LOCUS       NM_015971               1204 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), mRNA.
ACCESSION   NM_015971
VERSION     NM_015971.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1204)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1204)
  AUTHORS   Menezes,M.J., Guo,Y., Zhang,J., Riley,L.G., Cooper,S.T.,
            Thorburn,D.R., Li,J., Dong,D., Li,Z., Glessner,J., Davis,R.L.,
            Sue,C.M., Alexander,S.I., Arbuckle,S., Kirwan,P., Keating,B.J.,
            Xu,X., Hakonarson,H. and Christodoulou,J.
  TITLE     Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes
            congenital sensorineural deafness, progressive hepatic and renal
            failure and lactic acidemia
  JOURNAL   Hum Mol Genet 24 (8), 2297-2307 (2015)
   PUBMED   25556185
  REMARK    GeneRIF: Study identified MRPS7 mutation as a novel cause of
            congenital sensorineural deafness and progressive hepatic and renal
            failure.
REFERENCE   4  (bases 1 to 1204)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   5  (bases 1 to 1204)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1204)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 1204)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   8  (bases 1 to 1204)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   9  (bases 1 to 1204)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 1204)
  AUTHORS   Cavdar Koc,E., Blackburn,K., Burkhart,W. and Spremulli,L.L.
  TITLE     Identification of a mammalian mitochondrial homolog of ribosomal
            protein S7
  JOURNAL   Biochem Biophys Res Commun 266 (1), 141-146 (1999)
   PUBMED   10581179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022211.5.
            
            On Nov 23, 2018 this sequence version replaced NM_015971.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein. In the
            prokaryotic ribosome, the comparable protein is thought to play an
            essential role in organizing the 3' domain of the 16 S rRNA in the
            vicinity of the P- and A-sites. Pseudogenes corresponding to this
            gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.166676.1,
                                           SRR5189667.197372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000245539.11/
                                                  ENSP00000245539.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC022211.5         151526-151630
            106-297             AC022211.5         152144-152335
            298-361             AC022211.5         152451-152514
            362-529             AC022211.5         152987-153154
            530-1204            AC022211.5         155349-156023
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1204
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /note="mitochondrial ribosomal protein S7"
                     /db_xref="GeneID:51081"
                     /db_xref="HGNC:HGNC:14499"
                     /db_xref="MIM:611974"
     exon            1..105
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..751
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /EC_number="3.6.5.3"
                     /note="30S ribosomal protein S7 homolog; 28S ribosomal
                     protein S7, mitochondrial; bMRP-27a; mitochondrial small
                     ribosomal subunit protein uS7m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS7m"
                     /protein_id="NP_057055.2"
                     /db_xref="CCDS:CCDS11718.1"
                     /db_xref="GeneID:51081"
                     /db_xref="HGNC:HGNC:14499"
                     /db_xref="MIM:611974"
                     /translation="MAAPAVKVARGWSGLALGVRRAVLQLPGLTQVRWSRYSPEFKDP
                     LIDKEYYRKPVEELTEEEKYVRELKKTQLIKAAPAGKTSSVFEDPVISKFTNMMMIGG
                     NKVLARSLMIQTLEAVKRKQFEKYHAASAEEQATIERNPYTIFHQALKNCEPMIGLVP
                     ILKGGRFYQVPVPLPDRRRRFLAMKWMITECRDKKHQRTLMPEKLSHKLLEAFHNQGP
                     VIKRKHDLHKMAEANRALAHYRWW"
     exon            106..297
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /inference="alignment:Splign:2.1.0"
     exon            298..361
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /inference="alignment:Splign:2.1.0"
     exon            362..529
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /inference="alignment:Splign:2.1.0"
     exon            530..1204
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      869..874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /note="hexamer: AAGAAA"
     polyA_site      888
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /note="major polyA site"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /note="hexamer: TATAAA"
     polyA_site      1204
                     /gene="MRPS7"
                     /gene_synonym="bMRP27a; COXPD34; MRP-S; MRP-S7; RP-S7;
                     RPMS7; S7mt; uS7m"
                     /note="major polyA site"
ORIGIN      
        1 ggggtcctcg tggccagcca agatggctgc ccccgcagtg aaggttgccc gaggatggtc
       61 gggcctggcg ttgggcgtgc ggcgggctgt cttgcagctt ccagggctaa ctcaggtgag
      121 atggagccgc tatagtcctg aattcaagga tcccttgatt gacaaggaat attatcgcaa
      181 gccagtggag gagctaactg aggaggagaa atatgttcgg gagctcaaga agactcagct
      241 catcaaagct gctccagcag ggaaaacaag ttctgtgttt gaagacccag tcatcagtaa
      301 attcaccaac atgatgatga taggaggaaa caaagtactg gccagatccc tcatgattca
      361 gactctggaa gctgtgaaaa ggaagcagtt tgagaagtac catgccgctt ctgcagagga
      421 acaggcaacc atcgaacgca acccctacac catcttccat caagcactga aaaactgtga
      481 gcctatgatt gggctggtac ccatcctcaa gggaggccgt ttctaccagg tccctgtacc
      541 cctacccgac cggcgtcgcc gcttcctagc catgaagtgg atgatcactg agtgccggga
      601 taaaaagcac cagcggacac tgatgccgga gaagctgtca cacaagctgc tggaggcttt
      661 ccataaccag ggccccgtga tcaagaggaa gcatgacttg cacaagatgg cagaggccaa
      721 ccgtgccctg gcccactacc gctggtggta gagtctccag gaggagccca gggccctctg
      781 ccgcaagaaa cagtgtgagc tactgccacg ctgaaaacta cctgtgggtt aaggatgtag
      841 ttcctttgta agggtgggca ggcctcgtaa gaaagatgta gcagcatatt cactatccgt
      901 taatccttct ttctttgagg ctggaacttg ctctctctgc ccctatttcc ttgtaaagag
      961 ggagcacatt gacttgggaa tttcctccag gaaactcagg gctgttttct cttcccttag
     1021 gttggggcgg acctttggat atataaagga agcagtttta gtatcagaaa agatttatta
     1081 gaaaattctc acgctgaact ggtgtagcat gtggtgcagc attcagtgaa actggctgga
     1141 ggaaataggc ttgtttccag agttgtcctt atacaaaatg tataaaaagc agtttctggt
     1201 gtga
//
