LOCUS       NM_021821               1829 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S35 (MRPS35),
            transcript variant 1, mRNA.
ACCESSION   NM_021821
VERSION     NM_021821.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1829)
  AUTHORS   Jiang,C., Jiang,Z. and Zhang,X.
  TITLE     Circular RNA circMRPS35 represses malignant progression in
            osteosarcoma cells via targeting miR-105-5p/FOXO1
  JOURNAL   Aging (Albany NY) 16 (15), 11568-11576 (2024)
   PUBMED   39103205
  REMARK    GeneRIF: Circular RNA circMRPS35 represses malignant progression in
            osteosarcoma cells via targeting miR-105-5p/FOXO1.
REFERENCE   2  (bases 1 to 1829)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1829)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1829)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 1829)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   6  (bases 1 to 1829)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1829)
  AUTHORS   Ishiguchi,H., Izumi,H., Torigoe,T., Yoshida,Y., Kubota,H., Tsuji,S.
            and Kohno,K.
  TITLE     ZNF143 activates gene expression in response to DNA damage and
            binds to cisplatin-modified DNA
  JOURNAL   Int J Cancer 111 (6), 900-909 (2004)
   PUBMED   15300802
REFERENCE   8  (bases 1 to 1829)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1829)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 1829)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Koc,H., Moseley,A. and
            Spremulli,L.L.
  TITLE     Identification of four proteins from the small subunit of the
            mammalian mitochondrial ribosome using a proteomics approach
  JOURNAL   Protein Sci 10 (3), 471-481 (2001)
   PUBMED   11344316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA747094.1 and BC015862.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021821.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that has had
            confusing nomenclature in the literature. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. Pseudogenes corresponding to this gene are found on
            chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015862.1, SRR3476690.366597.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000081029.8/
                                                  ENSP00000081029.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               DA747094.1         60-562
            504-1829            BC015862.1         508-1833
FEATURES             Location/Qualifiers
     source          1..1829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..1829
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /note="mitochondrial ribosomal protein S35"
                     /db_xref="GeneID:60488"
                     /db_xref="HGNC:HGNC:16635"
                     /db_xref="MIM:611995"
     exon            1..124
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..984
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mitochondrial ribosomal protein S28; 28S
                     ribosomal protein S35, mitochondrial; S28mt; S35mt;
                     MRP-S35; 28S ribosomal protein S28, mitochondrial;
                     mitochondrial small ribosomal subunit protein mS35"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS35 isoform 1
                     precursor"
                     /protein_id="NP_068593.2"
                     /db_xref="CCDS:CCDS8714.1"
                     /db_xref="GeneID:60488"
                     /db_xref="HGNC:HGNC:16635"
                     /db_xref="MIM:611995"
                     /translation="MAAAALPAWLSLQSRARTLRAFSTAVYSATPVPTPSLPERTPGN
                     ERPPRRKALPPRTEKMAVDQDWPSVYPVAAPFKPSAVPLPVRMGYPVKKGVPMAKEGN
                     LELLKIPNFLHLTPVAIKKHCEALKDFCTEWPAALDSDEKCEKHFPIEIDSTDYVSSG
                     PSVRNPRARVVVLRVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQN
                     YDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNM
                     EINKEELLGTKEIEEYKKSVVSLKNEEENENSISQYKESVKRLLNVT"
     exon            125..165
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     exon            166..333
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     exon            334..394
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     exon            395..534
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     exon            535..644
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     exon            645..714
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1829
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1808..1813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /note="hexamer: AATAAA"
     polyA_site      1829
                     /gene="MRPS35"
                     /gene_synonym="HDCMD11P; MDS023; MRP-S28; MRPS28; mS35"
                     /note="major polyA site"
ORIGIN      
        1 gtcctcgcag ccatggcggc cgccgcgctc ccagcatggc tgtctctgca gtcgagggca
       61 aggactctgc gtgcattctc cactgccgtc tactcggcca ctccggtccc gacacctagc
      121 ctgccggaaa gaacacccgg aaatgaaagg ccaccaagaa gaaaggcact acctcctagg
      181 acagagaaaa tggctgttga ccaggactgg cctagtgttt acccagttgc agcaccattt
      241 aaaccctctg cagtacctct tcctgttcga atgggttatc cagtaaaaaa gggcgtgccc
      301 atggcaaagg agggaaatct agaactttta aagattccca attttctgca tttgactcct
      361 gtagcaatta aaaagcactg tgaagccctt aaagattttt gcactgagtg gccagccgca
      421 ctggacagtg acgagaaatg tgagaagcat tttccaattg aaattgacag cactgattat
      481 gtttcatcag gaccatctgt tcggaacccc agagcacgag tagtagtctt aagagtaaag
      541 ctttccagtt tgaatttaga tgatcacgca aagaagaaat taattaaact tgtaggagag
      601 cgatactgca agaccacaga tgtgcttacc atcaaaacag ataggtgccc tttaaggagg
      661 cagaattacg attatgcagt gtatctacta acagtgttat accatgagtc ttggaatact
      721 gaagaatggg aaaaaagtaa gactgaagca gacatggaag agtatatatg ggaaaatagc
      781 tcatcagaaa gaaatatcct ggaaacgctt ctccagatga aagctgctga gaaaaatatg
      841 gaaataaata aagaagagct ccttggtact aaagaaattg aagagtacaa aaagtctgtt
      901 gttagtctta aaaatgagga ggaaaatgaa aattccattt ctcagtacaa agaatccgtg
      961 aagagactat taaatgtgac atgaattatg gagtagaaaa atctgcttga tttattaatt
     1021 ttatgatata tgtgatcagt atctaatttg atataaaatt gaaaatgtta aaaaatcatt
     1081 ttttttcctc agagttaaaa ttatttccct catactaatg cttaatggca atgattactc
     1141 cagagttttt taatttttac actggggcaa tagactagga ggtctctgat ttcttcttgg
     1201 tctaaagtgt tttgatttta tttctacata atagctttgg tattcatgta tatacatgca
     1261 tttaattgtg attttatcac ctttcccatt tctttcccca caagctggca tttcagtagt
     1321 tgcttttgaa taatggtttt ggttacctgg gaaggcaggc ccagaaccca tttccttgac
     1381 ttgcagttcc gggctgtgtt cacatgactg ctgtctagct gatgcatttt tcacatttgt
     1441 caactctggt tagaaacagg tcctcaggag tattctctaa cctgatattt tctaaaaaga
     1501 tatgttgatt caactttgtt tagcatccta ctttctagat tgtggggctc attttgccag
     1561 ggccaagcta ccagaaaagt agaagtggag attacctggt atgtatctct ctgggtgccc
     1621 cagttagagc tgccacagct caggaaaaag atgaggcata acgaccttga atgtaattgg
     1681 agtaagtgac aaaataagaa ctaccctggg aaaccctgca ttcaatgtag ctgtcaattc
     1741 agtattttta agtacacctg tcagctgttt cttaccactt cgatggttgt gattaattta
     1801 aaatcaaaat aaaggaatta ctgagttta
//
