LOCUS       NM_206893               2311 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A10 (MS4A10), mRNA.
ACCESSION   NM_206893 XM_291890
VERSION     NM_206893.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2311)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 2311)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2311)
  AUTHORS   Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
REFERENCE   4  (bases 1 to 2311)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   5  (bases 1 to 2311)
  AUTHORS   Ishibashi,K., Suzuki,M., Sasaki,S. and Imai,M.
  TITLE     Identification of a new multigene four-transmembrane family (MS4A)
            related to CD20, HTm4 and beta subunit of the high-affinity IgE
            receptor
  JOURNAL   Gene 264 (1), 87-93 (2001)
   PUBMED   11245982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP004243.2 and AK122633.1.
            
            On Nov 23, 2018 this sequence version replaced NM_206893.3.
            
            Summary: Most MS4A genes, including MS4A10, encode proteins with at
            least 4 potential transmembrane domains and N- and C-terminal
            cytoplasmic domains encoded by distinct exons.[supplied by OMIM,
            Apr 2004].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122633.1, BC137259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308287.2/ ENSP00000311862.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AP004243.2         147280-147294
            16-254              AK122633.1         2-240
            255-255             AP004243.2         152426-152426
            256-897             AK122633.1         242-883
            898-2311            AP004243.2         161839-163252
FEATURES             Location/Qualifiers
     source          1..2311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2311
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /note="membrane spanning 4-domains A10"
                     /db_xref="GeneID:341116"
                     /db_xref="HGNC:HGNC:13368"
                     /db_xref="MIM:608403"
     exon            1..89
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     exon            90..294
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..915
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /note="CD20 antigen-like 7; membrane-spanning 4-domains,
                     subfamily A, member 10"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     10"
                     /protein_id="NP_996776.2"
                     /db_xref="CCDS:CCDS7992.1"
                     /db_xref="GeneID:341116"
                     /db_xref="HGNC:HGNC:13368"
                     /db_xref="MIM:608403"
                     /translation="MKAEATVIPSRCARGLPSWQVLSPVQPWQTSAPQNTTQPKLLAP
                     HQHEKSQKKSSLLKELGAFHITIALLHLVFGGYLASIVKNLHLVVLKSWYPFWGAASF
                     LISGILAITMKTFSKTYLKMLCLMTNLISLFCVLSGLFVISKDLFLESPFESPIWRMY
                     PNSTVHIQRLELALLCFTVLELFLPVPTAVTAWRGDCPSAKNDDACLVPNTPLHLKGL
                     PVEPPPSYQSVIQGDAQHKQHQRLREVKQVAPDTWIVTDGAAIWTQTAN"
     exon            295..414
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     exon            415..471
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     exon            472..603
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     exon            604..714
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     exon            715..833
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     exon            834..2311
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2294..2299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /note="hexamer: AATAAA"
     polyA_site      2311
                     /gene="MS4A10"
                     /gene_synonym="CD20L7; MS4A9"
                     /note="major polyA site"
ORIGIN      
        1 gatttcccag cgctgtctct ggggagctcc ggcagcgcaa gagggcaaag cacagctgga
       61 agctcagagc tgcagtccca ggtcctgggc cagggccccc atccagcatc aatgaaagca
      121 gaagccacag ttattcccag ccgttgtgct agggggctcc catcatggca agtcctcagc
      181 ccagtccagc cctggcagac aagtgcaccc cagaacacga cccagcccaa gctcctggct
      241 ccacaccagc acgagaagtc ccagaagaag agcagccttc ttaaggagct gggggccttc
      301 cacatcacca tcgctctgct gcacctggtc tttgggggct acctggcctc tatagtcaag
      361 aaccttcacc tggtggtgct gaagtcttgg tatccattct ggggggctgc ctcttttctc
      421 atttcaggga tcttggcgat aacaatgaag accttttcta aaacttacct gaagatgttg
      481 tgcctgatga caaacctcat cagcctcttt tgcgtgctgt ctggcctctt cgtcatctcc
      541 aaggatctct ttctggagag cccatttgag tccccgatct ggagaatgta ccccaactcc
      601 acggtccaca tccagaggct ggagctggcc ttgctctgct tcactgtcct agagctcttc
      661 ctgccagtgc ccacagctgt cacagcctgg agaggggact gcccatctgc aaagaatgat
      721 gatgcatgcc ttgttccgaa tacaccattg catctcaaag gcctgccggt ggagcccccg
      781 ccatcctacc agagtgtgat tcaaggcgac gcacaacaca agcaacatca gaggctcaga
      841 gaagttaagc aagttgcccc ggacacatgg atagtcactg acggagctgc gatctggacc
      901 cagactgcaa actgaagagc cactgcctga caatgcccaa acttggttgg agcatagccc
      961 ctgctctccc aaagttgcac tttcactggg aagatgagat ttgcacatac aaaaggctag
     1021 agcgatggtc tatacagcaa agtcagccct cacagctcct gggaacgctg tcctctcaga
     1081 taagccattt cttacatagt tgatggctcg atatctgtgg tggcccagat tgttttgttt
     1141 tgtttcgctt tgttttgttt tcttttgttt tgttgagatg gagtctcgct ctgttgccca
     1201 gcccagagta cagtggcact atctcagctc actgcaatct ccgcctccct ggttcaagtg
     1261 attctcctat ctcagcctcc caagtagctg ggactatagg cacacgccac cacgcccagc
     1321 taatttttat atttttagta gagacaggat tgcaccatat tggtcagcct ggtctcaaac
     1381 tcctgacctc aggtgatcca cctgcctcag cctcccaaag tgctgggatt acaggcgtga
     1441 gccactgtgc ccagcccagg ttttgaagtt gtccgagata gcagtctgct ctctactgcc
     1501 ttataaaatc cctgtgtgaa gggatgctct cagtatcatt tgcccttgca cagaatatcc
     1561 ctggggtttg aggttctttg aattctccct ctttgtcatc tctttcgctg ccacttctgg
     1621 ctgtggtcac tagcttggcc atagcacctc tcttctccac ttctgatctg ctgcttctaa
     1681 ccttctatag attgcagctg gctttaaaat agattgtaaa gtgtaaggca ttaggttctg
     1741 agacagcggc agagagagcc atgcaaatgt ttaggacaac ccagtctttc tttttttttt
     1801 tttttttttt tttttttgag acggagtctc actctgtcac ccaggctgga gtgctgtggt
     1861 gcaatctcgg ctcactgcaa cctctgcctc ccgagttcaa gcaattctcc tgcctcagcc
     1921 tcccgagtag ctgggattac aggcgaccgc caccacgcct ggctactttt tgtattttta
     1981 gtagagacag ggtttcacca cgttagccat gatggtctca aacttctgac ctcataatcc
     2041 acccaccttg gcctcccaaa gtgctaggat tacaggcatg agccaccacc cctggctgaa
     2101 acccaatctt tcaaaacatg aaagggggtg atggagaaaa ccttagcttg gttgtctaaa
     2161 gacatgggtg caaactctag gctagctctg ccaatcactt actgtgcggg tttgactcag
     2221 tcccttcccc tcactaggtc ccagtttctc catttgtaaa acaagcaatt gtgctacatt
     2281 gatggtttac atcaataaag gttgaaacgg c
//
