LOCUS       NM_152866               3556 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens membrane spanning 4-domains A1 (MS4A1), transcript
            variant 1, mRNA.
ACCESSION   NM_152866
VERSION     NM_152866.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3556)
  AUTHORS   Bobrowicz,M., Kusowska,A., Krawczyk,M., Zhylko,A., Forcados,C.,
            Slusarczyk,A., Barankiewicz,J., Domagala,J., Kubacz,M., Smida,M.,
            Dostalova,L., Marhelava,K., Fidyt,K., Pepek,M., Baranowska,I.,
            Szumera-Cieckiewicz,A., Inderberg,E.M., Walchli,S., Granica,M.,
            Graczyk-Jarzynka,A., Majchrzak,M., Poreba,M., Gehlert,C.L.,
            Peipp,M., Firczuk,M., Prochorec-Sobieszek,M. and Winiarska,M.
  TITLE     CD20 expression regulates CD37 levels in B-cell lymphoma -
            implications for immunotherapies
  JOURNAL   Oncoimmunology 13 (1), 2362454 (2024)
   PUBMED   38846084
  REMARK    GeneRIF: CD20 expression regulates CD37 levels in B-cell lymphoma -
            implications for immunotherapies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3556)
  AUTHORS   Xuan,Z., Liu,L., Zhang,G., Zheng,X., Jiang,J., Wang,K. and Huang,P.
  TITLE     Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+ were key
            subpopulations in intrahepatic cholangiocarcinoma
  JOURNAL   Biochim Biophys Acta Gen Subj 1867 (9), 130420 (2023)
   PUBMED   37433400
  REMARK    GeneRIF: Novel cell subtypes of SPP1 + S100P+, MS4A1-SPP1 + S100P+
            were key subpopulations in intrahepatic cholangiocarcinoma.
REFERENCE   3  (bases 1 to 3556)
  AUTHORS   Li,S. and Fang,Y.
  TITLE     MS4A1 as a Potential Independent Prognostic Factor of Breast Cancer
            Related to Lipid Metabolism and Immune Microenvironment Based on
            TCGA Database Analysis
  JOURNAL   Med Sci Monit 28, e934597 (2022)
   PUBMED   35091527
  REMARK    GeneRIF: MS4A1 as a Potential Independent Prognostic Factor of
            Breast Cancer Related to Lipid Metabolism and Immune
            Microenvironment Based on TCGA Database Analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3556)
  AUTHORS   Aitamer,M., Akil,H., Vignoles,C., Branchaud,M., Abraham,J.,
            Gachard,N., Feuillard,J., Jauberteau,M.O., Shirvani,H., Troutaud,D.
            and Bentayeb,H.
  TITLE     CD20 expression, TrkB activation and functional activity of diffuse
            large B cell lymphoma-derived small extracellular vesicles
  JOURNAL   Br J Cancer 125 (12), 1687-1698 (2021)
   PUBMED   34743199
  REMARK    GeneRIF: CD20 expression, TrkB activation and functional activity
            of diffuse large B cell lymphoma-derived small extracellular
            vesicles.
REFERENCE   5  (bases 1 to 3556)
  AUTHORS   Vlaming,M., Bilemjian,V., Freile,J.A., Lourens,H.J., van Rooij,N.,
            Huls,G., van Meerten,T., de Bruyn,M. and Bremer,E.
  TITLE     CD20 positive CD8 T cells are a unique and
            transcriptionally-distinct subset of T cells with distinct
            transmigration properties
  JOURNAL   Sci Rep 11 (1), 20499 (2021)
   PUBMED   34654826
  REMARK    GeneRIF: CD20 positive CD8 T cells are a unique and
            transcriptionally-distinct subset of T cells with distinct
            transmigration properties.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3556)
  AUTHORS   Kuster,H., Zhang,L., Brini,A.T., MacGlashan,D.W. and Kinet,J.P.
  TITLE     The gene and cDNA for the human high affinity immunoglobulin E
            receptor beta chain and expression of the complete human receptor
  JOURNAL   J Biol Chem 267 (18), 12782-12787 (1992)
   PUBMED   1535625
REFERENCE   7  (bases 1 to 3556)
  AUTHORS   Tedder,T.F., Klejman,G., Schlossman,S.F. and Saito,H.
  TITLE     Structure of the gene encoding the human B lymphocyte
            differentiation antigen CD20 (B1)
  JOURNAL   J Immunol 142 (7), 2560-2568 (1989)
   PUBMED   2466899
REFERENCE   8  (bases 1 to 3556)
  AUTHORS   Tedder,T.F., Disteche,C.M., Louie,E., Adler,D.A., Croce,C.M.,
            Schlossman,S.F. and Saito,H.
  TITLE     The gene that encodes the human CD20 (B1) differentiation antigen
            is located on chromosome 11 near the t(11;14)(q13;q32)
            translocation site
  JOURNAL   J Immunol 142 (7), 2555-2559 (1989)
   PUBMED   2466898
REFERENCE   9  (bases 1 to 3556)
  AUTHORS   Einfeld,D.A., Brown,J.P., Valentine,M.A., Clark,E.A. and
            Ledbetter,J.A.
  TITLE     Molecular cloning of the human B cell CD20 receptor predicts a
            hydrophobic protein with multiple transmembrane domains
  JOURNAL   EMBO J 7 (3), 711-717 (1988)
   PUBMED   2456210
REFERENCE   10 (bases 1 to 3556)
  AUTHORS   Tedder,T.F., Streuli,M., Schlossman,S.F. and Saito,H.
  TITLE     Isolation and structure of a cDNA encoding the B1 (CD20)
            cell-surface antigen of human B lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 85 (1), 208-212 (1988)
   PUBMED   2448768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD691924.1, AW504475.1,
            BC002807.2 and AP001034.5.
            
            On Sep 27, 2019 this sequence version replaced NM_152866.2.
            
            Summary: This gene encodes a member of the membrane-spanning 4A
            gene family. Members of this nascent protein family are
            characterized by common structural features and similar intron/exon
            splice boundaries and display unique expression patterns among
            hematopoietic cells and nonlymphoid tissues. This gene encodes a
            B-lymphocyte surface molecule which plays a role in the development
            and differentiation of B-cells into plasma cells. This family
            member is localized to 11q12, among a cluster of family members.
            Alternative splicing of this gene results in two transcript
            variants which encode the same protein. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript variant. Variants 1, 2 and 3 both encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1659327.1,
                                           SRR14038195.1509095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345732.9/ ENSP00000314620.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                CD691924.1         62-152
            92-570              AW504475.1         62-540
            571-1585            BC002807.2         296-1310
            1586-3556           AP001034.5         61823-63793
FEATURES             Location/Qualifiers
     source          1..3556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..3556
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="membrane spanning 4-domains A1"
                     /db_xref="GeneID:931"
                     /db_xref="HGNC:HGNC:7315"
                     /db_xref="MIM:112210"
     exon            1..99
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            100..188
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            189..537
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..1272
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="CD20 antigen; CD20 receptor; B-lymphocyte
                     cell-surface antigen B1; membrane-spanning 4-domains,
                     subfamily A, member 1; leukocyte surface antigen Leu-16"
                     /codon_start=1
                     /product="B-lymphocyte antigen CD20"
                     /protein_id="NP_690605.1"
                     /db_xref="CCDS:CCDS31570.1"
                     /db_xref="GeneID:931"
                     /db_xref="HGNC:HGNC:7315"
                     /db_xref="MIM:112210"
                     /translation="MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSF
                     FMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLA
                     ATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTP
                     YINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKR
                     TCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETE
                     TNFPEPPQDQESSPIENDSSP"
     exon            538..657
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            658..714
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            715..951
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1053
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..3556
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2769
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="major polyA site"
     polyA_site      2780
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="major polyA site"
     regulatory      2832..2837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="hexamer: AATAAA"
     polyA_site      2862
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="major polyA site"
     regulatory      3532..3537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="hexamer: AATAAA"
     polyA_site      3556
                     /gene="MS4A1"
                     /gene_synonym="B1; Bp35; CD20; CVID5; FMC7; LEU-16; S7"
                     /note="major polyA site"
ORIGIN      
        1 actcaccctc ccagtgtgct tgagaaacaa actgcaccca ctgaactccg cagctagcat
       61 ccaaatcagc ccttgagatt tgaggccttg gagactcaga tcctgaacaa gagagaacaa
      121 aatctctact ttgatggaac ttccattctg tggggaagag actgacaata agcaattaaa
      181 taaataagaa ctcagcagta ggccttgcct cagatccaag gtcactcgga agaggccatg
      241 tctaccctca atgacactca tggaggaaat gctgagagaa gcattcagat gcatgacaca
      301 aggtaagact gccaaaaatc ttgttcttgc tctcctcatt ttgttatttg ttttattttt
      361 aggagttttg agagcaaaat gacaacaccc agaaattcag taaatgggac tttcccggca
      421 gagccaatga aaggccctat tgctatgcaa tctggtccaa aaccactctt caggaggatg
      481 tcttcactgg tgggccccac gcaaagcttc ttcatgaggg aatctaagac tttgggggct
      541 gtccagatta tgaatgggct cttccacatt gccctggggg gtcttctgat gatcccagca
      601 gggatctatg cacccatctg tgtgactgtg tggtaccctc tctggggagg cattatgtat
      661 attatttccg gatcactcct ggcagcaacg gagaaaaact ccaggaagtg tttggtcaaa
      721 ggaaaaatga taatgaattc attgagcctc tttgctgcca tttctggaat gattctttca
      781 atcatggaca tacttaatat taaaatttcc cattttttaa aaatggagag tctgaatttt
      841 attagagctc acacaccata tattaacata tacaactgtg aaccagctaa tccctctgag
      901 aaaaactccc catctaccca atactgttac agcatacaat ctctgttctt gggcattttg
      961 tcagtgatgc tgatctttgc cttcttccag gaacttgtaa tagctggcat cgttgagaat
     1021 gaatggaaaa gaacgtgctc cagacccaaa tctaacatag ttctcctgtc agcagaagaa
     1081 aaaaaagaac agactattga aataaaagaa gaagtggttg ggctaactga aacatcttcc
     1141 caaccaaaga atgaagaaga cattgaaatt attccaatcc aagaagagga agaagaagaa
     1201 acagagacga actttccaga acctccccaa gatcaggaat cctcaccaat agaaaatgac
     1261 agctctcctt aagtgatttc ttctgttttc tgtttccttt tttaaacatt agtgttcata
     1321 gcttccaaga gacatgctga ctttcatttc ttgaggtact ctgcacatac gcaccacatc
     1381 tctatctggc ctttgcatgg agtgaccata gctccttctc tcttacattg aatgtagaga
     1441 atgtagccat tgtagcagct tgtgttgtca cgcttcttct tttgagcaac tttcttacac
     1501 tgaagaaagg cagaatgagt gcttcagaat gtgatttcct actaacctgt tccttggata
     1561 ggctttttag tatagtattt ttttttgtca ttttctccat caacaaccag ggagactgca
     1621 cctgatggaa aagatatatg actgcttcat gacattccta aactatcttt tttttattcc
     1681 acatctacgt ttttggtgga gtcccttttg catcattgtt ttaaggatga taaaaaaaaa
     1741 taacaactag ggacaataca gaacccattc catttatctt tctacagggc tgacattgtg
     1801 gcacattctt agagttacca caccccatga gggaagctct aaatagccaa cacccatctg
     1861 ttttttgtaa aaacagcata gcttatacat ggacatgtct ctgccttaac ttttcctaac
     1921 tcccactcta ggctattgtt tgcatgtcta cctactttta gccattatgc gagaaaagaa
     1981 aaaaatgacc atagaaaatg ccaccatgag gtgcccaaat ttcaaataat aattaacatt
     2041 tagttatatt tataatttcc agatgacaaa gtatttcatc aaataacttc atttgatgtt
     2101 ccatgatcaa gaaagaatcc ctatctctat tttacaagta attcaaagag gccaaataac
     2161 ttgtaaacaa gaaaaggtaa cttgtcaaca gtcataacta gtaattatga gagccttgtt
     2221 tcataaccag gtcttcttac tcaaatcctg tgatgtttga aataaccaaa ttgtctctcc
     2281 aatgtctgca taaactgtga gagccaagtc aacagctttt atcaagaatt tactctctga
     2341 ccagcaataa acaagcactg agagacacag agagccagat tcagatttta cccatgggga
     2401 taaaaagact cagactttca ccacatttgg aaaactactt gcatcataaa tatataataa
     2461 ctggtagttt atatgaagca gacactaagt gctatagaca ctctcagaat atcatacttg
     2521 gaaacaatgt aattaaaatg ccgaatctga gtcaacagct gccctacttt tcaattcaga
     2581 tatactagta ccttacctag aaataatgtt aacctagggt gaagtcacta taatctgtag
     2641 tctattattt gggcatttgc tacatgatga gtgctgccag attgtggcag gtaaagagac
     2701 aatgtaattt gcactcccta tgatatttct acatttttag cgaccactag tggaagacat
     2761 tccccaaaat tagaaaaaaa ggagatagaa gatttctgtc tatgtaaagt tctcaaaatt
     2821 tgttctaaat taataaaact atctttgtgt tcttttctgc aacagatgat tccaacatgg
     2881 gtgtttgtct attcttcttt actcttgaaa cattagacca tgggaggctc ttacagcctt
     2941 gagttgatat ttatacaacc caaatctagg tttgaacggt gaggtgtcag gtcatcaaat
     3001 attcatgtct atatagtctt acacaggttc tcaaaaaaaa tgttcatggg ataggtcatt
     3061 gataatggat tccttattct gagaactcca gacgactgaa atatatgaga gaaggaaaag
     3121 gacatagtag gagcaggcct gagaaaaaaa tgaaagtcag aaatctttaa aaaaatacaa
     3181 gatcttattt ctatcttatt ttttctcctc ttctgaaata tatatgagga ttcctctcca
     3241 aacccatggt ttctctaaga attttgagtc atttgtatga cctcaaataa ttagttttag
     3301 ctgacctcac ataactcctt ataataggag acatctttaa tgtctgctat taaagaagga
     3361 tgaaaattcc tatgaccttc tccccgatta tccctttggc aatatagagt caaataataa
     3421 cattgaccaa tagtaaacat gctttgccaa gaagtagaag atatattctc tagccttagt
     3481 ttttcctccc aatttgcatt tttgtaaaaa taatgttgta tccacaaagg aaataaactt
     3541 taaaaaccca agtgca
//
