LOCUS       NM_001406674            5813 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens mutS homolog 2 (MSH2), transcript variant 38, mRNA.
ACCESSION   NM_001406674
VERSION     NM_001406674.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5813)
  AUTHORS   Tu,X., Zhang,H. and Ren,H.
  TITLE     LINC01232 targeting miR-1250-3p/MSH2 axis attenuates mesangial cell
            proliferation and fibrosis in diabetic nephropathy
  JOURNAL   Mol Cell Biochem 479 (8), 2093-2103 (2024)
   PUBMED   37642881
  REMARK    GeneRIF: LINC01232 targeting miR-1250-3p/MSH2 axis attenuates
            mesangial cell proliferation and fibrosis in diabetic nephropathy.
REFERENCE   2  (bases 1 to 5813)
  AUTHORS   Li,M., Yan,X., Liu,H., Miao,W., Wu,W., Zhao,Y., Wang,C. and Liu,H.
  TITLE     Novel MSH2 and TSC2 variants in a Chinese family with Lynch
            syndrome and their synergistic impact in urothelial carcinoma
  JOURNAL   Transl Res 265, 26-35 (2024)
   PUBMED   37914149
  REMARK    GeneRIF: Novel MSH2 and TSC2 variants in a Chinese family with
            Lynch syndrome and their synergistic impact in urothelial
            carcinoma.
REFERENCE   3  (bases 1 to 5813)
  AUTHORS   Mirabdolhosseini,S.M., Yaghoob Taleghani,M., Rejali,L., Sadeghi,H.,
            Fatemi,N., Tavallaei,M., Famil Meyari,A., Saeidi,N., Ketabi
            Moghadam,P., Sadeghi,A., Asadzadeh Aghdaei,H., Zali,M.R. and
            Nazemalhosseini Mojarad,E.
  TITLE     Rare single-nucleotide variants of MLH1 and MSH2 genes in patients
            with Lynch syndrome
  JOURNAL   Cancer Rep (Hoboken) 7 (1), e1930 (2024)
   PUBMED   37919876
  REMARK    GeneRIF: Rare single-nucleotide variants of MLH1 and MSH2 genes in
            patients with Lynch syndrome.
REFERENCE   4  (bases 1 to 5813)
  AUTHORS   Sharbati,F., Tabriz,H.M. and Nazar,E.
  TITLE     Assessing the role of MSH2 and MSH6 gene expression deficiency in
            prostate cancer progression, a cross-sectional study
  JOURNAL   Cancer Treat Res Commun 40, 100826 (2024)
   PUBMED   38870667
  REMARK    GeneRIF: Assessing the role of MSH2 and MSH6 gene expression
            deficiency in prostate cancer progression, a cross-sectional study.
REFERENCE   5  (bases 1 to 5813)
  AUTHORS   Dutta,P., Pal,D., Roy,A., Mandal,R.K. and Panda,C.K.
  TITLE     Role of MLH1 and MSH2 deficiency in the development of
            tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical
            implications
  JOURNAL   Gene 888, 147746 (2023)
   PUBMED   37657688
  REMARK    GeneRIF: Role of MLH1 and MSH2 deficiency in the development of
            tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical
            implications.
REFERENCE   6  (bases 1 to 5813)
  AUTHORS   Wilson,T.M., Ewel,A., Duguid,J.R., Eble,J.N., Lescoe,M.K.,
            Fishel,R. and Kelley,M.R.
  TITLE     Differential cellular expression of the human MSH2 repair enzyme in
            small and large intestine
  JOURNAL   Cancer Res 55 (22), 5146-5150 (1995)
   PUBMED   7585562
REFERENCE   7  (bases 1 to 5813)
  AUTHORS   Wei,Q., Xu,X., Cheng,L., Legerski,R.J. and Ali-Osman,F.
  TITLE     Simultaneous amplification of four DNA repair genes and beta-actin
            in human lymphocytes by multiplex reverse transcriptase-PCR
  JOURNAL   Cancer Res 55 (21), 5025-5029 (1995)
   PUBMED   7585546
REFERENCE   8  (bases 1 to 5813)
  AUTHORS   Drummond,J.T., Li,G.M., Longley,M.J. and Modrich,P.
  TITLE     Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch
            repair to tumor cells
  JOURNAL   Science 268 (5219), 1909-1912 (1995)
   PUBMED   7604264
REFERENCE   9  (bases 1 to 5813)
  AUTHORS   Idos,G. and Valle,L.
  TITLE     Lynch Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301390
REFERENCE   10 (bases 1 to 5813)
  AUTHORS   Lynch,H.T., Schuelke,G.S., Kimberling,W.J., Albano,W.A.,
            Lynch,J.F., Biscone,K.A., Lipkin,M.L., Deschner,E.E., Mikol,Y.B.,
            Sandberg,A.A. et al.
  TITLE     Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and
            II). II. Biomarker studies
  JOURNAL   Cancer 56 (4), 939-951 (1985)
   PUBMED   4016686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079775.6 and AC138655.1.
            
            Summary: This locus is frequently mutated in hereditary
            nonpolyposis colon cancer (HNPCC). When cloned, it was discovered
            to be a human homolog of the E. coli mismatch repair gene mutS,
            consistent with the characteristic alterations in microsatellite
            sequences (RER+ phenotype) found in HNPCC. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Apr 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.262494.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AC079775.6         98145-98391
            248-402             AC079775.6         103390-103544
            403-681             AC079775.6         105083-105361
            682-828             AC079775.6         107403-107549
            829-978             AC079775.6         109258-109407
            979-1112            AC079775.6         111285-111418
            1113-1312           AC079775.6         124731-124930
            1313-1422           AC079775.6         140537-140646
            1423-1546           AC079775.6         158020-158143
            1547-1697           AC079775.6         161647-161797
            1698-1795           AC079775.6         165954-166051
            1796-2041           AC138655.1         27-272
            2042-2246           AC138655.1         1369-1573
            2247-2494           AC138655.1         3274-3521
            2495-2670           AC138655.1         5698-5873
            2671-2788           AC138655.1         37305-37422
            2789-2908           AC138655.1         58036-58155
            2909-5813           AC138655.1         59874-62778
FEATURES             Location/Qualifiers
     source          1..5813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21-p16.3"
     gene            1..5813
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /note="mutS homolog 2"
                     /db_xref="GeneID:4436"
                     /db_xref="HGNC:HGNC:7325"
                     /db_xref="MIM:609309"
     exon            1..247
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..3081
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /note="isoform 31 is encoded by transcript variant 38;
                     mutS homolog 2, colon cancer, nonpolyposis type 1; DNA
                     mismatch repair protein Msh2 transcript; MutS-like 2"
                     /codon_start=1
                     /product="DNA mismatch repair protein Msh2 isoform 31"
                     /protein_id="NP_001393603.1"
                     /db_xref="GeneID:4436"
                     /db_xref="HGNC:HGNC:7325"
                     /db_xref="MIM:609309"
                     /translation="MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYT
                     AHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEV
                     YKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQ
                     VGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQ
                     RGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKF
                     LELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCK
                     TPQGQRLVNQWIKQPLMDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAK
                     KFQRQAANLQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKF
                     QEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPG
                     KQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLNEEYTKN
                     KTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAI
                     LEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQT
                     GVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSAT
                     KDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVN
                     NLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQY
                     IGESQGYDIMEPAAKKCYLERENLRVTEPKDQCLILLTWKRKLRGGKRSACSRPERQN
                     QGSDRLTLSPRLECSGVILAHCNLHLPGSSHSPATASQVAGTTGGDFKRKSLVVCKAT
                     NPALKWIVPSPLNEFSFIHLEKHSLVLSMELQATSGGAQCPG"
     exon            248..402
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..681
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..828
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..978
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1112
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1312
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1422
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1546
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1697
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1795
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2041
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2246
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2494
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2670
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2788
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2908
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..5813
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3216..3221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /note="hexamer: AATAAA"
     polyA_site      3246
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
     regulatory      5792..5797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /note="hexamer: AATAAA"
     polyA_site      5813
                     /gene="MSH2"
                     /gene_synonym="COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2;
                     LYNCH1; MMRCS2; MSH-2"
                     /note="major polyA site"
ORIGIN      
        1 gcattttctt caaccaggag gtgaggaggt ttcgacatgg cggtgcagcc gaaggagacg
       61 ctgcagttgg agagcgcggc cgaggtcggc ttcgtgcgct tctttcaggg catgccggag
      121 aagccgacca ccacagtgcg ccttttcgac cggggcgact tctatacggc gcacggcgag
      181 gacgcgctgc tggccgcccg ggaggtgttc aagacccagg gggtgatcaa gtacatgggg
      241 ccggcaggag caaagaatct gcagagtgtt gtgcttagta aaatgaattt tgaatctttt
      301 gtaaaagatc ttcttctggt tcgtcagtat agagttgaag tttataagaa tagagctgga
      361 aataaggcat ccaaggagaa tgattggtat ttggcatata aggcttctcc tggcaatctc
      421 tctcagtttg aagacattct ctttggtaac aatgatatgt cagcttccat tggtgttgtg
      481 ggtgttaaaa tgtccgcagt tgatggccag agacaggttg gagttgggta tgtggattcc
      541 atacagagga aactaggact gtgtgaattc cctgataatg atcagttctc caatcttgag
      601 gctctcctca tccagattgg accaaaggaa tgtgttttac ccggaggaga gactgctgga
      661 gacatgggga aactgagaca gataattcaa agaggaggaa ttctgatcac agaaagaaaa
      721 aaagctgact tttccacaaa agacatttat caggacctca accggttgtt gaaaggcaaa
      781 aagggagagc agatgaatag tgctgtattg ccagaaatgg agaatcaggt tgcagtttca
      841 tcactgtctg cggtaatcaa gtttttagaa ctcttatcag atgattccaa ctttggacag
      901 tttgaactga ctacttttga cttcagccag tatatgaaat tggatattgc agcagtcaga
      961 gcccttaacc tttttcaggg ttctgttgaa gataccactg gctctcagtc tctggctgcc
     1021 ttgctgaata agtgtaaaac ccctcaagga caaagacttg ttaaccagtg gattaagcag
     1081 cctctcatgg ataagaacag aatagaggag agattgaatt tagtggaagc ttttgtagaa
     1141 gatgcagaat tgaggcagac tttacaagaa gatttacttc gtcgattccc agatcttaac
     1201 cgacttgcca agaagtttca aagacaagca gcaaacttac aagattgtta ccgactctat
     1261 cagggtataa atcaactacc taatgttata caggctctgg aaaaacatga aggaaaacac
     1321 cagaaattat tgttggcagt ttttgtgact cctcttactg atcttcgttc tgacttctcc
     1381 aagtttcagg aaatgataga aacaacttta gatatggatc aggtggaaaa ccatgaattc
     1441 cttgtaaaac cttcatttga tcctaatctc agtgaattaa gagaaataat gaatgacttg
     1501 gaaaagaaga tgcagtcaac attaataagt gcagccagag atcttggctt ggaccctggc
     1561 aaacagatta aactggattc cagtgcacag tttggatatt actttcgtgt aacctgtaag
     1621 gaagaaaaag tccttcgtaa caataaaaac tttagtactg tagatatcca gaagaatggt
     1681 gttaaattta ccaacagcaa attgacttct ttaaatgaag agtataccaa aaataaaaca
     1741 gaatatgaag aagcccagga tgccattgtt aaagaaattg tcaatatttc ttcaggctat
     1801 gtagaaccaa tgcagacact caatgatgtg ttagctcagc tagatgctgt tgtcagcttt
     1861 gctcacgtgt caaatggagc acctgttcca tatgtacgac cagccatttt ggagaaagga
     1921 caaggaagaa ttatattaaa agcatccagg catgcttgtg ttgaagttca agatgaaatt
     1981 gcatttattc ctaatgacgt atactttgaa aaagataaac agatgttcca catcattact
     2041 ggccccaata tgggaggtaa atcaacatat attcgacaaa ctggggtgat agtactcatg
     2101 gcccaaattg ggtgttttgt gccatgtgag tcagcagaag tgtccattgt ggactgcatc
     2161 ttagcccgag taggggctgg tgacagtcaa ttgaaaggag tctccacgtt catggctgaa
     2221 atgttggaaa ctgcttctat cctcaggtct gcaaccaaag attcattaat aatcatagat
     2281 gaattgggaa gaggaacttc tacctacgat ggatttgggt tagcatgggc tatatcagaa
     2341 tacattgcaa caaagattgg tgctttttgc atgtttgcaa cccattttca tgaacttact
     2401 gccttggcca atcagatacc aactgttaat aatctacatg tcacagcact caccactgaa
     2461 gagaccttaa ctatgcttta tcaggtgaag aaaggtgtct gtgatcaaag ttttgggatt
     2521 catgttgcag agcttgctaa tttccctaag catgtaatag agtgtgctaa acagaaagcc
     2581 ctggaacttg aggagtttca gtatattgga gaatcgcaag gatatgatat catggaacca
     2641 gcagcaaaga agtgctatct ggaaagagag aacctcagag tgacagagcc aaaagaccag
     2701 tgcctcattt tgctgacatg gaaaaggaaa cttcgtgggg gaaagagatc tgcttgcagt
     2761 cggccagaga gacagaacca gggcagtgac aggctcactc tgtcgcccag gctggagtgc
     2821 agtggtgtga tcttggctca ctgcaacctc cacctcccag gttcaagcca ttctcctgcc
     2881 acagcctccc aagtagctgg gactacagga ggagatttta aaaggaagtc tctggtggtt
     2941 tgtaaagcaa caaatcctgc tctcaagtgg atagttccaa gccctctcaa tgaattcagt
     3001 tttatacacc tggagaagca cagcctcgtc ctttccatgg agctacaagc cacatctggg
     3061 ggcgctcagt gcccaggctg agggggcacg cagagccctc ggggacgact caatgcacag
     3121 aggccactcc ttaagggccc ggctccctca aactgaggtg tccccatgct tggtcttccc
     3181 acagaagcca gcctggttgg ctgcttcaaa ggaggaataa agatgaggag ccatgatgca
     3241 aacaaaccca cacctttcag ctgcagccag ggaggtgctc tagaggccca cggagagctg
     3301 tgtgtctgct ctgctagccc gacctgcacc tgccctatgg gctggtaaag gggctgccca
     3361 cagcacctca gcacatgggt ctctctctct tttcatccag cccaaaatgt caaagcacaa
     3421 gggtctctgt cagggcctgg ctgtggtcac tggactgcgg ctgaggggta aggtgcaccc
     3481 ctcctctaat gggggcgcac ccctcctcta atgggggtgg ggctggagct aatggcacat
     3541 tccactctca gctgccacac acagatgggg aggttgatgg cccgcacaca ggaagtgagg
     3601 gatggtgggg actgaattta tggagcccct atcccagacc aagcactctg ctggtacttt
     3661 cacaggtgta atccccagag cagctcctgg gggaggtgtc attatgccgg tgaggaaacc
     3721 aaggctcaga gaagtaaggc agcacaggtc ccagccccac tccacctctt gaggcctgac
     3781 tcagccttag gttcagagaa tgcaactgtg atttttccct gagatgagca ttcaatcata
     3841 ctgcgccagg gtacttgctg tggccaaaac gcctgccctg gatctgtggc atgactttgt
     3901 gtcagaccct gtgcgataga aggagatgga agctgaggtt cagagacgtt aatgaccttg
     3961 aaggtcaggg tcacagaaaa tggcacaacc gggattgcaa ctcagttctg cccaatttca
     4021 aatctacctt cctgccacct ccttgccttg cctattgtcc ccctcccttc atatgacctg
     4081 ggacccagac tccctggttt tctggaaata ttctctctcc ttttggctca ttctgtgcac
     4141 tgtcccagtt ggtggtattg aggcacagct ctgcccagat cactctccag ctcagctgcc
     4201 ctgagctccc cagccccacc tttcaaggtc aggaatgact tatttccttt tctcttcgcc
     4261 tgtctgaatc ctcgccatca tctgacagca ctttcagctc accaggcatt taactgtgtg
     4321 ctgtcttgtg acagcccctg tcctgaccat tgtcccagag atttaaccct ttgtgttttt
     4381 ctatgttagc ttgccagtga ggacatggcc catgtcttgg acttcttgcc accctccaga
     4441 atgcaggtcc tcagggagca gctgctaaat tcccaacaga actgacagtt tgtccagtga
     4501 tcaccagcag acactgtacc agaaacattg tctccatctt agtttcagtt aactcaacat
     4561 gtttttgaga cctgctgtgt gccagacatg agggcagggg aaggaagact atggtgaata
     4621 agattgccca cagacctcca ggaacacacc tgtagtcaaa acacaattga gcttactggc
     4681 tcactgcaat gaggaagctt ggccaccatg gattctgggg catctcagtc agagggtatc
     4741 aaagagggct aattctagga gttgggcttg agttcttgag ttaggtgatt tatggaggac
     4801 ttaaggaagc aggcttcgct ctggatggga tgctgccaaa gagcggaagt acttctatga
     4861 ctgggcatct taattcttag ctggaagatg ggaacgacat agcgaggcca agctgtgatt
     4921 ggccaagaag cagcagttgc tcatactaac cagatgaggg atgtttggtc tttttagtgg
     4981 tttggacgat gttcttgttt tggtctgtgt ttggacatga ttatggggtg aatggtcttg
     5041 tttttctctc actccatctt ggtcataagg cggccttgcc tgatcagggg ttctgtgaaa
     5101 tgcttatgct ccatggcaga tcctcccagc cccactgtga gtgccaggcc agctctcggc
     5161 gctcaggggc tgccttcatc tttctcaaaa tgctgctgtg ctttgcagcc cataatagca
     5221 ttttactgga tgccattcat tattttttgt aaatgaaatt ctttccaagt gttccaattt
     5281 acttggctat atatgtgcat gtgtgcacac acgcgtactt aattccgtac atggagcaca
     5341 ctgctcagtt gtgaaaatgg gtgattttct ttcttttttt tttttgagat ggcatcttgc
     5401 tctgtcgccc aggctggagt gcactggcgc gatctcagct ctctgcaacc tccgcctccc
     5461 gggttcaagt gattctcctg cctcagcctc ctgagtagct gggattacag gcgcccacca
     5521 cgacgcccag ctaattttta tatttttaat agagacaggg tttcatcatg ttggccagga
     5581 tggtctcaat ctcttgacct cgtgatccgc ccgcctcggt ctcccaaagt gctgggatta
     5641 caggcgtgag ccaccgcgcc cagctgtgat tttcatttta agtttcttct atttgctttt
     5701 ataaatattt cacattttct gtggtgcaaa taggatagtt gctacttttg aaaccgtaag
     5761 ttcactccca acaagcactg ttaagtttat aaataaaaat gaataagata tga
//
