LOCUS       NM_139249               1187 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A6E (MS4A6E), transcript
            variant 1, mRNA.
ACCESSION   NM_139249 NM_001376909
VERSION     NM_139249.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1187)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1187)
  AUTHORS   Naj,A.C., Jun,G., Beecham,G.W., Wang,L.S., Vardarajan,B.N.,
            Buros,J., Gallins,P.J., Buxbaum,J.D., Jarvik,G.P., Crane,P.K.,
            Larson,E.B., Bird,T.D., Boeve,B.F., Graff-Radford,N.R., De
            Jager,P.L., Evans,D., Schneider,J.A., Carrasquillo,M.M.,
            Ertekin-Taner,N., Younkin,S.G., Cruchaga,C., Kauwe,J.S.,
            Nowotny,P., Kramer,P., Hardy,J., Huentelman,M.J., Myers,A.J.,
            Barmada,M.M., Demirci,F.Y., Baldwin,C.T., Green,R.C., Rogaeva,E.,
            St George-Hyslop,P., Arnold,S.E., Barber,R., Beach,T., Bigio,E.H.,
            Bowen,J.D., Boxer,A., Burke,J.R., Cairns,N.J., Carlson,C.S.,
            Carney,R.M., Carroll,S.L., Chui,H.C., Clark,D.G., Corneveaux,J.,
            Cotman,C.W., Cummings,J.L., DeCarli,C., DeKosky,S.T.,
            Diaz-Arrastia,R., Dick,M., Dickson,D.W., Ellis,W.G., Faber,K.M.,
            Fallon,K.B., Farlow,M.R., Ferris,S., Frosch,M.P., Galasko,D.R.,
            Ganguli,M., Gearing,M., Geschwind,D.H., Ghetti,B., Gilbert,J.R.,
            Gilman,S., Giordani,B., Glass,J.D., Growdon,J.H., Hamilton,R.L.,
            Harrell,L.E., Head,E., Honig,L.S., Hulette,C.M., Hyman,B.T.,
            Jicha,G.A., Jin,L.W., Johnson,N., Karlawish,J., Karydas,A.,
            Kaye,J.A., Kim,R., Koo,E.H., Kowall,N.W., Lah,J.J., Levey,A.I.,
            Lieberman,A.P., Lopez,O.L., Mack,W.J., Marson,D.C., Martiniuk,F.,
            Mash,D.C., Masliah,E., McCormick,W.C., McCurry,S.M., McDavid,A.N.,
            McKee,A.C., Mesulam,M., Miller,B.L., Miller,C.A., Miller,J.W.,
            Parisi,J.E., Perl,D.P., Peskind,E., Petersen,R.C., Poon,W.W.,
            Quinn,J.F., Rajbhandary,R.A., Raskind,M., Reisberg,B.,
            Ringman,J.M., Roberson,E.D., Rosenberg,R.N., Sano,M.,
            Schneider,L.S., Seeley,W., Shelanski,M.L., Slifer,M.A., Smith,C.D.,
            Sonnen,J.A., Spina,S., Stern,R.A., Tanzi,R.E., Trojanowski,J.Q.,
            Troncoso,J.C., Van Deerlin,V.M., Vinters,H.V., Vonsattel,J.P.,
            Weintraub,S., Welsh-Bohmer,K.A., Williamson,J., Woltjer,R.L.,
            Cantwell,L.B., Dombroski,B.A., Beekly,D., Lunetta,K.L.,
            Martin,E.R., Kamboh,M.I., Saykin,A.J., Reiman,E.M., Bennett,D.A.,
            Morris,J.C., Montine,T.J., Goate,A.M., Blacker,D., Tsuang,D.W.,
            Hakonarson,H., Kukull,W.A., Foroud,T.M., Haines,J.L., Mayeux,R.,
            Pericak-Vance,M.A., Farrer,L.A. and Schellenberg,G.D.
  TITLE     Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are
            associated with late-onset Alzheimer's disease
  JOURNAL   Nat Genet 43 (5), 436-441 (2011)
   PUBMED   21460841
  REMARK    GeneRIF: Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are
            associated with late-onset Alzheimer's disease.
REFERENCE   3  (bases 1 to 1187)
  AUTHORS   Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003127.2.
            
            On or before Sep 28, 2020 this sequence version replaced
            NM_001376909.1, NM_139249.3.
            
            Summary: This gene encodes a member of the membrane-spanning 4A
            gene family. Members of this nascent protein family are
            characterized by common structural features and similar intron/exon
            splice boundaries and display unique expression patterns among
            hematopoietic cells and nonlymphoid tissues. The gene encoding this
            protein is localized to 11q12.3, among a cluster of family members.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF354931.1, BC069322.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2144335, SAMEA2155628 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684409.1/ ENSP00000507799.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AP003127.2         31176-31329
            155-315             AP003127.2         38803-38963
            316-522             AP003127.2         41662-41868
            523-621             AP003127.2         43787-43885
            622-1187            AP003127.2         44697-45262
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1187
                     /gene="MS4A6E"
                     /note="membrane spanning 4-domains A6E"
                     /db_xref="GeneID:245802"
                     /db_xref="HGNC:HGNC:14285"
                     /db_xref="MIM:608402"
     exon            1..154
                     /gene="MS4A6E"
                     /inference="alignment:Splign:2.1.0"
     exon            155..315
                     /gene="MS4A6E"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..612
                     /gene="MS4A6E"
                     /note="membrane-spanning 4-domains, subfamily A, member
                     6E"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     6E"
                     /protein_id="NP_640342.1"
                     /db_xref="CCDS:CCDS7984.1"
                     /db_xref="GeneID:245802"
                     /db_xref="HGNC:HGNC:14285"
                     /db_xref="MIM:608402"
                     /translation="MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAK
                     VKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDY
                     HSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV"
     exon            316..522
                     /gene="MS4A6E"
                     /inference="alignment:Splign:2.1.0"
     exon            523..621
                     /gene="MS4A6E"
                     /inference="alignment:Splign:2.1.0"
     exon            622..1187
                     /gene="MS4A6E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      745..750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A6E"
                     /note="hexamer: TATAAA"
     polyA_site      773
                     /gene="MS4A6E"
                     /note="major polyA site"
     polyA_site      791
                     /gene="MS4A6E"
     polyA_site      814
                     /gene="MS4A6E"
                     /note="major polyA site"
     polyA_site      825
                     /gene="MS4A6E"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A6E"
                     /note="hexamer: AATAAA"
     polyA_site      1187
                     /gene="MS4A6E"
                     /note="major polyA site"
ORIGIN      
        1 atttcaccct tccattcatt ccaccatgtg aggacacagt ttgtcctatc tggaagatgc
       61 agcaacaaga taccatcttg gaagcaagca acgtgaccct aagtagatgc tgaacctgtg
      121 gcaccttgat cgtggacttc tcagttccaa aactttggca acaccattat gacatcacaa
      181 cctatttcca atgagaccat cataatgctc ccatcaaatg tcatcaactt ctcccaagca
      241 gagaaacccg aacccaccaa ccaggggcag gatagcctga agaaacgtct acaggcaaaa
      301 gtcaaagtta ttggggtgca tagcagcctg gctggaagca ttctgagtgc tctgtctgcc
      361 ctggtgggtt tcattctcct gtctgtcaac ccggctgcat taaatcctgc ctcattgcag
      421 tgtaagttgg acgaaaagga tataccaacc agacttcttc tttcttatga ttatcattca
      481 ccttacacca tggactgcca tagagccaaa gccagtctgg ctggaactct gtctctgatg
      541 ctggtttcta ctgtgttgga gttctgccta gctgtgctca ctgctgtgct gcagtggaaa
      601 cagactgtct gacttccctg gttactcatg tcctcaaaga cgactcatga tgctggatat
      661 gaagaactat tgacttcttg ggaaaaaacg gagaaatatt aattggaaag ttgattttta
      721 tgataatatg gaaaacctaa ccattataaa aaagcaaact tgagtttcct aaatgtaagc
      781 atttaaagta atgcatattt gttttaaaaa attatttcgc tgtcatttat gatatgtgtt
      841 cattggggat ctcttggttt gcctgatact gacttcagca aaagcacagg gctgtaaatt
      901 accatttact agactagcca aatagtctta gacatttccc agaaaactag gcagaatgat
      961 gattcaatgg atcacagtga ggcaaaggat acagcttttt cttatactcc tcaattgtga
     1021 acaggagtta actgatttgc tgtggtgcgc agactctttt atcacaggtg ctactgattt
     1081 atcccatgta ttttactcat tagtgcataa aggcaaaccc cataatgaag tctccgagtg
     1141 tatgaaagta gccggcttca aaataaaatc tttgagtgca tacttta
//
