LOCUS       NM_020831               4522 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens myocardin related transcription factor A (MRTFA),
            transcript variant 1, mRNA.
ACCESSION   NM_020831 XM_005261693
VERSION     NM_020831.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4522)
  AUTHORS   Yang,D., Yang,D., He,Y., Liu,J., Song,Y., Zhou,Y., Jiang,L.,
            Zeng,X., Xu,X., Xu,H., Li,J. and Dan,H.
  TITLE     MRTF-A/SRF signaling suppresses invasion of oral squamous cell
            carcinoma
  JOURNAL   Oral Dis 30 (4), 1919-1934 (2024)
   PUBMED   37154247
  REMARK    GeneRIF: MRTF-A/SRF signaling suppresses invasion of oral squamous
            cell carcinoma.
REFERENCE   2  (bases 1 to 4522)
  AUTHORS   Zhang,W., Zhao,J., Deng,L., Ishimwe,N., Pauli,J., Wu,W., Shan,S.,
            Kempf,W., Ballantyne,M.D., Kim,D., Lyu,Q., Bennett,M., Rodor,J.,
            Turner,A.W., Lu,Y.W., Gao,P., Choi,M., Warthi,G., Kim,H.W.,
            Barroso,M.M., Bryant,W.B., Miller,C.L., Weintraub,N.L.,
            Maegdefessel,L., Miano,J.M., Baker,A.H. and Long,X.
  TITLE     INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth
            Muscle Inflammation via Scaffolding MKL1 and USP10
  JOURNAL   Circulation 148 (1), 47-67 (2023)
   PUBMED   37199168
  REMARK    GeneRIF: INKILN is a Novel Long Noncoding RNA Promoting Vascular
            Smooth Muscle Inflammation via Scaffolding MKL1 and USP10.
REFERENCE   3  (bases 1 to 4522)
  AUTHORS   Hayashi,K., Horoiwa,S., Mori,K., Miyata,H., Labios,R.J., Morita,T.,
            Kobayashi,Y., Yamashiro,C., Higashijima,F., Yoshimoto,T., Kimura,K.
            and Nakagawa,Y.
  TITLE     Role of CRP2-MRTF interaction in functions of myofibroblasts
  JOURNAL   Cell Struct Funct 48 (1), 83-98 (2023)
   PUBMED   37164693
  REMARK    GeneRIF: Role of CRP2-MRTF interaction in functions of
            myofibroblasts.
REFERENCE   4  (bases 1 to 4522)
  AUTHORS   Al-Hetty,H.R.A.K., Ismaeel,G.L., Mohammad,W.T., Toama,M.A.,
            Kandeel,M., Saleh,M.M. and Turki Jalil,A.
  TITLE     SRF/MRTF-A and liver cirrhosis: Pathologic associations
  JOURNAL   J Dig Dis 23 (11), 614-619 (2022)
   PUBMED   36601855
  REMARK    GeneRIF: SRF/MRTF-A and liver cirrhosis: Pathologic associations.
            Review article
REFERENCE   5  (bases 1 to 4522)
  AUTHORS   Scharenberg,M.A., Pippenger,B.E., Sack,R., Zingg,D., Ferralli,J.,
            Schenk,S., Martin,I. and Chiquet-Ehrismann,R.
  TITLE     TGF-beta-induced differentiation into myofibroblasts involves
            specific regulation of two MKL1 isoforms
  JOURNAL   J Cell Sci 127 (Pt 5), 1079-1091 (2014)
   PUBMED   24424023
  REMARK    GeneRIF: TGFB1-mediated induction of the short MKL1 isoform
            initiates progression to later stages of differentiation towards a
            stationary myofibroblast.
REFERENCE   6  (bases 1 to 4522)
  AUTHORS   Kalita,K., Kuzniewska,B. and Kaczmarek,L.
  TITLE     MKLs: co-factors of serum response factor (SRF) in neuronal
            responses
  JOURNAL   Int J Biochem Cell Biol 44 (9), 1444-1447 (2012)
   PUBMED   22626970
  REMARK    Review article
REFERENCE   7  (bases 1 to 4522)
  AUTHORS   Cen,B., Selvaraj,A., Burgess,R.C., Hitzler,J.K., Ma,Z., Morris,S.W.
            and Prywes,R.
  TITLE     Megakaryoblastic leukemia 1, a potent transcriptional coactivator
            for serum response factor (SRF), is required for serum induction of
            SRF target genes
  JOURNAL   Mol Cell Biol 23 (18), 6597-6608 (2003)
   PUBMED   12944485
  REMARK    GeneRIF: Role of MKL1 in serum induction of c-fos and other
            SRE-regulated genes with a dominant negative MKL1 mutant (DN-MKL1)
            and RNA interference (RNAi) was assessed. DN-MKL1 and RNAi
            specifically blocked SRE-dependent reporter gene activation by
            serum and RhoA
REFERENCE   8  (bases 1 to 4522)
  AUTHORS   Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X.,
            Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C.,
            Chan,L.C., Squire,J., Scherer,S.W. and Hitzler,J.K.
  TITLE     Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13)
            of acute megakaryoblastic leukemia
  JOURNAL   Nat Genet 28 (3), 220-221 (2001)
   PUBMED   11431691
REFERENCE   9  (bases 1 to 4522)
  AUTHORS   Mercher,T., Coniat,M.B., Monni,R., Mauchauffe,M., Nguyen Khac,F.,
            Gressin,L., Mugneret,F., Leblanc,T., Dastugue,N., Berger,R. and
            Bernard,O.A.
  TITLE     Involvement of a human gene related to the Drosophila spen gene in
            the recurrent t(1;22) translocation of acute megakaryocytic
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5776-5779 (2001)
   PUBMED   11344311
REFERENCE   10 (bases 1 to 4522)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z86090.10, AL031594.9 and
            AL022238.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_020831.5.
            
            Summary: The protein encoded by this gene interacts with the
            transcription factor myocardin, a key regulator of smooth muscle
            cell differentiation. The encoded protein is predominantly nuclear
            and may help transduce signals from the cytoskeleton to the
            nucleus. This gene is involved in a specific translocation event
            that creates a fusion of this gene and the RNA-binding motif
            protein-15 gene. This translocation has been associated with acute
            megakaryocytic leukemia. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (5).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037859.2, AF368061.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000355630.10/ ENSP00000347847.5
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               Z86090.10          57152-57393         c
            243-304             Z86090.10          15348-15409         c
            305-566             AL031594.9         70254-70515         c
            567-632             AL022238.1         165449-165514       c
            633-688             AL022238.1         137727-137782       c
            689-764             AL022238.1         133633-133708       c
            765-926             AL022238.1         131834-131995       c
            927-1102            AL022238.1         126434-126609       c
            1103-1252           AL022238.1         125764-125913       c
            1253-1506           AL022238.1         123075-123328       c
            1507-1678           AL022238.1         122633-122804       c
            1679-2689           AL022238.1         120602-121612       c
            2690-2842           AL022238.1         119569-119721       c
            2843-2903           AL022238.1         119214-119274       c
            2904-4522           AL022238.1         112517-114135       c
FEATURES             Location/Qualifiers
     source          1..4522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1-q13.2"
     gene            1..4522
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /note="myocardin related transcription factor A"
                     /db_xref="GeneID:57591"
                     /db_xref="HGNC:HGNC:14334"
                     /db_xref="MIM:606078"
     exon            1..242
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            243..304
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            305..566
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..3421
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /note="isoform 5 is encoded by transcript variant 1;
                     non-AUG (GUG) translation initiation codon;
                     MKL/myocardin-like protein 1; basic, SAP and coiled-coil
                     domain; megakaryoblastic leukemia 1 protein;
                     megakaryocytic acute leukemia protein; megakaryoblastic
                     leukemia (translocation) 1; alternative protein MKL1"
                     /codon_start=1
                     /transl_except=(pos:326..328,aa:Met)
                     /product="myocardin-related transcription factor A isoform
                     5"
                     /protein_id="NP_065882.2"
                     /db_xref="CCDS:CCDS93172.1"
                     /db_xref="GeneID:57591"
                     /db_xref="HGNC:HGNC:14334"
                     /db_xref="MIM:606078"
                     /translation="MDFSSVVCLPPSVIAVNGLDGGGAGENDDEPVLVSLSAAPSPQS
                     EAVANELQELSLQPELTLGLHPGRNPNLPPLSERKNVLQLKLQQRRTREELVSQGIMP
                     PLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSAEPSLQAKQLK
                     LKRARLADDLNEKIAQRPGPMELVEKNILPVESSLKEAIIVGQVNYPKVADSSSFDED
                     SSDALSPEQPASHESQGSVPSPLEARVSEPLLSATSASPTQVVSQLPMGRDSREMLFL
                     AEQPPLPPPPLLPPSLTNGTTIPTAKSTPTLIKQSQPKSASEKSQRSKKAKELKPKVK
                     KLKYHQYIPPDQKQDRGAPPMDSSYAKILQQQQLFLQLQILNQQQQQHHNYQAILPAP
                     PKSAGEALGSSGTPPVRSLSTTNSSSSSGAPGPCGLARQNSTSLTGKPGALPANLDDM
                     KVAELKQELKLRSLPVSGTKTELIERLRAYQDQISPVPGAPKAPAATSILHKAGEVVV
                     AFPAARLSTGPALVAAGLAPAEVVVATVASSGVVKFGSTGSTPPVSPTPSERSLLSTG
                     DENSTPGDTFGEMVTSPLTQLTLQASPLQILVKEEGPRAGSCCLSPGGRAELEGRDKD
                     QMLQEKDKQIEALTRMLRQKQQLVERLKLQLEQEKRAQQPAPAPAPLGTPVKQENSFS
                     SCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQL
                     LLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPGLSSGSPQQPSSQPGSPAP
                     APSAQMDLEHPLQPLFGTPTSLLKKEPPGYEEAMSQQPKQQENGSSSQQMDDLFDILI
                     QSGEISADFKEPPSLPGKEKPSPKTVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGRL
                     EDFLESSTGLPLLTSGHDGPEPLSLIDDLHSQMLSSTAILDHPPSPMDTSELHFVPEP
                     SSTMGLDLADGHLDSMDWLELSSGGPVLSLAPLSTTAPSLFSTDFLDGHDLQLHWDSC
                     L"
     exon            567..632
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            633..688
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            689..764
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            765..926
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1102
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1252
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1506
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1678
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2689
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2842
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2903
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..4522
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4504..4509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /note="hexamer: AATAAA"
     polyA_site      4522
                     /gene="MRTFA"
                     /gene_synonym="BSAC; MAL; MKL; MKL1; MRTF-A"
                     /note="major polyA site"
ORIGIN      
        1 gggcccgcag cttccgtggc tgagaggagc cggcggcggc agtgtctgtg gtggccgcgg
       61 cggcgagagc gacggtccca tctttcccac cctcttggtt gccgctggcc acacgccctc
      121 cgctggcggc gacttctcag ctccgtgcgc ccgggctgga cagtgagcct cgagaggaga
      181 cgcgggcggc tagagccgga gtggggcgag ccgcggaacc cggccgggag ccgcgcgagg
      241 cgtgatcgga gggtatggtt ggcatggaat tgaatttcat ctgtctgtgg gaattgtaag
      301 caagattgcc atcacgaaag ccaaagtgga tttctccagt gtggtgtgcc tgcccccttc
      361 cgtcattgct gtgaatgggc tggacggagg aggggccggc gaaaatgatg atgaaccagt
      421 gctcgtgtcc ttatctgcgg cacccagtcc ccagagtgaa gctgttgcca atgaactgca
      481 ggagctctcc ttgcagcccg agctgaccct aggcctccac cctggcagga atcccaattt
      541 gcctccactt agtgagcgga agaatgtgct acagttgaaa ctccagcagc gccggacccg
      601 ggaagaactg gtgagccaag ggatcatgcc gcctttgaaa agtccagccg catttcatga
      661 gcagagaagg agcttggagc gggccaggac agaggactat ctcaaacgga agattcgttc
      721 ccggccggag agatcggagc tggtcaggat gcacattttg gaagagacct cggctgagcc
      781 atccctccag gccaagcagc tgaagctgaa gagagccaga ctagccgatg acctcaatga
      841 gaagattgca cagaggcctg gccccatgga gctggtggag aagaacatcc ttcctgttga
      901 gtccagcctg aaggaagcca tcattgtggg ccaggtgaac tatcccaaag tagcagacag
      961 ctcttccttc gatgaggaca gcagcgatgc cttatccccc gagcagcctg ccagccatga
     1021 gtcccagggt tctgtgccgt cacccctgga ggcccgagtc agcgaaccac tgctcagtgc
     1081 cacctctgca tcccccaccc aggttgtgtc tcaacttccg atgggccggg attccagaga
     1141 aatgcttttc ctggcagagc agcctcctct gcctccccca cctctgctgc ctcccagcct
     1201 caccaatgga accactatcc ccactgccaa gtccaccccc acactcatta agcaaagcca
     1261 acccaagtct gccagtgaga agtcacagcg cagcaagaag gccaaggagc tgaagccaaa
     1321 ggtgaagaag ctcaagtacc accagtacat ccccccggac cagaagcagg acaggggggc
     1381 accccccatg gactcatcct acgccaagat cctgcagcag cagcagctct tcctccagct
     1441 gcagatcctc aaccagcagc agcagcagca ccacaactac caggccatcc tgcctgcccc
     1501 gccaaagtca gcaggcgagg ccctgggaag cagcgggacc cccccagtac gcagcctctc
     1561 cactaccaat agcagctcca gctcgggcgc ccctgggccc tgtgggctgg cacgtcagaa
     1621 cagcacctca ctgactggca agccgggagc cctgccggcc aacctggacg acatgaaggt
     1681 ggcagagctg aagcaggagc tgaagttgcg atcactgcct gtctcgggca ccaaaactga
     1741 gctgattgag cgccttcgag cctatcaaga ccaaatcagc cctgtgccag gagcccccaa
     1801 ggcccctgcc gccacctcta tcctgcacaa ggctggcgag gtggtggtag ccttcccagc
     1861 ggcccggctg agcacggggc cagccctggt ggcagcaggc ctggctccag ctgaggtggt
     1921 ggtggccacg gtggccagca gtggggtggt gaagtttggc agcacgggct ccacgccccc
     1981 cgtgtctccc accccctcgg agcgctcact gctcagcacg ggcgatgaaa actccacccc
     2041 cggggacacc tttggtgaga tggtgacatc acctctgacg cagctgaccc tgcaggcctc
     2101 gccactgcag atcctcgtga aggaggaggg cccccgggcc gggtcctgtt gcctgagccc
     2161 tggggggcgg gcggagctag aggggcgcga caaggaccag atgctgcagg agaaagacaa
     2221 gcagatcgag gcgctgacgc gcatgctccg gcagaagcag cagctggtgg agcggctcaa
     2281 gctgcagctg gagcaggaga agcgagccca gcagcccgcc cccgcccccg cccccctcgg
     2341 cacccccgtg aagcaggaga acagcttctc cagctgccag ctgagccagc agcccctggg
     2401 ccccgctcac ccattcaacc ccagcctggc ggccccagcc accaaccaca tagacccttg
     2461 tgctgtggcc ccggggcccc cgtccgtggt ggtgaagcag gaagccttgc agcctgagcc
     2521 cgagccggtc cccgcccccc agttgcttct ggggcctcag ggccccagcc tcatcaaggg
     2581 ggttgcacct cccaccctca tcaccgactc cacagggacc caccttgtcc tcaccgtgac
     2641 caataagaat gcagacagcc ctggcctgtc cagtgggagc ccccagcagc cctcgtccca
     2701 gcctggctct ccagcgcctg ccccctctgc ccagatggac ctggagcacc cactgcagcc
     2761 cctctttggg acccccactt ctctgctgaa gaaggaacca cctggctatg aggaagccat
     2821 gagccagcag cccaaacagc aggaaaatgg ttcctcaagc cagcagatgg acgacctgtt
     2881 tgacattctc attcagagcg gagaaatttc agcagatttc aaggagccgc catccctgcc
     2941 agggaaggag aagccatccc cgaagacagt ctgtgggtcc cccctggcag cacagccatc
     3001 accttctgct gagctccccc aggctgcccc acctcctcca ggctcaccct ccctccctgg
     3061 acgcctggag gacttcctgg agagcagcac ggggctgccc ctgctgacca gtgggcatga
     3121 cgggccagag cccctttccc tcattgacga cctccatagc cagatgctga gcagcactgc
     3181 catcctggac caccccccgt cacccatgga cacctcggaa ttgcactttg ttcctgagcc
     3241 cagcagcacc atgggcctgg acctggctga tggccacctg gacagcatgg actggctgga
     3301 gctgtcgtca ggtggtcccg tgctgagcct agcccccctc agcaccacag cccccagcct
     3361 cttctccaca gacttcctcg atggccatga tttgcagctg cactgggatt cctgcttgta
     3421 gctctctggc tcaagacggg gtggggaagg ggctgggagc cagggtactc caatgcgtgg
     3481 ctctcctgcg tgattcggcc tctccacatg gttgtgagtc ttgacaatca cagcccctgc
     3541 tttttccctt ccctgggagg ctagaacaga gaagccctta ctcctggttc agtgccacgc
     3601 agggcagagg agagcagctg tcaagaagca gccctggctc tcacgctggg gttttggaca
     3661 cacggtcagg gtcagggcca tttcagcttg acctcctttt ttgaggtcag ggggcactgt
     3721 ctgtctggct acaatttggc taaggtaggt gaagcctggc caggcgggag gcttctcttc
     3781 tgacccaggg ctgagacagg ttaaggggtg aatctccttc ctttctctcc ctgctttgct
     3841 gtgaagggag aaattagcct gggcctctac cccctattcc ctgtgtctgc caaccccagg
     3901 atcccagggc tccctgccat tttagtgtct tggtgtagtg taaccattta gtggttggtg
     3961 gcaacaattt tatgtacagg tgtatatacc tctatattat atatcgacat acatatatat
     4021 ttttgggggg gggcggacag gagatgggtg caactccctc ccatcctact ctcacagaag
     4081 ggcctggatg caaggttacc cttgagctgt gtgccacagt ctggtgccca gtctggcatg
     4141 cagctaccca ggcccaccca tcacgtgtga ttgacatgta ggtaccctgc cacggcctat
     4201 gccccacctg ccctgcttcc tggctcctta tcagtgccat gagggcagag gtgctacctg
     4261 gccttcctgc caggagctct ccacccactc acattccgtc cccgccgcct cactgcagcc
     4321 agcgtggccc taggacagga ggagcttcgg gcccagcttc accctgcggt ggggctgagg
     4381 ggtggccatc tcctgccctg gggccactgg cttcacattc tgggctgact cataggggag
     4441 taggggtgga gtcaccaaaa ccagtgctgg gacaaagatg gggaaggtgt gtgaactttt
     4501 taaaataaac acaaaaacac ag
//
