LOCUS       NM_002442               2959 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens musashi RNA binding protein 1 (MSI1), transcript
            variant 1, mRNA.
ACCESSION   NM_002442
VERSION     NM_002442.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2959)
  AUTHORS   Yu,Q., Zhang,Y., Tian,Y., Peng,A., Cui,X., Ding,B., Yang,L.,
            Liu,Y., Ju,Y. and Gao,C.
  TITLE     Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer
            Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis
  JOURNAL   Appl Biochem Biotechnol 195 (12), 7322-7337 (2023)
   PUBMED   36995659
  REMARK    GeneRIF: Exosomal Circ_FMN2 Derived from the Serum of Colorectal
            Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1
            Axis.
            Erratum:[Appl Biochem Biotechnol. 2024 Jun;196(6):3673. doi:
            10.1007/s12010-023-04722-4.. PMID: 37755641]
REFERENCE   2  (bases 1 to 2959)
  AUTHORS   Chen,Y., Chen,Y., Li,Q., Liu,H., Han,J., Zhang,H., Cheng,L. and
            Lin,G.
  TITLE     Short C-terminal Musashi-1 proteins regulate pluripotency states in
            embryonic stem cells
  JOURNAL   Cell Rep 42 (10), 113308 (2023)
   PUBMED   37858462
  REMARK    GeneRIF: Short C-terminal Musashi-1 proteins regulate pluripotency
            states in embryonic stem cells.
REFERENCE   3  (bases 1 to 2959)
  AUTHORS   Haiduk,T.S., Sicking,M., Brucksken,K.A., Espinoza-Sanchez,N.A.,
            Eder,K.M., Kemper,B., Eich,H.T., Gotte,M., Greve,B. and
            Troschel,F.M.
  TITLE     Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are
            Associated with Therapy Resistance in Inflammatory Breast Cancer
  JOURNAL   Arch Med Res 54 (6), 102855 (2023)
   PUBMED   37481823
  REMARK    GeneRIF: Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are
            Associated with Therapy Resistance in Inflammatory Breast Cancer.
REFERENCE   4  (bases 1 to 2959)
  AUTHORS   Lachinani,L., Forouzanfar,M., Dormiani,K., Soltani,B.M.,
            Dolatshahi,K., Hakimian,S.M., Dokanehiifard,S. and
            Nasr-Esfahani,M.H.
  TITLE     The oncogene Musashi1 encodes novel miRNAs in breast cancer
  JOURNAL   Sci Rep 13 (1), 13710 (2023)
   PUBMED   37607966
  REMARK    GeneRIF: The oncogene Musashi1 encodes novel miRNAs in breast
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2959)
  AUTHORS   Nahas,G.R., Sherman,L.S., Sinha,G., El Far,M.H., Petryna,A.,
            Munoz,S.M., Silverio,K.A., Shaker,M., Neopane,P., Mariotti,V. and
            Rameshwar,P.
  TITLE     Increased expression of musashi 1 on breast cancer cells has
            implication to understand dormancy and survival in bone marrow
  JOURNAL   Aging (Albany NY) 15 (9), 3230-3248 (2023)
   PUBMED   36996499
  REMARK    GeneRIF: Increased expression of musashi 1 on breast cancer cells
            has implication to understand dormancy and survival in bone marrow.
REFERENCE   6  (bases 1 to 2959)
  AUTHORS   Shu,H.J., Saito,T., Watanabe,H., Ito,J.I., Takeda,H., Okano,H. and
            Kawata,S.
  TITLE     Expression of the Musashi1 gene encoding the RNA-binding protein in
            human hepatoma cell lines
  JOURNAL   Biochem Biophys Res Commun 293 (1), 150-154 (2002)
   PUBMED   12054577
  REMARK    GeneRIF: association between Musashi1 and the development of liver
            cancer
REFERENCE   7  (bases 1 to 2959)
  AUTHORS   Okano,H., Imai,T. and Okabe,M.
  TITLE     Musashi: a translational regulator of cell fate
  JOURNAL   J Cell Sci 115 (Pt 7), 1355-1359 (2002)
   PUBMED   11896183
  REMARK    Review article
REFERENCE   8  (bases 1 to 2959)
  AUTHORS   Sakakibara,S., Nakamura,Y., Satoh,H. and Okano,H.
  TITLE     Rna-binding protein Musashi2: developmentally regulated expression
            in neural precursor cells and subpopulations of neurons in
            mammalian CNS
  JOURNAL   J Neurosci 21 (20), 8091-8107 (2001)
   PUBMED   11588182
REFERENCE   9  (bases 1 to 2959)
  AUTHORS   Imai,T., Tokunaga,A., Yoshida,T., Hashimoto,M., Mikoshiba,K.,
            Weinmaster,G., Nakafuku,M. and Okano,H.
  TITLE     The neural RNA-binding protein Musashi1 translationally regulates
            mammalian numb gene expression by interacting with its mRNA
  JOURNAL   Mol Cell Biol 21 (12), 3888-3900 (2001)
   PUBMED   11359897
REFERENCE   10 (bases 1 to 2959)
  AUTHORS   Good,P., Yoda,A., Sakakibara,S., Yamamoto,A., Imai,T., Sawa,H.,
            Ikeuchi,T., Tsuji,S., Satoh,H. and Okano,H.
  TITLE     The human Musashi homolog 1 (MSI1) gene encoding the homologue of
            Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in
            CNS stem cells and neural progenitor cells
  JOURNAL   Genomics 52 (3), 382-384 (1998)
   PUBMED   9790759
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX393884.2, AB012851.1,
            AC003982.1 and AI583233.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002442.3.
            
            Summary: This gene encodes a protein containing two conserved
            tandem RNA recognition motifs. Similar proteins in other species
            function as RNA-binding proteins and play central roles in
            posttranscriptional gene regulation. Expression of this gene has
            been correlated with the grade of the malignancy and proliferative
            activity in gliomas and melanomas. A pseudogene for this gene is
            located on chromosome 11q13. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB012851.1, ERR3218377.421073.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257552.7/ ENSP00000257552.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BX393884.2         17-25
            10-1637             AB012851.1         1-1628
            1638-2527           AC003982.1         42760-43649         c
            2528-2959           AI583233.1         15-446              c
FEATURES             Location/Qualifiers
     source          1..2959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2959
                     /gene="MSI1"
                     /note="musashi RNA binding protein 1"
                     /db_xref="GeneID:4440"
                     /db_xref="HGNC:HGNC:7330"
                     /db_xref="MIM:603328"
     exon            1..132
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1162
                     /gene="MSI1"
                     /note="isoform a is encoded by transcript variant 1;
                     musashi1; RNA-binding protein Musashi homolog 1;
                     musashi-1"
                     /codon_start=1
                     /product="RNA-binding protein Musashi homolog 1 isoform a"
                     /protein_id="NP_002433.1"
                     /db_xref="CCDS:CCDS9196.1"
                     /db_xref="GeneID:4440"
                     /db_xref="HGNC:HGNC:7330"
                     /db_xref="MIM:603328"
                     /translation="METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFG
                     EVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQP
                     KMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESE
                     DIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLG
                     YPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAA
                     AAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYIS
                     AASPAPSTGFGHSLGGPLIATAFTNGYH"
     exon            133..173
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..255
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..340
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..382
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..475
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..524
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..607
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..725
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..806
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..863
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..932
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1120
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1183
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..2959
                     /gene="MSI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2939..2944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSI1"
                     /note="hexamer: AATAAA"
     polyA_site      2959
                     /gene="MSI1"
                     /note="major polyA site"
ORIGIN      
        1 atctgccccg cgccgagcgc cgccgccgcc gccgccgccg ccgctccgct gcccgcgccg
       61 cccgcggctc ccgatggaga ctgacgcgcc ccagcccggc ctcgcctccc cggactcgcc
      121 gcacgacccc tgcaagatgt tcatcggggg actcagttgg cagactacgc aggaagggct
      181 gcgcgaatac ttcggccagt tcggggaggt gaaggagtgt ctggtgatgc gggaccccct
      241 gaccaagaga tccaggggtt tcggcttcgt cactttcatg gaccaggcgg gggtggataa
      301 agtgctggcg caatcgcggc acgagctcga ctccaaaaca attgacccta aggtggcctt
      361 ccctcggcga gcacagccca agatggtgac tcgaacgaag aagatctttg tgggggggct
      421 gtcggtgaac accacggtgg aggacgtgaa gcaatatttt gagcagtttg ggaaggtgga
      481 cgacgccatg ctgatgtttg acaaaaccac caaccggcac cgagggttcg ggtttgtcac
      541 gtttgagagt gaggacatcg tggagaaagt gtgtgaaatt cattttcatg aaatcaacaa
      601 caaaatggtg gaatgtaaga aagctcagcc aaaggaggtg atgtcgccaa cgggctcagc
      661 ccgggggagg tctcgagtca tgccctacgg aatggacgcc ttcatgctgg gcatcggcat
      721 gctgggttac ccaggtttcc aagccacaac ctacgccagc cggagttata caggcctcgc
      781 ccctggctac acctaccagt tccccgaatt ccgtgtagag cggacccctc tcccgagcgc
      841 cccagtcctc cccgagctta cagccattcc tctcactgcc tacggaccaa tggcggcggc
      901 agcggcggca gcggctgtgg ttcgagggac aggctctcac ccctggacga tggctccccc
      961 tccaggttcg actcccagcc gcacaggggg cttcctgggg accaccagcc ccggccccat
     1021 ggccgagctc tacggggcgg ccaaccagga ctcgggggtc agcagttaca tcagcgccgc
     1081 cagccctgcc cccagcaccg gcttcggcca cagtcttggg ggccctttga ttgccacagc
     1141 cttcaccaat gggtaccact gaagcagggg acggtggcag gagcgcccca gcctgcagct
     1201 gactgaggac cacgagtgag ccagcgaggg ggcgggagac ctcagccgca gccgccgccc
     1261 cctcccctgc agcgactcgg acccgctact gcctgccccc aactccccgg gcccggcccc
     1321 tgccctgctg cccccaacag cgtctggctc ccctactaac gtccccctct tcgcccttgc
     1381 ccccatcccc acccgcccct ctcccggccc tgcttttatt tattttggat tagccggttg
     1441 cccaccccag ccctctggtc catccctccc tccgtgccgc gcccccctag gaccgccccc
     1501 tccccaaaag gcttttggat ttgtgcatag ctggagtgaa ggcggaggga gcctgctaca
     1561 ggccgcagcc caacccctgt tttttattca gatttcccct cctttaccct ttcccttttt
     1621 tttttttttt ttttttttaa agaaaccttt tttaaactat ttctaggttt gtgaatgtga
     1681 agccccaggc cgcagggggc aaggggccag gtgcccccca ccagctgaga acaaagtgtc
     1741 tatctgggtg tgggcccctg gccgcctccc tccagccctg gagaggaggg cagggctgcg
     1801 gggaggccag gccgagcccc tggaaccatc ccgtcctgta tcatatgtaa atactgtgag
     1861 gtgatgtgcc cacccctctc taagacccct cgggggtgag gggctccccc ctcccctgtt
     1921 tctgtcccct cagacaccgt tactgtaagc ttgcaggcct cagctgtggc cacggcaggc
     1981 ccgctctctc aggccctcag ggtcaaggcc ttggttggac ctgcccactc caaaaaccca
     2041 gtgtgggggc aaagggcgtg ggaagagcag ggcttgccca gcgacactgc tggacaggaa
     2101 ttaactctcc aaaggtctcc cctgctccct acctaggttg gggcttcatg gtttctgctc
     2161 agtctgtccc ccttccccct cgacccccgc aatgagtggg caccagggga cgctctggcg
     2221 agggcagacc ccaggggaaa gcaaagggcg tctcagggaa cccccacatt ctctcactga
     2281 agtttcccac caggatgacc ccacagccag agtcccttgg cagcccctca ccccagaccc
     2341 cccttctaag gaaaaagaga ggttcagagc gttggacctt catgaacagt ggcctggctg
     2401 gcgtggcagg gccaaggccc acccactgcc atcccccttc tgtgtgtccc tctcccccag
     2461 ttatgaggcc cagggcctga gctctcttcc ccagcattgc ccccacccgg aaaccccacc
     2521 tttggagagt taattgtctg tgtgaggtgc ttaacctatc agccctgaga acacaaagca
     2581 ataatctttg ttactgagat gcgcggctgt tcgtgttttg ggtttttttt ttttttaatg
     2641 tttcctaata aaagagaagc tgcattttat tggtttttat ttttaatttt ctacacgttt
     2701 gagctgagtc ctgagacact tagcttccct ctccctcatt cccggaccct tccaccccac
     2761 tgggcccaac catgggctca ggaccctgga attccgtttt ctgatttgct ttgggatttt
     2821 tttttttttt aagatgttac atggtgtttc gaagccagca agttaccatc ctccggtgtc
     2881 tcttctctcc acatctgtaa cttctttttc caggttttat tttcagtttt aaattcctaa
     2941 taaattattt gaaaacgtt
//
