LOCUS       NM_001098835            1961 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A15 (MS4A15), transcript
            variant 1, mRNA.
ACCESSION   NM_001098835
VERSION     NM_001098835.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1961)
  AUTHORS   Fang,Y., Yu,H. and Zhou,H.
  TITLE     MS4A15 acts as an oncogene in ovarian cancer through reprogramming
            energy metabolism
  JOURNAL   Biochem Biophys Res Commun 598, 47-54 (2022)
   PUBMED   35151203
  REMARK    GeneRIF: MS4A15 acts as an oncogene in ovarian cancer through
            reprogramming energy metabolism.
REFERENCE   2  (bases 1 to 1961)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC359370.1, CR747020.1, AP004243.2, BI818815.1 and BC031610.1.
            
            On May 17, 2019 this sequence version replaced NM_001098835.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY584608.1, BI818815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405633.4/ ENSP00000386022.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               DC359370.1         1-268
            269-359             CR747020.1         128-218
            360-360             AP004243.2         125820-125820
            361-644             BI818815.1         222-505
            645-1959            BC031610.1         222-1536
            1960-1961           AP004243.2         138679-138680
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1961
                     /gene="MS4A15"
                     /note="membrane spanning 4-domains A15"
                     /db_xref="GeneID:219995"
                     /db_xref="HGNC:HGNC:28573"
     exon            1..192
                     /gene="MS4A15"
                     /inference="alignment:Splign:2.1.0"
     exon            193..445
                     /gene="MS4A15"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..943
                     /gene="MS4A15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-spanning 4-domains subfamily A member 15"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     15 isoform 1"
                     /protein_id="NP_001092305.1"
                     /db_xref="CCDS:CCDS44617.1"
                     /db_xref="GeneID:219995"
                     /db_xref="HGNC:HGNC:28573"
                     /translation="MSAAPASNGVFVVIPPNNASGLCPPPAILPTSMCQPPGIMQFEE
                     PPLGAQTPRATQPPDLRPVETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVRRGHVGI
                     FFIEGGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMD
                     FGVTNRDVDRGYLAVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLPNAFSADFN
                     IPSPAASAPPAYDNVAYAQGVV"
     exon            446..568
                     /gene="MS4A15"
                     /inference="alignment:Splign:2.1.0"
     exon            569..625
                     /gene="MS4A15"
                     /inference="alignment:Splign:2.1.0"
     exon            626..718
                     /gene="MS4A15"
                     /inference="alignment:Splign:2.1.0"
     exon            719..832
                     /gene="MS4A15"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1961
                     /gene="MS4A15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A15"
                     /note="hexamer: AATAAA"
     polyA_site      1961
                     /gene="MS4A15"
                     /note="major polyA site"
ORIGIN      
        1 aggctctcac aagggcgggc tctcagaaga gctgccccca ccccctctcc cagccccctt
       61 cagctgaaat tgtctaagaa ctcattcttg gcgttcactg caagctataa gctctgcaag
      121 tggtgacccc gacgtgatcg ccttgaagtt acgcttgaag gaggaaaact catcaatttt
      181 cggggaatcc cgcctttgtt tcccaggctc tctgagcacg atgtctgcag ctcccgccag
      241 caatggagtg tttgttgtca tcccgccaaa caacgccagt ggcctctgcc cacctccggc
      301 cattctgccc acatccatgt gccaacctcc agggattatg cagtttgagg agccaccgct
      361 gggggcacag acaccaaggg ccacacagcc acctgacttg cggcccgtgg agacattcct
      421 gacaggagag cccaaagttt tggggacggt gcagatcctc atcggcctca tccacctagg
      481 ctttggcagc gtgctgctca tggttcgccg cggccacgtg ggcatcttct tcatcgaggg
      541 cggcgtcccc ttctggggag gagcctgctt catcatctcc ggatccctct cagtggcagc
      601 cgagaagaac cacaccagtt gcctggtgag gagcagcctg ggcaccaaca tcctcagcgt
      661 catggcggcc tttgctggga cagccattct gctcatggat tttggtgtta ccaaccggga
      721 tgtggacagg ggctatctgg ccgtgcttac tatcttcact gtcctggagt tcttcacagc
      781 ggtcattgcc atgcacttcg ggtgccaagc catccatgcc caggccagtg cacctgtgat
      841 cttcctgcca aacgccttca gcgcagactt caacatcccc agcccggcag cctctgcgcc
      901 ccctgcctat gacaatgtgg catatgccca aggagtcgtc tgagtagcag atgtggcacc
      961 tgcgggtgga gtccagcctt ttccctctgg gcccagcctc tccccacccc caccttgttc
     1021 atcaggggcc agccccatcc cagctgccct ccctcaccac atctacacat actccggcat
     1081 ctgagtgaag tgtccccagg gacatctctc ccacactttc cccagtgctt tctttctaaa
     1141 agacaccggg ctgacgtcag gggtgtgtgt ccttcagctc cctgagccct gtcacccttc
     1201 caggacaccc accttgtgca tctaagcatt tctctgctca ttggggaaat cctggcctca
     1261 ttggagactc aggttcgagg cctgccctga ccctcgggcc tcgggaaggt cagagagccc
     1321 ggaatcctcc agaatggaag agtctgactc tggcattcca cagaggtgcc gataccaggc
     1381 caaggcctca cagcagggta gtggcctggc cgcaggtctc ctggccccaa gatcagctct
     1441 gtcctttgtc atctgttgcc acatccatgg aactcaggtt tcctatttgg aaactagagt
     1501 gttgaaccag ataaggttca tcaggccctt ccagctcccc aggctccctg aagtcctggg
     1561 tctaggccag gcattgtccc cctgcttcct ggaaaccctc attttccttg tctgtaatat
     1621 gaagtcagca ttggccccgc cccccacccc ctaccatctc ccaatggagg ggaggttgca
     1681 ggggagagct gccgccagcc cactcctgag gcaccaccac agtcagcatc gacaggggca
     1741 cagcagtggc agtttgggac ctccctgtgc ctctcagcac tcccttcccc acccccatag
     1801 cccaaggaca aggctaccac agaaggttac cacaggacct gggcttcgtc tccaggggac
     1861 aaggagacac tgtcagcctg gtgttcacca ggcctggtag atgagatggc ttgtctcatc
     1921 cacaccacag aaggaaataa accatgtggc ttaaattttg a
//
