LOCUS       NM_001308027            2384 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens Myb/SANT DNA binding domain containing 2 (MSANTD2),
            transcript variant 3, mRNA.
ACCESSION   NM_001308027 XM_005271673
VERSION     NM_001308027.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Liu,H., Wang,X., Guo,Z., Sun,G., Lv,Q., Qin,C., Yuan,L., Wang,Y.,
            Du,M., Wang,M., Zhang,Z. and Chu,H.
  TITLE     LncRNA BCLET variant confers bladder cancer susceptibility through
            alternative splicing of MSANTD2 exon 1
  JOURNAL   Cancer Med 12 (13), 14440-14451 (2023)
   PUBMED   37211917
  REMARK    GeneRIF: LncRNA BCLET variant confers bladder cancer susceptibility
            through alternative splicing of MSANTD2 exon 1.
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Etchegaray,E., Baas,D., Naville,M., Haftek-Terreau,Z. and
            Volff,J.N.
  TITLE     The neurodevelopmental gene MSANTD2 belongs to a gene family formed
            by recurrent molecular domestication of Harbinger transposons at
            the base of vertebrates
  JOURNAL   Mol Biol Evol 39 (8) (2022) In press
   PUBMED   35980103
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 2384)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000866.4, DA379833.1, BC064919.1, H97225.1 and AK026995.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001308027.1.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064919.1, SRR1660805.165698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374979.8/ ENSP00000364118.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AP000866.4         119022-119023       c
            3-17                DA379833.1         1-15
            18-2132             BC064919.1         1-2115
            2133-2383           H97225.1           2-252               c
            2384-2384           AK026995.1         2226-2226
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..2384
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="Myb/SANT DNA binding domain containing 2"
                     /db_xref="GeneID:79684"
                     /db_xref="HGNC:HGNC:26266"
     exon            1..536
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1706
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myb/SANT-like DNA-binding domain-containing protein 2;
                     Myb/SANT-like DNA-binding domain containing 2"
                     /codon_start=1
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 2 isoform 3"
                     /protein_id="NP_001294956.1"
                     /db_xref="CCDS:CCDS76491.1"
                     /db_xref="GeneID:79684"
                     /db_xref="HGNC:HGNC:26266"
                     /translation="MAAPCGSELPANSPLKIPKMEVLSPASPGGLSDGNPSLSDPSTP
                     RGASPLGPGSAAGSGAAASGGLGLGLGGRSAASSSVSFSPGGGGGGAAAAAAAACRGM
                     SWTPAETNALIAVWGNERLVEARYQQLEGAGTVFGSKAPGPAMYERVSRALAELGYER
                     TPSQCRERIKTLRRCYSRVKEHGVGKRKSSYTFEQLEQVFGQGGWDAQPCQPVLINSS
                     GLYQELESDGSTMEDYSQEDWGNHSQDLHGYPTDQELDEIPVTKRTLKIKQESSEEAQ
                     KRDIMQNIVQILESVQLKWELFQSWTDFSRLHLSNKLAIFGIGYNTRWKEDIRYHYAE
                     ISSQVPLGKRLREYFNSEKPEGRIIMTRVQKMNWKNVYYKFLEITISEARCLELHMEI
                     DWIPIAHSKPTGGNVVQYLLPGGIPKSPGLYAIGYEECIERPLSPHMEQSSLDPGKEG
                     RVDLETLSAQASLQVEIEPTRIIYCYLGIAEVRTLQQCLFLHFQANTKTFSKDWVGIN
                     GFLSQNCIVDPGVSPKSIYIKFVEVERDFLSAGSLVECLEKAIGYPLKFNN"
     exon            537..792
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /inference="alignment:Splign:2.1.0"
     exon            793..853
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /inference="alignment:Splign:2.1.0"
     exon            854..2384
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="hexamer: AATAAG"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="hexamer: AATAGA"
     polyA_site      2166
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="major polyA site"
     polyA_site      2172
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="major polyA site"
     regulatory      2366..2371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="hexamer: ATTAAA"
     polyA_site      2384
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /note="major polyA site"
ORIGIN      
        1 gcggtgcagc ggcggccgct tggaagatgg ctgcgccctg tggctcggag ctgcccgcca
       61 actcgccgct aaaaattccg aagatggagg tgctttcccc ggcttctcct ggtggcctga
      121 gcgacggaaa tccatcgctg tccgaccctt ccacgcctcg gggtgcctcc ccgctcgggc
      181 cgggcagtgc ggcgggctcg ggggcagcgg cgtccggggg tctcgggctg gggctggggg
      241 gccgcagcgc cgcctcgtcc tcggtctcct tctcccctgg tggcggcggt ggcggggctg
      301 cggcagccgc cgccgccgcc tgccggggca tgtcgtggac gccagccgag acgaacgcgc
      361 tcatcgcagt gtggggcaac gagcggctgg tggaggcgcg gtaccagcag ctggagggag
      421 ccggcacggt gttcggcagc aaggcccccg ggccagccat gtacgagcgc gtgtcccggg
      481 ccctggccga gctgggctac gagcggaccc cgtcccagtg ccgggagcgc atcaagaccc
      541 ttcgcaggtg ttacagtcgg gtgaaagaac atggtgttgg gaaaagaaag agcagttaca
      601 catttgaaca gttggaacag gtgtttggtc agggaggatg ggatgctcag ccctgccagc
      661 ctgtacttat taacagtagt ggcttgtacc aggagctgga gtcagatggc agcactatgg
      721 aggactattc acaggaggac tggggaaacc acagtcagga tctccatggc tatccaacag
      781 atcaggaatt ggatgaaata cctgtcacaa agagaacatt aaaaataaaa caagagtctt
      841 ctgaagaagc acagaagaga gacatcatgc agaatattgt acagattttg gaatcggtac
      901 agttgaaatg ggaacttttt cagagctgga cagacttttc aaggctccat ctttctaata
      961 aactggccat ttttggaatt ggttataaca cccgttggaa agaggatatc cgttaccatt
     1021 atgctgagat cagctcccag gtgccccttg gcaagcgact tcgggagtac ttcaactctg
     1081 agaagcctga aggacggatc attatgaccc gagtgcagaa aatgaactgg aaaaatgttt
     1141 actacaaatt tttagagatc actattagcg aagctaggtg cttggagctg cacatggaaa
     1201 ttgactggat acccattgcc cactccaaac caactggtgg gaatgttgtt caatatttat
     1261 tgcctggggg tattcctaaa agcccaggcc tttatgccat tggctatgaa gaatgtattg
     1321 agaggcccct ctcaccacac atggagcaaa gttccctgga cccaggaaaa gagggccggg
     1381 ttgacctgga aaccctttca gcacaagcct cattacaggt ggaaatagaa cccacccgaa
     1441 ttatctattg ctacctcggg attgctgagg tcaggactct acagcagtgc ttatttttac
     1501 atttccaagc gaataccaaa accttcagca aagattgggt tggtattaac gggtttttgt
     1561 ctcagaactg tattgtggat cccggagttt cccccaaatc catctacatc aaatttgtag
     1621 aagtagagag ggattttctt tccgcaggct ctttagttga gtgcctggaa aaagccattg
     1681 gatacccctt aaaatttaac aactgaatgt catccttcat aaggatttgg gctcttagct
     1741 ccttcttctc tactcacttc ccattacccg gaccacccct catccagatg ccgccgtcag
     1801 actcttcatg gaaacccttt cttcaattgg gccagtacga cttctaagga atcatagtag
     1861 acttgggcca gaaaaaacag acctcacctg aaaatgctca ttttgagcaa gcaagatata
     1921 tagcgaactt gcatggtggg tcagctattt cttttttaaa aacagaaaaa caatttttaa
     1981 atggatttta gagccctaat ataaacaaat gtaggtacat tccatattgg acaaaactta
     2041 tactttgagt ttcatatgaa attgaaaaat tgtatttttt tcacaatgtt tcatttttac
     2101 acatctctat gtctctatat aagtaatatt tacaaccctg aataaataag caatagataa
     2161 tggcaagtta aatcttgatt cacagttaaa aagacttttt caatatcacc cttagctact
     2221 attgtatata atttagattt tcattttttt caccagccaa gtgttttgct atttccaatc
     2281 agtattgctt gcaaagacct ttgtttctgt gatgtaccaa ctttacagtt gtgttgccat
     2341 ttaaaccttt ttttaaaaaa aaaaaattaa agtaattcct ggcc
//
