LOCUS       NM_021201               2956 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A7 (MS4A7), transcript
            variant 1, mRNA.
ACCESSION   NM_021201
VERSION     NM_021201.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2956)
  AUTHORS   Zhou,L., Qiu,X., Meng,Z., Liu,T., Chen,Z., Zhang,P., Kuang,H.,
            Pan,T., Lu,Y., Qi,L., Olson,D.P., Xu,X.Z.S., Chen,Y.E., Li,S. and
            Lin,J.D.
  TITLE     Hepatic danger signaling triggers TREM2+ macrophage induction and
            drives steatohepatitis via MS4A7-dependent inflammasome activation
  JOURNAL   Sci Transl Med 16 (738), eadk1866 (2024)
   PUBMED   38478630
  REMARK    GeneRIF: Hepatic danger signaling triggers TREM2[+] macrophage
            induction and drives steatohepatitis via MS4A7-dependent
            inflammasome activation.
REFERENCE   2  (bases 1 to 2956)
  AUTHORS   Ni,B., Huang,G., Yang,R., Wang,Z., Song,H., Li,K., Zhang,Y., Wu,K.,
            Shi,G., Wang,X., Shen,J. and Liu,Y.
  TITLE     The short isoform of MS4A7 is a novel player in glioblastoma
            microenvironment, M2 macrophage polarization, and tumor progression
  JOURNAL   J Neuroinflammation 20 (1), 80 (2023)
   PUBMED   36944954
  REMARK    GeneRIF: The short isoform of MS4A7 is a novel player in
            glioblastoma microenvironment, M2 macrophage polarization, and
            tumor progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2956)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2956)
  AUTHORS   Zuccolo,J., Deng,L., Unruh,T.L., Sanyal,R., Bau,J.A., Storek,J.,
            Demetrick,D.J., Luider,J.M., Auer-Grzesiak,I.A., Mansoor,A. and
            Deans,J.P.
  TITLE     Expression of MS4A and TMEM176 Genes in Human B Lymphocytes
  JOURNAL   Front Immunol 4, 195 (2013)
   PUBMED   23874341
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2956)
  AUTHORS   Gingras,M.C., Lapillonne,H. and Margolin,J.F.
  TITLE     CFFM4: a new member of the CD20/FcepsilonRIbeta family
  JOURNAL   Immunogenetics 53 (6), 468-476 (2001)
   PUBMED   11685457
REFERENCE   6  (bases 1 to 2956)
  AUTHORS   Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
REFERENCE   7  (bases 1 to 2956)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   8  (bases 1 to 2956)
  AUTHORS   Ishibashi,K., Suzuki,M., Sasaki,S. and Imai,M.
  TITLE     Identification of a new multigene four-transmembrane family (MS4A)
            related to CD20, HTm4 and beta subunit of the high-affinity IgE
            receptor
  JOURNAL   Gene 264 (1), 87-93 (2001)
   PUBMED   11245982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK075106.1, BC020673.1,
            CD518120.1, AV685115.2, AV690480.2 and CA449361.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021201.4.
            
            Summary: This gene encodes a member of the membrane-spanning 4A
            gene family, members of which are characterized by common
            structural features and similar intron/exon splice boundaries and
            display unique expression patterns in hematopoietic cells and
            nonlymphoid tissues. This family member is associated with mature
            cellular function in the monocytic lineage, and it may be a
            component of a receptor complex involved in signal transduction.
            This gene is localized to 11q12, in a cluster of other family
            members. At least four alternatively spliced transcript variants
            encoding two distinct isoforms have been observed. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. It encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF309653.1, SRR1803617.281495.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300184.8/ ENSP00000300184.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK075106.1         52-80
            30-994              BC020673.1         1-965
            995-1819            AK075106.1         1046-1870
            1820-2054           CD518120.1         298-532
            2055-2060           AV685115.2         37-42
            2061-2148           CD518120.1         540-627
            2149-2318           AV690480.2         127-296
            2319-2956           CA449361.1         22-659              c
FEATURES             Location/Qualifiers
     source          1..2956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2956
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /note="membrane spanning 4-domains A7"
                     /db_xref="GeneID:58475"
                     /db_xref="HGNC:HGNC:13378"
                     /db_xref="MIM:606502"
     exon            1..133
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /inference="alignment:Splign:2.1.0"
     exon            134..293
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..869
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     four-span transmembrane protein 2; high affinity
                     immunoglobulin epsilon receptor beta subunit;
                     CD20/Fc-epsilon-RI-beta family member 4; membrane-spanning
                     4-domains subfamily A member 7; CD20 antigen-like 4"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member 7
                     isoform 1"
                     /protein_id="NP_067024.1"
                     /db_xref="CCDS:CCDS7985.1"
                     /db_xref="GeneID:58475"
                     /db_xref="HGNC:HGNC:13378"
                     /db_xref="MIM:606502"
                     /translation="MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTE
                     TTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLS
                     IISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLP
                     YSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSS
                     FSSTQSQDHIQQVKKSSSRSWI"
     exon            294..428
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /inference="alignment:Splign:2.1.0"
     exon            429..485
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /inference="alignment:Splign:2.1.0"
     exon            486..692
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /inference="alignment:Splign:2.1.0"
     exon            693..794
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /inference="alignment:Splign:2.1.0"
     exon            795..2956
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2933..2938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /note="hexamer: AATAAA"
     polyA_site      2956
                     /gene="MS4A7"
                     /gene_synonym="4SPAN2; CD20L4; CFFM4; MS4A8"
                     /note="major polyA site"
ORIGIN      
        1 aagtctcaga ggctggagag cagagcacca agatcgttct ggcaggaaca gccagtggga
       61 ggttccagct gagcgctccc cagaggtgag ctgatcccca gccacagcac acaggaccag
      121 gctgcgagaa cagcatcatc agcatcatgc tattacaatc ccaaaccatg ggggtttctc
      181 acagctttac accaaagggc atcactatcc ctcaaagaga gaaacctgga cacatgtacc
      241 aaaacgaaga ttacctgcag aacgggctgc caacagaaac caccgttctt gggactgtcc
      301 agatcctgtg ttgcctgttg atttcaagtc tgggggccat cttggttttt gctccctacc
      361 cctcccactt caatccagca atttccacca ctttgatgtc tgggtaccca tttttaggag
      421 ctctgtgttt tggcattact ggatccctct caattatctc tggaaaacaa tcaactaagc
      481 cctttgacct gagcagcttg acctcaaatg cagtgagttc tgttactgca ggagcaggcc
      541 tcttcctcct tgctgacagc atggtagccc tgaggactgc ctctcaacat tgtggctcag
      601 aaatggatta tctatcctca ttgccttatt cggagtacta ttatccaata tatgaaatca
      661 aagattgtct cctgaccagt gtcagtttaa caggtgtcct agtggtgatg ctcatcttca
      721 ctgtgctgga gctcttatta gctgcataca gttctgtctt ttggtggaaa cagctctact
      781 ccaacaaccc tgggagttca ttttcctcga cccagtcaca agatcatatc caacaggtca
      841 aaaagagttc ttcacggtct tggatataag taactcttgg cctcagagga aggaaaagca
      901 actcaacact catggtcaag tgtgattaga ctttcctgaa atctctgcca ttttagatac
      961 tgtgaaacaa actaaaaaaa aaaaagcttt tgttttgtat ttgtttacta tgagtcgtta
     1021 tttaatttct cttgaaaata atttcctcaa agcccaagtc aataaatgtt atcagccagt
     1081 cttccaaaat ggtcataaac tttataaact gctttgggta aactgagcag aaggtgatac
     1141 acagaaggga aaatgtgcac tcatgctagt gtgaatttgg taagttgcgt gactctgcag
     1201 gctgtttctg tattattttc acactcatat tgcttaaata ttacatatta gggattgtaa
     1261 gaaaacttta attaaaaatt aaagactata tataattaaa ctactctgcc ctggacactc
     1321 tctgagaaac agatctactg ggcccttttt catgagccat taggtggaag acagcaaaga
     1381 gatcttctca agtgcttagg attacctctc aacacacagc aagcatgtcc ctgcctccca
     1441 tgaatcttac catgtaaatc caaatctctg caatcctgtg gcaccaacca gtggtgctca
     1501 ttctattgtt taaaaatggc cttcttggct gggcgcggtg gctcactcct gtaatcccag
     1561 cactttggta ggccgaggtg gacggatcac ccgaggtcag gagtttgaga ccagcctggc
     1621 caacaaggtg aaaccctgtc tctactaaaa atacaaaaaa ttagccaggc atggtggtgc
     1681 gcacctgtag ttccagctac ttgggaggct gaggcagaag aatcacttga acccgggaag
     1741 gggaggttgc agtgagcgga gactgcacca ctgcattcca gcccggccta caagaacaaa
     1801 actccatctc aaaataaata aaaaaataaa taaaaataaa aatagactat atatagtctt
     1861 tgaattcatt tattttaaat aaatgaataa aataaaataa aaaagaatat tcagtcgttg
     1921 gcacataaac tatgttctct tctgtcattt cagggtagga gtcaatgaag acatcttagt
     1981 cttaacaagt tacagataat ctctgactgg catgttttct gcttctagct tggagctaaa
     2041 tgctgctcat gctgaaaaga ataatgtcta tttctttgtt tgggtattag ctctattttg
     2101 atctatagca cagttttgta attcagatca tcacccctgc actttgtacc acatgggcgt
     2161 attctttctt cccagtcatt gctgcaatta tcttgtctgt tctttgtgta atatgttctg
     2221 tgtgagcctc tgcattaaac tcgatttctt gggcaattat ggaaattcca gtgtggctgc
     2281 agtttaactt tgcactctct atgcatatga ggtttcctaa ataaatgagg agtagcatag
     2341 tttaaaatat atatatctta taactttcta caacaaagaa ttattgagtc caaatgtcat
     2401 cagtgctcat tttgagatac cctgctatcg atggtcgcta caaaccagga aatactcaag
     2461 ttattatgtg tatacattgg ttttagtttt atgaaacaat ttaccttcat gatctcatag
     2521 ttaaaattgt aataaattta ggaatataaa ggatcaatat gggaagcaaa atttctaaag
     2581 gcagtttctg ttgttttaat tagtatttgt gtagttcaaa ccaggaagga tttgactatc
     2641 attagatttt gcttaacttt atgaaagcta aaatattctc tgttataaag gggcaactcc
     2701 atctggtcct atagcatctt tactactgat ttttttttgt ttaatttgaa aatgcaaaga
     2761 attgttaaat gttcttaaat gttctcacta caaaaaaaga aaaaagataa ctacgtgagg
     2821 tgatggatat gttaattagc tggattgtgg taatcatttt ggaatgtata tgtatatcaa
     2881 aacatgtagt acaccctaaa tatatataat ttttatttgt caaatatacc tcaataaaga
     2941 tggaaaaaaa tcgaaa
//
