LOCUS       NP_001294956             559 aa            linear   PRI 27-APR-2025
DEFINITION  myb/SANT-like DNA-binding domain-containing protein 2 isoform 3
            [Homo sapiens].
ACCESSION   NP_001294956 XP_005271730
VERSION     NP_001294956.1
DBSOURCE    REFSEQ: accession NM_001308027.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 559)
  AUTHORS   Liu,H., Wang,X., Guo,Z., Sun,G., Lv,Q., Qin,C., Yuan,L., Wang,Y.,
            Du,M., Wang,M., Zhang,Z. and Chu,H.
  TITLE     LncRNA BCLET variant confers bladder cancer susceptibility through
            alternative splicing of MSANTD2 exon 1
  JOURNAL   Cancer Med 12 (13), 14440-14451 (2023)
   PUBMED   37211917
  REMARK    GeneRIF: LncRNA BCLET variant confers bladder cancer susceptibility
            through alternative splicing of MSANTD2 exon 1.
REFERENCE   2  (residues 1 to 559)
  AUTHORS   Etchegaray,E., Baas,D., Naville,M., Haftek-Terreau,Z. and
            Volff,J.N.
  TITLE     The neurodevelopmental gene MSANTD2 belongs to a gene family formed
            by recurrent molecular domestication of Harbinger transposons at
            the base of vertebrates
  JOURNAL   Mol Biol Evol 39 (8) (2022) In press
   PUBMED   35980103
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 559)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (residues 1 to 559)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000866.4, DA379833.1, BC064919.1, H97225.1 and AK026995.1.
            
            On Apr 21, 2015 this sequence version replaced XP_005271730.2.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064919.1, SRR1660805.165698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374979.8/ ENSP00000364118.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     Protein         1..559
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 2 isoform 3"
                     /note="myb/SANT-like DNA-binding domain-containing protein
                     2; Myb/SANT-like DNA-binding domain containing 2"
                     /calculated_mol_wt=61188
     Region          1..62
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P1R3.1)"
     Site            13
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q6P1R3.1)"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NZR2; propagated from
                     UniProtKB/Swiss-Prot (Q6P1R3.1)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NZR2; propagated from
                     UniProtKB/Swiss-Prot (Q6P1R3.1)"
     Site            32
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NZR2; propagated from
                     UniProtKB/Swiss-Prot (Q6P1R3.1)"
     Site            48
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18220336,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q6P1R3.1)"
     Region          104..195
                     /region_name="Myb_DNA-bind_4"
                     /note="Myb/SANT-like DNA-binding domain; pfam13837"
                     /db_xref="CDD:463994"
     Site            436
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6NZR2; propagated from
                     UniProtKB/Swiss-Prot (Q6P1R3.1)"
     CDS             1..559
                     /gene="MSANTD2"
                     /gene_synonym="C11orf61"
                     /coded_by="NM_001308027.2:27..1706"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS76491.1"
                     /db_xref="GeneID:79684"
                     /db_xref="HGNC:HGNC:26266"
ORIGIN      
        1 maapcgselp ansplkipkm evlspaspgg lsdgnpslsd pstprgaspl gpgsaagsga
       61 aasgglglgl ggrsaasssv sfspgggggg aaaaaaaacr gmswtpaetn aliavwgner
      121 lvearyqqle gagtvfgska pgpamyervs ralaelgyer tpsqcrerik tlrrcysrvk
      181 ehgvgkrkss ytfeqleqvf gqggwdaqpc qpvlinssgl yqelesdgst medysqedwg
      241 nhsqdlhgyp tdqeldeipv tkrtlkikqe sseeaqkrdi mqnivqiles vqlkwelfqs
      301 wtdfsrlhls nklaifgigy ntrwkediry hyaeissqvp lgkrlreyfn sekpegriim
      361 trvqkmnwkn vyykfleiti searclelhm eidwipiahs kptggnvvqy llpggipksp
      421 glyaigyeec ierplsphme qssldpgkeg rvdletlsaq aslqveiept riiycylgia
      481 evrtlqqclf lhfqantktf skdwvgingf lsqncivdpg vspksiyikf veverdflsa
      541 gslvecleka igyplkfnn
//
