LOCUS       NM_016183               2049 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens MRT4 homolog, ribosome maturation factor (MRTO4),
            mRNA.
ACCESSION   NM_016183
VERSION     NM_016183.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Zheng,Y., Huang,Y., Li,W. and Cheng,H.
  TITLE     MRTO4 Enhances Glycolysis to Facilitate HCC Progression by
            Inhibiting ALDOB
  JOURNAL   Med Sci Monit 30, e944685 (2024)
   PUBMED   38778508
  REMARK    GeneRIF: MRTO4 Enhances Glycolysis to Facilitate HCC Progression by
            Inhibiting ALDOB.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Cao,X., Khitun,A., Harold,C.M., Bryant,C.J., Zheng,S.J.,
            Baserga,S.J. and Slavoff,S.A.
  TITLE     Nascent alt-protein chemoproteomics reveals a pre-60S assembly
            checkpoint inhibitor
  JOURNAL   Nat Chem Biol 18 (6), 643-651 (2022)
   PUBMED   35393574
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Michalec-Wawiorka,B., Wawiorka,L., Derylo,K., Krokowski,D.,
            Boguszewska,A., Molestak,E., Szajwaj,M. and Tchorzewski,M.
  TITLE     Molecular behavior of human Mrt4 protein, MRTO4, in stress
            conditions is regulated by its C-terminal region
  JOURNAL   Int J Biochem Cell Biol 69, 233-240 (2015)
   PUBMED   26494001
  REMARK    GeneRIF: Human Mrt4 undergoes phosphorylation in vivo and serines
            S229, S233, and S235 are phosphorylated by CK2 kinase in vitro.
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Michalec,B., Krokowski,D., Grela,P., Wawiorka,L., Sawa-Makarska,J.,
            Grankowski,N. and Tchorzewski,M.
  TITLE     Subcellular localization of ribosomal P0-like protein MRT4 is
            determined by its N-terminal domain
  JOURNAL   Int J Biochem Cell Biol 42 (5), 736-748 (2010)
   PUBMED   20083226
  REMARK    GeneRIF: characterization of Mrt4; findings show Mrt4 is a
            trans-acting factor involved in ribosome maturation, with
            nucleus-cytoplasm shuttling capacity
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ670859.1, AY303790.1 and
            AL035413.19.
            
            On Nov 23, 2018 this sequence version replaced NM_016183.3.
            
            Summary: This gene encodes a protein sharing a low level of
            sequence similarity with ribosomal protein P0. While the precise
            function of the encoded protein is currently unknown, it appears to
            be involved in mRNA turnover and ribosome assembly. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.735471.1,
                                           SRR1803613.8636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330263.5/ ENSP00000364320.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               BQ670859.1         180-703
            525-1036            AY303790.1         505-1016
            1037-2049           AL035413.19        110150-111162       c
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2049
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /note="MRT4 homolog, ribosome maturation factor"
                     /db_xref="GeneID:51154"
                     /db_xref="HGNC:HGNC:18477"
                     /db_xref="MIM:620476"
     exon            1..59
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..751
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /note="60S acidic ribosomal protein PO; MRT4, mRNA
                     turnover 4, homolog; ribosome assembly factor MRTO4; mRNA
                     turnover 4 homolog; MRTO4 ribosome maturation factor"
                     /codon_start=1
                     /product="mRNA turnover protein 4 homolog"
                     /protein_id="NP_057267.2"
                     /db_xref="CCDS:CCDS191.1"
                     /db_xref="GeneID:51154"
                     /db_xref="HGNC:HGNC:18477"
                     /db_xref="MIM:620476"
                     /translation="MPKSKRDKKVSLTKTAKKGLELKQNLIEELRKCVDTYKYLFIFS
                     VANMRNSKLKDIRNAWKHSRMFFGKNKVMMVALGRSPSDEYKDNLHQVSKRLRGEVGL
                     LFTNRTKEEVNEWFTKYTEMDYARAGNKAAFTVSLDPGPLEQFPHSMEPQLRQLGLPT
                     ALKRGVVTLLSDYEVCKEGDVLTPEQARVLKLFGYEMAEFKVTIKYMWDSQSGRFQQM
                     GDDLPESASESTEESDSEDDD"
     exon            60..118
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            119..222
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            223..304
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            305..372
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            373..524
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            525..601
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     exon            602..2049
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /note="hexamer: AATAAA"
     polyA_site      1368
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
     regulatory      2028..2033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /note="hexamer: AGTAAA"
     polyA_site      2049
                     /gene="MRTO4"
                     /gene_synonym="C1orf33; dJ657E11.4; MRT4"
                     /note="major polyA site"
ORIGIN      
        1 accgtcttcc gccgcacgtg gattcagcgc gatgcccaaa tccaagcgcg acaagaaagt
       61 ctccttaacc aaaactgcca agaaaggctt ggaattgaaa caaaacctga tagaagagct
      121 tcggaaatgt gtggacacct acaagtacct tttcatcttc tctgtggcca acatgaggaa
      181 cagcaagctg aaggacatcc ggaacgcctg gaagcacagc cggatgttct ttggcaaaaa
      241 caaggtgatg atggtggcct tgggtcggag cccatctgat gaatacaaag acaacctgca
      301 ccaggtcagc aaaaggttga ggggtgaggt gggtctcctg ttcaccaacc gcacaaagga
      361 ggaggtgaat gagtggttca cgaaatacac agaaatggac tacgcccgag ctggtaacaa
      421 agcagctttc actgtgagcc tggatccagg gcccctggag cagttccccc actccatgga
      481 gccacagctc aggcagctgg gcctgcccac cgccctcaag agaggtgtgg tgactctgct
      541 gtctgactac gaggtgtgca aggagggcga tgtgctgacc ccagagcagg ctcgcgtcct
      601 gaagcttttt gggtatgaga tggctgaatt caaggtgacc atcaaataca tgtgggattc
      661 acagtcggga aggttccagc agatgggaga cgacttgcca gagagcgcat ctgagtccac
      721 agaagagtca gactcagaag atgatgactg aaagggactc gggactgaag gtctcctgga
      781 agcttctggg tctcactgga ccatcaggac tgctgccgcc cctctggaga gagcagcttt
      841 ttatttgtct gtagacaggg aacatgatgg gcactgacct cctgtaaaga ataaaactgt
      901 gggccgggcg cggtggctca cgcctggaat cccagcactt tgggaagccg aggtgggcag
      961 atcataaggt cgggagatta agaccatcct ggctaacacg gtgaaacccc gtctctacta
     1021 aaaatagaaa aaaaaactag ttgggcatag tggcatgtgc ctgtagtccc agctactcag
     1081 gaggctgagg caggagaatc acttgaaccc gggaggtgga ggttgccgtg agttgagatt
     1141 ggaccactgc tctccagcct gggcaacaga gtaaaactct gtcccaaaaa aaaaaaaaga
     1201 atacaacctt gcaggatgtc tctcctggag acagcaagag ggagaggagg gagagggctc
     1261 tttcttagaa aagaggcctt tggtgagccc agaagtttga aaccagcctg ggcaattcag
     1321 caagatcccg tctctacaaa aaataaaaaa aaattagtcg tggtgccact tgcctgtggt
     1381 ccccactgct tgggaggctg aggtgggaga attgcttaag cctgagagtt ggaggctcag
     1441 tgagccatga tcatgccact gcactccagc ctgggtggcc attgaattct gcgtggattg
     1501 cctcagtttg ccttgtcagc caacttccac tggctgcctt ggcactgcca tgacagcaca
     1561 gctccacacc agagctgggg tttctcttca gtcctgggta ccccttggca gagggatttg
     1621 ctgaggaaaa ttaggtatcc ttcctagccc tccacacact tccaaaccag ggctgcggat
     1681 ctgatggatg ccaggaagac agccttgggc tgagagtgac atcactgcaa gagttgagag
     1741 ccagcgtcta aagtgtccac ggcatcctgg gaggttttat ccttggtgac tctaatggta
     1801 gatttttgtc caccttgttc tatttgcttt tgtttgtttt tgatttttct gttttaaaat
     1861 tttaaggaga gatggggttt caccatgttg cccaggctgg tctcaaactc ctgagctcaa
     1921 gcgatctacc caccttggcc tcccaaagtg ctgggattat aggtgtgagc caccgcatcc
     1981 agcccacatt gttctatttg tatttcatga aagcagttct gaatgagagt aaatcagctt
     2041 cagggtgta
//
