LOCUS       NM_001365919            5035 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MSL complex subunit 1 (MSL1), transcript variant 2,
            mRNA.
ACCESSION   NM_001365919 XM_005257298
VERSION     NM_001365919.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5035)
  AUTHORS   Kunisky,A.K., Anyaeche,V.I., Herron,R.S., Park,C.Y. and Hwang,H.W.
  TITLE     Shift in MSL1 alternative polyadenylation in response to DNA damage
            protects cancer cells from chemotherapeutic agent-induced apoptosis
  JOURNAL   Cell Rep 37 (2), 109815 (2021)
   PUBMED   34644577
  REMARK    GeneRIF: Shift in MSL1 alternative polyadenylation in response to
            DNA damage protects cancer cells from chemotherapeutic
            agent-induced apoptosis.
REFERENCE   2  (bases 1 to 5035)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5035)
  AUTHORS   Monserrat,J., Morales Torres,C., Richardson,L., Wilson,T.S.,
            Patel,H., Domart,M.C., Horswell,S., Song,O.R., Jiang,M.,
            Crawford,M., Bui,M., Dalal,Y. and Scaffidi,P.
  TITLE     Disruption of the MSL complex inhibits tumour maintenance by
            exacerbating chromosomal instability
  JOURNAL   Nat Cell Biol 23 (4), 401-412 (2021)
   PUBMED   33837287
REFERENCE   4  (bases 1 to 5035)
  AUTHORS   Basilicata,M.F., Bruel,A.L., Semplicio,G., Valsecchi,C.I.K.,
            Aktas,T., Duffourd,Y., Rumpf,T., Morton,J., Bache,I.,
            Szymanski,W.G., Gilissen,C., Vanakker,O., Ounap,K., Mittler,G., van
            der Burgt,I., El Chehadeh,S., Cho,M.T., Pfundt,R., Tan,T.Y.,
            Kirchhoff,M., Menten,B., Vergult,S., Lindstrom,K., Reis,A.,
            Johnson,D.S., Fryer,A., McKay,V., Fisher,R.B., Thauvin-Robinet,C.,
            Francis,D., Roscioli,T., Pajusalu,S., Radtke,K., Ganesh,J.,
            Brunner,H.G., Wilson,M., Faivre,L., Kalscheuer,V.M., Thevenon,J.
            and Akhtar,A.
  CONSRTM   DDD Study
  TITLE     De novo mutations in MSL3 cause an X-linked syndrome marked by
            impaired histone H4 lysine 16 acetylation
  JOURNAL   Nat Genet 50 (10), 1442-1451 (2018)
   PUBMED   30224647
REFERENCE   5  (bases 1 to 5035)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5035)
  AUTHORS   Gironella,M., Malicet,C., Cano,C., Sandi,M.J., Hamidi,T.,
            Tauil,R.M., Baston,M., Valaco,P., Moreno,S., Lopez,F., Neira,J.L.,
            Dagorn,J.C. and Iovanna,J.L.
  TITLE     p8/nupr1 regulates DNA-repair activity after double-strand gamma
            irradiation-induced DNA damage
  JOURNAL   J Cell Physiol 221 (3), 594-602 (2009)
   PUBMED   19650074
  REMARK    GeneRIF: MSL1 plays an important role in mediating
            irradiation-induced DNA repair through formation of HAT complexes
            and interaction with 53BP1. P8 acts as a negative regulator of this
            process by interacting with MSL1 and preventing its role on HAT
            activity.
REFERENCE   7  (bases 1 to 5035)
  AUTHORS   Mendjan,S., Taipale,M., Kind,J., Holz,H., Gebhardt,P., Schelder,M.,
            Vermeulen,M., Buscaino,A., Duncan,K., Mueller,J., Wilm,M.,
            Stunnenberg,H.G., Saumweber,H. and Akhtar,A.
  TITLE     Nuclear pore components are involved in the transcriptional
            regulation of dosage compensation in Drosophila
  JOURNAL   Mol Cell 21 (6), 811-823 (2006)
   PUBMED   16543150
REFERENCE   8  (bases 1 to 5035)
  AUTHORS   Smith,E.R., Cayrou,C., Huang,R., Lane,W.S., Cote,J. and
            Lucchesi,J.C.
  TITLE     A human protein complex homologous to the Drosophila MSL complex is
            responsible for the majority of histone H4 acetylation at lysine 16
  JOURNAL   Mol Cell Biol 25 (21), 9175-9188 (2005)
   PUBMED   16227571
  REMARK    GeneRIF: A multisubunit human histone acetylase complex that
            contains homologs of the Drosophila MSL proteins MOF, MSL1 (hampin
            A), MSL2, and MSL3 was described. This complex is responsible for
            histone H4 lysine-16 acetylation of all cellular chromosomes.
            Erratum:[Mol Cell Biol. 2006 Jan;26(1):387]
REFERENCE   9  (bases 1 to 5035)
  AUTHORS   Gocke,C.B., Yu,H. and Kang,J.
  TITLE     Systematic identification and analysis of mammalian small
            ubiquitin-like modifier substrates
  JOURNAL   J Biol Chem 280 (6), 5004-5012 (2005)
   PUBMED   15561718
REFERENCE   10 (bases 1 to 5035)
  AUTHORS   Marin,I.
  TITLE     Evolution of chromatin-remodeling complexes: comparative genomics
            reveals the ancient origin of 'novel' compensasome genes
  JOURNAL   J Mol Evol 56 (5), 527-539 (2003)
   PUBMED   12698291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068669.21.
            
            On Sep 15, 2018 this sequence version replaced XM_005257298.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.15410.1,
                                           SRR1803617.186120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398532.9/ ENSP00000381543.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1410              AC068669.21        66942-68351
            1411-1634           AC068669.21        71154-71377
            1635-2017           AC068669.21        74216-74598
            2018-2065           AC068669.21        76508-76555
            2066-2130           AC068669.21        77005-77069
            2131-2198           AC068669.21        78013-78080
            2199-2323           AC068669.21        78505-78629
            2324-2396           AC068669.21        78798-78870
            2397-5035           AC068669.21        79250-81888
FEATURES             Location/Qualifiers
     source          1..5035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..5035
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /note="MSL complex subunit 1"
                     /db_xref="GeneID:339287"
                     /db_xref="HGNC:HGNC:27905"
                     /db_xref="MIM:614801"
     exon            1..1410
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..2487
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     MSL1-like 1; male-specific lethal 1-like 1; male-specific
                     lethal-1 homolog 1; male specific lethal 1 homolog"
                     /codon_start=1
                     /product="male-specific lethal 1 homolog isoform 2"
                     /protein_id="NP_001352848.1"
                     /db_xref="CCDS:CCDS92297.1"
                     /db_xref="GeneID:339287"
                     /db_xref="HGNC:HGNC:27905"
                     /db_xref="MIM:614801"
                     /translation="MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDEPGAAEAH
                     FLPRHRKLKEPGPPLASSQGGSPAPSPAGCGGKGRGLLLPAGAAPGQQEESWGGSVPL
                     PCPPPATKQAGIGGEPAAAGAGCSPRPKYQAVLPIQTGSLVAAAKEPTPWAGDKGGAA
                     SPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSMRKSPLGGGGGSGASSQ
                     AACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKKDNE
                     KERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHKRKSP
                     FGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRS
                     SVDTPPRLSTPQKGPSTHPKEKAFSSEIEDLPYLSTTEMYLCRWHQPPPSPLPLRESS
                     PKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHA
                     KLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMI
                     TPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRLEIQKKQTPHRTCRK"
     exon            1411..1634
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2017
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2065
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2130
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2198
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2323
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2396
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..5035
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4886..4891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /note="hexamer: AATAAA"
     polyA_site      4907
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /note="major polyA site"
     regulatory      5002..5007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
                     /note="hexamer: AATAAA"
     polyA_site      5035
                     /gene="MSL1"
                     /gene_synonym="MSL-1"
ORIGIN      
        1 atgcgtcctc cggttggcgg cggctgcggc ggtggcggct acgagcggct ccgttttttt
       61 aaagggaaac gctgaggcgc cgggggtgac tgtgggggag ggggaccccg agccgcggag
      121 acccccggga gaggcgacag accccctctc ccggagtagg agggctttgg gcggacccag
      181 ccctccaccc cctcctgagg aggagggggg ggaaatggag gctcggggcg gttgaggcga
      241 gctccggggc ggggggccgg ggcggggaag ggggggtgcg gggtggggag acgaggcggg
      301 cccggccggg ccaggggggg ccgaagcgag ctccggggat gagctcgggg gcggctgggt
      361 gcgagctcct gcctctgagg cgaaggcggc ggcggcggca gcagaggcgg cggcgaggcc
      421 cccatgggcc ggcggcgggc ctcagccgcg gcctccacgt ctccgcacgc cggcgggatg
      481 gcgcccgggc cccggaggag ccgcgctagc ggaggcctgc tgccgcgctg ctgaggcgag
      541 cccgccaaac tcccctcccc cccctcagtc ctcgaccccc cgcacctcgc cccttcccca
      601 ccccctcctc cgcctcggtg cccggcgctg ctccggacca ctatgaccat gagatccgcg
      661 gtgttcaagg cggccgcggc ccctgccggc ggcaatcctg agcagcgact ggactacgag
      721 cgggctgcgg cgctgggcgg gcccgaggac gagcctgggg cggccgaagc ccacttcctc
      781 ccccggcacc gtaagctcaa ggagccgggg cccccgctgg cctcctccca gggcgggagc
      841 cccgcgcctt ccccggccgg ctgcggcggc aagggccggg gcttgttact cccggccggg
      901 gcggcccccg ggcagcagga agagagctgg ggcggttcgg tgcccttgcc ctgtccgccc
      961 ccggccacca agcaagccgg cattgggggg gagcctgccg cagccggagc cggctgcagc
     1021 ccccggccca agtatcaggc ggtgctgccc attcagacgg gctctctcgt ggcggcggcc
     1081 aaagagccta cgccctgggc tggggacaag ggtggggcgg cctcccccgc tgccaccgcc
     1141 tcggacccgg cgggaccccc accactacct ctgcccgggc cgccacccct cgcgcccacc
     1201 gccaccgccg ggaccctggc ggccagcgag ggcagatgga agagtatgag gaagagccct
     1261 ctcgggggtg gtggcggctc gggagcctcc agtcaggccg cctgcctcaa acagatcctt
     1321 ctgctgcaat tggacctcat cgaacagcag cagcagcagc tgcaggccaa ggaaaaggag
     1381 atcgaggagc tgaagtcaga gagagacacg ctccttgctc ggattgaacg tatggaaagg
     1441 cggatgcagc tggtaaagaa ggataacgag aaagaaaggc acaagctgtt tcagggctat
     1501 gaaactgaag agagagagga aacagagcta tctgagaaaa ttaaactgga gtgccagccg
     1561 gagctttccg agacatccca gactctgcct cccaagccct tctcatgtgg gcggagtgga
     1621 aagggacata aaaggaaatc cccatttgga agtacagaaa gaaagactcc tgttaaaaag
     1681 ctggctcctg aattttcaaa agtcaaaaca aaaactccta agcactctcc tattaaagag
     1741 gaaccctgtg gttccttatc tgaaactgtt tgtaaacgtg aattgaggag ccaagaaacc
     1801 ccagaaaagc cccggtcttc agtggacacc ccaccaagac tctccactcc ccaaaaggga
     1861 cccagcaccc atcccaagga gaaagccttc tcaagtgaga tagaagattt gccgtacctt
     1921 tccaccacag aaatgtattt gtgtcgttgg caccagcctc ccccatcacc gttaccatta
     1981 cgggaatcct ctccaaagaa ggaggagact gtagcaaggt gtctgatgcc atcaagtgtt
     2041 gcaggagaaa cttcagtctt ggctgttcct tcttggaggg accactcagt agagcctcta
     2101 agggacccaa atccttcaga ccttttggag aacctggatg acagtgtgtt ttcgaagcgg
     2161 catgcaaaac tggagctgga tgagaagaga aggaaaagat gggatattca gaggatcagg
     2221 gaacaaagaa ttttacagcg actgcagctc agaatgtata aaaagaaagg aattcaggaa
     2281 tctgagcctg aggttacctc atttttccct gagccagatg atgttgaaag tttgatgatt
     2341 acccccttct tgcctgttgt agcatttgga cgaccattac caaaattaac tccacagaat
     2401 tttgagctac cctggttgga tgagcgtagc cgatgcagat tggagatcca gaagaagcaa
     2461 acacctcacc ggacgtgtag gaaatagctg tgctggcaag aaccctgtct tcagatagtt
     2521 gtagcatgcc attcccgaga gtggcagaga cctgtatatg tgacctttgt cctcacatat
     2581 gttatcactc gctgataata ccctttcata cttccttgac tttgttttca ttactctgat
     2641 ttcacaaaaa ctctttcatt cggctaattg tgagttatgg agggtgattg ggatttcttt
     2701 tccctttttt gggaaatggg ctctcaagct aaagctatag gatggcagat tcagaagttt
     2761 caggggtctg tttctataca tttgcctatg ttaaaggggt aaaagggctc tcttcattag
     2821 acatgtggaa gatgaagcag ccccttcctt tagagctgtg cctgcatggc actcttctca
     2881 ccctggtaca ccctccttat agtgggtata gtgattttta accctaaaat aaaacaaaca
     2941 acctcaccat gagctttagg accagaagag gaatgacaag tgaagcgatg aagcaagcca
     3001 tcttcacaga gtagaaaaga catcggagag ttggtagata actgtctgaa aagatagttg
     3061 ttcatttgaa actattctgt gatacagtca tgtgggaagg gatgtttggc tgtgattatt
     3121 ttttcagtta atggataaca atttctttac tgctcaaaaa ccaaaatctt tggaaaagaa
     3181 agtggggatg gttagtttca gaacaagtta cagctgtaaa caaaagcact tagtatttgg
     3241 gatggcatgc caaaacctgt ataaatgtcc ttgtatcaca tcacttctca agtattcctt
     3301 cattgggctt catcctttta gcagaactct tggtggtggg atagagactt agggagggta
     3361 gggggagagt gtggaaatag gtgcttcctt tggctggcaa atgtctacat cttgaaacaa
     3421 acagatgtac ctaatgagct tctccattca ctttgtaaaa ataatttgta tgtgtaccat
     3481 cttggtcctc tcccctcccg ttttgttaaa atatcaggat agcactccca ggccactttg
     3541 gtctcagtgt aagatcccta ttaactatct gaaaggaaaa tagagccaag acctctggtc
     3601 tcaaatatat aggaattgcc tttctttagt cttcaggact attgtgtgaa aacaagtagg
     3661 ggtctaatct cctagaaggt aggggctttt atccttaaag agaatatgtc cccagattat
     3721 tagcactttt agaggagaag ccaaggtatg tagggtgtgt ggctggccca tcagtggagc
     3781 acgaagagag aatgggatac cattgtggga agagaagaaa agttcctcag gggcctccca
     3841 ctgctaaagt tttttgtgag atgttgatct gtgcttcctg gatttgactt ttaaaggaat
     3901 tattctggca gcacatgtag tattcttgga tgatcttgct gctcttattt ctccttttgt
     3961 gtgtgtgtgt gtgtgtgtgt ggctatgggt tttcatttgt aactccatct gcttaggaga
     4021 gtgggctctc tataagggaa cctgctgtaa acttcattgc agcaaggatg tagagagaaa
     4081 taggacttaa ttccactagg ggctctcatc tcacacctta aggaggagat ttctagaaaa
     4141 actgggccag attttctttg ttctccatca ttttaatgtg gcaggctgtt cagttttctt
     4201 actcttacct atgtgatatt tcttcgtaac gtgtccaaaa agaaaaaaga cccaatcagt
     4261 gtctcttgac tttgttcttt gatccctcag tttcttcttg atttcagcat gtgtcgggtt
     4321 cctaattttg ggtatgagtt agcaaattta accattgtgt ttgtgcccta cccaggggac
     4381 tccccagttt ctgacttgaa gtagactgag aagaatccac gaggtgctat ctggccagat
     4441 ttaagtagat tctatttcct tggttctccc tctccctgag gacctcttat tttattgtcc
     4501 cctcttctag gttaattctc ctttgatttg actttgttga gaaggaggtt ggacagtaga
     4561 ttagcaaagt tccaagtgca aaattacagt gtgttagagt gtggggggaa aattagtctt
     4621 atttttccct acatgggata caacactgtg aattcaatct tcaactgaag gccctgcagt
     4681 tctcctaaaa catagttgtt tgtttttctt taacaaagtt taagctagtg ttaataaatt
     4741 aaaaaaaatt gcttgtctgt ctacttcagc tttgttttat gcccatttca tattgttgtc
     4801 tgtgttgtaa ttcataactt ttgataccat ttctgatgtg taaaattggt tgtcttgtaa
     4861 atatcttata aagagttcaa ttgtaaataa actattgtgg ctgttaattt ttgaacttct
     4921 gcttcaattt attatattta ttggcaaaca aacaattctg cttgtatatt tgaaacattg
     4981 gaaaaagaaa tccattttct caataaaaaa gaataacaca ttattttccc cttta
//
