LOCUS       NM_148975               1522 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A4A (MS4A4A), transcript
            variant 1, mRNA.
ACCESSION   NM_148975
VERSION     NM_148975.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Arthur,G.K., Ehrhardt-Humbert,L.C., Snider,D.B., Jania,C.,
            Tilley,S.L., Metcalfe,D.D. and Cruse,G.
  TITLE     The FcepsilonRIbeta homologue, MS4A4A, promotes FcepsilonRI signal
            transduction and store-operated Ca2+ entry in human mast cells
  JOURNAL   Cell Signal 71, 109617 (2020)
   PUBMED   32240745
  REMARK    GeneRIF: The FcepsilonRIbeta homologue, MS4A4A, promotes
            FcepsilonRI signal transduction and store-operated Ca(2+) entry in
            human mast cells.
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Deming,Y., Filipello,F., Cignarella,F., Cantoni,C., Hsu,S.,
            Mikesell,R., Li,Z., Del-Aguila,J.L., Dube,U., Farias,F.G.,
            Bradley,J., Budde,J., Ibanez,L., Fernandez,M.V., Blennow,K.,
            Zetterberg,H., Heslegrave,A., Johansson,P.M., Svensson,J.,
            Nellgard,B., Lleo,A., Alcolea,D., Clarimon,J., Rami,L.,
            Molinuevo,J.L., Suarez-Calvet,M., Morenas-Rodriguez,E.,
            Kleinberger,G., Ewers,M., Harari,O., Haass,C., Brett,T.J.,
            Benitez,B.A., Karch,C.M., Piccio,L. and Cruchaga,C.
  TITLE     The MS4A gene cluster is a key modulator of soluble TREM2 and
            Alzheimer's disease risk
  JOURNAL   Sci Transl Med 11 (505) (2019)
   PUBMED   31413141
REFERENCE   4  (bases 1 to 1522)
  AUTHORS   Mattiola,I., Tomay,F., De Pizzol,M., Silva-Gomes,R., Savino,B.,
            Gulic,T., Doni,A., Lonardi,S., Astrid Boutet,M., Nerviani,A.,
            Carriero,R., Molgora,M., Stravalaci,M., Morone,D., Shalova,I.N.,
            Lee,Y., Biswas,S.K., Mantovani,G., Sironi,M., Pitzalis,C.,
            Vermi,W., Bottazzi,B., Mantovani,A. and Locati,M.
  TITLE     The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK
            cell-mediated resistance to metastasis
  JOURNAL   Nat Immunol 20 (8), 1012-1022 (2019)
   PUBMED   31263276
  REMARK    GeneRIF: MS4A4A is a tetraspan molecule selectively expressed in
            macrophages during differentiation and polarization, essential for
            dectin-1-dependent activation of natural killer cell-mediated
            resistance to metastasis.
REFERENCE   5  (bases 1 to 1522)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   6  (bases 1 to 1522)
  AUTHORS   Elias-Sonnenschein,L.S., Helisalmi,S., Natunen,T., Hall,A.,
            Paajanen,T., Herukka,S.K., Laitinen,M., Remes,A.M., Koivisto,A.M.,
            Mattila,K.M., Lehtimaki,T., Verhey,F.R., Visser,P.J., Soininen,H.
            and Hiltunen,M.
  TITLE     Genetic loci associated with Alzheimer's disease and cerebrospinal
            fluid biomarkers in a Finnish case-control cohort
  JOURNAL   PLoS One 8 (4), e59676 (2013)
   PUBMED   23573206
  REMARK    GeneRIF: Single nucleotide polymorphisms in APOE-epsilon4, CLU and
            MS4A4A influence both Alzheimer disease risk and cerebrospinal
            fluid Amyloid-beta1-42 levels.
REFERENCE   7  (bases 1 to 1522)
  AUTHORS   Naj,A.C., Jun,G., Beecham,G.W., Wang,L.S., Vardarajan,B.N.,
            Buros,J., Gallins,P.J., Buxbaum,J.D., Jarvik,G.P., Crane,P.K.,
            Larson,E.B., Bird,T.D., Boeve,B.F., Graff-Radford,N.R., De
            Jager,P.L., Evans,D., Schneider,J.A., Carrasquillo,M.M.,
            Ertekin-Taner,N., Younkin,S.G., Cruchaga,C., Kauwe,J.S.,
            Nowotny,P., Kramer,P., Hardy,J., Huentelman,M.J., Myers,A.J.,
            Barmada,M.M., Demirci,F.Y., Baldwin,C.T., Green,R.C., Rogaeva,E.,
            St George-Hyslop,P., Arnold,S.E., Barber,R., Beach,T., Bigio,E.H.,
            Bowen,J.D., Boxer,A., Burke,J.R., Cairns,N.J., Carlson,C.S.,
            Carney,R.M., Carroll,S.L., Chui,H.C., Clark,D.G., Corneveaux,J.,
            Cotman,C.W., Cummings,J.L., DeCarli,C., DeKosky,S.T.,
            Diaz-Arrastia,R., Dick,M., Dickson,D.W., Ellis,W.G., Faber,K.M.,
            Fallon,K.B., Farlow,M.R., Ferris,S., Frosch,M.P., Galasko,D.R.,
            Ganguli,M., Gearing,M., Geschwind,D.H., Ghetti,B., Gilbert,J.R.,
            Gilman,S., Giordani,B., Glass,J.D., Growdon,J.H., Hamilton,R.L.,
            Harrell,L.E., Head,E., Honig,L.S., Hulette,C.M., Hyman,B.T.,
            Jicha,G.A., Jin,L.W., Johnson,N., Karlawish,J., Karydas,A.,
            Kaye,J.A., Kim,R., Koo,E.H., Kowall,N.W., Lah,J.J., Levey,A.I.,
            Lieberman,A.P., Lopez,O.L., Mack,W.J., Marson,D.C., Martiniuk,F.,
            Mash,D.C., Masliah,E., McCormick,W.C., McCurry,S.M., McDavid,A.N.,
            McKee,A.C., Mesulam,M., Miller,B.L., Miller,C.A., Miller,J.W.,
            Parisi,J.E., Perl,D.P., Peskind,E., Petersen,R.C., Poon,W.W.,
            Quinn,J.F., Rajbhandary,R.A., Raskind,M., Reisberg,B.,
            Ringman,J.M., Roberson,E.D., Rosenberg,R.N., Sano,M.,
            Schneider,L.S., Seeley,W., Shelanski,M.L., Slifer,M.A., Smith,C.D.,
            Sonnen,J.A., Spina,S., Stern,R.A., Tanzi,R.E., Trojanowski,J.Q.,
            Troncoso,J.C., Van Deerlin,V.M., Vinters,H.V., Vonsattel,J.P.,
            Weintraub,S., Welsh-Bohmer,K.A., Williamson,J., Woltjer,R.L.,
            Cantwell,L.B., Dombroski,B.A., Beekly,D., Lunetta,K.L.,
            Martin,E.R., Kamboh,M.I., Saykin,A.J., Reiman,E.M., Bennett,D.A.,
            Morris,J.C., Montine,T.J., Goate,A.M., Blacker,D., Tsuang,D.W.,
            Hakonarson,H., Kukull,W.A., Foroud,T.M., Haines,J.L., Mayeux,R.,
            Pericak-Vance,M.A., Farrer,L.A. and Schellenberg,G.D.
  TITLE     Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are
            associated with late-onset Alzheimer's disease
  JOURNAL   Nat Genet 43 (5), 436-441 (2011)
   PUBMED   21460841
  REMARK    GeneRIF: Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are
            associated with late-onset Alzheimer's disease.
REFERENCE   8  (bases 1 to 1522)
  AUTHORS   Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
REFERENCE   9  (bases 1 to 1522)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   10 (bases 1 to 1522)
  AUTHORS   Ishibashi,K., Suzuki,M., Sasaki,S. and Imai,M.
  TITLE     Identification of a new multigene four-transmembrane family (MS4A)
            related to CD20, HTm4 and beta subunit of the high-affinity IgE
            receptor
  JOURNAL   Gene 264 (1), 87-93 (2001)
   PUBMED   11245982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003970.3 and AP003127.2.
            
            On Nov 23, 2018 this sequence version replaced NM_148975.2.
            
            Summary: This gene encodes a member of the membrane-spanning 4A
            gene family. Members of this nascent protein family are
            characterized by common structural features, similar intron/exon
            splice boundaries, and display unique expression patterns in
            hematopoietic cells and nonlymphoid tissues. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020648.1, SRR5189655.122554.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337908.5/ ENSP00000338648.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AP003970.3         110984-111034
            52-211              AP003970.3         122543-122702
            212-340             AP003127.2         1118-1246
            341-397             AP003127.2         4922-4978
            398-556             AP003127.2         6480-6638
            557-658             AP003127.2         10021-10122
            659-1522            AP003127.2         12028-12891
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1522
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /note="membrane spanning 4-domains A4A"
                     /db_xref="GeneID:51338"
                     /db_xref="HGNC:HGNC:13371"
                     /db_xref="MIM:606547"
     exon            1..51
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..730
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /note="isoform 1 is encoded by transcript variant 1; Fc
                     epsilon receptor beta subunit homolog; CD20 antigen-like
                     1; four-span transmembrane protein 1; membrane-spanning
                     4-domains, subfamily A, member 4; membrane-spanning
                     4-domains subfamily A member 4A; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     4A isoform 1"
                     /protein_id="NP_683876.1"
                     /db_xref="CCDS:CCDS7982.1"
                     /db_xref="GeneID:51338"
                     /db_xref="HGNC:HGNC:13371"
                     /db_xref="MIM:606547"
                     /translation="MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMA
                     VIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIG
                     YTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSF
                     HHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVV
                     LILPSHSHMAETASPTPLNEV"
     exon            52..211
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /inference="alignment:Splign:2.1.0"
     exon            212..340
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /inference="alignment:Splign:2.1.0"
     exon            341..397
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /inference="alignment:Splign:2.1.0"
     exon            398..556
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /inference="alignment:Splign:2.1.0"
     exon            557..658
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /inference="alignment:Splign:2.1.0"
     exon            659..1522
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      893..898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /note="hexamer: AATAAA"
     polyA_site      916
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /note="major polyA site"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /note="hexamer: AATAAT"
     polyA_site      1008
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
     regulatory      1502..1507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /note="hexamer: AATAAA"
     polyA_site      1522
                     /gene="MS4A4A"
                     /gene_synonym="4SPAN1; CD20-L1; CD20L1; HDCME31P; MS4A4;
                     MS4A7"
                     /note="major polyA site"
ORIGIN      
        1 agagccctgc atgcatcaga cctacagcag acattgcagg cctgaagaaa gcaccttttc
       61 tgctgccatg acaaccatgc aaggaatgga acaggccatg ccaggggctg gccctggtgt
      121 gccccagctg ggaaacatgg ctgtcataca ttcacatctg tggaaaggat tgcaagagaa
      181 gttcttgaag ggagaaccca aagtccttgg ggttgtgcag attctgactg ccctgatgag
      241 ccttagcatg ggaataacaa tgatgtgtat ggcatctaat acttatggaa gtaaccctat
      301 ttccgtgtat atcgggtaca caatttgggg gtcagtaatg tttattattt caggatcctt
      361 gtcaattgca gcaggaatta gaactacaaa aggcctggtc cgaggtagtc taggaatgaa
      421 tatcaccagc tctgtactgg ctgcatcagg gatcttaatc aacacattta gcttggcgtt
      481 ttattcattc catcaccctt actgtaacta ctatggcaac tcaaataatt gtcatgggac
      541 tatgtccatc ttaatgggtc tggatggcat ggtgctcctc ctaagtgtgc tggaattctg
      601 cattgctgtg tccctctctg cctttggatg taaagtgctc tgttgtaccc ctggtggggt
      661 tgtgttaatt ctgccatcac attctcacat ggcagaaaca gcatctccca caccacttaa
      721 tgaggtttga ggccaccaaa agatcaacag acaaatgctc cagaaatcta tgctgactgt
      781 gacacaagag cctcacatga gaaattacca gtatccaact tcgatactga tagacttgtt
      841 gatattatta ttatatgtaa tccaattatg aactgtgtgt gtatagagag ataataaatt
      901 caaaattatg ttctcatttt tttccctgga actcaataac tcatttcact ggctctttat
      961 cgagagtact agaagttaaa ttaataaata atgcatttaa tgaggcaaca gcacttgaaa
     1021 gtttttcatt catcataaga actttatata aaggcattac attggcaaat aaggtttgga
     1081 agcagaagag caaaaaaaag atattgttaa aatgaggcct ccatgcaaaa cacatacttc
     1141 cctcccattt atttaacttt ttttttctcc tacctatggg gaccaaagtg ctttttcctt
     1201 caggaagtgg agatgcatgg ccatctcccc ctcccttttt ccttctcctg cttttctttc
     1261 cccatagaaa gtaccttgaa gtagcacagc ccgtccttgc atgtgcacga gctatcattt
     1321 gagtaaaagt atacatggag taaaaatcat attaagcatc agattcaact tatattttct
     1381 atttcatctt cttcctttcc cttctcccac cttctactgg gcataattat atcttaatca
     1441 tatatggaaa tgtgcaacat atggtatttg ttaaatacgt ttgtttttat tgcagagcaa
     1501 aaataaatca aattagaagc aa
//
