LOCUS       NM_032476                931 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S6 (MRPS6), mRNA.
ACCESSION   NM_032476
VERSION     NM_032476.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 931)
  AUTHORS   Lin,D., Yu,J., Lin,L., Ou,Q. and Quan,H.
  TITLE     MRPS6 modulates glucose-stimulated insulin secretion in mouse islet
            cells through mitochondrial unfolded protein response
  JOURNAL   Sci Rep 13 (1), 16173 (2023)
   PUBMED   37758822
  REMARK    GeneRIF: MRPS6 modulates glucose-stimulated insulin secretion in
            mouse islet cells through mitochondrial unfolded protein response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 931)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 931)
  AUTHORS   Oviya,R.P., Gopal,G., Shirley,S.S., Sridevi,V., Jayavelu,S. and
            Rajkumar,T.
  TITLE     Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and
            MRPS23 show dysregulation in breast cancer affecting tumorigenic
            cellular processes
  JOURNAL   Gene 790, 145697 (2021)
   PUBMED   33964376
  REMARK    GeneRIF: Mitochondrial ribosomal small subunit proteins (MRPS)
            MRPS6 and MRPS23 show dysregulation in breast cancer affecting
            tumorigenic cellular processes.
REFERENCE   4  (bases 1 to 931)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 931)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 931)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 931)
  AUTHORS   Reymond,A., Camargo,A.A., Deutsch,S., Stevenson,B.J.,
            Parmigiani,R.B., Ucla,C., Bettoni,F., Rossier,C., Lyle,R.,
            Guipponi,M., de Souza,S., Iseli,C., Jongeneel,C.V., Bucher,P.,
            Simpson,A.J. and Antonarakis,S.E.
  TITLE     Nineteen additional unpredicted transcripts from human chromosome
            21
  JOURNAL   Genomics 79 (6), 824-832 (2002)
   PUBMED   12036297
REFERENCE   8  (bases 1 to 931)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 931)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   10 (bases 1 to 931)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY061855.1 and DB571303.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032476.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that belongs to
            the ribosomal protein S6P family. Pseudogenes corresponding to this
            gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.483948.1, AY061855.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000399312.3/
                                                  ENSP00000382250.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-717               AY061855.1         56-772
            718-759             DB571303.1         259-300
            760-931             AY061855.1         815-986
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..931
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /note="mitochondrial ribosomal protein S6"
                     /db_xref="GeneID:64968"
                     /db_xref="HGNC:HGNC:14051"
                     /db_xref="MIM:611973"
     exon            1..168
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..501
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /note="28S ribosomal protein S6, mitochondrial;
                     mitochondrial small ribosomal subunit protein bS6m"
                     /codon_start=1
                     /product="small ribosomal subunit protein bS6m"
                     /protein_id="NP_115865.1"
                     /db_xref="CCDS:CCDS33548.1"
                     /db_xref="GeneID:64968"
                     /db_xref="HGNC:HGNC:14051"
                     /db_xref="MIM:611973"
                     /translation="MPRYELALILKAMQRPETAATLKRTIEALMDRGAIVRDLENLGE
                     RALPYRISAHSQQHNRGGYFLVDFYAPTAAVESMVEHLSRDIDVIRGNIVKHPLTQEL
                     KECEGIVPVPLAEKLYSTKKRKK"
     exon            169..308
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /inference="alignment:Splign:2.1.0"
     exon            309..931
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      863..868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /note="hexamer: AATAAA"
     polyA_site      885
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
     regulatory      912..917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /note="hexamer: AATAAA"
     polyA_site      931
                     /gene="MRPS6"
                     /gene_synonym="bS6m; C21orf101; MRP-S6; RPMS6; S6mt"
                     /note="major polyA site"
ORIGIN      
        1 gctttcgccg cctgggagcc gtccggcgca gcagtttcta ggtccccact gtccccgccg
       61 tcccgcccct tcgcgtcccg ggaaccggct ggcttccgag ccgcactcgc cgatcctcca
      121 ggcatgcccc gctacgagct ggctttaatc ctgaaagcca tgcagcggcc agagactgct
      181 gctactttga aacgtacgat agaggccctg atggacagag gagcaatagt gagggacttg
      241 gaaaacctgg gtgaacgagc gcttccttat aggatctctg cccacagtca gcagcacaac
      301 agaggcgggt atttcttggt ggatttttat gcacccaccg cagctgttga aagcatggtg
      361 gagcacttgt ctcgagatat agatgtgatt agagggaata ttgtcaaaca ccctctgacc
      421 caggaactaa aagaatgtga agggattgtc ccagtcccac tcgcagaaaa attatattcc
      481 acaaagaaga ggaagaagtg agaagattcg ccagatttta gccttatatg taattccttc
      541 acatttgggc agcatggacg agaaggaaga atttgcaagt ttggccttta tataagcatg
      601 tgttgcaggt gctgtttgat ttttctaagg tatttttagc ccttgatccc ctttgcttgc
      661 gagaggtggg gaactgctca ctgacagctt ctctgtaacc tgcagtacca gtggatcgtt
      721 cttgattttg ttttcattag tgtcatttct ttgtcattga ggacttttcc ccttacaaca
      781 gtaacaccat tttttgaaga gcaaaactta taatacctcc tgggattgtg agctagtcat
      841 tcagcctgtg taaccatgtg gaaataaaaa ttgacgacca atgtattata tggacaactt
      901 ttgctttgag taataaactt gattgtagga a
//
