LOCUS       NM_001198812            2434 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens MSANTD3-TMEFF1 readthrough (MSANTD3-TMEFF1), mRNA.
ACCESSION   NM_001198812
VERSION     NM_001198812.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353805.20 and AL831919.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription from the neighboring MSANTD3 (Myb/SANT-like
            DNA-binding domain containing 3) and TMEFF1 (transmembrane protein
            with EGF-like and two follistatin-like domains 1) genes. The
            read-through transcript encodes a fusion protein that shares
            sequence identity with the products of each individual gene.
            [provided by RefSeq, Aug 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831919.1, SRR1660807.234877.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 8577, 91283
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AL353805.20        107999-108363
            366-2434            AL831919.1         1-2069
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..2434
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /note="MSANTD3-TMEFF1 readthrough"
                     /db_xref="GeneID:100526694"
                     /db_xref="HGNC:HGNC:38838"
     exon            1..451
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1398
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /note="C9orf30-TMEFF1 readthrough; Tomoregulin-1;
                     Transmembrane protein with EGF-like and one
                     follistatin-like domain"
                     /codon_start=1
                     /product="MSANTD3-TMEFF1 fusion protein"
                     /protein_id="NP_001185741.1"
                     /db_xref="GeneID:100526694"
                     /db_xref="HGNC:HGNC:38838"
                     /translation="MQNNEIIKPAKYFSELEKSILLALVEKYKYVLECKKSDARTIAL
                     KQRTWQALAHEYNSQPSVSLRDFKQLKKCWENIKARTKKIMAHERREKVKRSVSPLLS
                     THVLGKEKIASMLPEQLYFLQSPPEEEPEYHPDASAQELNVRESDVRVCDESSCKYGG
                     VCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCY
                     SDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPV
                     CASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDA
                     SDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSIL
                     YVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTS
                     SRMV"
     exon            452..561
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..691
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..718
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..815
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..964
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1030
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1154
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1313
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..2434
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2415..2420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /note="hexamer: AATATA"
     polyA_site      2434
                     /gene="MSANTD3-TMEFF1"
                     /gene_synonym="C9orf2; C9orf3-TMEFF1; C9orf30-TMEFF1;
                     H7365; TMEFF1; TR-1"
                     /note="major polyA site"
ORIGIN      
        1 gatagctagc ggccaggaga aatacagtgg aaaatgcaaa acaacgaaat tataaagcct
       61 gccaaatact tctcagaatt ggaaaagagc atcctgctgg ctttagtaga aaagtataaa
      121 tatgtgctgg aatgtaagaa aagtgatgcg cgaactattg cccttaagca gcgtacctgg
      181 caggcgctgg cccacgaata caactctcag cccagcgtgt ccctgcggga tttcaaacag
      241 ctgaagaagt gctgggagaa catcaaggct cggaccaaaa aaattatggc ccatgaaagg
      301 agagagaaag tgaaacggag cgtcagccct ctcctgagta cccacgtcct agggaaggag
      361 aagatcgcca gcatgctgcc ggagcagctc tacttcctgc agagcccccc ggaggaggag
      421 cccgaatacc accccgacgc ctcagcccaa gaattaaatg tgagggagtc tgacgtaaga
      481 gtttgtgatg agtcatcatg taaatatgga ggagtctgta aagaagatgg agatggtttg
      541 aaatgtgcat gccaatttca gtgccataca aattatattc ctgtctgtgg atcaaatggg
      601 gacacttatc aaaatgaatg ctttctcaga agggctgctt gtaagcacca gaaagagata
      661 acagtaatag caagaggacc atgctactct gataatggat ctggatctgg agaaggagaa
      721 gaggaagggt caggggcaga agttcacaga aaacactcca agtgtggacc ctgcaaatat
      781 aaagctgagt gtgatgaaga tgcagaaaat gttgggtgtg tatgtaatat agattgcagt
      841 ggatacagtt ttaatcctgt gtgtgcttct gatgggagtt cctataacaa tccctgtttt
      901 gttcgagaag catcttgtat aaagcaagaa caaattgata taaggcatct tggtcattgc
      961 acagatacag atgacactag tttgttggga aagaaagatg atggactaca atatcgacca
     1021 gatgtgaaag atgctagtga tcaaagagaa gatgtttata ttggaaacca catgccttgc
     1081 cctgaaaacc tcaatggtta ctgcatccat ggaaaatgtg aattcatcta ttctactcag
     1141 aaggcttctt gtagatgtga atctggctac actggacagc actgtgaaaa gacagacttt
     1201 agtattctct atgtagtgcc aagtaggcaa aagctcactc atgttcttat tgcagcaatt
     1261 attggagctg tacagattgc catcatagta gcaattgtaa tgtgcataac aagaaaatgc
     1321 cccaaaaaca atagaggacg tcgacagaag caaaacctag gtcattttac ttcagatacg
     1381 tcatccagaa tggtttaaac tgatgacttt tatatgtaca ctgaccatgt gatgtacatt
     1441 tattatgtct ttttttaaag aatggaaata tttatttcag aggccttatt tttggacatt
     1501 tttagtgtag tactgttggc tcgtatttag aatattcagc tacgacagtt ttggactgtt
     1561 tagtagtctt tgttttatgt ttttaaatac agaaattgct ttcacaaatt tgtaccacat
     1621 ggtaattcta agacttgttc tttacccatg gaatgtaata tttttgcaaa gatggactac
     1681 ttcacaaatg gttataaagt catatccact tcttccacaa tgaccacagc aaatgaccaa
     1741 gcatgaacta aaggtaaaga tgtttacaga ttacttttct tacaaaaaaa atctagaaga
     1801 cactgtgttt aaatagatat ttaaatgttt ttgagattta gtaactgatt ttttagacac
     1861 tgcctatcgc atgaactgta aagctgtgtg tattaggtgt aaaatattta taagatatat
     1921 ggactgggga atttgattat tcctcccttt gaaaaaatag tcctaataat ttgaacaaat
     1981 atgttagtaa tgatggaaca gatcaatgaa aagtagatat agatattgtg aaaataggct
     2041 gtttaacaaa cagattggaa taaagcctat tctaccagtt aaactacttt aatacacatt
     2101 catttttaaa gaaaatgttt gttttaacat aaataaacaa atcgtatcag tgtttgtgaa
     2161 taaaatacaa aaatgattgt taatgattgg tgctcttaaa gtgagcttaa aatttatcca
     2221 agacgtatat ccaaatttgt cctgtagtaa tagattaata ttcatagatt gttggtgttt
     2281 aaagatctga agtgtgagta gaatgtattc agctgtttaa catgtagttt agatattcaa
     2341 aagtatgcat gtagaattta aagaatatgt taaaaattat taattttaat attttgtttg
     2401 gaaaagcatg ttataatata atgttttcac tata
//
