LOCUS       NM_000139               3648 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A2 (MS4A2), transcript
            variant 1, mRNA.
ACCESSION   NM_000139
VERSION     NM_000139.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3648)
  AUTHORS   Liu,J., Zhu,Q., Jiang,H., Zhang,L. and Cao,X.
  TITLE     Evaluation value and mechanism of ADRB2 and FCER1B gene
            polymorphisms in preterm infants with congenital respiratory
            diseases
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (13), 59-65 (2023)
   PUBMED   38158688
  REMARK    GeneRIF: Evaluation value and mechanism of ADRB2 and FCER1B gene
            polymorphisms in preterm infants with congenital respiratory
            diseases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3648)
  AUTHORS   Bitting,K., Hedgespeth,B., Ehrhardt-Humbert,L.C., Arthur,G.K.,
            Schubert,A.G., Bradding,P., Tilley,S.L. and Cruse,G.
  TITLE     Identification of redundancy between human FcepsilonRIbeta and
            MS4A6A proteins points toward additional complex mechanisms for
            FcepsilonRI trafficking and signaling
  JOURNAL   Allergy 78 (5), 1204-1217 (2023)
   PUBMED   36424895
  REMARK    GeneRIF: Identification of redundancy between human FcepsilonRIbeta
            and MS4A6A proteins points toward additional complex mechanisms for
            FcepsilonRI trafficking and signaling.
REFERENCE   3  (bases 1 to 3648)
  AUTHORS   Hua,L., Chen,Q., Liu,Q.H., Guo,Y.F., Cheng,R.H., Zhang,J.,
            Zhang,J.H., Wang,L.W. and Ji,R.X.
  TITLE     Interaction between antibiotic use and MS4A2 gene polymorphism on
            childhood eczema: a prospective birth cohort study
  JOURNAL   BMC Pediatr 21 (1), 314 (2021)
   PUBMED   34261469
  REMARK    GeneRIF: Interaction between antibiotic use and MS4A2 gene
            polymorphism on childhood eczema: a prospective birth cohort study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3648)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3648)
  AUTHORS   Ly,D., Zhu,C.Q., Cabanero,M., Tsao,M.S. and Zhang,L.
  TITLE     Role for High-Affinity IgE Receptor in Prognosis of Lung
            Adenocarcinoma Patients
  JOURNAL   Cancer Immunol Res 5 (9), 821-829 (2017)
   PUBMED   28775209
  REMARK    GeneRIF: Using immunohistochemistry, we validated that MS4A2, the
            beta subunit of the IgE receptor expressed on mast cells, is a
            favorable prognostic indicator and show that MS4A2 gene expression
            is an independent prognostic marker for early-stage lung cancer
            patient survival.
REFERENCE   6  (bases 1 to 3648)
  AUTHORS   Kuster,H., Zhang,L., Brini,A.T., MacGlashan,D.W. and Kinet,J.P.
  TITLE     The gene and cDNA for the human high affinity immunoglobulin E
            receptor beta chain and expression of the complete human receptor
  JOURNAL   J Biol Chem 267 (18), 12782-12787 (1992)
   PUBMED   1535625
REFERENCE   7  (bases 1 to 3648)
  AUTHORS   Maekawa,K., Imagawa,N., Tanaka,Y. and Harada,S.
  TITLE     Determination of the sequence coding for the beta subunit of the
            human high-affinity IgE receptor
  JOURNAL   FEBS Lett 302 (2), 161-165 (1992)
   PUBMED   1386024
REFERENCE   8  (bases 1 to 3648)
  AUTHORS   Bieber,T., de la Salle,H., Wollenberg,A., Hakimi,J., Chizzonite,R.,
            Ring,J., Hanau,D. and de la Salle,C.
  TITLE     Human epidermal Langerhans cells express the high affinity receptor
            for immunoglobulin E (Fc epsilon RI)
  JOURNAL   J Exp Med 175 (5), 1285-1290 (1992)
   PUBMED   1533242
REFERENCE   9  (bases 1 to 3648)
  AUTHORS   Le Coniat,M., Kinet,J.P. and Berger,R.
  TITLE     The human genes for the alpha and gamma subunits of the mast cell
            receptor for immunoglobulin E are located on human chromosome band
            1q23
  JOURNAL   Immunogenetics 32 (3), 183-186 (1990)
   PUBMED   2146219
REFERENCE   10 (bases 1 to 3648)
  AUTHORS   Tedder,T.F., Streuli,M., Schlossman,S.F. and Saito,H.
  TITLE     Isolation and structure of a cDNA encoding the B1 (CD20)
            cell-surface antigen of human B lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 85 (1), 208-212 (1988)
   PUBMED   2448768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA972757.1, D10583.1,
            AP001181.4 and GD138492.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000139.4.
            
            Summary: The allergic response involves the binding of allergen to
            receptor-bound IgE followed by cell activation and the release of
            mediators responsible for the manifestations of allergy. The
            IgE-receptor, a tetramer composed of an alpha, beta, and 2
            disulfide-linked gamma chains, is found on the surface of mast
            cells and basophils. This gene encodes the beta subunit of the high
            affinity IgE receptor which is a member of the membrane-spanning 4A
            gene family. Members of this nascent protein family are
            characterized by common structural features and similar intron/exon
            splice boundaries and display unique expression patterns among
            hematopoietic cells and nonlymphoid tissues. This family member is
            localized to 11q12, among a cluster of membrane-spanning 4A gene
            family members. Alternative splicing results in multiple transcript
            variants encoding distinct proteins. Additional transcript variants
            have been described but require experimental validation. [provided
            by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1) that traffics to the
            cytoplasmic membrane.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10583.1, BC074800.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278888.8/ ENSP00000278888.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DA972757.1         1-52
            53-946              D10583.1           1-894
            947-3488            AP001181.4         48088-50629
            3489-3648           GD138492.1         10-169
FEATURES             Location/Qualifiers
     source          1..3648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..3648
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /note="membrane spanning 4-domains A2"
                     /db_xref="GeneID:2206"
                     /db_xref="HGNC:HGNC:7316"
                     /db_xref="MIM:147138"
     exon            1..158
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..837
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /note="isoform 1 is encoded by transcript variant 1;
                     immunoglobulin E receptor, high affinity, beta
                     polypeptide; high affinity immunoglobulin epsilon receptor
                     subunit beta; Fc fragment of IgE, high affinity I,
                     receptor for; beta polypeptide; membrane-spanning
                     4-domains subfamily A member 2; igE Fc receptor subunit
                     beta; High affinity immunoglobulin epsilon receptor
                     beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc
                     epsilon receptor I beta-chain); high affinity IgE receptor
                     beta subunit"
                     /codon_start=1
                     /product="high affinity immunoglobulin epsilon receptor
                     subunit beta isoform 1"
                     /protein_id="NP_000130.1"
                     /db_xref="CCDS:CCDS7980.1"
                     /db_xref="GeneID:2206"
                     /db_xref="HGNC:HGNC:7316"
                     /db_xref="MIM:147138"
                     /translation="MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASS
                     PPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPF
                     WGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIH
                     IHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRV
                     YEELNIYSATYSELEDPGEMSPPIDL"
     exon            159..288
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /inference="alignment:Splign:2.1.0"
     exon            289..423
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /inference="alignment:Splign:2.1.0"
     exon            424..480
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /inference="alignment:Splign:2.1.0"
     exon            481..639
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /inference="alignment:Splign:2.1.0"
     exon            640..738
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /inference="alignment:Splign:2.1.0"
     exon            739..3648
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3624..3629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /note="hexamer: AATAAA"
     polyA_site      3648
                     /gene="MS4A2"
                     /gene_synonym="APY; ATOPY; FCER1B; FCERI; IGEL; IGER;
                     IGHER"
                     /note="major polyA site"
ORIGIN      
        1 aacccatttc aactgcctat tcagagcatg cagtaagagg aaatccacca agtctcaata
       61 taataatatt ctttattcct ggacagctcg gttaatgaaa aaatggacac agaaagtaat
      121 aggagagcaa atcttgctct cccacaggag ccttccagtg tgcctgcatt tgaagtcttg
      181 gaaatatctc cccaggaagt atcttcaggc agactattga agtcggcctc atccccacca
      241 ctgcatacat ggctgacagt tttgaaaaaa gagcaggagt tcctgggggt aacacaaatt
      301 ctgactgcta tgatatgcct ttgttttgga acagttgtct gctctgtact tgatatttca
      361 cacattgagg gagacatttt ttcatcattt aaagcaggtt atccattctg gggagccata
      421 tttttttcta tttctggaat gttgtcaatt atatctgaaa ggagaaatgc aacatatctg
      481 gtgagaggaa gcctgggagc aaacactgcc agcagcatag ctgggggaac gggaattacc
      541 atcctgatca tcaacctgaa gaagagcttg gcctatatcc acatccacag ttgccagaaa
      601 ttttttgaga ccaagtgctt tatggcttcc ttttccactg aaattgtagt gatgatgctg
      661 tttctcacca ttctgggact tggtagtgct gtgtcactca caatctgtgg agctggggaa
      721 gaactcaaag gaaacaaggt tccagaggat cgtgtttatg aagaattaaa catatattca
      781 gctacttaca gtgagttgga agacccaggg gaaatgtctc ctcccattga tttataagaa
      841 tcacgtgtcc agaacactct gattcacagc caaggatcca gaaggccaag gtcttgttaa
      901 ggggctactg gaaaaatttc tattctctcc acagcctgct ggttttacat tagatttatt
      961 cgcctgataa gaatattttg tttctgctgc ttctgtccac cttaatattc tccttctatt
     1021 tgtagatatg atagactcct atttttcttg ttttatatta tgaccacaca catctctgct
     1081 ggaaagtcaa catgtagtaa gcaagattta actgtttgat tataactgtg caaatacaga
     1141 aaaaaagaag gctggctgaa agttgagtta aactttgaca gtttgataat atttggttct
     1201 tagggttttt tttttttttt agcattctta atagttacag ttgggcatga tttgtaccat
     1261 ccacccatac ccacacagtc acagtcacac acacatatgt attacttaca ctatatataa
     1321 cttcctatgc aaatatttta ccaccagtca ataatacatt tttgccaaga catgaagttt
     1381 tataaagatc tgtataattg cctgaatcac cagcacattc actgacatga tattatttgc
     1441 agattgacaa gtaggaagtg gggaatttta ttaagttact cgttgtctgg ggaggtaaat
     1501 aggttaaaaa cagggaaatt ataagtgcag agattaacat ttcacaaatg tttagtgaaa
     1561 catttgtgaa aaaagaagac taaattaaga cctgagctga aataaagtga gtggaaatgg
     1621 aaataatggt tatatctaaa acatgtagaa aaagagtaac tggtagattt tgttaacaaa
     1681 ttaaagaata aagttagaca agcaactggt tgactaatac attaagcgtt tgagtctaag
     1741 atgaaaggag aacactggtt atgttgatag aatgataaaa agggtcgggc gcggaggctc
     1801 acgcctgtaa tcccagccct ttgggaggcc gaggtgggca gatcacgaag tcagtagttt
     1861 gagaccagcc tggccaacat agtgaaaccc cgtctctact aaaaatacaa aaaaaaaatt
     1921 agctgggtgt ggtggcagtc acctgtagtc ccagctactt gggaggctga ggcaggagaa
     1981 tcgcttcaac ctgggaggcg gaggttgcag tgagccgaga tcgcaccagt gcactccagc
     2041 cttggtgaca atgggagact ccatctcaaa aaaaaaaaaa aaaaaaaaaa agataaaaag
     2101 tcagaaatct gaaaagtgga ggaagagtac aaatagacct aaattaagct catttttagg
     2161 ctttgatttt ggggagacaa agggaaatgc agccatagag ggcctgatga catccaatac
     2221 agagttctgg taaagataaa atttgataca ggtttggtgt cattataaga gaaatcatta
     2281 ttaaatgaag caagttaaca ctctaagaga attattttga gatagaagtg aagctaagct
     2341 aaacttcaca tgcctataat tggagggaaa aactaaggat aaaatctagc ctagaagata
     2401 caataattag tcataaacat gcattgtgaa actgtagaga gcaggtagcc caaaatagag
     2461 aaagattaga taaagagaaa ataagtatcc atcagagaca gtatctctag gcttgggcaa
     2521 gagaaaagtc cacagtgata agcaactcca cctaaggcat gaatatgcgg cagagaaaac
     2581 agcaatagtg aatgaatgca aaaggtgctg agaaattcca cacatgagta ttgtgatgag
     2641 taaatgaata aaacatttgc aaagaccttt agagaaagag aatgggagca tatgtgagaa
     2701 ataagatagt tgattatgaa tagaaggtag tgaagaaaag caagctaaga aaaaattctg
     2761 tttataaaag aaggaaaaga tagtttatgt ttttagccta agtataagag tcctacagat
     2821 ggactgaaaa aaatcagtct gagagtatta gtcacaatta atgaaataat tacattttat
     2881 gtattgagga tgccaagatt aaaaggtgac aggtagatgt taatttccct agattgtgaa
     2941 agtgatcacg acaatcacac aacaaataat taagtgactt ggtatgcttt atttaattgt
     3001 agggcctgag gttttccatt ctcatttttc taaaatacaa ttttgtttct ccaaatttga
     3061 cagcagaata aaaaccctac cctttcactg tgtatcatgc taagctgcat ctctactctt
     3121 gatcatctgt aggtattaat cacatcactt ccatggcatg gatgttcaca tacagactct
     3181 taaccctggt ttaccaggac ctctaggagt ggatccaatc tatatcttta cagttgtata
     3241 gtatatgata tctcttttat ttcactcaat ttatattttc atcattgact acatatttct
     3301 tatacacaac acacaattta tgaatttttt ctcaagatca ttctgagagt tgccccaccc
     3361 tacctgcctt ttatagtatg cccacctcag gcagacacag agcacaatgc tggggttctc
     3421 ttcacactat cactgcccca aattgtcttt ctaaatttca acttcaatgt catcttctcc
     3481 atgaagacca ctgaatgaac accttttcat ccagccttaa tttcttgctc cataactact
     3541 ctatcccacg atgcagtatt gtatcattaa ttattagtgt gcttgtgacc tccttatgta
     3601 ttctcaatta cctgtatttg tgcaataaat tggaataatg taacttga
//
