LOCUS       NM_182640               1414 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S9 (MRPS9), mRNA.
ACCESSION   NM_182640
VERSION     NM_182640.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Jiang,J., Qi,T., Li,L., Pan,Y., Huang,L., Zhu,L., Zhang,D., Ma,X.
            and Qin,Y.
  TITLE     MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits
            Neuron Apoptosis and Protects Ischemic Stroke
  JOURNAL   J Mol Neurosci 74 (1), 23 (2024)
   PUBMED   38381220
  REMARK    GeneRIF: MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway
            Inhibits Neuron Apoptosis and Protects Ischemic Stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1414)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1414)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 1414)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   6  (bases 1 to 1414)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   7  (bases 1 to 1414)
  AUTHORS   Ishiguchi,H., Izumi,H., Torigoe,T., Yoshida,Y., Kubota,H., Tsuji,S.
            and Kohno,K.
  TITLE     ZNF143 activates gene expression in response to DNA damage and
            binds to cisplatin-modified DNA
  JOURNAL   Int J Cancer 111 (6), 900-909 (2004)
   PUBMED   15300802
REFERENCE   8  (bases 1 to 1414)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1414)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 1414)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Koc,H., Moseley,A. and
            Spremulli,L.L.
  TITLE     Identification of four proteins from the small subunit of the
            mammalian mitochondrial ribosome using a proteomics approach
  JOURNAL   Protein Sci 10 (3), 471-481 (2001)
   PUBMED   11344316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DT217261.1, BC057240.1 and
            BC036575.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182640.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.174354.1,
                                           SRR5189667.233727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000258455.8/
                                                  ENSP00000258455.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DT217261.1         45-54
            11-1400             BC057240.1         9-1398
            1401-1414           BC036575.1         1398-1411
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12.1"
     gene            1..1414
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /note="mitochondrial ribosomal protein S9"
                     /db_xref="GeneID:64965"
                     /db_xref="HGNC:HGNC:14501"
                     /db_xref="MIM:611975"
     exon            1..159
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1215
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /note="28S ribosomal protein S9, mitochondrial;
                     mitochondrial small ribosomal subunit protein uS9m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS9m"
                     /protein_id="NP_872578.1"
                     /db_xref="CCDS:CCDS2065.1"
                     /db_xref="GeneID:64965"
                     /db_xref="HGNC:HGNC:14501"
                     /db_xref="MIM:611975"
                     /translation="MAAPCVSYGGAVSYRLLLWGRGSLARKQGLWKTAAPELQTNVRS
                     QILRLRHTAFVIPKKNVPTSKRETYTEDFIKKQIEEFNIGKRHLANMMGEDPETFTQE
                     DIDRAIAYLFPSGLFEKRARPVMKHPEQIFPRQRAIQWGEDGRPFHYLFYTGKQSYYS
                     LMHDVYGMLLNLEKHQSHLQAKSLLPEKTVTRDVIGSRWLIKEELEEMLVEKLSDLDY
                     MQFIRLLEKLLTSQCGAAEEEFVQRFRRSVTLESKKQLIEPVQYDEQGMAFSKSEGKR
                     KTAKAEAIVYKHGSGRIKVNGIDYQLYFPITQDREQLMFPFHFVDRLGKHDVTCTVSG
                     GGRSAQAGAIRLAMAKALCSFVTEDEVEWMRQAGLLTTDPRVRERKKPGQEGARRKFT
                     WKKR"
     exon            160..339
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            340..402
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            403..433
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            434..513
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            514..599
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            600..675
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            676..844
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            845..953
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1123
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1414
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1384..1389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /note="hexamer: AATAAA"
     polyA_site      1396
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /note="major polyA site"
     polyA_site      1414
                     /gene="MRPS9"
                     /gene_synonym="MRP-S9; RPMS9; S9mt; uS9m"
                     /note="major polyA site"
ORIGIN      
        1 ggtcctggag ctcccacagc taacatggcg gcgccctgtg tgtcctacgg cggagcagtt
       61 tcgtaccggc ttcttctctg gggtaggggt agcctcgccc ggaagcaagg cctctggaaa
      121 accgcggccc ctgagttgca aacaaatgtc agatcccaga tattaaggct aagacatact
      181 gcatttgtaa taccaaagaa aaacgttcct acctcaaaac gtgaaactta cacagaggat
      241 tttattaaaa agcagattga agagttcaac ataggaaaga gacatttagc caacatgatg
      301 ggagaagatc cagaaacttt cactcaagaa gatattgaca gagctattgc ttaccttttc
      361 ccaagtggtt tgtttgagaa acgagccagg ccagtaatga agcatcctga acagattttt
      421 ccaagacaaa gagcaatcca gtggggagaa gatggccgtc catttcacta tctcttctat
      481 actggcaaac agtcatacta ttcattaatg catgatgtat atggaatgtt actcaattta
      541 gaaaaacatc aaagtcactt gcaagccaaa agtctgctcc cagaaaaaac tgtaaccaga
      601 gacgtgattg gcagcagatg gctgattaag gaggaactag aagaaatgtt agtggaaaaa
      661 ctgtcagatc tagattatat gcagttcatt cggctgctag aaaagttatt gacatcgcag
      721 tgtggtgctg ctgaggaaga atttgtgcag aggtttcgaa gaagtgtaac tcttgaatca
      781 aaaaaacagc tgattgaacc tgtacagtat gatgagcaag gaatggcctt tagcaaaagt
      841 gaaggtaaaa gaaagactgc aaaagcagaa gcaattgttt ataaacatgg aagtggaaga
      901 ataaaagtaa atggaattga ttaccagctt tacttcccga tcacacagga cagagaacag
      961 ctgatgttcc ctttccactt tgttgaccgg ctgggaaagc acgacgtgac ctgcacagtc
     1021 tcagggggcg ggaggtcagc gcaggctgga gcaatacgac tggcaatggc aaaagccttg
     1081 tgcagctttg tcaccgagga cgaggtcgag tggatgagac aagctggact acttactact
     1141 gatccacgtg tgagggaacg gaagaagcca ggccaagagg gagcccgcag aaagtttacg
     1201 tggaagaaac gctaagggtt tgctcccagg aaaggagagg aagagctata tatatgtgcc
     1261 gacatgtggc agacacacag taaataatgg ctgaccagca tgagggcagt actgtcagaa
     1321 atttctttga gctgtgagat ggatttattt ttaaatgcta ctttgtaaag gtgaccttta
     1381 aaaaataaaa ggaaaataaa gaatgttagt ttca
//
