS   Nolet,S., Mbikay,M. and Chretien,M.
  TITLE     Prostatic secretory protein PSP94: gene organization and promoter
            sequence in rhesus monkey and human
  JOURNAL   Biochim Biophys Acta 1089 (2), 247-249 (1991)
   PUBMED   2054385
REFERENCE   8  (bases 1 to 486)
  AUTHORS   Green,C.B., Liu,W.Y. and Kwok,S.C.
  TITLE     Cloning and nucleotide sequence analysis of the human
            beta-microseminoprotein gene
  JOURNAL   Biochem Biophys Res Commun 167 (3), 1184-1190 (1990)
   PUBMED   2322265
REFERENCE   9  (bases 1 to 486)
  AUTHORS   Ulvsback,M., Lindstrom,C., Weiber,H., Abrahamsson,P.A., Lilja,H.
            and Lundwall,A.
  TITLE     Molecular cloning of a small prostate protein, known as
            beta-microsemenoprotein, PSP94 or beta-inhibin, and demonstration
            of transcripts in non-genital tissues
  JOURNAL   Biochem Biophys Res Commun 164 (3), 1310-1315 (1989)
   PUBMED   2590204
REFERENCE   10 (bases 1 to 486)
  AUTHORS   Ito,Y., Tsuda,R. and Kimura,H.
  TITLE     Ultrastructural localizations of beta-microseminoprotein, a
            prostate-specific antigen, in human prostate and sperm: comparison
            with gamma-seminoprotein, another prostate-specific antigen
  JOURNAL   J Lab Clin Med 114 (3), 272-277 (1989)
   PUBMED   2475560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005257.1 and BM856408.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002443.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunoglobulin binding factor family. It is synthesized by the
            epithelial cells of the prostate gland and secreted into the
            seminal plasma. This protein has inhibin-like activity. It may have
            a role as an autocrine paracrine factor in uterine, breast and
            other female reproductive tissues. The expression of the encoded
            protein is found to be decreased in prostate cancer. Two
            alternatively spliced transcript variants encoding different
            isoforms are described for this gene. The use of alternate
            polyadenylation sites has been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (PSP94) encodes the full length
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF964983.1, BF965280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2153427
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000582163.3/ ENSP00000463092.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               BC005257.1         1-481
            482-486             BM856408.1         493-497
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..486
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /note="microseminoprotein beta"
                     /db_xref="GeneID:4477"
                     /db_xref="HGNC:HGNC:7372"
                     /db_xref="MIM:157145"
     exon            1..35
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..377
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /note="isoform a precursor is encoded by transcript
                     variant PSP94; seminal plasma beta-inhibin; prostate
                     secreted seminal plasma protein; immunoglobulin binding
                     factor; beta-microseminoprotein; prostate secretory
                     protein of 94 amino acids"
                     /codon_start=1
                     /product="beta-microseminoprotein isoform a precursor"
                     /protein_id="NP_002434.1"
                     /db_xref="CCDS:CCDS73096.1"
                     /db_xref="GeneID:4477"
                     /db_xref="HGNC:HGNC:7372"
                     /db_xref="MIM:157145"
                     /translation="MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGN
                     KHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKD
                     PKKTCSVSEWII"
     exon            36..141
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            142..247
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            248..486
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /inference="alignment:Splign:2.1.0"
     regulatory      465..470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /note="hexamer: AGTAAA"
     polyA_site      486
                     /gene="MSMB"
                     /gene_synonym="HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP;
                     PSP-94; PSP57; PSP94"
                     /note="major polyA site"
ORIGIN      
        1 gtacctgtct ataaggagtc ctgcttatca caatgaatgt tctcctgggc agcgttgtga
       61 tctttgccac cttcgtgact ttatgcaatg catcatgcta tttcatacct aatgagggag
      121 ttccaggaga ttcaaccagg aaatgcatgg atctcaaagg aaacaaacac ccaataaact
      181 cggagtggca gactgacaac tgtgagacat gcacttgcta cgaaacagaa atttcatgtt
      241 gcacccttgt ttctacacct gtgggttatg acaaagacaa ctgccaaaga atcttcaaga
      301 aggaggactg caagtatatc gtggtggaga agaaggaccc aaaaaagacc tgttctgtca
      361 gtgaatggat aatctaatgt gcttctagta ggcacagggc tcccaggcca ggcctcattc
      421 tcctctggcc tctaatagtc aatgattgtg tagccatgcc tatcagtaaa aagatttttg
      481 agcaaa
//
