LOCUS       NM_017716               1167 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A12 (MS4A12), transcript
            variant 1, mRNA.
ACCESSION   NM_017716
VERSION     NM_017716.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1167)
  AUTHORS   Han,J., Zhang,X., Liu,Y., Jing,L., Liu,Y.B. and Feng,L.
  TITLE     CLCA4 and MS4A12 as the significant gene biomarkers of primary
            colorectal cancer
  JOURNAL   Biosci Rep 40 (8) (2020)
   PUBMED   32797167
  REMARK    GeneRIF: CLCA4 and MS4A12 as the significant gene biomarkers of
            primary colorectal cancer.
REFERENCE   2  (bases 1 to 1167)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1167)
  AUTHORS   He,L., Deng,H.Y. and C Wang,X.
  TITLE     Decreased expression of MS4A12 inhibits differentiation and
            predicts early stage survival in colon cancer
  JOURNAL   Neoplasma 64 (1), 65-73 (2017)
   PUBMED   27881006
  REMARK    GeneRIF: In early stage colon cancer, the patients with low MS4A12
            expression had a poor survival, while in advanced stage colon
            cancer MS412 had little prognostic value.
REFERENCE   4  (bases 1 to 1167)
  AUTHORS   Koslowski,M., Tureci,O., Huber,C. and Sahin,U.
  TITLE     Selective activation of tumor growth-promoting Ca2+ channel MS4A12
            in colon cancer by caudal type homeobox transcription factor CDX2
  JOURNAL   Mol Cancer 8, 77 (2009)
   PUBMED   19781065
  REMARK    GeneRIF: RNA interference of CDX1 and CDX2 and chromatin
            immunoprecipitation in colon cancer cells revealed that MS4A12
            transcript and protein expression is essentially dependent on the
            presence of endogenous CDX2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1167)
  AUTHORS   Koslowski,M., Sahin,U., Dhaene,K., Huber,C. and Tureci,O.
  TITLE     MS4A12 is a colon-selective store-operated calcium channel
            promoting malignant cell processes
  JOURNAL   Cancer Res 68 (9), 3458-3466 (2008)
   PUBMED   18451174
  REMARK    GeneRIF: MS4A12 is a colon-selective store-operated calcium channel
            promoting malignant cell processes.
            Erratum:[Cancer Res. 2008 Jun 15;68(12):4958]
REFERENCE   6  (bases 1 to 1167)
  AUTHORS   Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
REFERENCE   7  (bases 1 to 1167)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP262076.1 and AK000224.1.
            
            On May 17, 2019 this sequence version replaced NM_017716.2.
            
            Summary: The protein encoded by this gene is a cell surface protein
            found primarily in the apical membrane of colonocytes. Silencing of
            this gene in colon cancer cells inhibits the proliferation, cell
            motility, and chemotactic invasion of cells. This gene is part of a
            cluster of similar genes found on chromosome 11. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000224.1, BC029793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000016913.8/ ENSP00000016913.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               BP262076.1         3-416
            415-1167            AK000224.1         415-1167
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1167
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /note="membrane spanning 4-domains A12"
                     /db_xref="GeneID:54860"
                     /db_xref="HGNC:HGNC:13370"
                     /db_xref="MIM:606550"
     exon            1..51
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            52..333
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..861
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane-spanning 4-domains subfamily A member 12"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     12 isoform 1"
                     /protein_id="NP_060186.2"
                     /db_xref="CCDS:CCDS7988.1"
                     /db_xref="GeneID:54860"
                     /db_xref="HGNC:HGNC:13370"
                     /db_xref="MIM:606550"
                     /translation="MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQ
                     GAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMH
                     IGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKG
                     SLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVAC
                     ATAHFANQANTTTNMSVLVIPNMYESNPVTPASSSAPPRCNNYSANAPK"
     exon            334..471
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            472..528
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            529..645
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            646..756
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1167
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /note="hexamer: AATAAA"
     polyA_site      1167
                     /gene="MS4A12"
                     /gene_synonym="Ms4a10"
                     /note="major polyA site"
ORIGIN      
        1 acacaggttg gagcagagaa agaggaaaca tagaggtgcc aaaggaacaa agacataatg
       61 atgtcatcca agccaacaag ccatgctgaa gtaaatgaaa ccatacccaa cccttaccca
      121 ccaagcagct ttatggctcc tggatttcaa cagcctctgg gttcaatcaa cttagaaaac
      181 caagctcagg gtgctcagcg tgctcagccc tacggcatca catctccggg aatctttgct
      241 agcagtcaac cgggtcaagg aaatatacaa atgataaatc caagtgtggg aacagcagta
      301 atgaacttta aagaagaagc aaaggcacta ggggtgatcc agatcatggt tggattgatg
      361 cacattggtt ttggaattgt tttgtgttta atatccttct cttttagaga agtattaggt
      421 tttgcctcta ctgctgttat tggtggatac ccattctggg gtggcctttc ttttattatc
      481 tctggctctc tctctgtgtc agcatccaag gagctttccc gttgtctggt gaaaggcagc
      541 ctgggaatga acattgttag ttctatcttg gccttcattg gagtgattct gctgctggtg
      601 gatatgtgca tcaatggggt agctggccaa gactactggg ccgtgctttc tggaaaaggc
      661 atttcagcca cgctgatgat cttctccctc ttggagttct tcgtagcttg tgccacagcc
      721 cattttgcca accaagcaaa caccacaacc aatatgtctg tcctggttat tccaaatatg
      781 tatgaaagca accctgtgac accagcgtct tcttcagctc ctcccagatg caacaactac
      841 tcagctaatg cccctaaata gtaaaagaaa aaggggtatc agtctaatct catggagaaa
      901 aactacttgc aaaaacttct taagaagatg tcttttattg tctacaatga tttctagtct
      961 ttaaaaactg tgtttgagat ttgtttttag gttggtcgct aatgatggct gtatctccct
     1021 tcactgtctc ttcctacatt accactacta catgctggca aaggtgaagg atcagaggac
     1081 tgaaaaatga ttctgcaact ctcttaaagt tagaaatgtt tctgttcata ttactttttc
     1141 cttaataaaa tgtcattaga aacaaaa
//
