LOCUS       NM_080655               1880 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Myb/SANT DNA binding domain containing 3 (MSANTD3),
            transcript variant 1, mRNA.
ACCESSION   NM_080655
VERSION     NM_080655.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1880)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1880)
  AUTHORS   Andreasen,S., Varma,S., Barasch,N., Thompson,L.D.R., Miettinen,M.,
            Rooper,L., Stelow,E.B., Agander,T.K., Seethala,R.R., Chiosea,S.I.,
            Homoe,P., Wessel,I., Larsen,S.R., Erentaite,D., Bishop,J.A.,
            Ulhoi,B.P., Kiss,K., Melchior,L.C., Pollack,J.R. and West,R.B.
  TITLE     The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell
            Carcinoma of the Salivary Gland
  JOURNAL   Am J Surg Pathol 43 (4), 489-496 (2019)
   PUBMED   30520817
  REMARK    GeneRIF: we find the HTN3-MSANTD3 gene fusion to be a recurrent
            event in acinic cell carcinoma with prominent serous
            differentiation and an indolent clinical course
REFERENCE   3  (bases 1 to 1880)
  AUTHORS   Barasch,N., Gong,X., Kwei,K.A., Varma,S., Biscocho,J., Qu,K.,
            Xiao,N., Lipsick,J.S., Pelham,R.J., West,R.B. and Pollack,J.R.
  TITLE     Recurrent rearrangements of the Myb/SANT-like DNA-binding domain
            containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma
  JOURNAL   PLoS One 12 (2), e0171265 (2017)
   PUBMED   28212443
  REMARK    GeneRIF: MSANTD3 rearrangement as a recurrent event in salivary
            gland AcCC
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1880)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353805.20, DR159535.1, BC008993.1 and BU620865.1.
            
            On Feb 27, 2020 this sequence version replaced NM_080655.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1, 2 and 3 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008993.1, SRR14038195.412054.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395067.7/ ENSP00000378506.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL353805.20        93236-93305
            71-217              DR159535.1         1-147
            218-1377            BC008993.1         1-1160
            1378-1871           BU620865.1         27-520              c
            1872-1880           BU620865.1         17-25               c
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..1880
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /note="Myb/SANT DNA binding domain containing 3"
                     /db_xref="GeneID:91283"
                     /db_xref="HGNC:HGNC:23370"
     exon            1..251
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /inference="alignment:Splign:2.1.0"
     exon            252..702
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1112
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /note="isoform a is encoded by transcript variant 1;
                     UPF0439 protein C9orf30; myb/SANT-like DNA-binding
                     domain-containing protein 3; Myb/SANT-like DNA-binding
                     domain containing 3"
                     /codon_start=1
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 3 isoform a"
                     /protein_id="NP_542386.1"
                     /db_xref="CCDS:CCDS6749.1"
                     /db_xref="GeneID:91283"
                     /db_xref="HGNC:HGNC:23370"
                     /translation="MQNNEIIKPAKYFSELEKSILLALVEKYKYVLECKKSDARTIAL
                     KQRTWQALAHEYNSQPSVSLRDFKQLKKCWENIKARTKKIMAHERREKVKRSVSPLLS
                     THVLGKEKIASMLPEQLYFLQSPPEEEPEYHPDASAQESFAVSNRELCDDEKEFIHFP
                     VCEGTSQPEPSCSAVRITANKNYRSKTSQEGALKKMHEEEHHQQMSILQLQLIQMNEV
                     HVAKIQQIERECEMAEEEHRIKMEVLNKKKMYWERKLQTFTKEWPVSSFNRPFPNSP"
     exon            703..1880
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /note="hexamer: AATATA"
     polyA_site      1377
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /note="major polyA site"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
                     /note="hexamer: TATAAA"
     polyA_site      1438
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
     polyA_site      1453
                     /gene="MSANTD3"
                     /gene_synonym="C9orf30; L8"
ORIGIN      
        1 ctcggcggcg ccgacggacc ggcaggcggc gggcggtccg cgagggggcg gcggcgtccg
       61 ggctttgtgg ccgcggcgcg cgcggcgggg cctggccggc cgggggcgcg ccgccgccgc
      121 cgccgccgcc cggcgttcgg gagcccgcgg ccctcccggc cgccctgctt gcgagaggag
      181 cccaggccgc ccgccctcgc gcctcgccgg cccctccccc ggtcgccgcg gctgccgcgc
      241 cgccgctgca ggatagctag cggccaggag aaatacagtg gaaaatgcaa aacaacgaaa
      301 ttataaagcc tgccaaatac ttctcagaat tggaaaagag catcctgctg gctttagtag
      361 aaaagtataa atatgtgctg gaatgtaaga aaagtgatgc gcgaactatt gcccttaagc
      421 agcgtacctg gcaggcgctg gcccacgaat acaactctca gcccagcgtg tccctgcggg
      481 atttcaaaca gctgaagaag tgctgggaga acatcaaggc tcggaccaaa aaaattatgg
      541 cccatgaaag gagagagaaa gtgaaacgga gcgtcagccc tctcctgagt acccacgtcc
      601 tagggaagga gaagatcgcc agcatgctgc cggagcagct ctacttcctg cagagccccc
      661 cggaggagga gcccgaatac caccccgacg cctcagccca agaatcattt gctgtttcaa
      721 atagagaact gtgcgatgat gagaaagagt tcatacattt tccagtatgt gaggggacct
      781 ctcaacctga accctcgtgt tcagctgtca gaataacagc caataaaaac tacaggagca
      841 aaacctctca ggaaggtgct ttaaaaaaga tgcatgagga agaacaccat caacaaatgt
      901 ccatcttaca actgcaactg atacaaatga atgaggtgca tgtggccaaa atccagcaga
      961 tagagcgaga gtgtgagatg gcagaggagg aacacaggat aaaaatggaa gttctcaata
     1021 aaaagaagat gtattgggaa agaaaactac aaacttttac caaggaatgg cctgtttcct
     1081 catttaaccg gccctttccc aattcgccct aagactttgg gggtggctct cttgtaatta
     1141 atctgtgttg gcaaagaatg tctggaacat ggacttggcg gtcagtaacc tgtaacagag
     1201 ctacaactag gaaaattaga gtggtagtag tcacttattt aagaattcat tcaggtaaac
     1261 agctgcaccc tctgtacccc ttaagtggca aagaagctgt tatagtcttc tgaaaattat
     1321 cactatgagt gctataattc tgaatataat gtctcttaat tagaattcat acaagaacca
     1381 cgtgtgagtg ttgttgttgt tgtttttttt tttaatcaaa tgcaagtgtg actataaagg
     1441 agtgtggctg attttttttt ttttcttttt tctttttaaa cagacagcag aacttttcta
     1501 tccaaatgaa tgccgtccca tggaaagtgg ctgtcctggg aggctacacg tttctccaat
     1561 ggtgatgctg ttgctcagaa cttgctagag gtctttaggg aacctccgtg agagctgcag
     1621 caccttttta attttctcgg tgtcatcctc tgagtatgga ttttctgttt ttaaacagcc
     1681 caaagtttag aagggtattt tctaatgtgg ctcataaacc accttttaag gcctttcctc
     1741 aaacaggagt tctaaataag tctccaacaa tagtagtttt gttggagcta aggatgtaac
     1801 tactttgagg aagaaatgtt cgtttagatt tctacattct gttatgttgg ttttattaaa
     1861 aaaaaaaaaa agacttgcaa
//
