LOCUS       NM_001354471            2318 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A18 (MS4A18), mRNA.
ACCESSION   NM_001354471 XM_011545420
VERSION     NM_001354471.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2318)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP004243.2.
            
            On Feb 22, 2021 this sequence version replaced NM_001354471.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2144835,
                              SAMEA2152474 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000529108.6/ ENSP00000431607.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AP004243.2         86667-86741
            76-558              AP004243.2         91251-91733
            559-672             AP004243.2         95481-95594
            673-729             AP004243.2         98925-98981
            730-825             AP004243.2         100849-100944
            826-939             AP004243.2         102977-103090
            940-2318            AP004243.2         105597-106975
FEATURES             Location/Qualifiers
     source          1..2318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2318
                     /gene="MS4A18"
                     /note="membrane spanning 4-domains A18"
                     /db_xref="GeneID:728588"
                     /db_xref="HGNC:HGNC:37636"
     exon            1..75
                     /gene="MS4A18"
                     /inference="alignment:Splign:2.1.0"
     exon            76..558
                     /gene="MS4A18"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1284
                     /gene="MS4A18"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     18"
                     /protein_id="NP_001341400.1"
                     /db_xref="GeneID:728588"
                     /db_xref="HGNC:HGNC:37636"
                     /translation="MTEQVIGANSVPGIIAPDNVHVIQPSNPVASGNHLQPSEVTTYP
                     ISPKVIHCDTGRANLQNLLVVNQNSAAGVQSQPIGYQRQYPVGTASLQTVPGVIQYTQ
                     GTTNLQTWPGDLQNPLNANPGLTHTSNSSQWNTSFASFTSFNPKKFINEEVRTLGAIQ
                     ILIGLTHIFSAINPVLYYYPFVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSS
                     ISFNIISALFAFAGIFIIITDLSLYYVTTYSKAVSGGLLPFALLEFILTCVVSHFGCQ
                     ATCCRQFENVAVIPTVFSFNPANTTTSPVNATTGPVNAATGPVSATNGPVNTTIHPVN
                     TTTSPVNTTTSPVNVTTGPVNANIGPVNVTTGPVNTTTAPAKATTSCVNAIHTSNVPP
                     NPRTKK"
     exon            559..672
                     /gene="MS4A18"
                     /inference="alignment:Splign:2.1.0"
     exon            673..729
                     /gene="MS4A18"
                     /inference="alignment:Splign:2.1.0"
     exon            730..825
                     /gene="MS4A18"
                     /inference="alignment:Splign:2.1.0"
     exon            826..939
                     /gene="MS4A18"
                     /inference="alignment:Splign:2.1.0"
     exon            940..2318
                     /gene="MS4A18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2295..2300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A18"
                     /note="hexamer: AATAAA"
     polyA_site      2318
                     /gene="MS4A18"
                     /note="major polyA site"
ORIGIN      
        1 agaatttcta gatcaggctg cagaaaccca cagagcctga agaaagagca tccaaagact
       61 tcccaggagc acaagcagtt gtacaccatg accgaacagg tgattggagc caacagtgta
      121 cctggcatta ttgccccaga taatgttcac gtcatccagc ccagcaaccc tgtggcctct
      181 ggaaatcatc tgcagccttc agaggtgacc acttacccaa tctcaccaaa agtaatccac
      241 tgtgatacag gaagagcaaa cttacagaat ctactcgtgg tgaaccagaa ctcagcagca
      301 ggtgtacaga gtcaacccat tgggtatcag cgacagtatc cagtgggaac agccagtttg
      361 cagacggtgc ctggagtgat ccaatacaca cagggaacca cgaatctcca gacatggcct
      421 ggagaccttc agaatcctct gaatgctaac cctgggctga cacacacctc aaactcatcc
      481 cagtggaaca cgtcatttgc atcatttact tcatttaatc ccaagaaatt cataaatgag
      541 gaggtcagaa cattaggggc catccagatc ctcatcggcc tgacgcacat tttctctgca
      601 attaaccctg tgctgtatta ctatcctttt gtgacctggt tgtcagggta cccgctctgg
      661 ggaggattat cctatattgt atctggatcc ctctcagtat gggctgcaaa ggaccccagt
      721 ccttgtgtgg tgaacagcag catcagcttc aacatcatca gcgcactctt cgcctttgcc
      781 gggatcttca ttatcattac agatctgagc ctttactatg tgacgacata ttcaaaggcg
      841 gtttctggcg gtcttctccc ctttgccctc ctggagttca tcctcacttg tgtggtctca
      901 cattttgggt gccaggctac ctgctgcaga caatttgaga atgtggcagt gattccaacc
      961 gtattcagtt tcaacccagc caataccacc accagccctg tcaatgctac cactggtcct
     1021 gtcaatgctg ccactggccc tgtcagtgcc accaatggtc ctgtcaatac taccattcac
     1081 cctgtcaaca ccaccaccag ccctgtcaac accaccacca gccctgtcaa tgttaccact
     1141 ggtcctgtca atgctaacat tggccctgtc aatgtgacaa ctggccccgt taacactacc
     1201 actgcccctg ccaaagctac caccagttgt gtcaatgcta tccacaccag caatgtaccc
     1261 ccgaaccctc gtaccaagaa atagctgatt tgcacagaga tagatgacat gggatgcctg
     1321 tctcaatgac aaggggatac actgtagctg tatcttttct tctccctgaa acttccatga
     1381 ccatgaccct agccttgttg ccagactgaa atgaacaagc atttcctctc ctcttcactc
     1441 ctaagcttca tttttgtttg ttattgatgt cttttttttc attcataaat aattttcctt
     1501 tggctctcag tatcttttaa ccttggcaaa gttcagggtg cattttggtt ccgtggttcc
     1561 tgatgtatgc tcactgttga aaaaccggtt ctaaatcggt gcctcagcca tggaattctt
     1621 gtaggtccaa cttcttccca gtccgcagct ctaactctga cacggttctc ccacacagag
     1681 gagggggagc aatgtggagt gtgttcagta ttcccaggtg taggaggagg aaaatctttg
     1741 tgacctagag ttaggtgaag agtttttaaa caagacacca aaaatacaat tcacaaaagg
     1801 aaaaaaatca ataagttgga cttagaatta aaaacagttg ctctgtgaaa gatcttgcta
     1861 agataaaaag tcataggctg gaagaaaata tttgcaaatc atatatctga caaaggacat
     1921 gtttccacaa tatataaaga actctctaaa ctcaacagta taaaaaaaaa tctaatcaca
     1981 aaatggacaa aaggcttgaa cagaggctct aacaaagaga atatagggtt gcaaataagc
     2041 gtatgaaaag atgttcaatg ttattagcca ttaagtacaa tgaaataaca ctacacacct
     2101 attagaatgg ctgaaattaa aaatactgat aataccaagt gctggtgaaa acagagcaac
     2161 tggaggtctc agatgttgtt aggatgtaaa tggcactgct actctggaaa acagcttggc
     2221 tgattattat aaagcaaagt atacacttac catatgactc agcaatcttg ttcctgggta
     2281 tttatcctag agaaaataaa acttacttcc acacgaaa
//
