LOCUS       NM_138962               6379 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens musashi RNA binding protein 2 (MSI2), transcript
            variant 1, mRNA.
ACCESSION   NM_138962
VERSION     NM_138962.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6379)
  AUTHORS   Zhong,B.H., Ma,Y.T., Sun,J., Tang,J.T. and Dong,M.
  TITLE     Transcription factor FOXF2 promotes the development and progression
            of pancreatic cancer by targeting MSI2
  JOURNAL   Oncol Rep 52 (1) (2024)
   PUBMED   38847273
  REMARK    GeneRIF: Transcription factor FOXF2 promotes the development and
            progression of pancreatic cancer by targeting MSI2.
REFERENCE   2  (bases 1 to 6379)
  AUTHORS   Meng,X., Na,R., Peng,X., Li,H., Ouyang,W., Zhou,W., You,X., Li,Y.,
            Pu,X., Zhang,K., Xia,J., Wang,J., Tang,H., Zhuang,G. and Peng,Z.
  TITLE     Musashi-2 potentiates colorectal cancer immune infiltration by
            regulating the post-translational modifications of HMGB1 to promote
            DCs maturation and migration
  JOURNAL   Cell Commun Signal 22 (1), 117 (2024)
   PUBMED   38347600
  REMARK    GeneRIF: Musashi-2 potentiates colorectal cancer immune
            infiltration by regulating the post-translational modifications of
            HMGB1 to promote DCs maturation and migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6379)
  AUTHORS   Zhang,J., Duan,Y., Wu,P., Chang,Y., Wang,Y., Hu,T., Liu,C.,
            Chen,X., Zong,S., Chen,X., Wu,Y., Jin,L., Lan,Y., Liu,X., Cheng,X.,
            Ding,F., Li,T., Chen,X., Guo,Y., Chen,Y., Yang,W., Zhang,L.,
            Zou,Y., Cheng,T., Zhu,X. and Zhang,Y.
  TITLE     Clonal evolution dissection reveals that a high MSI2 level promotes
            chemoresistance in T-cell acute lymphoblastic leukemia
  JOURNAL   Blood 143 (4), 320-335 (2024)
   PUBMED   37801708
  REMARK    GeneRIF: Clonal evolution dissection reveals that a high MSI2 level
            promotes chemoresistance in T-cell acute lymphoblastic leukemia.
REFERENCE   4  (bases 1 to 6379)
  AUTHORS   Haiduk,T.S., Sicking,M., Brucksken,K.A., Espinoza-Sanchez,N.A.,
            Eder,K.M., Kemper,B., Eich,H.T., Gotte,M., Greve,B. and
            Troschel,F.M.
  TITLE     Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are
            Associated with Therapy Resistance in Inflammatory Breast Cancer
  JOURNAL   Arch Med Res 54 (6), 102855 (2023)
   PUBMED   37481823
  REMARK    GeneRIF: Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are
            Associated with Therapy Resistance in Inflammatory Breast Cancer.
REFERENCE   5  (bases 1 to 6379)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6379)
  AUTHORS   Moore,M.A.
  TITLE     A cancer fate in the hands of a samurai
  JOURNAL   Nat Med 16 (9), 963-965 (2010)
   PUBMED   20823875
  REMARK    GeneRIF: MSI2 has a crucial role in both normal and malignant
            hematopoiesis.
REFERENCE   7  (bases 1 to 6379)
  AUTHORS   Ito,T., Kwon,H.Y., Zimdahl,B., Congdon,K.L., Blum,J., Lento,W.E.,
            Zhao,C., Lagoo,A., Gerrard,G., Foroni,L., Goldman,J., Goh,H.,
            Kim,S.H., Kim,D.W., Chuah,C., Oehler,V.G., Radich,J.P., Jordan,C.T.
            and Reya,T.
  TITLE     Regulation of myeloid leukaemia by the cell-fate determinant
            Musashi
  JOURNAL   Nature 466 (7307), 765-768 (2010)
   PUBMED   20639863
  REMARK    GeneRIF: Msi2 expression is not only highly upregulated during
            human chronic myeloid leukemia progression but is also an early
            indicator of poorer prognosis
REFERENCE   8  (bases 1 to 6379)
  AUTHORS   De Weer,A., Speleman,F., Cauwelier,B., Van Roy,N., Yigit,N.,
            Verhasselt,B., De Moerloose,B., Benoit,Y., Noens,L., Selleslag,D.,
            Lippert,E., Struski,S., Bastard,C., De Paepe,A., Vandenberghe,P.,
            Hagemeijer,A., Dastugue,N. and Poppe,B.
  CONSRTM   Groupe Francais de Cytogenetique Hematologique (GFCH)
  TITLE     EVI1 overexpression in t(3;17) positive myeloid malignancies
            results from juxtaposition of EVI1 to the MSI2 locus at 17q22
  JOURNAL   Haematologica 93 (12), 1903-1907 (2008)
   PUBMED   18815193
  REMARK    GeneRIF: The EVI1 gene locus was rearranged in all 13 myeloid
            malignancies patients and was associated with EVI1 overexpression.
            In 9 out of 13 patients, the 17q breakpoints clustered in a 250 kb
            region on band 17q22 encompassing the MSI2 gene
REFERENCE   9  (bases 1 to 6379)
  AUTHORS   Barbouti,A., Hoglund,M., Johansson,B., Lassen,C., Nilsson,P.G.,
            Hagemeijer,A., Mitelman,F. and Fioretos,T.
  TITLE     A novel gene, MSI2, encoding a putative RNA-binding protein is
            recurrently rearranged at disease progression of chronic myeloid
            leukemia and forms a fusion gene with HOXA9 as a result of the
            cryptic t(7;17)(p15;q23)
  JOURNAL   Cancer Res 63 (6), 1202-1206 (2003)
   PUBMED   12649177
REFERENCE   10 (bases 1 to 6379)
  AUTHORS   Sakakibara,S., Nakamura,Y., Satoh,H. and Okano,H.
  TITLE     Rna-binding protein Musashi2: developmentally regulated expression
            in neural precursor cells and subpopulations of neurons in
            mammalian CNS
  JOURNAL   J Neurosci 21 (20), 8091-8107 (2001)
   PUBMED   11588182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091181.8, BC001526.2,
            AC015883.6, AC005325.1 and AI416968.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138962.3.
            
            Summary: This gene encodes an RNA-binding protein that is a member
            of the Musashi protein family. The encoded protein is
            transcriptional regulator that targets genes involved in
            development and cell cycle regulation. Mutations in this gene are
            associated with poor prognosis in certain types of cancers. This
            gene has also been shown to be rearranged in certain cancer cells.
            [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript, and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.364895.1, BC001526.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284073.7/ ENSP00000284073.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC091181.8         124390-124436       c
            48-540              BC001526.2         1-493
            541-541             AC015883.6         88114-88114         c
            542-1444            BC001526.2         495-1397
            1445-6375           AC005325.1         96471-101401        c
            6376-6379           AI416968.1         21-24               c
FEATURES             Location/Qualifiers
     source          1..6379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..6379
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /note="musashi RNA binding protein 2"
                     /db_xref="GeneID:124540"
                     /db_xref="HGNC:HGNC:18585"
                     /db_xref="MIM:607897"
     exon            1..282
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1207
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /note="isoform a is encoded by transcript variant 1;
                     RNA-binding protein Musashi homolog 2; musashi-2; musashi
                     homolog 2"
                     /codon_start=1
                     /product="RNA-binding protein Musashi homolog 2 isoform a"
                     /protein_id="NP_620412.1"
                     /db_xref="CCDS:CCDS11596.1"
                     /db_xref="GeneID:124540"
                     /db_xref="HGNC:HGNC:18585"
                     /db_xref="MIM:607897"
                     /translation="MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKF
                     GEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQ
                     PKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFEN
                     EDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLG
                     YPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGA
                     NSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH"
     exon            283..323
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            324..405
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            406..490
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            491..532
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            533..625
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            626..674
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            675..757
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            758..872
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            873..947
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1010
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1165
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1238
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..6379
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6360..6365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /note="hexamer: AATAAA"
     polyA_site      6379
                     /gene="MSI2"
                     /gene_synonym="MSI2H"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgaggca gcggggctga gctaagccga gcccacgtgt gacggctctc gccgctgccc
       61 cggctccgcc gctcgcagag agattcggag gagcccgggc gggggggagg aggaggggga
      121 ggagggagcg gagatctcgg ggctcggagc cggccgccgc tccgctccga tcgctgtggg
      181 gcttggtttt ttgggggtgg gggggcgggg gggctcagat atggaggcaa atgggagcca
      241 aggcacctcg ggcagcgcca acgactccca gcacgacccc ggtaaaatgt ttatcggtgg
      301 actgagctgg cagacctcac cagatagcct tagagactat tttagcaaat ttggagaaat
      361 tagagaatgt atggtcatga gagatcccac tacgaaacgc tccagaggct tcggtttcgt
      421 cacgttcgca gacccagcaa gtgtagataa agtattaggt cagccccacc atgagttaga
      481 ttccaagacg attgacccca aagttgcatt tcctcgtcga gcgcaaccca agatggtcac
      541 aagaacaaag aaaatatttg taggcgggtt atctgcgaac acagtagtgg aagatgtaaa
      601 gcaatatttc gagcagtttg gcaaggtgga agatgcaatg ctgatgtttg ataaaactac
      661 caacaggcac agagggtttg gctttgtcac ttttgagaat gaagatgttg tggagaaagt
      721 ctgtgagatt catttccatg aaatcaataa taaaatggta gaatgtaaga aagctcagcc
      781 gaaagaagtc atgttcccac ctgggacaag aggccgggcc cggggactgc cttacaccat
      841 ggacgcgttc atgcttggca tggggatgct gggatatccc aacttcgtgg cgacctatgg
      901 ccgtggctac cccggatttg ctccaagcta tggctatcag ttcccaggct tcccagcagc
      961 ggcttatgga ccagtggcag cagcggcggt ggcggcagca agaggatcag gctccaaccc
     1021 ggcgcggccc ggaggcttcc cgggggccaa cagcccagga cctgtcgccg atctctacgg
     1081 ccctgccagc caggactccg gagtggggaa ttacataagt gcggccagcc cacagccggg
     1141 ctcgggcttc ggccacggca tagctggacc tttgattgca acggccttta caaatggata
     1201 ccattgagca ggtgctttcg ttgccatctc actctgagag catacctgga tgtccaggca
     1261 agactgggcg aagtttctga gtggcccttt gtttaggtga tgtcctcaga cctggacccc
     1321 caccagcctc actccccatc ccaaccagag atggctcact tcggatcgag ggttgactac
     1381 atctcatcat ctcacgaatc tgctgtaata taagacaaca gcttttaaat gtgtatataa
     1441 cccatgattt cggttttgtt ttgttttgtt tttcttgatg gtttccctct ccctccctct
     1501 cttcccattc tccttttaaa tctctttgaa tcacatttgg tagtgatttt gacttagtcc
     1561 agtagtcaca tagctttaat atctagttca aagctaacca tagtataatt gttatattaa
     1621 ggagttattt tttcttaaaa catttttttt tgcttgtttt ggttctgttc tcacttttaa
     1681 aggatgctga gatggtaata tgactctcca tattttggta ccaattctga gactgtatga
     1741 attttcaggt ggaactttag cacacactga agcaaagttg tgaagtgcag ggcgggaggt
     1801 gggcgtgagc tttctatttt gcgttgtaga agaagtgaga tgtagtaagc taattaacag
     1861 actttctagc agttcttttt gtgatgtctc tttgttaatc tgagtctatc tattttcggc
     1921 aataaggtaa ggacgacagt gttttgagtg tcctcctttt ctataagtgc tttttttctg
     1981 ttgaaagagg tgatattata aggttttttg aaattgtgaa ttctaaaaaa gaaatgttgt
     2041 aaatacaatt ccattaacta catagaaact attaagaaag agagaatcaa aaatattttt
     2101 gtgagggagt cggtcccagg cagtttgatg ctctgtggaa ggaggcggga agggaacgtt
     2161 ggccaagtca gttactgaga tgaagatcgc ccagctgcca ggaccacccc aggacaagtt
     2221 agagcactgt ttagctcctt tgtctgtgtg atagacctaa gaactgtatt agtgttgtac
     2281 cagcctatta acctcttgtc tgtgcacagc ttcaaatgtt accgtctagt tagattttta
     2341 tttaaaatat gaaaaactgc ttttcccaag atgtttttta aaaacaaagc tacaatttta
     2401 atatttaaca tatttaaagt ttcaaagcac acctgtttgg cttgggtggg ggtggggtgg
     2461 gggggacatt ctttttcagt cttaattttt aaatatttga tcattttcta ttgtccaatc
     2521 atttcagcac ctccaaaggt ccctaggaca ctttgcctct cttctccccc tgccccccac
     2581 cctgctccca catctggggg cccatgggcc aggagtggat aagcctgcat taatacaacc
     2641 tttctccatt cactttctat ttacaaatta ggaaagcaac cttttggttt atatatattt
     2701 tttttaatac ctcagtgctg caagtatcac cagagaggct atggaagaat ttttttttaa
     2761 tttattgtag atgtaaacag aattttaaaa ataaaaagta taaacatcac tgcactgtga
     2821 ctggtgggaa aaactgacag tttcctcttt gcacatgttt aacatttggc tgttataata
     2881 tatggtcctc ggttggggaa agatacttat gatgaaggat attttttaat ttaacttttt
     2941 tttaaatatt ggtaataggt cggcaacagc aactatagaa gtacaactca atagatggca
     3001 ttaaaacata ttgtagtgtg gatatatatt ttttcttttt taaaatgtga tattgacgtt
     3061 ttattaatat tttttaaatt gttacgttta taaatttggt acttaaggca cagccagtat
     3121 gagacactga atgcgacatt tattataaag agctgctgca ctcctatttt tataaatttt
     3181 actaacaaag tagactaatg tagacattca cagacatggt agggcaaaag catcttcaaa
     3241 ctaaagactc caaaatgcta actcagaaag aaagaaaaaa cccgttttca attctaatga
     3301 aacagcaaca acattttttt taattaaaaa aaaaatcatg ttctttgttt ttctaataaa
     3361 atgttaggtt gtttggtgag gtttttttgt tgtttttttc ctttctttgt ttcttttctt
     3421 ttcccccaaa caaccagatt aaatgctgag cgcttttaaa atatcaaaac ttgttcaagt
     3481 cataaaacaa caaaacataa gttttattta aaaaaaaaaa aagaaagaaa aaatagtaaa
     3541 ttcccagaaa ttcagtgttt agacgaggga atttaattcc tattttgtcc atgttggtga
     3601 tgtactgtac ttcccttcct tttctctgca tcccccatca cctcatagaa gactctttgt
     3661 tgatcattgt atgttaataa tgtataaaat ggctatcttg taagcgtgct gtcctggtac
     3721 tagtgtagcg actttttttc tcctctttct tctagtacat attgataggt ataacataat
     3781 taaggtttaa aaaaaattag acatagttat tcagatttag gaccagtaag gatagaactt
     3841 tctcttattt atgaaaaaaa atgctaataa ttttggggca gttttttcct ttaattattt
     3901 ttttcaattt caagtttaat tttattttag ctgatctgat gtggtttcaa ctaacccaag
     3961 gtctcaccat gttaaaatgc cggcggactc tacggcgttt tgtagatccc ccccccccca
     4021 cccactgtga aggggtgcca tactacctta aatgctaatg ctagatatgc aaaactggat
     4081 ttttttaatt tattttttaa aagagggagg catggtatat taaaatgatt ttactaagag
     4141 aaaaaatatt tttttaagaa tgctcagaag aaattgataa tctgtgtgaa tatgttttag
     4201 atgtttatat accttttgaa gagacccagt agcccatagc acaaatcttg tggaaatccg
     4261 atatgtttta atgtggctac ctaggtttaa ggttcacgtt agtcccccca ttccatctag
     4321 aagtccattt tgaaagattt ttgtaaattc ttttaacact gatgtttcag cctcgtcttt
     4381 gtttcagtta agctcaatgg cgaacatggg aaccaccttt cgccttccct gggggagaaa
     4441 ccctcttggc tgatggcttt tccccggaat tatcaaacag ccaccgggtg actttctggc
     4501 ttccagatcc atctgcctga gacccccgaa ctcctctcct cccaagcaga ggcgagtgag
     4561 tggcattagc tcccggaccc attcccggtc ctagctgggc atggggctga cggagatgac
     4621 caagccttgg tctgctctct agcagcttcc acagacttgg ctcgtggcct tccttatatc
     4681 cactgggaac aaacagcctc gcgctctata ccaaacagcc tcgcgctcta tcccagtcgc
     4741 ccattagctt gattcaaaca aagccccagc aggcctttgc gtttttatcc ttcataacct
     4801 tcatcttaat ttgaacttgt agcttggact ttaaggtagc atggctctat tgctgtcaat
     4861 ttactgtttc actgcacagc aatcacagcc agtgaatgtt acacacatct tgctagacta
     4921 gtataaaaat cattgggtaa ttgttggttc taatgacctg aaaggtgttc agtttttgtt
     4981 cttggttttg ttttgttttt gatttcttgg gggtgggttt tgcttgttgt tccttttcat
     5041 ttgggggttt ttggggaaaa aatttatttt tggttccaaa tagaaaaaca aaacctattt
     5101 tgatctttag tgcaaacgag ggctagggac ttagcctcct ccaccacctc cacactgctt
     5161 cattctgcca ttcactcact gcagcatatt caagaataaa gcaatatcgt ttactacatt
     5221 ttttattgaa ggtcagccat gctttctgta ttatattgca tatgaaattg tttacaaaag
     5281 aaacactaac tcatacttct ctttattggt tgcaagtggc acgcaggaac agagggagag
     5341 tggggggctg gtgggggagg ggagattttt tttttttttt cttgaatgtg cttcgcaagc
     5401 caggctatct tccaaggaag gcagacagtg ggagagcaga gggactgact gcaggcaagc
     5461 acattgaaga aagacactgg cgggtttccc caccctcacc ccaaagcaga aaactagcag
     5521 acgtcagctc agccccgtcc tgggcacaga cactacacaa ggagacgctg gaagttaagc
     5581 aatactttaa tactgtaata tgtttgtttt ctttttcttt cttttttttc taccaaaaaa
     5641 aagtaagtaa actaaaacac aaaaacatat aaataaaatc catccctctt gtcggggacc
     5701 tgcagggggg caaccttaat ccaaacacct ggctatcaaa taatcagaat gtattgtctc
     5761 agacaggatt tcagttccgg gaggcagggg catgatgggg gagggggccg gaggctgaga
     5821 gacaaaagtt ccagagcctc cctcgaaggt tctctactac tgtattctgt acataatgta
     5881 ccatcccatg tggaatctgt gagtgtcctc ttaagtagcg tgggctagcc aatctgccgt
     5941 tcatggtgta ttgtaaactc cgaattccat atgtaatagg atgcaagtct aagcgtttca
     6001 tgtggacata aatgtatcta aataaaactt tccctagcac tgtggctgac ctcaccctta
     6061 cttttatact ttagtatgaa actgatgaga actttggtag tgagtatttt ttttatatat
     6121 atacatatat atgtactatc tatatatata tctcaagcat ctttcaggtc tttgtgtgtg
     6181 gctttcttaa agccctgttg taaaaaatta ctatgtggat ggcagtctct cacatcacag
     6241 atgtggaaag tataatttta tatttgtatt ttcaaataaa taagtttgtg aaaggtttcc
     6301 atcctctact gtggtccaga aatcaatgtg tttgtctgac aaaaaaaaaa ataaaataaa
     6361 ataaactgtt ttgaacaga
//
