LOCUS       NM_031457               1311 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A8 (MS4A8), mRNA.
ACCESSION   NM_031457
VERSION     NM_031457.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1311)
  AUTHORS   Zuccolo,J., Deng,L., Unruh,T.L., Sanyal,R., Bau,J.A., Storek,J.,
            Demetrick,D.J., Luider,J.M., Auer-Grzesiak,I.A., Mansoor,A. and
            Deans,J.P.
  TITLE     Expression of MS4A and TMEM176 Genes in Human B Lymphocytes
  JOURNAL   Front Immunol 4, 195 (2013)
   PUBMED   23874341
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1311)
  AUTHORS   Michel,J., Schonhaar,K., Schledzewski,K., Gkaniatsou,C., Sticht,C.,
            Kellert,B., Lasitschka,F., Geraud,C., Goerdt,S. and Schmieder,A.
  TITLE     Identification of the novel differentiation marker MS4A8B and its
            murine homolog MS4A8A in colonic epithelial cells lost during
            neoplastic transformation in human colon
  JOURNAL   Cell Death Dis 4 (1), e469 (2013)
   PUBMED   23348583
  REMARK    GeneRIF: MS4A8B is a novel differentiation marker of the intestinal
            epithelium that supports the maintenance of a physiological barrier
            function in the gut by modulating the transcriptome and by
            conferring an increased resistance to reactive oxygen species.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1311)
  AUTHORS   Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
REFERENCE   4  (bases 1 to 1311)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   5  (bases 1 to 1311)
  AUTHORS   Ishibashi,K., Suzuki,M., Sasaki,S. and Imai,M.
  TITLE     Identification of a new multigene four-transmembrane family (MS4A)
            related to CD20, HTm4 and beta subunit of the high-affinity IgE
            receptor
  JOURNAL   Gene 264 (1), 87-93 (2001)
   PUBMED   11245982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF237905.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031457.1.
            
            Summary: This gene encodes a member of the membrane-spanning 4A
            gene family. Members of this protein family are characterized by
            common structural features and similar intron/exon splice
            boundaries and display unique expression patterns among
            hematopoietic cells and nonlymphoid tissues. The gene encoding this
            protein is localized to 11q12.3, among a cluster of family members.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022895.1, AF237905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300226.7/ ENSP00000300226.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1311              AF237905.1         39-1349
FEATURES             Location/Qualifiers
     source          1..1311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1311
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /note="membrane spanning 4-domains A8"
                     /db_xref="GeneID:83661"
                     /db_xref="HGNC:HGNC:13380"
                     /db_xref="MIM:606549"
     exon            1..164
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /inference="alignment:Splign:2.1.0"
     exon            165..384
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..918
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /note="four-span transmembrane protein 4;
                     membrane-spanning 4-domains, subfamily A, member 8B"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     8"
                     /protein_id="NP_113645.1"
                     /db_xref="CCDS:CCDS7990.1"
                     /db_xref="GeneID:83661"
                     /db_xref="HGNC:HGNC:13380"
                     /db_xref="MIM:606549"
                     /translation="MNSMTSAVPVANSVLVVAPHNGYPVTPGIMSHVPLYPNSQPQVH
                     LVPGNPPSLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSIS
                     FYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL
                     SIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVS
                     VIYPNIYAANPVITPEPVTSPPSYSSEIQANK"
     exon            385..507
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /inference="alignment:Splign:2.1.0"
     exon            508..567
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /inference="alignment:Splign:2.1.0"
     exon            568..699
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /inference="alignment:Splign:2.1.0"
     exon            700..813
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1311
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /note="hexamer: AATAAA"
     polyA_site      1311
                     /gene="MS4A8"
                     /gene_synonym="4SPAN4; CD20L5; MS4A4; MS4A8B"
                     /note="major polyA site"
ORIGIN      
        1 agcatgtaac ctggcctgca tccaggaaat agaggacttc ggatccttct aaccctacca
       61 cccaactggc cccagtacat tcattctctc aggaaaaaaa acaaggtccc cacagcaaag
      121 aaaaggaata ggatcaagag atacgtggct gctggcagag caagcatgaa ttcgatgact
      181 tcagcagttc cggtggccaa ttctgtgttg gtggtggcac cccacaatgg ttatcctgtg
      241 accccaggaa ttatgtctca cgtgcccctg tatccaaaca gccagccgca agtccaccta
      301 gttcctggga acccacctag tttggtgtcg aatgtgaatg ggcagcctgt gcagaaagct
      361 ctgaaagaag gcaaaacctt gggggccatc cagatcatca ttggcctggc tcacatcggc
      421 ctcggctcca tcatggcgac ggttctcgta ggggaatacc tgtctatttc attctacgga
      481 ggctttccct tctggggagg cttgtggttt atcatttcag gatctctctc cgtggcagca
      541 gaaaatcagc catattctta ttgcctgctg tctggcagtt tgggcttgaa catcgtcagt
      601 gcaatctgct ctgcagttgg agtcatactc ttcatcacag atctaagtat tccccaccca
      661 tatgcctacc ccgactatta tccttacgcc tggggtgtga accctggaat ggcgatttct
      721 ggcgtgctgc tggtcttctg cctcctggag tttggcatcg catgcgcatc ttcccacttt
      781 ggctgccagt tggtctgctg tcaatcaagc aatgtgagtg tcatctatcc aaacatctat
      841 gcagcaaacc cagtgatcac cccagaaccg gtgacctcac caccaagtta ttccagtgag
      901 atccaagcaa ataagtaagg ctacagattc tggaagcatc tttcactggg accaaaagaa
      961 gtcctcctcc ctttctgggc ttccataacc caggtcgttc ctgttctgac agctgaggaa
     1021 acgtctctcc cactgtttgt actctcacct tcattcttca attcagtcta ggaaaccatg
     1081 ctgtttctct atcaagaaga agacagagat tttaaacaga tgttaaccaa gagggactcc
     1141 ctagggcaca tgcatcagca catatgtggg catccagcct ctggggcctt ggcacacaca
     1201 cattcgtgtg ctctgctgca tgtgagcttg tgggttagag gaacaaatat ctagacattc
     1261 aatcttcact ctttcaattg tgcattcatt taataaatag atactgagca t
//
