LOCUS       NM_006138               1618 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A3 (MS4A3), transcript
            variant 1, mRNA.
ACCESSION   NM_006138
VERSION     NM_006138.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Zhao,H., Pomicter,A.D., Eiring,A.M., Franzini,A., Ahmann,J.,
            Hwang,J.Y., Senina,A., Helton,B., Iyer,S., Yan,D., Khorashad,J.S.,
            Zabriskie,M.S., Agarwal,A., Redwine,H.M., Bowler,A.D., Clair,P.M.,
            McWeeney,S.K., Druker,B.J., Tyner,J.W., Stirewalt,D.L.,
            Oehler,V.G., Varambally,S., Berrett,K.C., Vahrenkamp,J.M.,
            Gertz,J., Varley,K.E., Radich,J.P. and Deininger,M.W.
  TITLE     MS4A3 promotes differentiation in chronic myeloid leukemia by
            enhancing common beta-chain cytokine receptor endocytosis
  JOURNAL   Blood 139 (5), 761-778 (2022)
   PUBMED   34780648
  REMARK    GeneRIF: MS4A3 promotes differentiation in chronic myeloid leukemia
            by enhancing common beta-chain cytokine receptor endocytosis.
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Ishibashi,T., Yokota,T., Satoh,Y., Ichii,M., Sudo,T., Doi,Y.,
            Ueda,T., Nagate,Y., Hamanaka,Y., Tanimura,A., Ezoe,S.,
            Shibayama,H., Oritani,K. and Kanakura,Y.
  TITLE     Identification of MS4A3 as a reliable marker for early myeloid
            differentiation in human hematopoiesis
  JOURNAL   Biochem Biophys Res Commun 495 (3), 2338-2343 (2018)
   PUBMED   29274779
  REMARK    GeneRIF: These results suggest that cell surface expression of
            MS4A3 is useful to distinguish granulocyte/macrophage
            lineage-committed progenitors from other lineage-related ones in
            early human hematopoiesis. In conclusion, MS4A3 is useful to
            monitor early stage of myeloid differentiation in human
            hematopoiesis.
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Skov,V., Burton,M., Thomassen,M., Stauffer Larsen,T., Riley,C.H.,
            Brinch Madelung,A., Kjaer,L., Bondo,H., Stamp,I., Ehinger,M.,
            Dahl-Sorensen,R., Brochmann,N., Nielsen,K., Thiele,J., Jensen,M.K.,
            Weis Bjerrum,O., Kruse,T.A. and Hasselbalch,H.C.
  TITLE     A 7-Gene Signature Depicts the Biochemical Profile of Early
            Prefibrotic Myelofibrosis
  JOURNAL   PLoS One 11 (8), e0161570 (2016)
   PUBMED   27579896
  REMARK    GeneRIF: a 7-gene signature was identified which correctly
            predicted the primary prefibrotic myelofibrosis group with a
            sensitivity of 100% and a specificity of 89%. The 7 genes included
            MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Heller,G., Rommer,A., Steinleitner,K., Etzler,J., Hackl,H.,
            Heffeter,P., Tomasich,E., Filipits,M., Steinmetz,B., Topakian,T.,
            Klingenbrunner,S., Ziegler,B., Spittler,A., Zochbauer-Muller,S.,
            Berger,W. and Wieser,R.
  TITLE     EVI1 promotes tumor growth via transcriptional repression of MS4A3
  JOURNAL   J Hematol Oncol 8, 28 (2015)
   PUBMED   25886616
  REMARK    GeneRIF: Our data reveal MS4A3 as a novel direct target of EVI1 in
            human myeloid cells, and show that its repression plays a role in
            EVI1 mediated tumor aggressiveness.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Chinami,M., Yano,Y., Yang,X., Salahuddin,S., Moriyama,K.,
            Shiroishi,M., Turner,H., Shirakawa,T. and Adra,C.N.
  TITLE     Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated
            phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase
            activity of KAP, dissociates cyclin A, and facilitates KAP
            dephosphorylation of Cdk2
  JOURNAL   J Biol Chem 280 (17), 17235-17242 (2005)
   PUBMED   15671017
  REMARK    GeneRIF: HTm4 binding to KAP.Cdk2.cyclin A complex enhances the
            phosphatase activity of KAP, dissociates cyclin A, and facilitates
            KAP dephosphorylation of Cdk2
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Donato,J.L., Ko,J., Kutok,J.L., Cheng,T., Shirakawa,T., Mao,X.Q.,
            Beach,D., Scadden,D.T., Sayegh,M.H. and Adra,C.N.
  TITLE     Human HTm4 is a hematopoietic cell cycle regulator
  JOURNAL   J Clin Invest 109 (1), 51-58 (2002)
   PUBMED   11781350
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Adra,C.N., Lelias,J.M., Kobayashi,H., Kaghad,M., Morrison,P.,
            Rowley,J.D. and Lim,B.
  TITLE     Cloning of the cDNA for a hematopoietic cell-specific protein
            related to CD20 and the beta subunit of the high-affinity IgE
            receptor: evidence for a family of proteins with four
            membrane-spanning regions
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 10178-10182 (1994)
   PUBMED   7524084
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL601630.1, BC008487.1 and
            L35848.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006138.4.
            
            Summary: This gene encodes a member of the membrane-spanning 4A
            gene family. Members of this protein family are characterized by
            common structural features and similar intron/exon splice
            boundaries and display unique expression patterns among
            hematopoietic cells and nonlymphoid tissues. This family member
            likely plays a role in signal transduction and may function as a
            subunit associated with receptor complexes. The gene encoding this
            protein is localized to 11q12, among a cluster of related family
            members. Alternative splicing may result in multiple transcript
            variants; however, not all variants have been fully described.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L35848.1, BC008487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278865.8/ ENSP00000278865.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL601630.1         38-55
            19-1615             BC008487.1         1-1597
            1616-1617           L35848.1           1631-1632
            1618-1618           BC008487.1         1600-1600
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1618
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /note="membrane spanning 4-domains A3"
                     /db_xref="GeneID:932"
                     /db_xref="HGNC:HGNC:7317"
                     /db_xref="MIM:606498"
     exon            1..76
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..247
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..736
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /note="isoform a is encoded by transcript variant 1;
                     hematopoietic cell 4 transmembrane protein; IgE receptor
                     beta chain; CD20 antigen homolog; IgE receptor beta
                     subunit; CD20 antigen-like protein; hematopoietic-specific
                     transmembrane protein 4; membrane-spanning 4-domains,
                     subfamily A, member 3 (hematopoietic cell-specific);
                     membrane-spanning 4-domains subfamily A member 3"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member 3
                     isoform a"
                     /protein_id="NP_006129.4"
                     /db_xref="CCDS:CCDS31567.1"
                     /db_xref="GeneID:932"
                     /db_xref="HGNC:HGNC:7317"
                     /db_xref="MIM:606498"
                     /translation="MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQ
                     KAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSS
                     GTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESP
                     DLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV"
     exon            248..385
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            386..442
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            443..604
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            605..706
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1618
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /note="hexamer: AATAAA"
     polyA_site      1618
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /note="major polyA site"
ORIGIN      
        1 cttttctgag tgtctcctac ttgcgacaag gtggacttgg gaggaaagcc gtctgccaaa
       61 gcctgaagcc tccaagccat aaacaacccc aatggcctcc cacgaagttg ataatgcaga
      121 gctggggtca gcctctgccc atggtacccc aggcagtgag gcgggaccag aagagctgaa
      181 tacttctgtc taccagccca tagatggatc accagattat cagaaagcaa aattacaagt
      241 tcttggggcc atccagatcc tgaatgcagc aatgattctg gctttgggtg tctttctggg
      301 ttccttgcaa tacccatacc acttccaaaa gcacttcttt ttcttcacct tctacacagg
      361 ctacccgatt tggggtgctg tgtttttctg tagttcagga accttgtctg ttgtagcagg
      421 gataaaaccc acaagaacat ggatacagaa cagttttgga atgaacattg ccagtgctac
      481 aattgcacta gtggggactg cttttctctc actaaatata gcagttaata tccagtcatt
      541 aaggagttgt cactcttcat cagagtcacc ggacctatgc aattacatgg gctccatatc
      601 aaatggcatg gtgtctctac tgctgattct caccttgctg gaattatgcg taaccatctc
      661 taccatagcc atgtggtgca atgcaaactg ctgtaattca agagaggaaa tttcctcacc
      721 tcccaattct gtgtaatcaa gaatacctcc ttaattctga gagcatgaat atttgacctt
      781 aaatctccag tgactcagag cttcacccac aaactcagga gaacataagc ctgctcgtaa
      841 agctcaatcc ttctatcatg gcaccaatca caagaacctt ggacgtttga ctgactctat
      901 cctttctctc ctaactataa atcctatttg tgtgtcgtgg gtatggaagg acagatatat
      961 ttctttaggc attcttggat atctgtaact tctatgatca ttactccaaa gttgtttcca
     1021 gaaattggtt ctatttcttc ttatccacct actccattgc tttatgaggt ttaaggaagg
     1081 aaggcggtat aatccctatt caatatattt tttctaaaat ccaacttctg accgcccagt
     1141 aggaagaaaa atgagacatt ttttccatta cagagaaatg cttcttgact ttaacatcag
     1201 cattataaaa agtgtcaaat aaaaaattac catcattatc attaaaataa attttcactg
     1261 tatttgagat gggagggtta aggctcaggg attttatttc agtgaactgc tggaactcac
     1321 acatgccctg atatgtaaat gatgatttat gttggcgagt ctgagagcaa gcccaaatgt
     1381 gttcttcaaa ggacaatggg aaactgtaaa gtagagaact aaagaataag gcctttagaa
     1441 tctgacacat ctgggttcaa attctgaaac tgtcacttat tacctgtatg aacatgggca
     1501 aattatctaa tctctctgat ctatttttcc tcatctgtaa aataggtgta ataataacaa
     1561 ctactttgtc ggttgctctg agggttaaat gaaaataaaa agaaaatgtg aaacagca
//
