LOCUS       NM_032597               2908 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A14 (MS4A14), transcript
            variant 1, mRNA.
ACCESSION   NM_032597 XM_495876
VERSION     NM_032597.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2908)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2908)
  AUTHORS   Lee,H.A., Ahn,E.H., Kim,J.H., Kim,J.O., Ryu,C.S., Lee,J.Y.,
            Cho,S.H., Lee,W.S. and Kim,N.K.
  TITLE     Association study of frameshift and splice variant polymorphisms
            with risk of idiopathic recurrent pregnancy loss
  JOURNAL   Mol Med Rep 18 (2), 2417-2426 (2018)
   PUBMED   29956771
  REMARK    GeneRIF: Interaction analysis demonstrated that the following
            genotypes: MS4A14 DI+II, SLC2A DI+II and ABCB 5 CG+GG, were
            associated with a prothrombin time >/=12 sec and with Recurrent
            pregnancy loss (RPL) risk
REFERENCE   3  (bases 1 to 2908)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003127.2 and AY094610.1.
            
            On May 17, 2019 this sequence version replaced NM_032597.4.
            
            Transcript Variant: This variant (1) has multiple coding region
            differences, compared to variant 4, which results in a shorter
            protein (isoform 1), compared to isoform 4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY094610.1, AF367473.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300187.11/ ENSP00000300187.6
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AP003127.2         100380-100406
            28-648              AY094610.1         57-677
            649-2908            AP003127.2         119418-121677
FEATURES             Location/Qualifiers
     source          1..2908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2908
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /note="membrane spanning 4-domains A14"
                     /db_xref="GeneID:84689"
                     /db_xref="HGNC:HGNC:30706"
     exon            1..258
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2160
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-spanning 4-domains, subfamily A, member 16;
                     testes development-related NYD-SP21; MS4A13 protein;
                     testis development protein NYD-SP21; membrane-spanning
                     4-domains subfamily A member 14"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     14 isoform 1"
                     /protein_id="NP_115986.3"
                     /db_xref="CCDS:CCDS31569.1"
                     /db_xref="GeneID:84689"
                     /db_xref="HGNC:HGNC:30706"
                     /translation="MESTSQDRRATHVITIKPNETVLTAFPYRPHSSLLDFLKGEPRV
                     LGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGALIFILTGYLTVTDKK
                     SKLLGQGVTGMNVISSLVAITGITFTILSYRHQDKYCQMPSFEEICVFSRTLFIVLFF
                     LPSDVTQNSEQPAPEENDQLQFVLQEEFSSDDSTTNAQSVIFGGYAFFKLTLSRSPLV
                     SQPGNKGREFVPDEQKQSILPSPKFSEEEIEPLPPTLEKKPSENMSIQLDSTFKQMKD
                     EDLQSAIVQPSQMQTKLLQDQAASLQVFPSHSALKLEDISPEDLPSQALPVEGLSEQT
                     MPSKSTSSHVKQSSNLTANDLPPQGILSQDTSSQDMLFHDMTSQDMQSLDMLSQDTPS
                     HAMPPQDIPSQDMLSQALSAHAILPEASTSHIVQFPEIQHLLQQPPDLQPENTEPQNQ
                     QILQMSYQDIRSEVMEETKEWKSEEELHRRKSSRRHSLNQQTKALQYLRRHSLDVQAK
                     GQKSSKRHSLDQQSKGWQSPKQKSLDQQIKDWLSPKRHSVDKQAQLNQTKEQLPDQQA
                     EDQQAKGEQYPEGQSKDGQVKDQQTDKEQNSKKQTQDQQTEDQPAQEKKSPKGQFQNV
                     QAEGQQAQVEKVPKLLCQDSESQIQQYQFWQFHKGNLQAGQPRTVNLLAKNPLTG"
     exon            259..387
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /inference="alignment:Splign:2.1.0"
     exon            388..438
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /inference="alignment:Splign:2.1.0"
     exon            439..588
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /inference="alignment:Splign:2.1.0"
     exon            589..2908
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2819..2824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /note="hexamer: AATAAA"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /note="hexamer: AACAAA"
     polyA_site      2840
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
                     /note="major polyA site"
     polyA_site      2846
                     /gene="MS4A14"
                     /gene_synonym="MS4A16; NYD-SP21"
ORIGIN      
        1 agagtcatca ctaagggctc atctctgagg gctccatgtg actctggtgg agaggtagat
       61 catgatttgg gcggcaatgt ttgctcactc tttcccttac tagagttctg ccatagaatc
      121 atggagtcaa catcccagga cagaagggca actcacgtca tcactataaa accaaacgaa
      181 actgtattga ctgcatttcc ctacagacct catagctctc tgctggattt tctgaaggga
      241 gagccaagag tcttgggggc tacccagatc ctgcttgctc taatcattgt gggctttgga
      301 actatatttg cacttaatta catcggtttc tcccaaagac ttccccttgt tgtcctcaca
      361 ggatatccat tctggggagc acttattttt attcttacag gatacctcac agtaaccgat
      421 aagaaatcaa aacttctggg tcaaggtgtc acgggcatga atgttatcag ctccttggtt
      481 gcgataactg ggattacttt caccattctc agctacagac atcaagacaa gtactgccag
      541 atgccatcct ttgaagaaat atgtgttttc agtagaactc ttttcattgt tctgtttttc
      601 ttgccttcgg atgttactca aaatagtgaa caacctgccc cagaagaaaa tgatcaatta
      661 caatttgtgc ttcaagaaga gttttccagt gatgattcaa caacaaatgc acaatctgtt
      721 atctttggag gctatgcttt cttcaagtta acactctcta ggagtccttt agtctcccaa
      781 ccaggtaata aaggtagaga atttgtgcca gatgaacaaa agcaaagtat ccttccatct
      841 cccaaatttt cagaggaaga aattgaacct ttgcctccca cactagagaa aaagccctca
      901 gaaaatatgt ccattcagct agactctaca tttaaacaaa tgaaagatga agatctacaa
      961 tctgctattg tacaaccttc tcaaatgcaa accaagcttc tgcaggacca agctgcgtca
     1021 ctccaagttt ttccatccca ttctgcacta aaactcgaag atatatcacc tgaagacttg
     1081 ccatcccaag ctctaccagt agaaggcctg tcagaacaaa ccatgccatc taagtctaca
     1141 tcatcccatg tcaaacagtc ttctaatctg acagctaatg acctgccccc tcaaggcata
     1201 ctatcccaag acacatcatc tcaagatatg ctgtttcatg acatgacatc ccaagatatg
     1261 caatccctag atatgctatc tcaagacaca ccatcccacg ccatgccacc tcaagacata
     1321 ccttcccaag atatgctatc ccaagctcta tcagcgcatg ccatattacc tgaagcctca
     1381 acatcccata ttgtgcagtt ccctgaaata caacacctac ttcagcagcc cccagatctt
     1441 caaccagaaa acactgaacc tcaaaaccag caaattttac aaatgtcata tcaagatatt
     1501 agatcagaag ttatggaaga gaccaaagaa tggaaatctg aggaggaact ccatagaaga
     1561 aaatcctcaa gacggcattc cttaaaccag caaaccaaag ccttgcaata cttaaggaga
     1621 cattctttag acgtgcaagc caaaggccag aaatcctcaa agaggcattc cttagatcag
     1681 caaagcaaag gctggcaatc tccaaagcag aaatccttag accagcaaat caaagactgg
     1741 ctatccccaa agaggcactc cgtagataag caagctcaac ttaatcaaac taaagagcaa
     1801 ctcccagatc agcaagctga agatcagcaa gccaaagggg aacaataccc agaaggacaa
     1861 tctaaagatg gacaagttaa agaccagcag actgataagg agcaaaactc aaagaagcaa
     1921 acccaggatc agcaaactga agaccagccg gcccaagaga agaaatcccc gaaaggacaa
     1981 ttccaaaatg ttcaagccga aggacagcaa gctcaggtgg agaaagtgcc aaaactgtta
     2041 tgccaagatt cagaatccca aatacagcaa taccaattct ggcaattcca caaaggcaat
     2101 ctccaggctg gacaacccag gactgtcaat cttttggcca agaatcccct gactggataa
     2161 ctcagggctg gagaaacaaa gattataaag cacgagaatg gcaatttgaa atgaagcact
     2221 ggcaaacaca ggatctatta gagaaagaag ccctaaagca gaaagctcta taccaagaag
     2281 tccaaaccca gcacgcaaca gcccaacata acctagaatg tcaagacact caagataaag
     2341 accaacaaga ccttcaatcc agagttacac aaaaaggaga tatgtacact agagacatca
     2401 aaccagggga catgaaatgt atagggcaaa cctcagggga cctgcaatca gaagacgtga
     2461 aggcagattt tcattcttct tctggccaaa gctcagtaca agacacatgt ttagcctatt
     2521 tgtccaatct agattcagaa caagatgtgc aaccagacac ttcagcttcc tcaaattcat
     2581 ataaagaaga tgtgaattta acttctactt catgtgatcc aaaagatcaa cagcaatctg
     2641 aagactctga ctaacatgca gaatctaccc aataccacac tgcccccatt aatggaatta
     2701 aattgggaaa aacaatattg cctcctccaa tctgtgttct caactgtggt tgccacctca
     2761 ttaacttaca aaaaaatgaa gggcatgctg agcactcaaa caatttgttc ttacttaaaa
     2821 taaaatgaca acaaaccaaa tgttaacact gtatcatcac tttatgtatg tgaagaaata
     2881 attcacatgt atattccttg tcatcaaa
//
