LOCUS       NM_031902               3298 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S5 (MRPS5), transcript
            variant 1, mRNA.
ACCESSION   NM_031902
VERSION     NM_031902.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3298)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3298)
  AUTHORS   Akbergenov,R., Duscha,S., Fritz,A.K., Juskeviciene,R., Oishi,N.,
            Schmitt,K., Shcherbakov,D., Teo,Y., Boukari,H., Freihofer,P.,
            Isnard-Petit,P., Oettinghaus,B., Frank,S., Thiam,K., Rehrauer,H.,
            Westhof,E., Schacht,J., Eckert,A., Wolfer,D. and Bottger,E.C.
  TITLE     Mutant MRPS5 affects mitoribosomal accuracy and confers
            stress-related behavioral alterations
  JOURNAL   EMBO Rep 19 (11) (2018)
   PUBMED   30237157
  REMARK    GeneRIF: Mutation V336Y in MRPS5 confers mitoribosomal misreading
            in in organello translation.
REFERENCE   3  (bases 1 to 3298)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 3298)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   5  (bases 1 to 3298)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3298)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 3298)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   8  (bases 1 to 3298)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   9  (bases 1 to 3298)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 3298)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Koc,H., Moseley,A. and
            Spremulli,L.L.
  TITLE     Identification of four proteins from the small subunit of the
            mammalian mitochondrial ribosome using a proteomics approach
  JOURNAL   Protein Sci 10 (3), 471-481 (2001)
   PUBMED   11344316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092835.4.
            
            On Nov 23, 2018 this sequence version replaced NM_031902.4.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that belongs to
            the ribosomal protein S5P family. Pseudogenes corresponding to this
            gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1807429.1,
                                           SRR18074969.2316298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000272418.7/
                                                  ENSP00000272418.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC092835.4         40239-40313         c
            76-156              AC092835.4         36370-36450         c
            157-294             AC092835.4         33571-33708         c
            295-420             AC092835.4         28421-28546         c
            421-654             AC092835.4         26680-26913         c
            655-689             AC092835.4         24928-24962         c
            690-780             AC092835.4         23145-23235         c
            781-827             AC092835.4         20182-20228         c
            828-885             AC092835.4         19342-19399         c
            886-948             AC092835.4         18979-19041         c
            949-1085            AC092835.4         8891-9027           c
            1086-3298           AC092835.4         3874-6086           c
FEATURES             Location/Qualifiers
     source          1..3298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..3298
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /note="mitochondrial ribosomal protein S5"
                     /db_xref="GeneID:64969"
                     /db_xref="HGNC:HGNC:14498"
                     /db_xref="MIM:611972"
     exon            1..75
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1310
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /note="isoform a is encoded by transcript variant 1;
                     mitochondrial 28S ribosomal protein S5; 28S ribosomal
                     protein S5, mitochondrial; mitochondrial small ribosomal
                     subunit protein uS5m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS5m isoform a"
                     /protein_id="NP_114108.1"
                     /db_xref="CCDS:CCDS2010.1"
                     /db_xref="GeneID:64969"
                     /db_xref="HGNC:HGNC:14498"
                     /db_xref="MIM:611972"
                     /translation="MATAVRAVGCLPVLCSGTAGHLLGRQCSLNTLPAASILAWKSVL
                     GNGHLSSLGTRDTHPYASLSRALQTQCCISSPSHLMSQQYRPYSFFTKLTADELWKGA
                     LAETGAGAKKGRGKRTKKKKRKDLNRGQIIGEGRYGFLWPGLNVPLMKNGAVQTIAQR
                     SKEEQEKVEADMIQQREEWDRKKKMKVKRERGWSGNSWGGISLGPPDPGPCGETYEDF
                     DTRILEVRNVFTMTAKEGRKKSIRVLVAVGNGKGAAGFSIGKATDRMDAFRKAKNRAV
                     HHLHYIERYEDHTIFHDISLRFKRTHIKMKKQPKGYGLRCHRAIITICRLIGIKDMYA
                     KVSGSINMLSLTQGLFRGLSRQETHQQLADKKGLHVVEIREECGPLPIVVASPRGPLR
                     KDPEPEDEVPDVKLDWEDVKTAQGMKRSVWSNLKRAAT"
     exon            76..156
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            157..294
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            295..420
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            421..654
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            655..689
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            690..780
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            781..827
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            828..885
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            886..948
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1085
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..3298
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1440..1445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /note="hexamer: AATAAA"
     polyA_site      1460
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /note="major polyA site"
     polyA_site      2317
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /note="hexamer: TATAAA"
     regulatory      3261..3266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
                     /note="hexamer: AATAAA"
     polyA_site      3262
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
     polyA_site      3298
                     /gene="MRPS5"
                     /gene_synonym="MRP-S5; S5mt; uS5m"
ORIGIN      
        1 gcggctcgga ctccagcatg gcgaccgcgg tgcgcgctgt gggctgcctc cccgtgctgt
       61 gtagcgggac ggcaggtcat ttattgggga ggcagtgttc cctaaacacc ttaccagcag
      121 cttccatttt ggcatggaag agtgttctcg gcaatggcca tttgtcatca ctgggaacca
      181 gagacaccca tccctacgcc agcttgagcc gtgcactgca gacacaatgc tgtatttctt
      241 ctcccagtca cctgatgagc cagcagtata gaccatatag tttcttcact aaattgactg
      301 cagatgagct gtggaaaggc gctttagcag agactggtgc tggagcaaaa aaaggaagag
      361 gcaaaagaac taaaaagaag aaaagaaagg atctgaacag gggtcagatc attggtgaag
      421 ggcgttatgg ttttctatgg cccggactga atgtccctct tatgaaaaat ggagcagtgc
      481 agaccattgc ccaaagaagc aaggaagagc aggagaaggt ggaggcagac atgatccagc
      541 agagagaaga gtgggaccga aagaagaaga tgaaggttaa acgggagcga ggatggagtg
      601 gaaactcatg gggaggcatc agtcttggcc cccctgaccc tggtccctgt ggagaaacat
      661 atgaggattt tgataccagg atacttgagg taagaaacgt tttcactatg actgcgaaag
      721 agggaagaaa gaaatcgatc cgtgtcttgg tggctgtggg gaacggaaaa ggagctgcag
      781 gtttttctat tgggaaagct actgatcgga tggatgcttt caggaaagca aagaacagag
      841 cagttcacca tttgcattat atagaacgat atgaagacca tacaatattc catgatattt
      901 cattaagatt taaaaggacg catatcaaga tgaagaaaca acccaaaggt tacggcctcc
      961 gctgccacag ggccatcatc accatctgcc ggctcattgg catcaaagac atgtatgcca
     1021 aggtctctgg gtccattaat atgctcagcc tcacccaggg cctcttccgt gggctctcca
     1081 gacaggaaac ccatcaacag ctggctgata agaagggcct ccatgttgtg gaaatccggg
     1141 aggaatgtgg ccctctgccc attgtggttg cgtccccccg ggggcccttg aggaaggatc
     1201 cagagccaga agatgaggtt ccagacgtca aactggactg ggaagatgtg aagactgcac
     1261 agggaatgaa gcgctctgtg tggtctaatt tgaagagagc cgccacgtaa cctctctggc
     1321 cttgtgcagc cagttcctgt gctgccctgc acctaggaga gactcagccc ctcacagctt
     1381 gggatgttac cttgcctttt gtttgttttg agggaagttt aatctttaaa ctctttggaa
     1441 ataaataatt atagctttca tttgttgagc acatgttata tgccaatgtg atagaacctt
     1501 tacatacata tctcagttca agactacttt aaatattcat ccaaagtaac aaaagtaaat
     1561 gaattaggga gacggggtta ataatttgac ccaatcagta ataatgtaca caatgataat
     1621 tgctgtagta attatagcta atatatatga actcattcat ccaaagtgaa tgtgattaac
     1681 ttcattttac agagcagtta agtaacttga ctaccgtgag gaacttccaa accgttttcc
     1741 acagtggaaa tggaagttgt aggctactat tgggaatgtt aaatggtata ttaattgtat
     1801 accattgcaa ttttgacttg tatttccctg atggctgatg atgttgaaca tcttttcatg
     1861 tgctgattgg ccatttgtat atgttttttg gagaaatgtc tattcagagc ctttgcccat
     1921 ttaaaaagtt attttttatt attattgagt tccttatagt ttctagatat aagcccccct
     1981 atcatacatg ctttacagaa gtttttaccc attctgtgga atatatatat ttttatttct
     2041 ttgcatactc tttctgcccc acccacatcc tctttctggg acactgatga ccaaaatgtt
     2101 gaatctttta ctattgtccc gtgagtccct gaggcgctgt ttattttttt tccagtctgt
     2161 tttctctgtg ttgctcagtt taggtaattt ctattgtttt atcttcagaa taactggtta
     2221 tttactcttt cctttccatt ctgctcttga accatccatg cagtacttta actttgactg
     2281 tcattgtata tttcagttaa aatttccatt tggtttattt tttatgtctt ctctttattt
     2341 gctgaggcta tttgctgaga cttttttttt ctttaaatgg cttcaagagt gtttataatt
     2401 gctcactgaa gcatttttat ggtggctgct ttaaaatctt tgtcatcagg taggtgtggt
     2461 ggctcacgcc tataacccca gcactttgtg aaggtgaggc aggaggattg cttcagccca
     2521 ggagtttgag atcagcctag gcaacaaagt gagacctcat ctctacaaaa agtaaaagta
     2581 aatttaaaag ttagacacac atggtggtgt atgcctgtag tcccagctac ataggaggct
     2641 gaagtgggag gatcatttga ttgcaggagg ttgaggctgc agtgagcctt gttcatgcca
     2701 ctccagcctg ggtggcagag tgagaccttg tctccaaaaa aaaaaaaaaa attgtcataa
     2761 agtttcaaca tctgtgtcat cttagtgttg acatcccttg aggttttttc tcattcaagt
     2821 ttacaatgtc ctagttcttg ttatgatgag tgactttggc tgtatcctgg tcatcttcac
     2881 tgttatgaag ctctgggagt tatttaaatc tctcagcatg cttcctctga cggtgctggt
     2941 atgggatggg gcactgcctc gttactgcct ggtgaggatg gagatccagg tttcctcctg
     3001 tcgctgtcct cgggacctct gctgaggcct ttctgctgga agtaggagga gcaccctaat
     3061 ggcaccgtgg gatagggagc aggccatgtt aggctggatg gtgaaagttt tcagcctgtg
     3121 acgttgtctg gtgtgggtgg gtcccctttt tttgtgtgtg gtattttgct agagtaaggt
     3181 agttatttcc taaaacttat ctgtcctgtt agttttcctt cttaagtacc taacaaatat
     3241 aaagacaatg aactttaagc aataaaagac aatgatcctt tggagagggg aaacaaaa
//
